JPS588044A - １１−デオキソグリチルレチン酸水素マレ−ト及びそれを有効成分とする医薬 - Google Patents

１１−デオキソグリチルレチン酸水素マレ−ト及びそれを有効成分とする医薬

Info

Publication number
JPS588044A
JPS588044A JP56104406A JP10440681A JPS588044A JP S588044 A JPS588044 A JP S588044A JP 56104406 A JP56104406 A JP 56104406A JP 10440681 A JP10440681 A JP 10440681A JP S588044 A JPS588044 A JP S588044A
Authority
JP
Japan
Prior art keywords
deoxoglycyrrhetinic
compound
acid
formula
ulcer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56104406A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0148254B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Shigeru Toyoshima
豊島　滋
Hajime Fujimura
一 藤村
Shunsuke Ito
俊介 伊藤
Yasuharu Kondo
近藤　安治
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MARUZEN SEIYAKU KK
Original Assignee
MARUZEN SEIYAKU KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MARUZEN SEIYAKU KK filed Critical MARUZEN SEIYAKU KK
Priority to JP56104406A priority Critical patent/JPS588044A/ja
Priority to US06/394,114 priority patent/US4448788A/en
Priority to AT82105994T priority patent/ATE13523T1/de
Priority to DE8282105994T priority patent/DE3263882D1/de
Priority to EP82105994A priority patent/EP0069380B1/en
Publication of JPS588044A publication Critical patent/JPS588044A/ja
Publication of JPH0148254B2 publication Critical patent/JPH0148254B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/32—Unsaturated compounds containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/60—Maleic acid esters; Fumaric acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP56104406A 1981-07-06 1981-07-06 １１−デオキソグリチルレチン酸水素マレ−ト及びそれを有効成分とする医薬 Granted JPS588044A (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP56104406A JPS588044A (ja) 1981-07-06 1981-07-06 １１−デオキソグリチルレチン酸水素マレ−ト及びそれを有効成分とする医薬
US06/394,114 US4448788A (en) 1981-07-06 1982-07-01 11-Deoxoglycyrrhetinic acid hydrogen maleate, process for its production, and its use as a medicine
AT82105994T ATE13523T1 (de) 1981-07-06 1982-07-05 11-deoxoglycyrrhetinsaeurehydrogenmaleinat, verfahren zu dessen herstellung und seine verwendung als medikament.
DE8282105994T DE3263882D1 (en) 1981-07-06 1982-07-05 11-deoxoglycyrrhetinic acid hydrogen maleate, process for its production, and its use as a medicine
EP82105994A EP0069380B1 (en) 1981-07-06 1982-07-05 11-deoxoglycyrrhetinic acid hydrogen maleate, process for its production, and its use as a medicine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56104406A JPS588044A (ja) 1981-07-06 1981-07-06 １１−デオキソグリチルレチン酸水素マレ−ト及びそれを有効成分とする医薬

Publications (2)

Publication Number Publication Date
JPS588044A true JPS588044A (ja) 1983-01-18
JPH0148254B2 JPH0148254B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-10-18

Family

ID=14379827

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56104406A Granted JPS588044A (ja) 1981-07-06 1981-07-06 １１−デオキソグリチルレチン酸水素マレ−ト及びそれを有効成分とする医薬

Country Status (5)

Country Link
US (1) US4448788A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0069380B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS588044A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE13523T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3263882D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613613A (en) * 1983-09-13 1986-09-23 Mitsubishi Yuka Pharmaceutical Co., Ltd. γ-butyrolactone derivatives, process for preparing the same and immunomodulating compositions containing the same as active ingredients
JPS63135351A (ja) * 1986-11-28 1988-06-07 Sanwa Kagaku Kenkyusho Co Ltd グリチルレチン酸誘導体、その製法及び該化合物を有効成分とする抗潰瘍剤

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU553789B2 (en) * 1982-06-30 1986-07-24 Biorex Laboratories Ltd. Glycyrrhetinic acid derivatives in cream compositions
IT1215626B (it) * 1982-07-26 1990-02-22 Isf Spa Derivato dell'acido ursolico farmacologicamente attivo.
GB2140809A (en) * 1983-06-01 1984-12-05 Biorex Laboratories Ltd New derivatives of glycyrrhetinic acid
US4987151A (en) * 1989-06-19 1991-01-22 The Trustees Of Columbia University In The City Of New York Triterpene derivatives cholesterol acyltransferase inhibitors and methods of using same
US5519008A (en) * 1992-09-10 1996-05-21 Glycomed Incorporated Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (E-selectin) and LECAM-1 (L-selectin)
US5527890A (en) * 1993-04-16 1996-06-18 Glycomed Incorporated Derivatives of triterpenoid acids and uses thereof
GB0105772D0 (en) * 2001-03-08 2001-04-25 Sterix Ltd Use
GB0604899D0 (en) * 2006-03-10 2006-04-19 York Pharma Plc Derivatives of 18-glycyrrhetinic acid
CN101899081B (zh) * 2009-05-31 2012-09-05 江苏正大天晴药业股份有限公司 甘草次酸酯类衍生物合成方法以及脱氧甘草次酸酯化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1051001B (it) * 1971-08-06 1981-04-21 Isf Spa Processo per la preparazione dell acido 3 o beta carbossipropionil ibbeta glicirretico
GB1435622A (en) * 1973-11-07 1976-05-12 Biorex Laboratories Ltd Erythrodiol derivatives
GB1475075A (en) * 1974-09-11 1977-06-01 Biorex Laboratories Ltd Derivatives of glycyrrhetinic and oleanolic acids
GB1476053A (en) * 1975-02-07 1977-06-10 Biorex Laboratories Ltd Glycyrrhetinic acid derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4613613A (en) * 1983-09-13 1986-09-23 Mitsubishi Yuka Pharmaceutical Co., Ltd. γ-butyrolactone derivatives, process for preparing the same and immunomodulating compositions containing the same as active ingredients
JPS63135351A (ja) * 1986-11-28 1988-06-07 Sanwa Kagaku Kenkyusho Co Ltd グリチルレチン酸誘導体、その製法及び該化合物を有効成分とする抗潰瘍剤

Also Published As

Publication number Publication date
EP0069380B1 (en) 1985-05-29
JPH0148254B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-10-18
US4448788A (en) 1984-05-15
EP0069380A1 (en) 1983-01-12
ATE13523T1 (de) 1985-06-15
DE3263882D1 (en) 1985-07-04

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