DE3226320C2 - - Google Patents

Info

Publication number
DE3226320C2
DE3226320C2 DE3226320A DE3226320A DE3226320C2 DE 3226320 C2 DE3226320 C2 DE 3226320C2 DE 3226320 A DE3226320 A DE 3226320A DE 3226320 A DE3226320 A DE 3226320A DE 3226320 C2 DE3226320 C2 DE 3226320C2
Authority
DE
Germany
Prior art keywords
serum
cells
medium
plasminogen activator
conditioning
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3226320A
Other languages
German (de)
English (en)
Other versions
DE3226320A1 (de
Inventor
Zvi Rehovot Il Bohak
Avinoam Petach Tikvah Il Kadouri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd filed Critical Yeda Research and Development Co Ltd
Publication of DE3226320A1 publication Critical patent/DE3226320A1/de
Application granted granted Critical
Publication of DE3226320C2 publication Critical patent/DE3226320C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6462—Plasminogen activators u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE19823226320 1981-07-15 1982-07-14 Plasminogenaktivator und verfahren zu seiner herstellung Granted DE3226320A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL63317A IL63317A (en) 1981-07-15 1981-07-15 Production of plasminogen activator

Publications (2)

Publication Number Publication Date
DE3226320A1 DE3226320A1 (de) 1983-02-10
DE3226320C2 true DE3226320C2 (OSRAM) 1989-08-17

Family

ID=11052764

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19823226320 Granted DE3226320A1 (de) 1981-07-15 1982-07-14 Plasminogenaktivator und verfahren zu seiner herstellung

Country Status (6)

Country Link
JP (1) JPS5865219A (OSRAM)
DE (1) DE3226320A1 (OSRAM)
FR (1) FR2510604B1 (OSRAM)
GB (1) GB2104081B (OSRAM)
IL (1) IL63317A (OSRAM)
IT (1) IT1195939B (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
JPS60158115A (ja) * 1984-01-30 1985-08-19 Meiji Milk Prod Co Ltd プラズミノーゲンアクチベーターの製造法
JPS60259187A (ja) * 1984-04-19 1985-12-21 マイルス・ラボラトリ−ス・インコ−ポレ−テツド プラスミノーゲン活性化因子を増収する方法
EP0163751B1 (en) * 1984-06-05 1989-09-20 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a plasminogen activator
US4550080A (en) * 1984-06-05 1985-10-29 Asahi Kasei Kogyo Kabushiki Kaisha Process for the preparation of a plasminogen activator
WO1989009257A1 (en) * 1988-03-22 1989-10-05 Invitron Corporation METHOD TO ENHANCE tPA PRODUCTION
US5210037A (en) * 1988-03-22 1993-05-11 Centocor Incorporated Method to enhance TPA production
DE4128953A1 (de) * 1991-08-30 1993-03-04 Basf Ag Verfahren zur kultivierung von saeugerzellen im fliessbettreaktor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4232124A (en) * 1979-04-23 1980-11-04 Mann George F Method of producing plasminogen activator
JPS55144887A (en) * 1979-04-26 1980-11-12 Asahi Chem Ind Co Ltd Preparation of physiologically active substance

Also Published As

Publication number Publication date
IL63317A0 (en) 1981-10-30
FR2510604B1 (fr) 1985-07-12
JPS5865219A (ja) 1983-04-18
IT1195939B (it) 1988-11-03
JPH0137115B2 (OSRAM) 1989-08-04
DE3226320A1 (de) 1983-02-10
GB2104081B (en) 1985-06-12
FR2510604A1 (fr) 1983-02-04
IT8222392A0 (it) 1982-07-14
IL63317A (en) 1985-05-31
IT8222392A1 (it) 1984-01-14
GB2104081A (en) 1983-03-02

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee