DE3038198A1 - Verwendung waessrigr extrakte von rotweintrester und die sie enthaltenden zusammensetzungen - Google Patents
Verwendung waessrigr extrakte von rotweintrester und die sie enthaltenden zusammensetzungenInfo
- Publication number
- DE3038198A1 DE3038198A1 DE19803038198 DE3038198A DE3038198A1 DE 3038198 A1 DE3038198 A1 DE 3038198A1 DE 19803038198 DE19803038198 DE 19803038198 DE 3038198 A DE3038198 A DE 3038198A DE 3038198 A1 DE3038198 A1 DE 3038198A1
- Authority
- DE
- Germany
- Prior art keywords
- extracts
- red wine
- medicament according
- aqueous
- elution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 235000020095 red wine Nutrition 0.000 title claims description 14
- 239000000284 extract Substances 0.000 title claims description 13
- 239000000203 mixture Substances 0.000 title claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title description 2
- 239000003814 drug Substances 0.000 claims description 13
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- 238000010828 elution Methods 0.000 claims description 4
- 238000004108 freeze drying Methods 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 3
- 208000006558 Dental Calculus Diseases 0.000 claims description 2
- 241000219094 Vitaceae Species 0.000 claims description 2
- 240000006365 Vitis vinifera Species 0.000 claims description 2
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 2
- 239000003125 aqueous solvent Substances 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 235000002532 grape seed extract Nutrition 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 238000001179 sorption measurement Methods 0.000 claims description 2
- 235000021021 grapes Nutrition 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 239000000047 product Substances 0.000 description 11
- 239000006286 aqueous extract Substances 0.000 description 8
- 101800004538 Bradykinin Proteins 0.000 description 6
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 description 6
- 102100035792 Kininogen-1 Human genes 0.000 description 6
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 description 6
- 241000700159 Rattus Species 0.000 description 5
- 230000004856 capillary permeability Effects 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- COXVTLYNGOIATD-HVMBLDELSA-N CC1=C(C=CC(=C1)C1=CC(C)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S(O)(=O)=O)S(O)(=O)=O)\N=N\C1=CC=C2C(=CC(=C(N)C2=C1O)S(O)(=O)=O)S(O)(=O)=O Chemical compound CC1=C(C=CC(=C1)C1=CC(C)=C(C=C1)\N=N\C1=C(O)C2=C(N)C(=CC(=C2C=C1)S(O)(=O)=O)S(O)(=O)=O)\N=N\C1=CC=C2C(=CC(=C(N)C2=C1O)S(O)(=O)=O)S(O)(=O)=O COXVTLYNGOIATD-HVMBLDELSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- 229960003699 evans blue Drugs 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000000859 sublimation Methods 0.000 description 2
- 230000008022 sublimation Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 206010007191 Capillary fragility Diseases 0.000 description 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- YYVIFBVXJYYHCW-UHFFFAOYSA-N Malvin Natural products COc1cc(cc(OC)c1O)C2=C(Cc3c(OC4OC(CO)C(O)C(O)C4O)cc(O)cc3O2)OC5OC(CO)C(O)C(O)C5O YYVIFBVXJYYHCW-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241001593968 Vitis palmata Species 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000008365 aqueous carrier Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000003889 eye drop Substances 0.000 description 1
- 229940012356 eye drops Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 235000015243 ice cream Nutrition 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- CILLXFBAACIQNS-BTXJZROQSA-O malvin Chemical compound COC1=C(O)C(OC)=CC(C=2C(=CC=3C(O[C@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)=CC(O)=CC=3[O+]=2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1 CILLXFBAACIQNS-BTXJZROQSA-O 0.000 description 1
- 229940117886 malvin Drugs 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 208000001297 phlebitis Diseases 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 201000002282 venous insufficiency Diseases 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7925065A FR2466989A1 (fr) | 1979-10-09 | 1979-10-09 | Application a titre de medicaments d'extraits aqueux de marcs de raisins rouges, et compositions pharmaceutiques renfermant lesdits extraits |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3038198A1 true DE3038198A1 (de) | 1981-05-07 |
Family
ID=9230478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19803038198 Withdrawn DE3038198A1 (de) | 1979-10-09 | 1980-10-09 | Verwendung waessrigr extrakte von rotweintrester und die sie enthaltenden zusammensetzungen |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE885574A (https=) |
| CH (1) | CH651209A5 (https=) |
| DE (1) | DE3038198A1 (https=) |
| FR (1) | FR2466989A1 (https=) |
| GR (1) | GR70759B (https=) |
| IT (1) | IT1144015B (https=) |
| PT (1) | PT71883B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999006526A1 (en) * | 1997-07-29 | 1999-02-11 | Tarac Distillers Pty. Ltd. | Process for the recovery and improvement of wine extract and derivatives from grape marc |
| CN104958372A (zh) * | 2015-06-28 | 2015-10-07 | 四川金堂海纳生物医药技术研究所 | 一种治疗血栓性静脉炎的外用药物及其制备方法 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2314812C2 (ru) * | 2005-11-22 | 2008-01-20 | Закрытое Акционерное Общество "Канонфарма Продакшн" | Твердая лекарственная форма диосмина |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2378070A1 (fr) * | 1977-01-25 | 1978-08-18 | Roussillon Alimentaire La Cata | Procede d'extraction d'anthocyanes a partir de marcs de raisins, lies et vins |
-
1979
- 1979-10-09 FR FR7925065A patent/FR2466989A1/fr active Granted
-
1980
- 1980-10-07 PT PT71883A patent/PT71883B/pt unknown
- 1980-10-07 GR GR63073A patent/GR70759B/el unknown
- 1980-10-08 BE BE0/202362A patent/BE885574A/fr not_active IP Right Cessation
- 1980-10-08 IT IT49848/80A patent/IT1144015B/it active
- 1980-10-08 CH CH7527/80A patent/CH651209A5/fr not_active IP Right Cessation
- 1980-10-09 DE DE19803038198 patent/DE3038198A1/de not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999006526A1 (en) * | 1997-07-29 | 1999-02-11 | Tarac Distillers Pty. Ltd. | Process for the recovery and improvement of wine extract and derivatives from grape marc |
| CN104958372A (zh) * | 2015-06-28 | 2015-10-07 | 四川金堂海纳生物医药技术研究所 | 一种治疗血栓性静脉炎的外用药物及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| IT8049848A0 (it) | 1980-10-08 |
| BE885574A (fr) | 1981-04-08 |
| GR70759B (https=) | 1983-03-16 |
| IT1144015B (it) | 1986-10-29 |
| CH651209A5 (en) | 1985-09-13 |
| FR2466989B1 (https=) | 1982-10-08 |
| PT71883A (fr) | 1980-11-01 |
| PT71883B (fr) | 1982-04-02 |
| FR2466989A1 (fr) | 1981-04-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8180 | Miscellaneous part 1 |
Free format text: DIE BEZEICHNUNG LAUTET RICHTIG: VERWENDUNG WAESSRIGER EXTRAKTE VON ROTWEINTRESTER UND DIE SIE ENTHALTENDEN ZUSAMMENSETZUNGEN |
|
| 8141 | Disposal/no request for examination |