DE3026271A1 - 8-aethylaminomethylergol-8-en- und 8-aethylaminomethylergolinderivate, verfahren zur herstellung derselben und diese enthaltende arzneimittel - Google Patents
8-aethylaminomethylergol-8-en- und 8-aethylaminomethylergolinderivate, verfahren zur herstellung derselben und diese enthaltende arzneimittelInfo
- Publication number
- DE3026271A1 DE3026271A1 DE19803026271 DE3026271A DE3026271A1 DE 3026271 A1 DE3026271 A1 DE 3026271A1 DE 19803026271 DE19803026271 DE 19803026271 DE 3026271 A DE3026271 A DE 3026271A DE 3026271 A1 DE3026271 A1 DE 3026271A1
- Authority
- DE
- Germany
- Prior art keywords
- radical
- methanesulfonyl
- derivatives
- methyl
- azido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 238000004519 manufacturing process Methods 0.000 title description 3
- 229940126601 medicinal product Drugs 0.000 title description 3
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- -1 ethylaminomethyl radical Chemical class 0.000 claims description 60
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- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 40
- 150000003839 salts Chemical class 0.000 claims description 18
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- 239000003921 oil Substances 0.000 description 1
- 239000006259 organic additive Substances 0.000 description 1
- XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 description 1
- 229960001723 oxytocin Drugs 0.000 description 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229940097325 prolactin Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
- 229960003147 reserpine Drugs 0.000 description 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003459 sulfonic acid esters Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 230000001457 vasomotor Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU79GO1452A HU180467B (en) | 1979-07-12 | 1979-07-12 | Process for producing new ergol-8-ene- and ergoline-sceleted compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3026271A1 true DE3026271A1 (de) | 1981-02-12 |
| DE3026271C2 DE3026271C2 (en, 2012) | 1991-07-25 |
Family
ID=10996898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19803026271 Granted DE3026271A1 (de) | 1979-07-12 | 1980-07-11 | 8-aethylaminomethylergol-8-en- und 8-aethylaminomethylergolinderivate, verfahren zur herstellung derselben und diese enthaltende arzneimittel |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4299836A (en, 2012) |
| JP (1) | JPS5653677A (en, 2012) |
| AU (1) | AU532293B2 (en, 2012) |
| BE (1) | BE884171A (en, 2012) |
| CA (1) | CA1149801A (en, 2012) |
| CH (1) | CH644120A5 (en, 2012) |
| DE (1) | DE3026271A1 (en, 2012) |
| DK (1) | DK160874C (en, 2012) |
| ES (1) | ES8106536A1 (en, 2012) |
| FR (1) | FR2460949A1 (en, 2012) |
| GB (1) | GB2055370B (en, 2012) |
| HU (1) | HU180467B (en, 2012) |
| IL (1) | IL60548A (en, 2012) |
| IT (1) | IT1149840B (en, 2012) |
| NL (1) | NL8004000A (en, 2012) |
| PH (1) | PH16358A (en, 2012) |
| SE (1) | SE436880B (en, 2012) |
| SU (2) | SU1053752A3 (en, 2012) |
| ZA (1) | ZA804198B (en, 2012) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713457A (en) * | 1985-02-21 | 1987-12-15 | Maruko Seiyaku Co., Ltd. | Ergoline derivatives and acid addition salts thereof |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3623438C2 (de) * | 1986-07-10 | 1998-04-09 | Schering Ag | In 2-Stellung mit radioaktivem Iod markierte Ergolinylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Diagnostika |
| US5242678A (en) * | 1986-07-10 | 1993-09-07 | Schering Aktiengesellschaft | BR*-diagnostics for monoamine receptors |
| DE10066158B4 (de) * | 2000-08-24 | 2007-08-09 | Neurobiotec Gmbh | Verwendung eines transdermalen therapeutischen Systems zur Behandlung des Restless-Legs-Syndroms |
| DE10053397A1 (de) * | 2000-10-20 | 2002-05-02 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
| US20070243240A9 (en) * | 2000-08-24 | 2007-10-18 | Fred Windt-Hanke | Transdermal therapeutic system |
| US7398562B2 (en) | 2004-03-10 | 2008-07-15 | Easy Rhino Designs, Inc. | Article with 3-dimensional secondary element |
| RU2274640C1 (ru) * | 2004-09-15 | 2006-04-20 | Всероссийский научно-исследовательский институт лекарственных и ароматических растений ("ВИЛАР") | СПОСОБ БРОМИРОВАНИЯ α И β-ЭРГОКРИПТИНОВ |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL128196C (en, 2012) * | 1961-05-29 | |||
| US3985752A (en) * | 1974-12-06 | 1976-10-12 | Eli Lilly And Company | 6-Methyl-8-(substituted) methylergolines |
| IT1064473B (it) * | 1976-11-24 | 1985-02-18 | Simes | Sulfamoil derivati dell'8-beta-amminometilergolina |
-
1979
- 1979-07-12 HU HU79GO1452A patent/HU180467B/hu not_active IP Right Cessation
-
1980
- 1980-07-04 BE BE1/9882A patent/BE884171A/fr not_active IP Right Cessation
- 1980-07-09 PH PH24263A patent/PH16358A/en unknown
- 1980-07-10 FR FR8015360A patent/FR2460949A1/fr active Granted
- 1980-07-10 US US06/167,341 patent/US4299836A/en not_active Expired - Lifetime
- 1980-07-11 DE DE19803026271 patent/DE3026271A1/de active Granted
- 1980-07-11 CA CA000355996A patent/CA1149801A/en not_active Expired
- 1980-07-11 ES ES493335A patent/ES8106536A1/es not_active Expired
- 1980-07-11 IT IT23387/80A patent/IT1149840B/it active
- 1980-07-11 JP JP9412380A patent/JPS5653677A/ja active Granted
- 1980-07-11 ZA ZA00804198A patent/ZA804198B/xx unknown
- 1980-07-11 NL NL8004000A patent/NL8004000A/nl not_active Application Discontinuation
- 1980-07-11 CH CH533980A patent/CH644120A5/de not_active IP Right Cessation
- 1980-07-11 SE SE8005126A patent/SE436880B/sv not_active IP Right Cessation
- 1980-07-11 IL IL60548A patent/IL60548A/xx unknown
- 1980-07-11 GB GB8022824A patent/GB2055370B/en not_active Expired
- 1980-07-11 DK DK300080A patent/DK160874C/da not_active IP Right Cessation
- 1980-07-11 SU SU802949069A patent/SU1053752A3/ru active
- 1980-07-11 AU AU60349/80A patent/AU532293B2/en not_active Ceased
-
1982
- 1982-02-23 SU SU823394304A patent/SU1072806A3/ru active
Non-Patent Citations (1)
| Title |
|---|
| BERDE, B. - SCHILD, H.O.: Ergot Alkaloids and related Compounds, Springer Verlag, Berlin, Heidelberg, New York 1978, S. 433 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713457A (en) * | 1985-02-21 | 1987-12-15 | Maruko Seiyaku Co., Ltd. | Ergoline derivatives and acid addition salts thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5653677A (en) | 1981-05-13 |
| IT1149840B (it) | 1986-12-10 |
| FR2460949B1 (en, 2012) | 1983-01-21 |
| IT8023387A0 (it) | 1980-07-11 |
| US4299836A (en) | 1981-11-10 |
| ZA804198B (en) | 1981-07-29 |
| AU532293B2 (en) | 1983-09-22 |
| SU1053752A3 (ru) | 1983-11-07 |
| ES8106536A1 (es) | 1981-10-16 |
| HU180467B (en) | 1983-03-28 |
| DE3026271C2 (en, 2012) | 1991-07-25 |
| DK300080A (da) | 1981-01-13 |
| IL60548A (en) | 1983-07-31 |
| GB2055370A (en) | 1981-03-04 |
| DK160874B (da) | 1991-04-29 |
| AU6034980A (en) | 1981-01-15 |
| JPH0210834B2 (en, 2012) | 1990-03-09 |
| PH16358A (en) | 1983-09-08 |
| DK160874C (da) | 1992-02-24 |
| FR2460949A1 (fr) | 1981-01-30 |
| SE8005126L (sv) | 1981-01-13 |
| GB2055370B (en) | 1983-05-05 |
| SE436880B (sv) | 1985-01-28 |
| CA1149801A (en) | 1983-07-12 |
| IL60548A0 (en) | 1980-09-16 |
| CH644120A5 (de) | 1984-07-13 |
| NL8004000A (nl) | 1981-01-14 |
| BE884171A (fr) | 1981-01-05 |
| SU1072806A3 (ru) | 1984-02-07 |
| ES493335A0 (es) | 1981-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |