DE3152229C2 - - Google Patents

Info

Publication number
DE3152229C2
DE3152229C2 DE3152229T DE3152229T DE3152229C2 DE 3152229 C2 DE3152229 C2 DE 3152229C2 DE 3152229 T DE3152229 T DE 3152229T DE 3152229 T DE3152229 T DE 3152229T DE 3152229 C2 DE3152229 C2 DE 3152229C2
Authority
DE
Germany
Prior art keywords
lactone
hydroxy
vitamin
hydrogen
acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3152229T
Other languages
German (de)
English (en)
Other versions
DE3152229T1 (de
Inventor
H Paaren
H Deluca
M Fivizzani
H Schnoes
J Wichmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of DE3152229T1 publication Critical patent/DE3152229T1/de
Application granted granted Critical
Publication of DE3152229C2 publication Critical patent/DE3152229C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE813152229T 1980-08-04 1981-07-16 Process for preparing vitamin d-lactones Granted DE3152229T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17494480A 1980-08-04 1980-08-04
US06/228,486 US4336193A (en) 1980-08-04 1981-01-26 Process for preparing vitamin D-lactones
PCT/US1981/000961 WO1982000465A1 (en) 1980-08-04 1981-07-16 Process for preparing vitamin d-lactones

Publications (2)

Publication Number Publication Date
DE3152229T1 DE3152229T1 (de) 1982-08-26
DE3152229C2 true DE3152229C2 ( ) 1991-05-02

Family

ID=26870699

Family Applications (3)

Application Number Title Priority Date Filing Date
DE813152229T Granted DE3152229T1 (de) 1980-08-04 1981-07-16 Process for preparing vitamin d-lactones
DE3153723A Expired - Lifetime DE3153723C2 ( ) 1980-08-04 1981-07-16
DE3153427A Expired - Lifetime DE3153427C2 ( ) 1980-08-04 1981-07-16

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE3153723A Expired - Lifetime DE3153723C2 ( ) 1980-08-04 1981-07-16
DE3153427A Expired - Lifetime DE3153427C2 ( ) 1980-08-04 1981-07-16

Country Status (6)

Country Link
US (1) US4336193A ( )
JP (5) JPH0237355B2 ( )
AU (1) AU7453581A ( )
DE (3) DE3152229T1 ( )
GB (2) GB2092152B ( )
WO (1) WO1982000465A1 ( )

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3247836A1 (de) * 1981-12-29 1983-07-07 Teijin Ltd., Osaka Arzneimittel und verwendung derselben zur steuerung der serumcalciumkonzentration bei warmbluetern
US4632784A (en) * 1983-01-28 1986-12-30 Hoffmann-La Roche Inc. Process for the preparation of 1α,23,25-trihydroxycholecalciferol-26-oic acid 23,26-lactone
US4749710A (en) * 1985-05-01 1988-06-07 Hoffmann-La Roche Inc. Immunosuppressive agents
AU5185790A (en) * 1989-02-16 1990-09-05 University Of Georgia Research Foundation, Inc., The Treatment of tibial dyschondroplasia
US5366736A (en) * 1989-02-16 1994-11-22 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
US5316770A (en) * 1989-02-16 1994-05-31 University Of Georgia Research Foundation, Inc. Vitamin D derivative feed compositions and methods of use
BRPI1007415A2 (pt) * 2009-01-27 2016-02-16 Berg Biosystems Llc vitamina d3 e análogos da mesma para aliviar os efeitos colaterais associados com quimioterapia
KR101880032B1 (ko) 2009-08-14 2018-07-20 베르그 엘엘씨 탈모증 치료용 비타민 ｄ3 및 이의 유사체들
CN105492081A (zh) 2013-05-29 2016-04-13 博格有限责任公司 使用维生素d预防或减轻化疗诱发的脱发

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS46327Y1 ( ) * 1966-07-26 1971-01-08
US3547911A (en) * 1968-12-23 1970-12-15 Syntex Corp Synthesis of antheridiol and its derivatives
US4026882A (en) * 1976-03-08 1977-05-31 Hoffmann-La Roche Inc. Syntheses of 3,24R,25- and 3,24S,25-trihydroxy-5,7-cholestadiene 24,25-ketals and alkanoyl derivatives thereof
US4183852A (en) * 1977-07-18 1980-01-15 Kaiser Emil T Process for preparing 25-hydroxycholesterol
US4134904A (en) * 1977-08-30 1979-01-16 Kaiser Emil T Synthesis of steroids
JPS5822479B2 (ja) * 1977-09-07 1983-05-09 帝人株式会社 １α−ヒドロキシ−２４−オキソ−ビタミンＤ↓３およびその製造法
JPS5584324U ( ) * 1978-12-06 1980-06-10
ATE2150T1 (de) * 1979-05-18 1983-01-15 F. Hoffmann-La Roche & Co. Aktiengesellschaft Verfahren zur herstellung von cholestenderivaten und neue zwischenprodukte in deren herstellung.
JPS61278652A (ja) * 1985-06-03 1986-12-09 Matsumoto Kikai Kk タ−ニングロ−ルに於ける歩み止め装置

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Chem.Abstr., Vol. 91, Nr. 121312, 1979 *
Chem.Abstr., Vol. 91, Nr. 207725, 1979 *
Chem.Pharm.Bull., Vol. 28, 9, 1980, S. 2852-54 *
HOUBEN-WEYL: Methoden der organischen Chemie, Bd. VI/2, 1963, S. 656-57 *
Tetrahedron Letters, Vol. 21, 1980, S. 4667-70 *

Also Published As

Publication number Publication date
JPH02231449A (ja) 1990-09-13
GB8332540D0 (en) 1984-01-11
JPH0372239B2 ( ) 1991-11-18
JPH0372238B2 ( ) 1991-11-18
DE3153427C2 ( ) 1991-05-08
GB2142028B (en) 1985-09-25
GB2092152B (en) 1985-02-06
JPH02237997A (ja) 1990-09-20
US4336193A (en) 1982-06-22
GB2092152A (en) 1982-08-11
DE3152229T1 (de) 1982-08-26
JPS57501179A ( ) 1982-07-08
JPH0237355B2 ( ) 1990-08-23
DE3153723C2 ( ) 1991-07-25
JPH02237998A (ja) 1990-09-20
WO1982000465A1 (en) 1982-02-18
AU7453581A (en) 1982-03-02
JPH02231470A (ja) 1990-09-13
JPH0349902B2 ( ) 1991-07-31
GB2142028A (en) 1985-01-09

Similar Documents

Publication Publication Date Title
DE3390212C2 ( )
DE2463203C2 ( )
DE2012167C2 (de) 25-Hydroxycholecalciferol-hydrat und Verfahren sowie Zwischenprodukte zu seiner Herstellung
DE2526981C3 (de) lalpha^4-Dihyaroxycholecalciferol-Derivate, Verfahren zu ihrer Herstellung und pharmazeutische Mittel
CH658050A5 (de) Zwischenprodukte zur herstellung von 1-alpha-hydroxylierten vitamin d-derivaten.
DE3051094C2 ( )
DE3933034A1 (de) 24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung
CH641445A5 (de) Seitenketten-fluorierte vitamin d verbindungen.
DE3448360C2 ( )
DE3152229C2 ( )
DE4011682A1 (de) 24-oxa-derivate in der vitamin d-reihe
DE3490636C2 (de) Hydroxyvitamin D¶2¶-Isomere, Zwischenprodukt zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
CH647760A5 (de) Verfahren zur herstellung von 1-hydroxycalciferolen und deren derivaten.
CH650240A5 (de) 24,24-difluor-1alpha,25-dihydroxycholecalciferol.
US4367177A (en) Process for preparing 23,25-dihydroxyvitamin D3
DE3490427C2 ( )
DE3045288C2 ( )
DE3048698C2 ( )
DE3243150A1 (de) Trihydroxy-vitamin-d(pfeil abwaerts)3(pfeil abwaerts)-verbindungen
DE2812741A1 (de) Vitamin d tief 3 -derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE3590020C2 (de) In der Seitenkette ungesättigte 1-Hydroxyvitamin D-Verbindungen
EP0051247B1 (de) 4-Thia- und 4-Sulfinyl-PGI1-Derivate, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende pharmazeutische Präparate
DE1793659C3 (de) Gonan-Derivate
DE2306580C2 (de) Verfahren zur Herstellung von 16-Acylderivaten des Gitoxigenindigitoxosids
DE3106127A1 (de) Vitamin d-derivate und verfahren zu deren herstellung

Legal Events

Date Code Title Description
8172 Supplementary division/partition in:

Ref document number: 3153427

Country of ref document: DE

Q171 Divided out to:

Ref document number: 3153427

Country of ref document: DE

AH Division in

Ref document number: 3153427

Country of ref document: DE

D2 Grant after examination
AH Division in

Ref document number: 3153427

Country of ref document: DE

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee