AT387213B - Verfahren zur herstellung von neuen 2-amino-3(halogenbenzoyl)-methylphenylessigsaeurederivaten und von phamrazeutischen zubereitungen, welche diese enthalten - Google Patents

Verfahren zur herstellung von neuen 2-amino-3(halogenbenzoyl)-methylphenylessigsaeurederivaten und von phamrazeutischen zubereitungen, welche diese enthalten

Info

Publication number
AT387213B
AT387213B AT0043382A AT43382A AT387213B AT 387213 B AT387213 B AT 387213B AT 0043382 A AT0043382 A AT 0043382A AT 43382 A AT43382 A AT 43382A AT 387213 B AT387213 B AT 387213B
Authority
AT
Austria
Prior art keywords
phamrazeutic
halogenbenzoyl
preparations
amino
contain
Prior art date
Application number
AT0043382A
Other languages
English (en)
Other versions
ATA43382A (de
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of ATA43382A publication Critical patent/ATA43382A/de
Application granted granted Critical
Publication of AT387213B publication Critical patent/AT387213B/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32—Phenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
AT0043382A 1981-02-17 1982-02-05 Verfahren zur herstellung von neuen 2-amino-3(halogenbenzoyl)-methylphenylessigsaeurederivaten und von phamrazeutischen zubereitungen, welche diese enthalten AT387213B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23453181A 1981-02-17 1981-02-17

Publications (2)

Publication Number Publication Date
ATA43382A ATA43382A (de) 1988-05-15
AT387213B true AT387213B (de) 1988-12-27

Family

ID=22881752

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0043382A AT387213B (de) 1981-02-17 1982-02-05 Verfahren zur herstellung von neuen 2-amino-3(halogenbenzoyl)-methylphenylessigsaeurederivaten und von phamrazeutischen zubereitungen, welche diese enthalten

Country Status (32)

Country Link
JP (1) JPS57149256A (de)
KR (1) KR880002289B1 (de)
AT (1) AT387213B (de)
AU (1) AU7950382A (de)
BE (1) BE892156A (de)
CA (1) CA1173852A (de)
CH (1) CH651294A5 (de)
DE (1) DE3204854C2 (de)
DK (1) DK155936C (de)
EG (1) EG15798A (de)
ES (1) ES509622A0 (de)
FI (1) FI73970C (de)
FR (1) FR2499981B1 (de)
GB (1) GB2093027B (de)
GR (1) GR76516B (de)
HK (1) HK90384A (de)
HU (1) HU187644B (de)
IE (1) IE52289B1 (de)
IL (1) IL64724A0 (de)
IT (1) IT1157001B (de)
KE (1) KE3454A (de)
LU (1) LU83928A1 (de)
MY (1) MY8500908A (de)
NL (1) NL8200607A (de)
NO (1) NO160133C (de)
NZ (1) NZ199745A (de)
PL (1) PL139815B1 (de)
PT (1) PT74441B (de)
SE (1) SE453387B (de)
SG (1) SG68584G (de)
YU (1) YU44333B (de)
ZA (1) ZA82697B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683242A (en) * 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
US5475034A (en) * 1994-06-06 1995-12-12 Alcon Laboratories, Inc. Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders
US6034266A (en) * 1996-03-11 2000-03-07 Fundacao Oswaldo Cruz-Fiocruz Gem-difluoro derivative of phenylacetamide and phenylacetic acid and their pharmaceutical uses
BR9600975A (pt) * 1996-03-11 1997-12-30 Fundacao Oswaldo Cruz Derivados do ácido gem-difluorfenilacético e de gem-difluorfenilacetamida processo de sua preparação e suas aplicações farmacêuticas
AR030345A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes relacionados con angiogenesis
AR030346A1 (es) * 2000-08-14 2003-08-20 Alcon Inc Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico
AU2002247284A1 (en) 2001-04-02 2002-10-15 Alcon, Inc. Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac
TWI358290B (en) 2004-12-02 2012-02-21 Alcon Inc Topical nepafenac formulations

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT347433B (de) * 1975-08-13 1978-12-27 Robins Co Inc A H Verfahren zur herstellung von neuen 2-amino-3- (5- bzw. 6-)-benzoylphenylessigsaeuren, ihren alkylestern und salzen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (de) * 1967-07-31 1971-03-24
US3997368A (en) * 1975-06-24 1976-12-14 Bell Telephone Laboratories, Incorporated Elimination of stacking faults in silicon devices: a gettering process
FR2366015A1 (fr) * 1975-11-05 1978-04-28 Robins Co Inc A H Nouveaux acides amino-2 benzoyl-3 (5 et 6) phenylacetiques et leurs esters et sels de metaux alcalins, utiles notamment comme anti-inflammatoires, et leur procede de preparation
IL61945A (en) * 1980-02-19 1984-09-30 Robins Co Inc A H 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT347433B (de) * 1975-08-13 1978-12-27 Robins Co Inc A H Verfahren zur herstellung von neuen 2-amino-3- (5- bzw. 6-)-benzoylphenylessigsaeuren, ihren alkylestern und salzen

Also Published As

Publication number Publication date
ATA43382A (de) 1988-05-15
FR2499981A1 (fr) 1982-08-20
IT8267152A0 (it) 1982-02-10
ES8301895A1 (es) 1982-12-16
DK155936B (da) 1989-06-05
NL8200607A (nl) 1982-09-16
CH651294A5 (fr) 1985-09-13
JPH0365338B2 (de) 1991-10-11
FI73970C (fi) 1987-12-10
IL64724A0 (en) 1982-03-31
GB2093027A (en) 1982-08-25
SG68584G (en) 1985-03-15
CA1173852A (en) 1984-09-04
DK67382A (da) 1982-08-18
SE8200891L (sv) 1982-08-18
IE820310L (en) 1982-08-17
YU44333B (en) 1990-06-30
PT74441A (en) 1982-03-01
NZ199745A (en) 1985-07-12
FR2499981B1 (fr) 1986-05-23
IE52289B1 (en) 1987-09-02
GB2093027B (en) 1984-07-04
JPS57149256A (en) 1982-09-14
ES509622A0 (es) 1982-12-16
ZA82697B (en) 1983-01-26
DE3204854C2 (de) 1994-06-16
LU83928A1 (fr) 1983-06-07
PL235095A1 (de) 1982-11-08
HK90384A (en) 1984-11-23
DK155936C (da) 1989-11-06
KR880002289B1 (ko) 1988-10-22
DE3204854A1 (de) 1982-09-09
KE3454A (en) 1984-10-12
NO160133B (no) 1988-12-05
NO820468L (no) 1982-08-18
FI820392L (fi) 1982-08-18
EG15798A (en) 1986-06-30
IT1157001B (it) 1987-02-11
MY8500908A (en) 1985-12-31
SE453387B (sv) 1988-02-01
BE892156A (fr) 1982-06-16
KR830008990A (ko) 1983-12-16
PL139815B1 (en) 1987-02-28
GR76516B (de) 1984-08-10
NO160133C (no) 1989-03-15
YU32582A (en) 1985-06-30
HU187644B (en) 1986-02-28
FI73970B (fi) 1987-08-31
PT74441B (pt) 1983-08-24
AU7950382A (en) 1982-08-26

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EIH Change in the person of patent owner
EEIH Change in the person of patent owner
ELJ Ceased due to non-payment of the annual fee
REN Ceased due to non-payment of the annual fee