DE3229122A1 - Anellierte 4h-1,4-benzothiazine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel - Google Patents

Anellierte 4h-1,4-benzothiazine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Info

Publication number
DE3229122A1
DE3229122A1 DE19823229122 DE3229122A DE3229122A1 DE 3229122 A1 DE3229122 A1 DE 3229122A1 DE 19823229122 DE19823229122 DE 19823229122 DE 3229122 A DE3229122 A DE 3229122A DE 3229122 A1 DE3229122 A1 DE 3229122A1
Authority
DE
Germany
Prior art keywords
general formula
compounds
alkyl
alkoxy
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19823229122
Other languages
German (de)
English (en)
Inventor
Wolf Dieter Dipl.-Chem. Dr. Busse
Rudi Dipl.-Biol. Dr. 5650 Solingen Grützmann
Mithat Dipl.-Chem. Dr. Mardin
Horst Dipl.-Chem. Dr. 5600 Wuppertal Meyer
Ekkehard Dipl.-Chem. Dr. 5600 Wuppertal Niemers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE19823229122 priority Critical patent/DE3229122A1/de
Priority to NO832625A priority patent/NO832625L/no
Priority to EP83107175A priority patent/EP0101898A1/de
Priority to PT77097A priority patent/PT77097B/pt
Priority to AU17414/83A priority patent/AU1741483A/en
Priority to IL69388A priority patent/IL69388A0/xx
Priority to JP58139537A priority patent/JPS5944370A/ja
Priority to KR1019830003619A priority patent/KR840005725A/ko
Priority to FI832784A priority patent/FI832784L/fi
Priority to GR72112A priority patent/GR79355B/el
Priority to DK354583A priority patent/DK354583A/da
Priority to ZA835673A priority patent/ZA835673B/xx
Priority to ES524713A priority patent/ES524713A0/es
Priority to HU832742A priority patent/HU189314B/hu
Priority to PH29350A priority patent/PH18784A/en
Publication of DE3229122A1 publication Critical patent/DE3229122A1/de
Priority to US06/770,895 priority patent/US4636497A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/18—[b, e]-condensed with two six-membered rings
    • C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE19823229122 1982-08-04 1982-08-04 Anellierte 4h-1,4-benzothiazine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel Withdrawn DE3229122A1 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE19823229122 DE3229122A1 (de) 1982-08-04 1982-08-04 Anellierte 4h-1,4-benzothiazine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
NO832625A NO832625L (no) 1982-08-04 1983-07-19 Anellerte 4h-1,4-bensotiazoner, fremgangsmaate til deres fremstilling og ders anvendelse som legemiddel
EP83107175A EP0101898A1 (de) 1982-08-04 1983-07-22 Anellierte 4H-1,4-Benzothiazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PT77097A PT77097B (en) 1982-08-04 1983-07-25 Process for the preparation of 4h-1,4-curied benzothiazines having a lipoxygenase inhibition effect and their application for the preparation of pharmaceutical compositions having a lipoxygenase inhibition effect
AU17414/83A AU1741483A (en) 1982-08-04 1983-07-29 4-benzothiazine derivatives
IL69388A IL69388A0 (en) 1982-08-04 1983-08-01 Fused 4h-1,4-benzothiazines,their preparation and pharmaceutical compositions containing them
JP58139537A JPS5944370A (ja) 1982-08-04 1983-08-01 融合環４ｈ−１，４−ベンゾチアジン、その製法及び医薬としての使用
KR1019830003619A KR840005725A (ko) 1982-08-04 1983-08-02 융합 4h-1,4-벤조티아진의 제조방법
FI832784A FI832784L (fi) 1982-08-04 1983-08-02 Kondenserade 4h-1,4-benzotiaziner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
GR72112A GR79355B (https=) 1982-08-04 1983-08-02
DK354583A DK354583A (da) 1982-08-04 1983-08-03 Anellerede 4h-1,4-benzothiaziner, deres fremstilling og anvendelse
ZA835673A ZA835673B (en) 1982-08-04 1983-08-03 Fused 4h-1,4-benzothiazines,processes for their preparation,and their use as medicaments
ES524713A ES524713A0 (es) 1982-08-04 1983-08-03 Procedimiento para la obtencion de 4h-1,4-benzotiazinas anilladas.
HU832742A HU189314B (en) 1982-08-04 1983-08-03 Process for producing anellated /orthocondesed/ 4h-1,4-benzothiazines and pharmaceutical compositions containing them as active agents
PH29350A PH18784A (en) 1982-08-04 1983-08-04 Fused 4h-1,4-benzothiazines,method of use and pharmaceutical composition containing them
US06/770,895 US4636497A (en) 1982-08-04 1985-08-29 Anti-thrombotic pharmaceutical compositions comprising tricyclo-4H-1,4-benzothiazine derivatives and method of use therefor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823229122 DE3229122A1 (de) 1982-08-04 1982-08-04 Anellierte 4h-1,4-benzothiazine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
DE3229122A1 true DE3229122A1 (de) 1984-02-09

Family

ID=6170117

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19823229122 Withdrawn DE3229122A1 (de) 1982-08-04 1982-08-04 Anellierte 4h-1,4-benzothiazine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Country Status (16)

Country Link
US (1) US4636497A (https=)
EP (1) EP0101898A1 (https=)
JP (1) JPS5944370A (https=)
KR (1) KR840005725A (https=)
AU (1) AU1741483A (https=)
DE (1) DE3229122A1 (https=)
DK (1) DK354583A (https=)
ES (1) ES524713A0 (https=)
FI (1) FI832784L (https=)
GR (1) GR79355B (https=)
HU (1) HU189314B (https=)
IL (1) IL69388A0 (https=)
NO (1) NO832625L (https=)
PH (1) PH18784A (https=)
PT (1) PT77097B (https=)
ZA (1) ZA835673B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0149297A1 (en) * 1983-12-27 1985-07-24 Merck Frosst Canada Inc. Process for preparing 3H-Phenothlazin-3-ones
US5994349A (en) * 1997-10-27 1999-11-30 Howard University 3-carboalkoxy-2, 3-dihydro-1H-phenothiazin-4[10H]-one derivatives

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3484745D1 (de) * 1983-10-05 1991-08-01 Merck Frosst Canada Inc Inhibitoren fuer die leukotrien-biosynthese.
EP0155623A3 (en) * 1984-03-19 1985-12-27 Merck & Co. Inc. Use of lipoxygenase inhibitors for the preparations of cytoprotective pharmaceutical compostions and process for the preparation of a cytoprotective pharmaceutical composition
US4500708A (en) * 1984-04-23 1985-02-19 G. D. Serle & Co. Benzothiazine derivatives
DE3426564A1 (de) * 1984-07-19 1986-01-30 Bayer Ag, 5090 Leverkusen Verwendung von 4h-1,4-benzothiazinen bei der prophylaxe und therapie von erkrankungen der atemwege, entzuendungen/rheuma, thromboembolischen erkrankungen, ischaemien und infarkten, herzrhythmusstoerungen, arteriosklerose und dermatosen, arzneimittel zu diesem zweck sowie wirkstoffe, die in diesen arzneimitteln enthalten sind
DE3540702A1 (de) * 1985-11-16 1987-05-21 Bayer Ag 1h-pyrido-(2,3-b) (1,4)-thiazine
DE3545097A1 (de) * 1985-12-19 1987-07-02 Bayer Ag 1-h-pyrido-(3,2-b)(1,4)-thiazine
US4921838A (en) * 1987-06-16 1990-05-01 Trustees Of Boston University Angiogenic and blood perfusion inducing properties of amphiphilic compounds
US5981294A (en) * 1995-11-29 1999-11-09 Metrika, Inc. Device for blood separation in a diagnostic device
RU2167156C1 (ru) * 2000-02-11 2001-05-20 Государственный научный центр РФ "НИОПИК" Способ получения 2-трифторметилфенотиазина

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1088055B (de) * 1958-05-16 1960-09-01 Chem Fab Promonta Ges Mit Besc Verfahren zur Herstellung von Hexahydrophenthiazin-9-dioxyden
DE1151802B (de) * 1960-04-28 1963-07-25 Chem Fab Promonta Ges Mit Besc Verfahren zur Herstellung von cycloalkylierten 2,3-Dihydro-1,4-benzthiazinen
US3422101A (en) * 1967-05-05 1969-01-14 Mcneilab Inc Tetrahydrothienobenzothiazines
US4512990A (en) * 1982-02-18 1985-04-23 Syntex (U.S.A.), Inc. Benzthiazine analogs as antiinflammatory agents

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0149297A1 (en) * 1983-12-27 1985-07-24 Merck Frosst Canada Inc. Process for preparing 3H-Phenothlazin-3-ones
US5994349A (en) * 1997-10-27 1999-11-30 Howard University 3-carboalkoxy-2, 3-dihydro-1H-phenothiazin-4[10H]-one derivatives
EP1027055A4 (en) * 1997-10-27 2001-12-05 Univ Howard 3-CARBOYLKOXY-2,3-DIHYDRO-1H-PHENOTHIAZIN-4 (10H] -ONE DERIVATIVES

Also Published As

Publication number Publication date
PT77097B (en) 1986-03-12
HU189314B (en) 1986-06-30
AU1741483A (en) 1984-02-09
IL69388A0 (en) 1983-11-30
FI832784A0 (fi) 1983-08-02
JPS5944370A (ja) 1984-03-12
ZA835673B (en) 1984-04-25
PT77097A (en) 1983-08-01
DK354583A (da) 1984-02-05
ES8404607A1 (es) 1984-05-01
FI832784A7 (fi) 1984-02-05
ES524713A0 (es) 1984-05-01
NO832625L (no) 1984-02-06
DK354583D0 (da) 1983-08-03
GR79355B (https=) 1984-10-22
KR840005725A (ko) 1984-11-16
US4636497A (en) 1987-01-13
EP0101898A1 (de) 1984-03-07
FI832784L (fi) 1984-02-05
PH18784A (en) 1985-09-25

Similar Documents

Publication Publication Date Title
DE3204126A1 (de) Pyrazoloxazine, -thiazine, -chinoline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0183159A2 (de) 1-Heteroaryl-4-aryl-pyrazolin-5-one zur Verwendung als Arzneimittel
DE3229122A1 (de) Anellierte 4h-1,4-benzothiazine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2841667A1 (de) Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
EP0185909B1 (de) 5-Alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-on-Verbindungen sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3927931A1 (de) Disubstituierte (chinolin-2-yl-methoxy)phenylessigsaeure-derivate
DE2602643A1 (de) 1,2-benzisothiazolinone-3, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3927930A1 (de) Cyclisch substituierte (chinolin-2-yl-methoxy)phenyl-essig-saeure-derivate
DE2617673A1 (de) 3,4-dihydrospiro-2h-1,3-benzoxazine
DE3532279A1 (de) 1,4-benzoxathiin-derivate
DE60311233T2 (de) Chinolinderivate
EP0072960B1 (de) 1,5-Diphenylpyrazolin-3-on-Verbindungen sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3118126A1 (de) Sulfenamide zur verwendung in arzneimitteln
DE3246148A1 (de) Pyrazolo(4.3-b)(1.4)oxazine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE2402672A1 (de) 2-(phenoxyalkylthio)-imidazole und derivate davon
EP0100527B1 (de) 4H-1,4-Benzothiazine zur Verwendung als Arzneimittel
DE3125059A1 (de) Dioxybenzoletherderivate, diese enthaltende arzneimittel, verfahren zu ihrer herstellung und ihre verwendung
EP0088323B1 (de) Imidazothiadiazolalkencarbonsäureamide, neue Zwischenprodukte zu ihrer Herstellung, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE2406198A1 (de) Verfahren zur herstellung von neuen 2-amino-6-dialkylaminodihydropyridinen und ihre verwendung als arzneimittel
DE3020421A1 (de) Imidazoazolalkensaeureamide, neue zwischenprodukte zu ihrer herstellung, ihre herstellung und ihre verwendung in arzneimitteln
EP0424722B1 (de) Substituierte (Chinolin-2-yl-methoxy)phenyl-thioharnstoffe
EP0009174A1 (de) Neue (5-(3,4-Dihydroisochinolin-1-yl)-1H-benzimidazol-2-yl)-carbaminsäurealkylester, Verfahren zu ihrer Herstellung, sie enthaltende Arzneimittel und Verfahren zur Herstellung von anthelmintisch wirksamen Mitteln
EP0064657A1 (de) Ringförmige Sulfenamide, Verfahren zu ihrer Herstellung, sie enthaltende Arzneimittel und deren Herstellung
DE2310746A1 (de) Verfahren zur herstellung von neuen 1,4-dihydrochinolinen sowie ihre verwendung als arzneimittel
EP0214437A2 (de) Verfahren zur Herstellung von 1,4-Dihydropyridinderivaten über neue Zwischenprodukte

Legal Events

Date Code Title Description
8130 Withdrawal