DE3204854C2 - 2-Amino-3-(halogenbenzoyl)-methylphenylessigsäuren, deren Ester und Salze, pharmazeutische Zubereitungen, welche diese Verbindungen enthalten - Google Patents

2-Amino-3-(halogenbenzoyl)-methylphenylessigsäuren, deren Ester und Salze, pharmazeutische Zubereitungen, welche diese Verbindungen enthalten

Info

Publication number
DE3204854C2
DE3204854C2 DE3204854A DE3204854A DE3204854C2 DE 3204854 C2 DE3204854 C2 DE 3204854C2 DE 3204854 A DE3204854 A DE 3204854A DE 3204854 A DE3204854 A DE 3204854A DE 3204854 C2 DE3204854 C2 DE 3204854C2
Authority
DE
Germany
Prior art keywords
amino
compounds
compound
sodium
chlorobenzoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3204854A
Other languages
German (de)
English (en)
Other versions
DE3204854A1 (de
Inventor
David Allan Walsh
Dwight Allen Shamblee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of DE3204854A1 publication Critical patent/DE3204854A1/de
Application granted granted Critical
Publication of DE3204854C2 publication Critical patent/DE3204854C2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32Phenylacetic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
DE3204854A 1981-02-17 1982-02-11 2-Amino-3-(halogenbenzoyl)-methylphenylessigsäuren, deren Ester und Salze, pharmazeutische Zubereitungen, welche diese Verbindungen enthalten Expired - Fee Related DE3204854C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23453181A 1981-02-17 1981-02-17

Publications (2)

Publication Number Publication Date
DE3204854A1 DE3204854A1 (de) 1982-09-09
DE3204854C2 true DE3204854C2 (de) 1994-06-16

Family

ID=22881752

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3204854A Expired - Fee Related DE3204854C2 (de) 1981-02-17 1982-02-11 2-Amino-3-(halogenbenzoyl)-methylphenylessigsäuren, deren Ester und Salze, pharmazeutische Zubereitungen, welche diese Verbindungen enthalten

Country Status (32)

Country Link
JP (1) JPS57149256A (es)
KR (1) KR880002289B1 (es)
AT (1) AT387213B (es)
AU (1) AU7950382A (es)
BE (1) BE892156A (es)
CA (1) CA1173852A (es)
CH (1) CH651294A5 (es)
DE (1) DE3204854C2 (es)
DK (1) DK155936C (es)
EG (1) EG15798A (es)
ES (1) ES8301895A1 (es)
FI (1) FI73970C (es)
FR (1) FR2499981B1 (es)
GB (1) GB2093027B (es)
GR (1) GR76516B (es)
HK (1) HK90384A (es)
HU (1) HU187644B (es)
IE (1) IE52289B1 (es)
IL (1) IL64724A0 (es)
IT (1) IT1157001B (es)
KE (1) KE3454A (es)
LU (1) LU83928A1 (es)
MY (1) MY8500908A (es)
NL (1) NL8200607A (es)
NO (1) NO160133C (es)
NZ (1) NZ199745A (es)
PL (1) PL139815B1 (es)
PT (1) PT74441B (es)
SE (1) SE453387B (es)
SG (1) SG68584G (es)
YU (1) YU44333B (es)
ZA (1) ZA82697B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683242A (en) * 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
US5475034A (en) * 1994-06-06 1995-12-12 Alcon Laboratories, Inc. Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
BR9600975A (pt) * 1996-03-11 1997-12-30 Fundacao Oswaldo Cruz Derivados do ácido gem-difluorfenilacético e de gem-difluorfenilacetamida processo de sua preparação e suas aplicações farmacêuticas
US6034266A (en) * 1996-03-11 2000-03-07 Fundacao Oswaldo Cruz-Fiocruz Gem-difluoro derivative of phenylacetamide and phenylacetic acid and their pharmaceutical uses
AR030345A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes relacionados con angiogenesis
AR030346A1 (es) 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico
WO2002078681A2 (en) 2001-04-02 2002-10-10 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac
TWI358290B (en) 2004-12-02 2012-02-21 Alcon Inc Topical nepafenac formulations

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (es) * 1967-07-31 1971-03-24
US3997368A (en) * 1975-06-24 1976-12-14 Bell Telephone Laboratories, Incorporated Elimination of stacking faults in silicon devices: a gettering process
CH577461A5 (es) * 1975-08-13 1976-07-15 Robins Co Inc A H
FR2366015A1 (fr) * 1975-11-05 1978-04-28 Robins Co Inc A H Nouveaux acides amino-2 benzoyl-3 (5 et 6) phenylacetiques et leurs esters et sels de metaux alcalins, utiles notamment comme anti-inflammatoires, et leur procede de preparation
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
KR830008990A (ko) 1983-12-16
FI73970C (fi) 1987-12-10
GB2093027B (en) 1984-07-04
IT1157001B (it) 1987-02-11
ZA82697B (en) 1983-01-26
KE3454A (en) 1984-10-12
MY8500908A (en) 1985-12-31
JPS57149256A (en) 1982-09-14
GR76516B (es) 1984-08-10
CH651294A5 (fr) 1985-09-13
AU7950382A (en) 1982-08-26
FI73970B (fi) 1987-08-31
EG15798A (en) 1986-06-30
HK90384A (en) 1984-11-23
NO820468L (no) 1982-08-18
IE52289B1 (en) 1987-09-02
ES509622A0 (es) 1982-12-16
KR880002289B1 (ko) 1988-10-22
SE453387B (sv) 1988-02-01
SG68584G (en) 1985-03-15
LU83928A1 (fr) 1983-06-07
PL235095A1 (es) 1982-11-08
DK155936B (da) 1989-06-05
IT8267152A0 (it) 1982-02-10
IE820310L (en) 1982-08-17
YU44333B (en) 1990-06-30
FR2499981A1 (fr) 1982-08-20
NO160133C (no) 1989-03-15
JPH0365338B2 (es) 1991-10-11
BE892156A (fr) 1982-06-16
IL64724A0 (en) 1982-03-31
PT74441B (pt) 1983-08-24
PL139815B1 (en) 1987-02-28
GB2093027A (en) 1982-08-25
CA1173852A (en) 1984-09-04
ATA43382A (de) 1988-05-15
DK155936C (da) 1989-11-06
AT387213B (de) 1988-12-27
NZ199745A (en) 1985-07-12
DE3204854A1 (de) 1982-09-09
ES8301895A1 (es) 1982-12-16
PT74441A (en) 1982-03-01
NO160133B (no) 1988-12-05
YU32582A (en) 1985-06-30
HU187644B (en) 1986-02-28
DK67382A (da) 1982-08-18
FR2499981B1 (fr) 1986-05-23
SE8200891L (sv) 1982-08-18
FI820392L (fi) 1982-08-18
NL8200607A (nl) 1982-09-16

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Legal Events

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8128 New person/name/address of the agent

Representative=s name: SCHWABE, H., DIPL.-ING. SANDMAIR, K., DIPL.-CHEM.

8110 Request for examination paragraph 44
8127 New person/name/address of the applicant

Owner name: A. H. ROBINS CO., INC. (N.D.GES.D.STAATES DELAWARE

8128 New person/name/address of the agent

Representative=s name: SCHWABE, H., DIPL.-ING. SANDMAIR, K., DIPL.-CHEM.

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee