DE3020137A1 - 1,2-dihydropyrido eckige klammer auf 3,2-e eckige klammer zu -as-triazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel - Google Patents
1,2-dihydropyrido eckige klammer auf 3,2-e eckige klammer zu -as-triazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittelInfo
- Publication number
- DE3020137A1 DE3020137A1 DE19803020137 DE3020137A DE3020137A1 DE 3020137 A1 DE3020137 A1 DE 3020137A1 DE 19803020137 DE19803020137 DE 19803020137 DE 3020137 A DE3020137 A DE 3020137A DE 3020137 A1 DE3020137 A1 DE 3020137A1
- Authority
- DE
- Germany
- Prior art keywords
- dihydropyrido
- radical
- deep
- triazine
- radicals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims description 37
- 150000001875 compounds Chemical class 0.000 title claims description 25
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 claims description 50
- 239000002253 acid Substances 0.000 claims description 45
- YZEFUHIDWUTUJO-UHFFFAOYSA-N 1,2-dihydropyrido[3,2-e][1,2,4]triazine Chemical class C1=CC=C2N=CNNC2=N1 YZEFUHIDWUTUJO-UHFFFAOYSA-N 0.000 claims description 35
- 150000003839 salts Chemical class 0.000 claims description 27
- 125000000623 heterocyclic group Chemical group 0.000 claims description 26
- 125000000217 alkyl group Chemical group 0.000 claims description 24
- 239000003795 chemical substances by application Substances 0.000 claims description 22
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 20
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 15
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 11
- JDWSWQMLJIQTEP-UHFFFAOYSA-N 5-hydroxypyrazol-3-one Chemical group OC1=CC(=O)N=N1 JDWSWQMLJIQTEP-UHFFFAOYSA-N 0.000 claims description 10
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- LEVJVKGPFAQPOI-UHFFFAOYSA-N phenylmethanone Chemical compound O=[C]C1=CC=CC=C1 LEVJVKGPFAQPOI-UHFFFAOYSA-N 0.000 claims description 10
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 9
- 239000011230 binding agent Substances 0.000 claims description 9
- 125000005843 halogen group Chemical group 0.000 claims description 9
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- DGLKHURUHQEVNX-UHFFFAOYSA-N (3-hexyl-2h-pyrido[3,2-e][1,2,4]triazin-1-yl)-phenylmethanone Chemical compound N1C(CCCCCC)=NC2=CC=CN=C2N1C(=O)C1=CC=CC=C1 DGLKHURUHQEVNX-UHFFFAOYSA-N 0.000 claims description 2
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- HUUWLWMOVWTEBD-UHFFFAOYSA-N 1-(3-hexyl-2h-pyrido[3,2-e][1,2,4]triazin-1-yl)propan-1-one Chemical compound C1=CN=C2N(C(=O)CC)NC(CCCCCC)=NC2=C1 HUUWLWMOVWTEBD-UHFFFAOYSA-N 0.000 claims description 2
- NNIUQPUHVURYFZ-UHFFFAOYSA-N 1-[2-acetyl-3-(3,4,5-trimethoxyphenyl)pyrido[3,2-e][1,2,4]triazin-1-yl]ethanone Chemical compound COC1=C(OC)C(OC)=CC(C=2N(N(C3=NC=CC=C3N=2)C(C)=O)C(C)=O)=C1 NNIUQPUHVURYFZ-UHFFFAOYSA-N 0.000 claims description 2
- CXJYKIPENDHARZ-UHFFFAOYSA-N 1-[3-(3,4,5-trimethoxyphenyl)-2h-pyrido[3,2-e][1,2,4]triazin-1-yl]propan-1-one Chemical compound N=1C2=CC=CN=C2N(C(=O)CC)NC=1C1=CC(OC)=C(OC)C(OC)=C1 CXJYKIPENDHARZ-UHFFFAOYSA-N 0.000 claims description 2
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- 239000000654 additive Substances 0.000 claims description 2
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- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- -1 alkylcarbonyl radicals Chemical class 0.000 description 117
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU79EE2664A HU179159B (en) | 1979-05-25 | 1979-05-25 | Process for producing new pyrido-square bracket-3,2-e-square bracket closed-asimmetrical-triasine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3020137A1 true DE3020137A1 (de) | 1981-01-29 |
Family
ID=10995851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19803020137 Withdrawn DE3020137A1 (de) | 1979-05-25 | 1980-05-27 | 1,2-dihydropyrido eckige klammer auf 3,2-e eckige klammer zu -as-triazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4320127A (enExample) |
| JP (1) | JPS55157585A (enExample) |
| AT (1) | AT375371B (enExample) |
| AU (1) | AU534540B2 (enExample) |
| BE (1) | BE883355A (enExample) |
| CH (1) | CH646168A5 (enExample) |
| CS (1) | CS244406B2 (enExample) |
| DD (1) | DD154489A5 (enExample) |
| DE (1) | DE3020137A1 (enExample) |
| ES (1) | ES491806A0 (enExample) |
| FR (1) | FR2457291A1 (enExample) |
| GB (1) | GB2051792B (enExample) |
| GR (1) | GR68491B (enExample) |
| HU (1) | HU179159B (enExample) |
| IT (1) | IT1212416B (enExample) |
| NL (1) | NL8003036A (enExample) |
| SU (1) | SU982542A3 (enExample) |
| YU (1) | YU135780A (enExample) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3549631A (en) * | 1968-09-27 | 1970-12-22 | American Cyanamid Co | 3,6 - disubstituted - pyrido(3,2-e) - triazines and 3,6 - disubstituted - 1,2 - dihydropyrido(3,2-e)-triazines |
| JPS5469686A (en) * | 1977-11-15 | 1979-06-04 | Omron Tateisi Electronics Co | Input control system |
-
1979
- 1979-05-25 HU HU79EE2664A patent/HU179159B/hu not_active IP Right Cessation
-
1980
- 1980-03-24 GR GR62044A patent/GR68491B/el unknown
- 1980-05-19 BE BE1/9825A patent/BE883355A/fr not_active IP Right Cessation
- 1980-05-20 FR FR8011208A patent/FR2457291A1/fr active Granted
- 1980-05-20 YU YU01357/80A patent/YU135780A/xx unknown
- 1980-05-23 CS CS803659A patent/CS244406B2/cs unknown
- 1980-05-23 AU AU58711/80A patent/AU534540B2/en not_active Ceased
- 1980-05-23 JP JP6796680A patent/JPS55157585A/ja active Pending
- 1980-05-23 AT AT0278180A patent/AT375371B/de not_active IP Right Cessation
- 1980-05-23 GB GB8017172A patent/GB2051792B/en not_active Expired
- 1980-05-23 CH CH404280A patent/CH646168A5/de not_active IP Right Cessation
- 1980-05-23 ES ES491806A patent/ES491806A0/es active Granted
- 1980-05-23 DD DD80221352A patent/DD154489A5/de unknown
- 1980-05-23 US US06/152,833 patent/US4320127A/en not_active Expired - Lifetime
- 1980-05-23 SU SU802928212A patent/SU982542A3/ru active
- 1980-05-23 IT IT8022280A patent/IT1212416B/it active
- 1980-05-27 NL NL8003036A patent/NL8003036A/nl not_active Application Discontinuation
- 1980-05-27 DE DE19803020137 patent/DE3020137A1/de not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| Ungarischen Patentschrift 168 501 |
Also Published As
| Publication number | Publication date |
|---|---|
| CH646168A5 (de) | 1984-11-15 |
| US4320127A (en) | 1982-03-16 |
| GB2051792A (en) | 1981-01-21 |
| AT375371B (de) | 1984-07-25 |
| HU179159B (en) | 1982-08-28 |
| CS365980A2 (en) | 1985-09-17 |
| FR2457291A1 (fr) | 1980-12-19 |
| FR2457291B1 (enExample) | 1983-06-10 |
| YU135780A (en) | 1983-02-28 |
| GB2051792B (en) | 1983-06-29 |
| NL8003036A (nl) | 1980-11-27 |
| IT8022280A0 (it) | 1980-05-23 |
| ATA278180A (de) | 1983-12-15 |
| SU982542A3 (ru) | 1982-12-15 |
| GR68491B (enExample) | 1982-01-07 |
| ES8106518A1 (es) | 1981-08-01 |
| JPS55157585A (en) | 1980-12-08 |
| CS244406B2 (en) | 1986-07-17 |
| BE883355A (fr) | 1980-11-19 |
| AU5871180A (en) | 1980-11-27 |
| ES491806A0 (es) | 1981-08-01 |
| DD154489A5 (de) | 1982-03-24 |
| IT1212416B (it) | 1989-11-22 |
| AU534540B2 (en) | 1984-02-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8130 | Withdrawal |