DE3142521A1 - "verfahren und vorrichtung zum definierten abkuehlen plattenfoermiger koerper durch waermeabgabe an siedende kaeltemittel" - Google Patents
"verfahren und vorrichtung zum definierten abkuehlen plattenfoermiger koerper durch waermeabgabe an siedende kaeltemittel"Info
- Publication number
- DE3142521A1 DE3142521A1 DE19813142521 DE3142521A DE3142521A1 DE 3142521 A1 DE3142521 A1 DE 3142521A1 DE 19813142521 DE19813142521 DE 19813142521 DE 3142521 A DE3142521 A DE 3142521A DE 3142521 A1 DE3142521 A1 DE 3142521A1
- Authority
- DE
- Germany
- Prior art keywords
- container
- freezing
- cooling
- frozen food
- plastic bag
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000009835 boiling Methods 0.000 title claims abstract description 7
- 239000003507 refrigerant Substances 0.000 title claims description 11
- 238000000034 method Methods 0.000 title abstract description 46
- 238000001816 cooling Methods 0.000 claims abstract description 56
- 238000007710 freezing Methods 0.000 claims abstract description 25
- 230000008014 freezing Effects 0.000 claims abstract description 25
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000004033 plastic Substances 0.000 claims abstract description 12
- 239000007788 liquid Substances 0.000 claims abstract description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 9
- 239000000725 suspension Substances 0.000 claims abstract description 5
- 229910052751 metal Inorganic materials 0.000 claims description 7
- 239000002184 metal Substances 0.000 claims description 7
- 238000009413 insulation Methods 0.000 claims description 6
- 239000012774 insulation material Substances 0.000 claims description 5
- 238000012546 transfer Methods 0.000 claims description 3
- 238000011088 calibration curve Methods 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 22
- 210000004369 blood Anatomy 0.000 abstract description 6
- 239000008280 blood Substances 0.000 abstract description 6
- 238000004321 preservation Methods 0.000 abstract description 4
- 239000006285 cell suspension Substances 0.000 abstract description 3
- 239000002826 coolant Substances 0.000 abstract 2
- -1 for example Substances 0.000 abstract 1
- 239000012520 frozen sample Substances 0.000 abstract 1
- 238000007654 immersion Methods 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 235000013611 frozen food Nutrition 0.000 description 36
- 210000004027 cell Anatomy 0.000 description 14
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 9
- 229940050526 hydroxyethylstarch Drugs 0.000 description 9
- 210000003743 erythrocyte Anatomy 0.000 description 7
- 239000000243 solution Substances 0.000 description 6
- 238000010257 thawing Methods 0.000 description 6
- 238000011084 recovery Methods 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- 108010091326 Cryoglobulins Proteins 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 230000002528 anti-freeze Effects 0.000 description 3
- 210000000601 blood cell Anatomy 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- 235000013324 preserved food Nutrition 0.000 description 3
- 210000001185 bone marrow Anatomy 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000011810 insulating material Substances 0.000 description 2
- 229920001568 phenolic resin Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- VEMLQICWTSVKQH-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;propane-1,2,3-triol Chemical compound OCC(O)CO.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O VEMLQICWTSVKQH-BTVCFUMJSA-N 0.000 description 1
- 108010053481 Antifreeze Proteins Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 101100048435 Caenorhabditis elegans unc-18 gene Proteins 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241001024304 Mino Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920006328 Styrofoam Polymers 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000007798 antifreeze agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000011130 autologous cell therapy Methods 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 208000015294 blood coagulation disease Diseases 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 230000009852 coagulant defect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 238000005138 cryopreservation Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920003223 poly(pyromellitimide-1,4-diphenyl ether) Polymers 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 239000008261 styrofoam Substances 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003634 thrombocyte concentrate Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
- F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/142—Apparatus
- A01N1/144—Apparatus for temperature control, e.g. refrigerators or freeze-drying apparatus
- A01N1/145—Stationary or portable vessels generating cryogenic temperatures, e.g. liquid nitrogen baths
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Combustion & Propulsion (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Thermal Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813142521 DE3142521A1 (de) | 1981-10-27 | 1981-10-27 | "verfahren und vorrichtung zum definierten abkuehlen plattenfoermiger koerper durch waermeabgabe an siedende kaeltemittel" |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19813142521 DE3142521A1 (de) | 1981-10-27 | 1981-10-27 | "verfahren und vorrichtung zum definierten abkuehlen plattenfoermiger koerper durch waermeabgabe an siedende kaeltemittel" |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3142521A1 true DE3142521A1 (de) | 1983-07-21 |
| DE3142521C2 DE3142521C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1987-11-19 |
Family
ID=6144905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19813142521 Granted DE3142521A1 (de) | 1981-10-27 | 1981-10-27 | "verfahren und vorrichtung zum definierten abkuehlen plattenfoermiger koerper durch waermeabgabe an siedende kaeltemittel" |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE3142521A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2633036A1 (fr) * | 1988-06-21 | 1989-12-22 | Inst Kriobiologii | Appareil pour le refroidissement et la congelation d'objets biologiques |
| US5105627A (en) * | 1990-04-20 | 1992-04-21 | Nihon Freezer Co., Ltd. | Cryopreservation container of animal cell |
| WO1997043586A1 (de) * | 1996-05-11 | 1997-11-20 | Bernd Mingers | Verfahren und vorrichtung zum gefrieren von zellsuspensionen |
| DE19716913A1 (de) * | 1997-04-23 | 1998-11-05 | Mingers Bernd Dipl Ing | Modulare Lagervorrichtung zur tiefkalten Aufbewahrung von mit tiefgefrorener Zellsuspension befüllten, flächigen Kunststoffbeuteln |
| WO1999010693A2 (de) | 1997-08-21 | 1999-03-04 | Ingo Heschel | Verfahren und vorrichtung zum kühlen, insbesondere gefrieren eines kühlgutes |
| US8177123B2 (en) | 2008-09-24 | 2012-05-15 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| US9161527B2 (en) | 2007-12-21 | 2015-10-20 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
-
1981
- 1981-10-27 DE DE19813142521 patent/DE3142521A1/de active Granted
Non-Patent Citations (2)
| Title |
|---|
| US-Z.: "Cryo-Letters", 2, (1981), S. 247-256 * |
| US-Z.: "Cryo-Letters", 2, (1981), S. 291-300 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2633036A1 (fr) * | 1988-06-21 | 1989-12-22 | Inst Kriobiologii | Appareil pour le refroidissement et la congelation d'objets biologiques |
| US5105627A (en) * | 1990-04-20 | 1992-04-21 | Nihon Freezer Co., Ltd. | Cryopreservation container of animal cell |
| WO1997043586A1 (de) * | 1996-05-11 | 1997-11-20 | Bernd Mingers | Verfahren und vorrichtung zum gefrieren von zellsuspensionen |
| DE19716913A1 (de) * | 1997-04-23 | 1998-11-05 | Mingers Bernd Dipl Ing | Modulare Lagervorrichtung zur tiefkalten Aufbewahrung von mit tiefgefrorener Zellsuspension befüllten, flächigen Kunststoffbeuteln |
| WO1999010693A2 (de) | 1997-08-21 | 1999-03-04 | Ingo Heschel | Verfahren und vorrichtung zum kühlen, insbesondere gefrieren eines kühlgutes |
| US6393860B1 (en) | 1997-08-21 | 2002-05-28 | Ingo Heschel | Method and device for refrigerating a sample |
| US9161527B2 (en) | 2007-12-21 | 2015-10-20 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| US9301520B2 (en) | 2007-12-21 | 2016-04-05 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| US9933113B2 (en) | 2007-12-21 | 2018-04-03 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| US10088106B2 (en) | 2007-12-21 | 2018-10-02 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
| US8177123B2 (en) | 2008-09-24 | 2012-05-15 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
Also Published As
| Publication number | Publication date |
|---|---|
| DE3142521C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1987-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |