DE3068706D1 - Novel benzodiazepine compounds, their preparation, intermediates employed in their preparation, and pharmaceutical compositions containing them - Google Patents
Novel benzodiazepine compounds, their preparation, intermediates employed in their preparation, and pharmaceutical compositions containing themInfo
- Publication number
- DE3068706D1 DE3068706D1 DE8080303649T DE3068706T DE3068706D1 DE 3068706 D1 DE3068706 D1 DE 3068706D1 DE 8080303649 T DE8080303649 T DE 8080303649T DE 3068706 T DE3068706 T DE 3068706T DE 3068706 D1 DE3068706 D1 DE 3068706D1
- Authority
- DE
- Germany
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- benzodiazepine compounds
- novel benzodiazepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7935846 | 1979-10-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3068706D1 true DE3068706D1 (en) | 1984-08-30 |
Family
ID=10508540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8080303649T Expired DE3068706D1 (en) | 1979-10-16 | 1980-10-15 | Novel benzodiazepine compounds, their preparation, intermediates employed in their preparation, and pharmaceutical compositions containing them |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US4404137A (en:Method) |
| EP (1) | EP0027390B1 (en:Method) |
| JP (1) | JPS5663987A (en:Method) |
| KR (2) | KR850000471B1 (en:Method) |
| AR (2) | AR228041A1 (en:Method) |
| AT (1) | AT373889B (en:Method) |
| AU (1) | AU538500B2 (en:Method) |
| BE (1) | BE885729A (en:Method) |
| BG (2) | BG34907A3 (en:Method) |
| CA (1) | CA1159056A (en:Method) |
| CH (1) | CH646700A5 (en:Method) |
| CS (1) | CS244409B2 (en:Method) |
| DD (1) | DD153692A5 (en:Method) |
| DE (1) | DE3068706D1 (en:Method) |
| DK (1) | DK437480A (en:Method) |
| ES (1) | ES495948A0 (en:Method) |
| FI (1) | FI67550C (en:Method) |
| FR (1) | FR2467851A1 (en:Method) |
| GB (1) | GB8327127D0 (en:Method) |
| GR (1) | GR70720B (en:Method) |
| HU (1) | HU182213B (en:Method) |
| IE (1) | IE50358B1 (en:Method) |
| IL (1) | IL61264A (en:Method) |
| IT (1) | IT1143047B (en:Method) |
| LU (1) | LU82853A1 (en:Method) |
| MX (1) | MX6233E (en:Method) |
| NZ (1) | NZ195248A (en:Method) |
| PH (2) | PH16288A (en:Method) |
| PL (2) | PL135044B1 (en:Method) |
| PT (1) | PT71913B (en:Method) |
| RO (2) | RO85822B (en:Method) |
| YU (1) | YU261580A (en:Method) |
| ZA (1) | ZA806342B (en:Method) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4404137A (en) * | 1979-10-16 | 1983-09-13 | Lilly Industries Limited | Pyrazolo [3,4-b][1,5]benzodiazepine compounds |
| US4431589A (en) * | 1980-12-11 | 1984-02-14 | Lilly House | Benzodiazepine compounds and their use as pharmaceuticals |
| US4596799A (en) * | 1985-01-29 | 1986-06-24 | Ciba-Geigy Corporation | 9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines |
| TW219896B (en:Method) * | 1988-07-07 | 1994-02-01 | Duphar Int Res | |
| GB8819059D0 (en) * | 1988-08-11 | 1988-09-14 | Lilly Industries Ltd | Benzodiazepine compounds & their use as pharmaceuticals |
| US5631250A (en) * | 1995-03-24 | 1997-05-20 | Eli Lilly And Company | Process and solvate of 2-methyl-thieno-benzodiazepine |
| US5637584A (en) * | 1995-03-24 | 1997-06-10 | Eli Lilly And Company | Solvate of olanzapine |
| NZ541014A (en) * | 2003-01-23 | 2008-05-30 | Acadia Pharm Inc | Use of N-desmethylclozapine to treat schizophrenia while increasing the level of activity of a muscarinic receptor |
| US20050085463A1 (en) * | 2003-01-23 | 2005-04-21 | Weiner David M. | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| US20050250767A1 (en) * | 2003-01-23 | 2005-11-10 | Weiner David M | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
| PT1696931E (pt) * | 2003-12-22 | 2009-06-12 | Acadia Pharm Inc | Análogos diaril[a,d]ciclo-hepteno substituídos com amino utilizados como agonistas muscarínicos e métodos de tratamento de perturbações neuropsiquiátricas |
| CN1950346A (zh) * | 2004-04-01 | 2007-04-18 | 阿卡蒂亚药品公司 | N－去甲基氯氮平的晶形 |
| WO2007053618A1 (en) * | 2005-10-31 | 2007-05-10 | Acadia Pharmaceuticals Inc. | Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders |
| JP5438482B2 (ja) * | 2009-12-03 | 2014-03-12 | Ｊｕｋｉ株式会社 | ミシン、ミシンの縫製データ編集装置及びミシンの縫製データ編集プログラム |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3450694A (en) * | 1966-02-23 | 1969-06-17 | Abbott Lab | Substituted benzoxazepines and benzothiazepines |
| US3758479A (en) * | 1967-03-22 | 1973-09-11 | Sandoz Ag | Nitro and sulphamoyl substituted dibenzodiazepines |
| DE1795183B1 (de) * | 1968-08-20 | 1972-07-20 | Thomae Gmbh Dr K | 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel |
| CA918659A (en) * | 1969-07-31 | 1973-01-09 | Yoshitomi Pharmaceutical Industries | 11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines |
| US4115568A (en) * | 1974-11-26 | 1978-09-19 | Lilly Industries Limited | Thieno[3,2-b]-[1,5]benzodiazepines |
| US4172831A (en) * | 1974-11-26 | 1979-10-30 | Lilly Industries Limited | Thieno-benzodiazepines |
| US3951981A (en) * | 1975-02-24 | 1976-04-20 | American Cyanamid Company | Substituted benzodiazepines and method of use |
| US3953430A (en) * | 1975-02-24 | 1976-04-27 | American Cyanamid Company | Substituted benzodiazepin-10-ones and method of use |
| DE2707269A1 (de) * | 1977-02-19 | 1978-08-24 | Hoechst Ag | Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung |
| DE2707270A1 (de) * | 1977-02-19 | 1978-08-24 | Hoechst Ag | Pyrazolo-diazepine und verfahren zu ihrer herstellung |
| US4097597A (en) * | 1977-02-23 | 1978-06-27 | Abbott Laboratories | Dibenzo b,e! 1,4!diazepines |
| IT7851496A0 (it) * | 1977-10-31 | 1978-10-13 | Sandoz Ag | Menti pirazinobenzossazepine loro preparazione e loro impiego quali medica |
| CH643263A5 (de) * | 1979-05-11 | 1984-05-30 | Sandoz Ag | Benzodiazepine, ihre herstellung und verwendung. |
| DK334580A (da) * | 1979-08-03 | 1981-02-04 | Byk Gulden Lomberg Chem Fab | Fremgangsmaade til fremstilling af substituerede tetraazatricycler |
| US4404137A (en) * | 1979-10-16 | 1983-09-13 | Lilly Industries Limited | Pyrazolo [3,4-b][1,5]benzodiazepine compounds |
-
1980
- 1980-10-02 US US06/193,200 patent/US4404137A/en not_active Expired - Lifetime
- 1980-10-11 GR GR63138A patent/GR70720B/el unknown
- 1980-10-13 FR FR8021823A patent/FR2467851A1/fr active Granted
- 1980-10-13 IL IL61264A patent/IL61264A/xx unknown
- 1980-10-13 RO RO108967A patent/RO85822B/ro unknown
- 1980-10-13 YU YU02615/80A patent/YU261580A/xx unknown
- 1980-10-13 MX MX809093U patent/MX6233E/es unknown
- 1980-10-13 RO RO102349A patent/RO81351B/ro unknown
- 1980-10-13 NZ NZ195248A patent/NZ195248A/xx unknown
- 1980-10-13 CS CS806938A patent/CS244409B2/cs unknown
- 1980-10-13 PH PH24717A patent/PH16288A/en unknown
- 1980-10-14 AT AT0510180A patent/AT373889B/de not_active IP Right Cessation
- 1980-10-14 CA CA000362328A patent/CA1159056A/en not_active Expired
- 1980-10-14 AU AU63252/80A patent/AU538500B2/en not_active Ceased
- 1980-10-14 PT PT71913A patent/PT71913B/pt unknown
- 1980-10-14 CH CH763980A patent/CH646700A5/fr not_active IP Right Cessation
- 1980-10-14 IT IT49899/80A patent/IT1143047B/it active
- 1980-10-15 HU HU802502A patent/HU182213B/hu not_active IP Right Cessation
- 1980-10-15 KR KR1019800003960A patent/KR850000471B1/ko not_active Expired
- 1980-10-15 DD DD80224618A patent/DD153692A5/de unknown
- 1980-10-15 ZA ZA00806342A patent/ZA806342B/xx unknown
- 1980-10-15 FI FI803253A patent/FI67550C/fi not_active IP Right Cessation
- 1980-10-15 PL PL1980231270A patent/PL135044B1/pl unknown
- 1980-10-15 BG BG049366A patent/BG34907A3/xx unknown
- 1980-10-15 EP EP80303649A patent/EP0027390B1/en not_active Expired
- 1980-10-15 JP JP14423180A patent/JPS5663987A/ja active Pending
- 1980-10-15 PL PL1980227306A patent/PL126824B1/pl unknown
- 1980-10-15 LU LU82853A patent/LU82853A1/fr unknown
- 1980-10-15 DK DK437480A patent/DK437480A/da not_active Application Discontinuation
- 1980-10-15 BE BE6/47291A patent/BE885729A/fr not_active IP Right Cessation
- 1980-10-15 DE DE8080303649T patent/DE3068706D1/de not_active Expired
- 1980-10-15 BG BG057344A patent/BG35042A3/xx unknown
- 1980-10-15 ES ES495948A patent/ES495948A0/es active Granted
- 1980-10-15 IE IE2135/80A patent/IE50358B1/en unknown
- 1980-10-16 AR AR282893A patent/AR228041A1/es active
-
1982
- 1982-07-21 AR AR290034A patent/AR228101A1/es active
- 1982-07-28 PH PH27643A patent/PH17759A/en unknown
- 1982-09-29 US US06/426,580 patent/US4486591A/en not_active Expired - Fee Related
-
1983
- 1983-10-11 GB GB838327127A patent/GB8327127D0/en active Pending
-
1984
- 1984-07-24 KR KR1019840004388A patent/KR850000472B1/ko not_active Expired
- 1984-08-06 US US06/638,181 patent/US4542131A/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8328 | Change in the person/name/address of the agent |
Free format text: TUERK, D., DIPL.-CHEM. DR.RER.NAT. GILLE, C., DIPL.-ING., PAT.-ANW., 4000 DUESSELDORF |
|
| 8339 | Ceased/non-payment of the annual fee |