DE3209708A1 - Peptidderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel - Google Patents

Peptidderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Info

Publication number
DE3209708A1
DE3209708A1 DE19823209708 DE3209708A DE3209708A1 DE 3209708 A1 DE3209708 A1 DE 3209708A1 DE 19823209708 DE19823209708 DE 19823209708 DE 3209708 A DE3209708 A DE 3209708A DE 3209708 A1 DE3209708 A1 DE 3209708A1
Authority
DE
Germany
Prior art keywords
formula
alkyl
acid
compound
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19823209708
Other languages
German (de)
English (en)
Inventor
Jeffrey N. Yonkers N.Y. Barton
John R. Mamaroneck N.Y. Regan
John T. Greenwich Conn. Suh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
USV Pharmaceutical Corp
Original Assignee
USV Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by USV Pharmaceutical Corp filed Critical USV Pharmaceutical Corp
Publication of DE3209708A1 publication Critical patent/DE3209708A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
DE19823209708 1981-03-19 1982-03-17 Peptidderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel Withdrawn DE3209708A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24540781A 1981-03-19 1981-03-19

Publications (1)

Publication Number Publication Date
DE3209708A1 true DE3209708A1 (de) 1982-10-21

Family

ID=22926526

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19823209708 Withdrawn DE3209708A1 (de) 1981-03-19 1982-03-17 Peptidderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Country Status (21)

Country Link
JP (1) JPS57165355A (pt)
KR (1) KR890001146B1 (pt)
AU (1) AU558451B2 (pt)
BE (1) BE892552A (pt)
CH (1) CH658455A5 (pt)
DE (1) DE3209708A1 (pt)
DK (1) DK120982A (pt)
ES (3) ES510498A0 (pt)
FI (1) FI820974L (pt)
FR (1) FR2502149A1 (pt)
GB (1) GB2095252B (pt)
IE (1) IE53076B1 (pt)
IL (1) IL65247A (pt)
IN (1) IN156096B (pt)
IT (1) IT1150697B (pt)
NL (1) NL8201066A (pt)
NO (1) NO820903L (pt)
NZ (1) NZ200047A (pt)
PH (1) PH18657A (pt)
SE (1) SE8201654L (pt)
ZA (1) ZA821833B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4555502A (en) * 1982-09-30 1985-11-26 Merck & Co., Inc. Aminoacyl-containing dipeptide derivatives useful as antihypertensives
US4410807A (en) * 1982-03-26 1983-10-18 Kay Industries, Inc. Regulating device for polyphase electrical circuits
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
DE3302125A1 (de) * 1983-01-22 1984-07-26 Boehringer Ingelheim KG, 6507 Ingelheim Aminosaeure-derivate, verfahren zu ihrer herstellung und verwendung
FI841052A (fi) * 1983-03-16 1984-09-17 Usv Pharma Corp Foereningar foer behandling av blodtryckssjukdomar.
DE3333454A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3622297A1 (de) * 1986-07-03 1988-01-07 Basf Ag Disazothiophenfarbstoffe
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
ES2122941B1 (es) * 1997-05-29 1999-07-01 Esteve Quimica Sa Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.
PT1333026E (pt) 2002-01-30 2007-09-17 Servier Lab ''processo para a preparação de perindopril com elevado grau de pureza e intermediários úteis para a sua síntese''
CA2510773C (en) 2002-12-16 2010-04-13 Lupin Limited Crystalline form of quinapril hydrochloride and process for preparing the same
DE60321233D1 (de) * 2003-02-28 2008-07-03 Servier S A Lab Verfahren zur herstellung von perindopril

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
EP0278530A3 (de) * 1980-08-30 1989-08-02 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application

Also Published As

Publication number Publication date
FR2502149A1 (fr) 1982-09-24
NO820903L (no) 1982-09-20
ES8404317A1 (es) 1984-05-16
FI820974L (fi) 1982-09-20
NL8201066A (nl) 1982-10-18
ZA821833B (en) 1983-01-26
ES521031A0 (es) 1984-12-01
KR830009065A (ko) 1983-12-17
ES521030A0 (es) 1984-05-16
IE820635L (en) 1982-09-19
GB2095252A (en) 1982-09-29
AU8158482A (en) 1982-09-23
JPS57165355A (en) 1982-10-12
ES8307718A1 (es) 1983-08-01
IN156096B (pt) 1985-05-11
ES510498A0 (es) 1983-08-01
KR890001146B1 (ko) 1989-04-25
IT1150697B (it) 1986-12-17
FR2502149B1 (pt) 1985-01-18
SE8201654L (sv) 1982-09-20
AU558451B2 (en) 1987-01-29
GB2095252B (en) 1985-04-17
BE892552A (fr) 1982-09-20
NZ200047A (en) 1985-07-12
IT8220259A0 (it) 1982-03-18
IE53076B1 (en) 1988-06-08
ES8501363A1 (es) 1984-12-01
IL65247A0 (en) 1982-05-31
IL65247A (en) 1987-07-31
CH658455A5 (de) 1986-11-14
PH18657A (en) 1985-08-29
DK120982A (da) 1982-09-20

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Legal Events

Date Code Title Description
8141 Disposal/no request for examination