ES8106536A1 - Procedimiento de preparacion de nuevos derivados ergol-8- enos y ergolinos y de sus sales de adicion acidas - Google Patents

Procedimiento de preparacion de nuevos derivados ergol-8- enos y ergolinos y de sus sales de adicion acidas

Info

Publication number
ES8106536A1
ES8106536A1 ES493335A ES493335A ES8106536A1 ES 8106536 A1 ES8106536 A1 ES 8106536A1 ES 493335 A ES493335 A ES 493335A ES 493335 A ES493335 A ES 493335A ES 8106536 A1 ES8106536 A1 ES 8106536A1
Authority
ES
Spain
Prior art keywords
group
stands
compounds
general formula
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493335A
Other languages
English (en)
Other versions
ES493335A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES493335A0 publication Critical patent/ES493335A0/es
Publication of ES8106536A1 publication Critical patent/ES8106536A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS ERGOL-8-ENOS Y ERGOLINOS, ASI COMO DE SUS SALES DE ADICION ACIDAS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA GENERAL (I) CON DOS EQUIVALENTES, POR LO MENOS DE UN CLORURO DE ALQUILSULFONILO INFERIOR O UN CLORURO ACIDO FENIL-SULFONICO, DISCRECIONALMENTE SUSTITUIDO CON UN GRUPO ALQUILO INFERIOR. OPCIONALMENTE EL COMPUESTO RESULTANTE (II) SE HACE REACCIONAR CON UNA AZIDA METALICA ALCALINA O BIEN SE TRATA CON UN AGENTE HALOGENADOR PARA FORMAR EL DERIVADO 2-HALOGENADO, O BIEN SE TRATA CON UN ACIDO PARA OBTENER LA SAL DE ADICION ACIDA CORRESPONDIENTE. *FORMULA*
ES493335A 1979-07-12 1980-07-11 Procedimiento de preparacion de nuevos derivados ergol-8- enos y ergolinos y de sus sales de adicion acidas Expired ES8106536A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU79GO1452A HU180467B (en) 1979-07-12 1979-07-12 Process for producing new ergol-8-ene- and ergoline-sceleted compounds

Publications (2)

Publication Number Publication Date
ES493335A0 ES493335A0 (es) 1981-07-16
ES8106536A1 true ES8106536A1 (es) 1981-10-16

Family

ID=10996898

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493335A Expired ES8106536A1 (es) 1979-07-12 1980-07-11 Procedimiento de preparacion de nuevos derivados ergol-8- enos y ergolinos y de sus sales de adicion acidas

Country Status (19)

Country Link
US (1) US4299836A (es)
JP (1) JPS5653677A (es)
AU (1) AU532293B2 (es)
BE (1) BE884171A (es)
CA (1) CA1149801A (es)
CH (1) CH644120A5 (es)
DE (1) DE3026271A1 (es)
DK (1) DK160874C (es)
ES (1) ES8106536A1 (es)
FR (1) FR2460949A1 (es)
GB (1) GB2055370B (es)
HU (1) HU180467B (es)
IL (1) IL60548A (es)
IT (1) IT1149840B (es)
NL (1) NL8004000A (es)
PH (1) PH16358A (es)
SE (1) SE436880B (es)
SU (2) SU1053752A3 (es)
ZA (1) ZA804198B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2173189B (en) * 1985-02-21 1988-04-27 Maruko Pharmaceutical Co Ergoline derivatives and salts thereof and pharmaceutical compositions thereof
DE3623438C2 (de) * 1986-07-10 1998-04-09 Schering Ag In 2-Stellung mit radioaktivem Iod markierte Ergolinylharnstoffderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Diagnostika
US5242678A (en) * 1986-07-10 1993-09-07 Schering Aktiengesellschaft BR*-diagnostics for monoamine receptors
US20070243240A9 (en) * 2000-08-24 2007-10-18 Fred Windt-Hanke Transdermal therapeutic system
DE10043321B4 (de) * 2000-08-24 2005-07-28 Neurobiotec Gmbh Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung
DE10053397A1 (de) * 2000-10-20 2002-05-02 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL128196C (es) * 1961-05-29
US3985752A (en) * 1974-12-06 1976-10-12 Eli Lilly And Company 6-Methyl-8-(substituted) methylergolines
IT1064473B (it) * 1976-11-24 1985-02-18 Simes Sulfamoil derivati dell'8-beta-amminometilergolina

Also Published As

Publication number Publication date
DK160874C (da) 1992-02-24
ES493335A0 (es) 1981-07-16
NL8004000A (nl) 1981-01-14
IL60548A (en) 1983-07-31
SU1072806A3 (ru) 1984-02-07
DE3026271C2 (es) 1991-07-25
DK160874B (da) 1991-04-29
JPS5653677A (en) 1981-05-13
IT1149840B (it) 1986-12-10
SU1053752A3 (ru) 1983-11-07
AU6034980A (en) 1981-01-15
US4299836A (en) 1981-11-10
FR2460949B1 (es) 1983-01-21
DK300080A (da) 1981-01-13
BE884171A (fr) 1981-01-05
GB2055370A (en) 1981-03-04
PH16358A (en) 1983-09-08
CH644120A5 (de) 1984-07-13
IT8023387A0 (it) 1980-07-11
HU180467B (en) 1983-03-28
DE3026271A1 (de) 1981-02-12
FR2460949A1 (fr) 1981-01-30
CA1149801A (en) 1983-07-12
IL60548A0 (en) 1980-09-16
SE8005126L (sv) 1981-01-13
JPH0210834B2 (es) 1990-03-09
GB2055370B (en) 1983-05-05
SE436880B (sv) 1985-01-28
AU532293B2 (en) 1983-09-22
ZA804198B (en) 1981-07-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303