DE3062075D1 - Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use - Google Patents

Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use

Info

Publication number
DE3062075D1
DE3062075D1 DE8080107181T DE3062075T DE3062075D1 DE 3062075 D1 DE3062075 D1 DE 3062075D1 DE 8080107181 T DE8080107181 T DE 8080107181T DE 3062075 T DE3062075 T DE 3062075T DE 3062075 D1 DE3062075 D1 DE 3062075D1
Authority
DE
Germany
Prior art keywords
polypeptides
processes
production
pharmaceutical compositions
monocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080107181T
Other languages
German (de)
English (en)
Inventor
Wilfried Bauer
Janos Dr Pless
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Application granted granted Critical
Publication of DE3062075D1 publication Critical patent/DE3062075D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE8080107181T 1979-11-27 1980-11-19 Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use Expired DE3062075D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1052479 1979-11-27
CH457480 1980-06-13

Publications (1)

Publication Number Publication Date
DE3062075D1 true DE3062075D1 (en) 1983-03-24

Family

ID=25695798

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8080107181T Expired DE3062075D1 (en) 1979-11-27 1980-11-19 Polypeptides, processes for their production, pharmaceutical compositions comprising said polypeptides and their use
DE1993175086 Active DE19375086I2 (de) 1979-11-27 1980-11-19 Polypeptide Verfahren zu ihrer Herstellung pharmazeutische Zusammensetzungen die diese Polypeptide enthalten und ihre Verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1993175086 Active DE19375086I2 (de) 1979-11-27 1980-11-19 Polypeptide Verfahren zu ihrer Herstellung pharmazeutische Zusammensetzungen die diese Polypeptide enthalten und ihre Verwendung

Country Status (25)

Country Link
US (1) US4395403A (https=)
EP (1) EP0029579B1 (https=)
JP (1) JPS5690048A (https=)
AT (1) ATE2512T1 (https=)
AU (1) AU543198B2 (https=)
CA (1) CA1182109A (https=)
CS (1) CS228140B2 (https=)
CY (1) CY1327A (https=)
DE (2) DE3062075D1 (https=)
DK (1) DK150146C (https=)
ES (2) ES8301463A1 (https=)
FI (1) FI72981C (https=)
GR (1) GR71636B (https=)
HK (1) HK30686A (https=)
HU (1) HU185920B (https=)
IE (1) IE50571B1 (https=)
IL (1) IL61561A (https=)
KE (1) KE3606A (https=)
LU (1) LU88344I2 (https=)
MY (1) MY8500072A (https=)
NL (1) NL930137I2 (https=)
NZ (1) NZ195640A (https=)
PH (1) PH22841A (https=)
PT (1) PT72103B (https=)
SG (1) SG8786G (https=)

Families Citing this family (62)

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DK81082A (da) * 1981-03-06 1982-09-07 Sandoz Ag Fremgangsmaade til fremstilling af polypeptider
CH655505B (https=) * 1982-08-24 1986-04-30
US4663435A (en) * 1982-12-06 1987-05-05 Merck & Co., Inc. Bridged cyclic hexapeptide somatostatin analogs
FR2554347B1 (fr) * 1983-11-07 1986-10-03 Immunotech Sa Acide pressinique, ses derives aminoacides substitues et homologues de configuration d ainsi que les derives n- et c- terminal-substitues et leurs applications dans les domaines therapeutique, biologique ou immunologique
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
GB8423431D0 (en) * 1984-09-17 1984-10-24 Sandoz Ltd Organic compounds
US4650787A (en) * 1985-04-25 1987-03-17 Schally Andrew Victor Biologically active octapeptides
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US4904642A (en) * 1985-09-12 1990-02-27 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
JPH085913B2 (ja) * 1985-09-12 1996-01-24 ザ・アドミニストレ−タ−ズ・オブ・ザ・ツ−レイン・エデユケイシヨナル・フアンド 治療用ソマトスタチン同族体
GR862206B (en) * 1985-09-12 1986-12-31 Univ Tulane Therapeutic somatostatin analogs
HU198626B (en) * 1986-05-27 1989-11-28 Sandoz Ag Process for producing pharmaceutical compositions comprising somatostatin analogues as active ingredient
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
GB2193891B (en) * 1986-08-18 1990-07-25 Sandoz Ltd Nasal pharmaceutical composition containing a somatostatin anologue.
DE3726517A1 (de) * 1986-08-18 1988-03-03 Sandoz Ag Nasale zusammensetzungen, welche octreotid enthalten
GB8620035D0 (en) * 1986-08-18 1986-10-01 Sandoz Ltd Organic compounds
DE3790635B4 (de) * 1986-10-13 2007-11-22 Novartis Ag Verfahren zur Herstellung eines Peptidalkohols und Ausgangsverbindungen dafür
NL194729C (nl) * 1986-10-13 2003-01-07 Novartis Ag Werkwijze voor de bereiding van peptidealcoholen via vaste fase.
US4871717A (en) * 1987-01-07 1989-10-03 Administrators Of The Tulane Educational Fund Peptides
US5073541A (en) * 1987-11-18 1991-12-17 Administrators Of The Tulane Educational Fund Treatment of small cell lung cancer with somatostatin analogs
ZA895838B (en) * 1988-08-18 1991-03-27 Syntex Inc Pharmaceutical compounds
US5006510A (en) * 1989-06-20 1991-04-09 Ellis Wladislaw V Method for relieving chronic pain with a somatostatin analog composition
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
US5084443A (en) * 1989-12-04 1992-01-28 Biomeasure, Inc. Promoting expression of acetylcholine receptors with lhrh antagonist
WO1991009056A1 (en) * 1989-12-08 1991-06-27 The Administrators Of The Tulane Educational Fund Octapeptide analogs of somatostatin having threonine at the sixth position
ES2134798T3 (es) * 1991-02-08 1999-10-16 Biomeasure Inc Uso de analogos de somatostatina para el tratamiento de melanomas.
US5504069A (en) * 1993-02-11 1996-04-02 Biomeasure, Inc. Inhibition of trauma-induced tumor growth
GB9402767D0 (en) * 1994-02-14 1994-04-06 Sandoz Ltd Improvements in or relating to organic compounds
US5597894A (en) * 1995-06-05 1997-01-28 The Louisiana State University Medical Center Foundation Multi-tyrosinated somatostatin analogs
US5830431A (en) * 1995-06-07 1998-11-03 Mallinckrodt Medical, Inc. Radiolabeled peptide compositions for site-specific targeting
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
EP0824103A1 (en) * 1996-08-13 1998-02-18 Chang-Shinn Su Method for synthesis of Tyr-3-octreotide
US6262229B1 (en) 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
WO1998051330A1 (en) * 1997-05-13 1998-11-19 Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) Method and compositions for treating hyperlipidemia and other conditions
US6004928A (en) * 1997-05-13 1999-12-21 Biomeasure, Incorporated Method of treating hyperlipidemia
AU7655098A (en) * 1997-05-13 1998-12-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Somatostatin and somatostatin agonists for decreasing body weight
ES2216290T3 (es) * 1997-05-13 2004-10-16 Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. Somatostatina y agonistas de la somatostatina para el tratamiento de insensibilidad a la insulina y de sindrome x.
ES2144357B1 (es) * 1998-01-29 2000-12-16 Lipotec Sa Procedimiento para la obtencion del analogo de somatostatina octreotide.
US5968903A (en) * 1998-05-07 1999-10-19 Biomeasure, Incorporated Inhibition of H. pylori proliferation
US6159935A (en) * 1999-11-29 2000-12-12 Pharmacia & Upjohn Co. Method for preventing diarrhea
RU2196144C1 (ru) * 2001-05-14 2003-01-10 Самуков Владимир Васильевич Защищенные производные октреотида
BR0210915A (pt) 2001-06-08 2004-06-08 Sod Conseils Rech Applic Análogos quiméricos de somatostatina-dopamina
EP2316468A1 (en) 2002-02-22 2011-05-04 Shire LLC Delivery system and methods for protecting and administering dextroamphetamine
US6987167B2 (en) 2002-05-22 2006-01-17 Wockhardt Limited Process for production of the somatostatin analog, octreotide
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
WO2004092202A1 (en) * 2003-04-07 2004-10-28 Novetide, Ltd. Process for production of cyclic peptides
CN101791409A (zh) 2003-04-22 2010-08-04 研究及应用科学协会股份有限公司 肽载体
ATE469912T1 (de) * 2004-10-04 2010-06-15 Novetide Ltd Gegenionenaustauschverfahren für peptide
ES2755032T3 (es) * 2005-12-22 2020-04-21 Novartis Ag Formulación de liberación sostenida que comprende octreótido y dos o más polímeros de poliláctido-co-glicólido
WO2007110765A2 (en) * 2006-03-28 2007-10-04 Wockhardt Ltd Processes for the preparation of octreotide
TW200819137A (en) * 2006-10-31 2008-05-01 Iner Aec Executive Yuan Method for preparation of lipid-spacer radical- reactions of functional group-peptide
US20090082259A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched octreotide
EP2172189A1 (en) 2008-10-01 2010-04-07 Novartis AG Pharmaceutical Compositions
EP2213307A1 (en) 2009-02-03 2010-08-04 Novartis AG Injectable depot formulations
WO2010089757A2 (en) 2008-11-07 2010-08-12 Usv Limited An improved process for synthesis of cyclic octapeptide
US20120053172A1 (en) 2009-02-12 2012-03-01 Cooperatieve Mirzorg U.A. Use of a combination of diazoxide and metformin for treating obesity or obesity related disorders
WO2013046233A2 (en) 2011-09-30 2013-04-04 Mylan Laboratories Ltd Process for the preparation of octreotide acetate
CN103102390B (zh) * 2011-11-09 2015-01-28 杭州华津允上医药有限公司 一种奥曲肽的制备方法
WO2013132505A1 (en) 2012-03-09 2013-09-12 Natco Pharma Limited Improved process for preparation of octreotide by solution phase peptide synthesis
JP6869720B2 (ja) 2013-06-13 2021-05-12 アンチセンス セラピューティクス リミテッド 併用療法
CN108395469A (zh) * 2018-02-01 2018-08-14 滨海吉尔多肽有限公司 一种假脯氨酸二肽的合成方法
GB202012334D0 (en) 2020-08-07 2020-09-23 Avon Polymer Prod Ltd Monitoring system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4105603A (en) * 1977-03-28 1978-08-08 The Salk Institute For Biological Studies Peptides which effect release of hormones
US4140767A (en) * 1977-12-01 1979-02-20 Merck & Co., Inc. Somatostatin analogs
US4139526A (en) * 1977-12-01 1979-02-13 Merck & Co., Inc. Somatostatin analogs
US4190648A (en) * 1979-03-13 1980-02-26 Merck & Co., Inc. Peptides having somatostatin activity
US4225472A (en) * 1979-05-29 1980-09-30 American Home Products Corporation Truncated somatostatin analogs
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4282143A (en) * 1980-06-13 1981-08-04 American Home Products Corporation Octapeptides lowering growth hormone

Also Published As

Publication number Publication date
FI72981B (fi) 1987-04-30
LU88344I2 (fr) 1994-05-04
DK150146B (da) 1986-12-15
ES510751A0 (es) 1983-04-16
KE3606A (en) 1986-03-17
IE802452L (en) 1981-05-27
NL930137I2 (nl) 1997-02-03
JPS5690048A (en) 1981-07-21
NZ195640A (en) 1984-07-06
AU6468880A (en) 1981-06-04
CA1182109A (en) 1985-02-05
HU185920B (en) 1985-04-28
IL61561A0 (en) 1980-12-31
AU543198B2 (en) 1985-04-04
FI803634L (fi) 1981-05-28
CY1327A (en) 1986-06-27
HK30686A (en) 1986-05-09
IE50571B1 (en) 1986-05-14
EP0029579B1 (en) 1983-02-16
ES497113A0 (es) 1982-12-01
US4395403A (en) 1983-07-26
DK150146C (da) 1987-06-01
GR71636B (https=) 1983-06-20
DE19375086I2 (de) 2003-01-09
IL61561A (en) 1985-02-28
ES8305701A1 (es) 1983-04-16
PT72103A (fr) 1980-12-01
SG8786G (en) 1987-03-27
ATE2512T1 (de) 1983-03-15
MY8500072A (en) 1985-12-31
PH22841A (en) 1989-01-19
PT72103B (fr) 1982-01-28
NL930137I1 (nl) 1993-11-01
ES8301463A1 (es) 1982-12-01
CS228140B2 (en) 1984-05-14
DK501980A (da) 1981-05-28
JPS6351159B2 (https=) 1988-10-13
EP0029579A1 (en) 1981-06-03
FI72981C (fi) 1987-08-10

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SANDOZ-PATENT-GMBH, 7850 LOERRACH, DE

V448 Application of spc

Free format text: PRODUCT NAME: OCTREOTIDACETAT (1:1,4-2,5); REGISTRATION NO/DATE: 15415.00.00, 15415.01.00, 15415.02.00, 15415.03.00; 19900629

Spc suppl protection certif: 193 75 086

Filing date: 19930630

8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

V457 Spc granted

Free format text: PRODUCT NAME: OCTREOTIDACETAT (1:1,4-2,5); REGISTRATION NO/DATE: 15415.00.00, 15415.01.00, 15415.02.00, 15415.03.00; 19900629

Spc suppl protection certif: 193 75 086

Filing date: 19930630

V464 Spc expired

Free format text: PRODUCT NAME: OCTREOTIDACETAT (1:1,4-2,5); REGISTRATION NO/DATE: 15415.00.00, 15415.01.00, 15415.02.00, 15415.03.00; 19900629

Spc suppl protection certif: 193 75 086

Filing date: 19930630