DE3024723A1 - Prostacyclin-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate - Google Patents

Prostacyclin-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate

Info

Publication number
DE3024723A1
DE3024723A1 DE19803024723 DE3024723A DE3024723A1 DE 3024723 A1 DE3024723 A1 DE 3024723A1 DE 19803024723 DE19803024723 DE 19803024723 DE 3024723 A DE3024723 A DE 3024723A DE 3024723 A1 DE3024723 A1 DE 3024723A1
Authority
DE
Germany
Prior art keywords
formula
hydroxy
decarboxy
deoxy
hydroxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19803024723
Other languages
German (de)
English (en)
Inventor
John Charles Sih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/054,720 external-priority patent/US4225507A/en
Priority claimed from US06/054,811 external-priority patent/US4225508A/en
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DE3024723A1 publication Critical patent/DE3024723A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE19803024723 1979-07-05 1980-06-30 Prostacyclin-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate Withdrawn DE3024723A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/054,720 US4225507A (en) 1979-07-05 1979-07-05 19-Hydroxy-19-methyl-PGI2 compounds
US06/054,811 US4225508A (en) 1979-07-05 1979-07-05 19-Hydroxy-PGI2 compounds

Publications (1)

Publication Number Publication Date
DE3024723A1 true DE3024723A1 (de) 1981-01-15

Family

ID=26733395

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803024723 Withdrawn DE3024723A1 (de) 1979-07-05 1980-06-30 Prostacyclin-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate

Country Status (6)

Country Link
CH (1) CH645369A5 (nl)
DE (1) DE3024723A1 (nl)
FR (1) FR2460944B1 (nl)
GB (1) GB2055811B (nl)
IT (1) IT1131550B (nl)
NL (1) NL8003829A (nl)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3035713A1 (de) * 1980-09-22 1982-04-29 F. Hoffmann-La Roche & Co. AG, 4002 Basel Prostacycline

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2048254B (en) * 1979-04-02 1983-05-25 Upjohn Co 19,20 -didehydro-19-hydroxy and 19-oxo-prostaglandin derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3035713A1 (de) * 1980-09-22 1982-04-29 F. Hoffmann-La Roche & Co. AG, 4002 Basel Prostacycline

Also Published As

Publication number Publication date
IT8023142A0 (it) 1980-06-30
GB2055811A (en) 1981-03-11
GB2055811B (en) 1983-06-02
FR2460944A1 (fr) 1981-01-30
IT1131550B (it) 1986-06-25
CH645369A5 (de) 1984-09-28
NL8003829A (nl) 1981-01-07
FR2460944B1 (fr) 1987-05-07

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Legal Events

Date Code Title Description
8128 New person/name/address of the agent

Representative=s name: HENKEL, G., DR.PHIL. FEILER, L., DR.RER.NAT. HAENZ

8141 Disposal/no request for examination