DE3034198A1 - Gereinigtes polypeptid, verfahren zum isolieren und verwendung desselben sowie pharmazeutische zusammensetzung und waessrige sterile loesung - Google Patents
Gereinigtes polypeptid, verfahren zum isolieren und verwendung desselben sowie pharmazeutische zusammensetzung und waessrige sterile loesungInfo
- Publication number
- DE3034198A1 DE3034198A1 DE19803034198 DE3034198A DE3034198A1 DE 3034198 A1 DE3034198 A1 DE 3034198A1 DE 19803034198 DE19803034198 DE 19803034198 DE 3034198 A DE3034198 A DE 3034198A DE 3034198 A1 DE3034198 A1 DE 3034198A1
- Authority
- DE
- Germany
- Prior art keywords
- boehmert
- psp
- purified polypeptide
- pro
- asx
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229960000396 atropine Drugs 0.000 description 1
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
- 229960002028 atropine sulfate Drugs 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000006167 equilibration buffer Substances 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 201000001421 hyperglycemia Diseases 0.000 description 1
- 230000035873 hypermotility Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 108010056579 pancreatic spasmolytic polypeptide Proteins 0.000 description 1
- 210000004923 pancreatic tissue Anatomy 0.000 description 1
- 230000003836 peripheral circulation Effects 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
- 229960003147 reserpine Drugs 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Reinforced Plastic Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7931518 | 1979-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3034198A1 true DE3034198A1 (de) | 1981-04-09 |
Family
ID=10507754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19803034198 Withdrawn DE3034198A1 (de) | 1979-09-11 | 1980-09-11 | Gereinigtes polypeptid, verfahren zum isolieren und verwendung desselben sowie pharmazeutische zusammensetzung und waessrige sterile loesung |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS609760B2 (enExample) |
| AT (1) | AT373149B (enExample) |
| AU (1) | AU537523B2 (enExample) |
| BE (1) | BE885199A (enExample) |
| CA (1) | CA1160624A (enExample) |
| CH (1) | CH646414A5 (enExample) |
| DE (1) | DE3034198A1 (enExample) |
| DK (1) | DK380880A (enExample) |
| ES (1) | ES8105699A1 (enExample) |
| FI (1) | FI802828A7 (enExample) |
| FR (1) | FR2464942A1 (enExample) |
| IT (1) | IT1195032B (enExample) |
| NL (1) | NL8005084A (enExample) |
| NO (1) | NO802683L (enExample) |
| SE (1) | SE8006333L (enExample) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB924815A (en) * | 1959-12-24 | 1963-05-01 | Maurice Roux | Improvements in methods of preparation of polypeptides of spasmolytic activity |
-
1980
- 1980-09-08 DK DK380880A patent/DK380880A/da not_active Application Discontinuation
- 1980-09-09 NL NL8005084A patent/NL8005084A/nl not_active Application Discontinuation
- 1980-09-10 CH CH681480A patent/CH646414A5/de not_active IP Right Cessation
- 1980-09-10 SE SE8006333A patent/SE8006333L/xx not_active Application Discontinuation
- 1980-09-10 AT AT0455180A patent/AT373149B/de not_active IP Right Cessation
- 1980-09-10 ES ES494917A patent/ES8105699A1/es not_active Expired
- 1980-09-10 FI FI802828A patent/FI802828A7/fi not_active Application Discontinuation
- 1980-09-10 FR FR8019545A patent/FR2464942A1/fr active Granted
- 1980-09-10 NO NO802683A patent/NO802683L/no unknown
- 1980-09-11 IT IT24588/80A patent/IT1195032B/it active
- 1980-09-11 BE BE6/47265A patent/BE885199A/fr not_active IP Right Cessation
- 1980-09-11 AU AU62317/80A patent/AU537523B2/en not_active Ceased
- 1980-09-11 DE DE19803034198 patent/DE3034198A1/de not_active Withdrawn
- 1980-09-11 CA CA000360561A patent/CA1160624A/en not_active Expired
- 1980-09-11 JP JP55125375A patent/JPS609760B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES494917A0 (es) | 1981-06-16 |
| AU6231780A (en) | 1981-03-19 |
| DK380880A (da) | 1981-05-12 |
| FR2464942A1 (fr) | 1981-03-20 |
| ES8105699A1 (es) | 1981-06-16 |
| SE8006333L (sv) | 1981-03-12 |
| NO802683L (no) | 1981-05-07 |
| ATA455180A (de) | 1983-05-15 |
| NL8005084A (nl) | 1981-03-13 |
| CA1160624A (en) | 1984-01-17 |
| AT373149B (de) | 1983-12-27 |
| FI802828A7 (fi) | 1981-03-11 |
| IT1195032B (it) | 1988-09-28 |
| IT8024588A0 (it) | 1980-09-11 |
| CH646414A5 (en) | 1984-11-30 |
| JPS56123996A (en) | 1981-09-29 |
| BE885199A (fr) | 1981-03-11 |
| AU537523B2 (en) | 1984-06-28 |
| JPS609760B2 (ja) | 1985-03-12 |
| FR2464942B1 (enExample) | 1984-10-26 |
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| Date | Code | Title | Description |
|---|---|---|---|
| AG | Has addition no. |
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