DE3239360C2 - - Google Patents
Info
- Publication number
- DE3239360C2 DE3239360C2 DE3239360T DE3239360T DE3239360C2 DE 3239360 C2 DE3239360 C2 DE 3239360C2 DE 3239360 T DE3239360 T DE 3239360T DE 3239360 T DE3239360 T DE 3239360T DE 3239360 C2 DE3239360 C2 DE 3239360C2
- Authority
- DE
- Germany
- Prior art keywords
- interferon
- blood
- plasma
- patient
- absorption
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000014150 Interferons Human genes 0.000 claims description 50
- 108010050904 Interferons Proteins 0.000 claims description 50
- 229940079322 interferon Drugs 0.000 claims description 50
- 210000004369 blood Anatomy 0.000 claims description 43
- 239000008280 blood Substances 0.000 claims description 43
- 238000010521 absorption reaction Methods 0.000 claims description 18
- 208000026935 allergic disease Diseases 0.000 claims description 13
- 206010020751 Hypersensitivity Diseases 0.000 claims description 11
- 208000023275 Autoimmune disease Diseases 0.000 claims description 10
- 230000007815 allergy Effects 0.000 claims description 8
- 230000001225 therapeutic effect Effects 0.000 claims description 8
- 239000000126 substance Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 description 31
- 210000000265 leukocyte Anatomy 0.000 description 13
- 238000000034 method Methods 0.000 description 13
- 239000002594 sorbent Substances 0.000 description 13
- 239000000306 component Substances 0.000 description 8
- 239000002250 absorbent Substances 0.000 description 6
- 230000002745 absorbent Effects 0.000 description 6
- 210000003462 vein Anatomy 0.000 description 6
- 210000000601 blood cell Anatomy 0.000 description 5
- 210000001367 artery Anatomy 0.000 description 4
- 239000011324 bead Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 4
- 230000001363 autoimmune Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000009610 hypersensitivity Effects 0.000 description 3
- 102000053602 DNA Human genes 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 230000001064 anti-interferon Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 210000005003 heart tissue Anatomy 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000005373 porous glass Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000003172 anti-dna Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011049 pearl Substances 0.000 description 1
- 238000002616 plasmapheresis Methods 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
- A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Cardiology (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/247,205 US4362155A (en) | 1981-03-24 | 1981-03-24 | Method and apparatus for the treatment of autoimmune and allergic diseases |
| PCT/US1982/000332 WO1982003331A1 (en) | 1981-03-24 | 1982-03-18 | Method and apparatus for the treatment of autoimmune and allergic diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3239360T1 DE3239360T1 (de) | 1983-03-10 |
| DE3239360C2 true DE3239360C2 (enExample) | 1990-04-26 |
Family
ID=22934031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE823239360T Granted DE3239360T1 (de) | 1981-03-24 | 1982-03-18 | Verfahren und vorrichtung zur behandlung von allergischen krankheiten |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US4362155A (enExample) |
| EP (1) | EP0074999A4 (enExample) |
| JP (1) | JPS58500354A (enExample) |
| CA (1) | CA1206880A (enExample) |
| DE (1) | DE3239360T1 (enExample) |
| GB (1) | GB2122496B (enExample) |
| WO (1) | WO1982003331A1 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4605394A (en) * | 1982-12-03 | 1986-08-12 | Simon V. Skurkovich | Methods for the treatment of pathological conditions by removing interferon from the organism |
| US4824432A (en) * | 1981-03-24 | 1989-04-25 | S.V.S. Laboratories, Inc. | Method for treating AIDS and other immune deficiencies and immune disorders |
| US4362155A (en) * | 1981-03-24 | 1982-12-07 | Skurkovich Simon V | Method and apparatus for the treatment of autoimmune and allergic diseases |
| US4687808A (en) * | 1982-08-12 | 1987-08-18 | Biospecific Technologies, Inc. | Activation of biocompatible polymers with biologicals whose binding complements are pathological effectors |
| US4737544A (en) * | 1982-08-12 | 1988-04-12 | Biospecific Technologies, Inc. | Biospecific polymers |
| SE8206708D0 (sv) * | 1982-11-16 | 1982-11-25 | Gambro Ab | Kolonn for anvendning i samband med skordning av antikroppar |
| SE451946B (sv) * | 1982-12-10 | 1987-11-09 | Gambro Lundia Ab | Anordning for avlegsnande av en eller flera fraktioner ur helblod, plasma eller liknande kroppsvetskor |
| US4643718A (en) * | 1983-02-22 | 1987-02-17 | Applied Immunesciences, Inc. | Therapeutic apheresis |
| US4540401A (en) * | 1983-02-22 | 1985-09-10 | Applied Immune Sciences, Inc. | In vivo therapeutic apheresis using lipid vesicles |
| US4599306A (en) * | 1983-04-15 | 1986-07-08 | Amgen | Monoclonal antibodies which specifically bind to human immune interferon |
| US4685900A (en) * | 1983-06-01 | 1987-08-11 | Biospecific Technologies, Inc. | Therapeutic device |
| US4751181A (en) * | 1984-12-31 | 1988-06-14 | Duke University | Methods and compositions useful in the diagnosis and treatment of autoimmune diseases |
| DE3705637A1 (de) * | 1987-02-21 | 1988-09-29 | Bissendorf Peptide Gmbh | Vorrichtung zur entfernung von lokal applizierten wirkstoffen gegen solide tumoren |
| CA1335792C (en) * | 1987-08-18 | 1995-06-06 | Chaim O. Jacob | Method and dosage form using an antagonist to gamma interferon to control mhc-associated autoimmune disease |
| US5733254A (en) * | 1987-10-15 | 1998-03-31 | Cypress Bioscience, Inc. | Method for treating patients suffering from immune thrombocytopenic purpura |
| JP2673567B2 (ja) * | 1987-12-10 | 1997-11-05 | 株式会社日本抗体研究所 | 血液中の顆粒球除去方法及びこれに用いる顆粒球除去装置 |
| US4963265A (en) * | 1988-05-06 | 1990-10-16 | Applied Immunesciences, Inc. | Plasma processing device with anaphylatoxin remover |
| JPH0720493B2 (ja) * | 1988-05-06 | 1995-03-08 | アプライド イミューンサイエンシズ，インコーポレイティド | 血漿成分の変性及び再構成装置 |
| US5022988A (en) * | 1988-05-06 | 1991-06-11 | Applied Immunesciences | Device for plasma modification--composition and remodeling |
| US4964848A (en) * | 1988-06-27 | 1990-10-23 | Bloom Philip M | Treatment of multiple sclerosis with lymphocytapheresis and chemo-immunosuppression |
| US4935002A (en) * | 1988-06-29 | 1990-06-19 | Biodynamics, Inc. | Apparatus and method for the autotransfusion of blood |
| EP0426857A4 (en) * | 1989-02-08 | 1991-10-16 | Kuraray Co. Ltd. | Peptide and adsorbent comprising same immobilized on carrier |
| ATE138204T1 (de) * | 1990-03-12 | 1996-06-15 | Du Pont | Träger für biochemisch aktive substanzen |
| US5211850A (en) * | 1991-07-26 | 1993-05-18 | Research Medical, Inc. | Plasma filter sorbent system for removal of components from blood |
| US5324253A (en) * | 1992-03-02 | 1994-06-28 | Mcrea James C | Cannula apparatus and system for heparin removal from blood |
| WO1994019031A1 (en) * | 1993-02-18 | 1994-09-01 | Baxter International Inc. | Apheresis system incorporating alternative site for anticoagulant addition |
| US5888511A (en) | 1993-02-26 | 1999-03-30 | Advanced Biotherapy Concepts, Inc. | Treatment of autoimmune diseases, including AIDS |
| US6863890B1 (en) * | 1993-02-26 | 2005-03-08 | Advanced Biotherapy, Inc. | Treatment of AIDS with antibodies to gamma interferon, alpha interferon and TNF-alpha |
| US5626843A (en) * | 1993-02-26 | 1997-05-06 | Advanced Biotherapy Concepts, Inc. | Treatment of autoimmune diseases, including AIDS, by removel of interferons, TNFs and receptors therefor |
| US20030059428A1 (en) * | 1993-02-26 | 2003-03-27 | Boris Skurkovich | Treatment of autoimmune diseases |
| US5753227A (en) * | 1993-07-23 | 1998-05-19 | Strahilevitz; Meir | Extracorporeal affinity adsorption methods for the treatment of atherosclerosis, cancer, degenerative and autoimmune diseases |
| US5545339A (en) * | 1994-02-25 | 1996-08-13 | Pall Corporation | Method for processing biological fluid and treating separated component |
| US5868936A (en) * | 1996-06-20 | 1999-02-09 | Baxter International Inc. | Affinity membrane system and method of using same |
| US20030228310A1 (en) * | 1996-12-23 | 2003-12-11 | Advanced Biotherapy, Inc. | Treatment of skin diseases |
| US20030086925A1 (en) * | 1996-12-23 | 2003-05-08 | Advanced Biotherapy, Inc. | Treatment of autoimmune diseases |
| US20030223995A1 (en) * | 1996-12-23 | 2003-12-04 | Advanced Biotherapy, Inc. | Treatment of pemphigus vulgaris |
| US8197430B1 (en) * | 1998-05-22 | 2012-06-12 | Biopheresis Technologies, Inc. | Method and system to remove cytokine inhibitor in patients |
| US6620382B1 (en) * | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
| US20040199099A1 (en) * | 1998-07-10 | 2004-10-07 | Matson James R | Hemofiltration systems, methods and devices used to treat inflammatory mediator related disease |
| US6287516B1 (en) * | 1998-07-10 | 2001-09-11 | Immunocept, L.L.C. | Hemofiltration systems, methods, and devices used to treat inflammatory mediator related disease |
| AU1843200A (en) | 1998-12-09 | 2000-06-26 | Protein Design Labs, Inc. | Animal model for psoriasis for the prevention and treatment of psoriasis in humans |
| US6379708B1 (en) * | 1999-11-20 | 2002-04-30 | Cytologic, Llc | Method for enhancing immune responses in mammals |
| US7291122B2 (en) | 2000-03-24 | 2007-11-06 | Immunocept, L.L.C. | Hemofiltration methods for treatment of diseases in a mammal |
| US6736972B1 (en) | 2000-03-24 | 2004-05-18 | Immunocept, L.L.C. | Method and system for providing therapeutic agents with hemofiltration for reducing inflammatory mediator related diseases |
| US6787040B2 (en) | 2000-05-16 | 2004-09-07 | Immunocept, L.L.C. | Method and system for colloid exchange therapy |
| AU2002246955B2 (en) * | 2001-01-09 | 2007-03-22 | Baylor Research Institute | Methods for treating autoimmune diseases in a subject and in vitro diagnostic assays |
| JP2005523745A (ja) * | 2002-04-26 | 2005-08-11 | ウェルスタット バイオロジクス コーポレイション | プラズマフェレシスまたは交換輸血を用いる免疫剤治療 |
| BRPI0313399A2 (pt) * | 2002-08-13 | 2016-11-08 | Arbios Technologies Inc | terapia de troca de plasma seletiva |
| US20040052790A1 (en) * | 2002-09-18 | 2004-03-18 | Advanced Biotherapy, Inc. | Treatment of schizophrenia |
| US7022097B2 (en) | 2003-05-09 | 2006-04-04 | Morton Glickman | Method for treating glandular diseases and malignancies |
| RU2378016C2 (ru) * | 2004-04-30 | 2010-01-10 | Байофересиз Текнолоджиз, Инк. | Способ и система для удаления у пациентов растворимых tnfr1, tnfr2 и il2 |
| US20050276806A1 (en) * | 2004-06-15 | 2005-12-15 | Advanced Biotherapy, Inc. | Treatment of autism |
| CA2582471A1 (en) * | 2004-10-07 | 2006-04-13 | Universitaet Zuerich | Type i interferon blocking agents for prevention and treatment of psoriasis |
| DE102004054747A1 (de) * | 2004-11-12 | 2006-05-24 | Fresenius Medical Care Deutschland Gmbh | Verfahren und Vorrichtung zur Abreicherung wenigstens einer Komponente eines fluiden Mediums |
| US7888481B2 (en) * | 2005-02-10 | 2011-02-15 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
| CA2597265C (en) * | 2005-02-10 | 2015-03-24 | Baylor Research Institute | Anti-interferon alpha monoclonal antibodies and methods for use |
| US20070065514A1 (en) * | 2005-09-22 | 2007-03-22 | Howell Mark D | Method for enhancing immune responses in mammals |
| US9388382B2 (en) * | 2005-10-05 | 2016-07-12 | The Board Of Trustees Of The University Of Illinois | Isolation of CD14 negative, CD45 positive and CD117 positive embryonic-like stem cells free of monocytes from human umbilical cord blood mononuclear cells |
| US20080075690A1 (en) * | 2006-09-22 | 2008-03-27 | Mark Douglas Howell | Method for enhancing immune responses in mammals |
| US8835163B2 (en) * | 2006-10-18 | 2014-09-16 | The Board Of Trustees Of The University Of Illinois | Embryonic-like stem cells derived from adult human peripheral blood and methods of use |
| CN102083859B (zh) | 2008-05-07 | 2014-09-17 | 阿哥斯医疗公司 | 人源化抗人干扰素-α抗体 |
| CN102471753B (zh) * | 2009-12-08 | 2014-10-22 | 伊利诺伊大学理事会 | 干细胞免疫调节应用方法和设备 |
| WO2018119422A1 (en) * | 2016-12-22 | 2018-06-28 | Duke University | Polycationic microfibers and methods of using the same |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5239997A (en) * | 1975-09-26 | 1977-03-28 | Asahi Chemical Ind | Blood processor |
| FR2351665A1 (fr) * | 1976-05-21 | 1977-12-16 | Elf Aquitaine | Procede de purification de preparations possedant notamment une activite interferon, preparations purifiees ainsi obtenues et leur application en tant que medicament |
| NL7605805A (nl) * | 1976-05-28 | 1977-11-30 | Stichting Rega V Z W | Werkwijze voor het zuiveren van interferon. |
| JPS52155888A (en) * | 1976-06-22 | 1977-12-24 | Mitsui Toatsu Chemicals | Device for continuously removing material in blood flow |
| FR2389380B1 (enExample) * | 1977-05-02 | 1980-02-29 | Anvar | |
| US4252653A (en) * | 1978-08-25 | 1981-02-24 | Stolle Research And Development Corporation | Hemoperfusion device for specific modification or removal of components of whole blood |
| US4223672A (en) * | 1979-02-08 | 1980-09-23 | Baxter Travenol Laboratories, Inc. | Variable volume plasma treatment chamber for an apparatus for the extracorporeal treatment of disease |
| US4215688A (en) * | 1979-02-09 | 1980-08-05 | Baxter Travenol Laboratories, Inc. | Apparatus for the extracorporeal treatment of disease |
| US4362155A (en) * | 1981-03-24 | 1982-12-07 | Skurkovich Simon V | Method and apparatus for the treatment of autoimmune and allergic diseases |
-
1981
- 1981-03-24 US US06/247,205 patent/US4362155A/en not_active Expired - Fee Related
-
1982
- 1982-03-18 CA CA000398746A patent/CA1206880A/en not_active Expired
- 1982-03-18 JP JP57501221A patent/JPS58500354A/ja active Pending
- 1982-03-18 GB GB08229936A patent/GB2122496B/en not_active Expired
- 1982-03-18 DE DE823239360T patent/DE3239360T1/de active Granted
- 1982-03-18 EP EP19820901251 patent/EP0074999A4/en not_active Withdrawn
- 1982-03-18 WO PCT/US1982/000332 patent/WO1982003331A1/en not_active Ceased
- 1982-12-03 US US06/446,713 patent/US4581010A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0074999A4 (en) | 1983-07-04 |
| WO1982003331A1 (en) | 1982-10-14 |
| EP0074999A1 (en) | 1983-03-30 |
| GB2122496B (en) | 1985-03-06 |
| JPS58500354A (ja) | 1983-03-10 |
| DE3239360T1 (de) | 1983-03-10 |
| CA1206880A (en) | 1986-07-02 |
| US4581010A (en) | 1986-04-08 |
| GB2122496A (en) | 1984-01-18 |
| US4362155A (en) | 1982-12-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8127 | New person/name/address of the applicant |
Owner name: SKURKOVICH, SIMON, ROCKVILLE, MD., US |
|
| 8110 | Request for examination paragraph 44 | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |