DE3100968A1 - Anthracyclinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel - Google Patents

Anthracyclinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Info

Publication number
DE3100968A1
DE3100968A1 DE19813100968 DE3100968A DE3100968A1 DE 3100968 A1 DE3100968 A1 DE 3100968A1 DE 19813100968 DE19813100968 DE 19813100968 DE 3100968 A DE3100968 A DE 3100968A DE 3100968 A1 DE3100968 A1 DE 3100968A1
Authority
DE
Germany
Prior art keywords
trifluoroacetyl
demethoxy
methyl
daunorubicin
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19813100968
Other languages
German (de)
English (en)
Inventor
Luigi 20151 Milano Bernardi
Pietro 20154 Milano Giardino
Osvaldo 21013 Gallarate Sapini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of DE3100968A1 publication Critical patent/DE3100968A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/202—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring the aromatic ring being a naphthalene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Saccharide Compounds (AREA)
DE19813100968 1980-01-16 1981-01-14 Anthracyclinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel Ceased DE3100968A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8001387 1980-01-16

Publications (1)

Publication Number Publication Date
DE3100968A1 true DE3100968A1 (de) 1982-01-14

Family

ID=10510664

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19813100968 Ceased DE3100968A1 (de) 1980-01-16 1981-01-14 Anthracyclinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Country Status (3)

Country Link
JP (1) JPS56100779A (fr)
BE (1) BE887081A (fr)
DE (1) DE3100968A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3301489A1 (de) * 1982-01-26 1983-08-04 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinglycoside, verfahren zu deren herstellung, arzneimittel und zwischenverbindung

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8308301A1 (es) * 1981-07-29 1983-08-16 Sumitomo Chemical Co Un procedimiento para la preparacion de derivados de aminonaftaceno.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2652391A1 (de) * 1975-11-18 1977-05-26 Farmaceutici Italia Daunosaminylanthracyclinone, verfahren zur herstellung und arzneimittel, die diese verbindungen enthalten
US4046878A (en) * 1974-06-12 1977-09-06 Societa' Farmaceutici Italia S.P.A. Daunomycin analogues, their preparation and use
GB1550879A (en) * 1976-12-22 1979-08-22 Farmaceutici Italia Antitumour glycosides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4046878A (en) * 1974-06-12 1977-09-06 Societa' Farmaceutici Italia S.P.A. Daunomycin analogues, their preparation and use
DE2652391A1 (de) * 1975-11-18 1977-05-26 Farmaceutici Italia Daunosaminylanthracyclinone, verfahren zur herstellung und arzneimittel, die diese verbindungen enthalten
GB1550879A (en) * 1976-12-22 1979-08-22 Farmaceutici Italia Antitumour glycosides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3301489A1 (de) * 1982-01-26 1983-08-04 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclinglycoside, verfahren zu deren herstellung, arzneimittel und zwischenverbindung

Also Published As

Publication number Publication date
BE887081A (fr) 1981-05-04
JPS56100779A (en) 1981-08-12

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection