DE3018545A1 - 2- eckige klammer auf mercapto-1- oxo(nieder-alkyl) eckige klammer zu -1,2,3,4-tetrahydroisochinolin-3- carbonsaeuren - Google Patents

2- eckige klammer auf mercapto-1- oxo(nieder-alkyl) eckige klammer zu -1,2,3,4-tetrahydroisochinolin-3- carbonsaeuren

Info

Publication number
DE3018545A1
DE3018545A1 DE19803018545 DE3018545A DE3018545A1 DE 3018545 A1 DE3018545 A1 DE 3018545A1 DE 19803018545 DE19803018545 DE 19803018545 DE 3018545 A DE3018545 A DE 3018545A DE 3018545 A1 DE3018545 A1 DE 3018545A1
Authority
DE
Germany
Prior art keywords
ing
solution
tetrahydroisoquinoline
angle clamp
dipl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19803018545
Other languages
German (de)
English (en)
Inventor
David E Portlock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Chilcott Pharmaceuticals Inc
Original Assignee
Morton Norwich Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morton Norwich Products Inc filed Critical Morton Norwich Products Inc
Publication of DE3018545A1 publication Critical patent/DE3018545A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE19803018545 1979-05-16 1980-05-14 2- eckige klammer auf mercapto-1- oxo(nieder-alkyl) eckige klammer zu -1,2,3,4-tetrahydroisochinolin-3- carbonsaeuren Withdrawn DE3018545A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3931779A 1979-05-16 1979-05-16

Publications (1)

Publication Number Publication Date
DE3018545A1 true DE3018545A1 (de) 1980-11-27

Family

ID=21904828

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803018545 Withdrawn DE3018545A1 (de) 1979-05-16 1980-05-14 2- eckige klammer auf mercapto-1- oxo(nieder-alkyl) eckige klammer zu -1,2,3,4-tetrahydroisochinolin-3- carbonsaeuren

Country Status (7)

Country Link
JP (1) JPS55153769A (enExample)
BE (1) BE883320A (enExample)
DE (1) DE3018545A1 (enExample)
FR (1) FR2456733A1 (enExample)
GB (2) GB2048863B (enExample)
IT (1) IT1133009B (enExample)
NL (1) NL8002828A (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052870A1 (de) * 1980-11-25 1982-06-02 Hoechst Aktiengesellschaft Aminosäurederivate und Verfahren zu ihrer Herstellung
WO1993023378A1 (en) * 1992-05-19 1993-11-25 Warner-Lambert Company Substituted 1,2,3,4-tetrahydroisoquinolines with angiotensin ii receptor antagonist properties

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595675A (en) * 1979-09-19 1986-06-17 Hoechst Aktiengesellschaft Bicyclic α-iminocarboxylic acid compounds having hypotensive activity
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US5200416A (en) * 1980-05-12 1993-04-06 Usv Pharmaceutical Corporation Cyclic amides
US4344949A (en) 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4432971A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4427665A (en) 1982-05-19 1984-01-24 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted imino acids and their use in hypotensive compositions
US4736066A (en) * 1982-07-19 1988-04-05 E. R. Squibb & Sons, Inc. Intermediate for substituted peptide compounds
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
US4621092A (en) * 1982-07-22 1986-11-04 E. R. Squibb & Sons, Inc. Substituted proline compounds, composition and method of use
US4623729A (en) 1982-07-22 1986-11-18 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4742067A (en) * 1982-07-22 1988-05-03 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4524212A (en) * 1982-09-27 1985-06-18 E. R. Squibb & Sons, Inc. Acyloxyketone substituted imino and amino acids
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4642315A (en) * 1982-11-18 1987-02-10 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4456595A (en) * 1982-12-06 1984-06-26 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy aroly peptides
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5572169A (en) * 1978-11-27 1980-05-30 Tanabe Seiyaku Co Ltd Isoquinoline derivative and its preparation
EP0018104B1 (en) * 1979-03-26 1983-05-25 Takeda Chemical Industries, Ltd. Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
FR2470767A1 (fr) * 1979-12-07 1981-06-12 Science Union & Cie Nouveaux iminoacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzymes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052870A1 (de) * 1980-11-25 1982-06-02 Hoechst Aktiengesellschaft Aminosäurederivate und Verfahren zu ihrer Herstellung
WO1993023378A1 (en) * 1992-05-19 1993-11-25 Warner-Lambert Company Substituted 1,2,3,4-tetrahydroisoquinolines with angiotensin ii receptor antagonist properties

Also Published As

Publication number Publication date
GB2048863B (en) 1983-06-15
GB2116542B (en) 1984-02-15
JPS55153769A (en) 1980-11-29
NL8002828A (nl) 1980-11-18
IT1133009B (it) 1986-07-09
GB2048863A (en) 1980-12-17
IT8048675A0 (it) 1980-05-14
FR2456733B1 (enExample) 1983-08-26
BE883320A (fr) 1980-11-14
FR2456733A1 (fr) 1980-12-12
GB2116542A (en) 1983-09-28

Similar Documents

Publication Publication Date Title
DE3018545A1 (de) 2- eckige klammer auf mercapto-1- oxo(nieder-alkyl) eckige klammer zu -1,2,3,4-tetrahydroisochinolin-3- carbonsaeuren
EP0089637B1 (de) Neue Derivate bicyclischer Aminosäuren, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung sowie neue bicyclische Aminosäuren als Zwischenstufen und Verfahren zu deren Herstellung
DD201887A5 (de) Verfahren zur herstellung von 1-carboxyalkanoylindolin-2-carbonsaeuren
DE2354389A1 (de) Chinazolinverbindungen und verfahren zu ihrer herstellung
DE3211676A1 (de) Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
EP0142739B1 (de) Aminosäurederivate und Verfahren zu ihrer Herstellung
DE2914059A1 (de) 4-thiazolidincarbonsaeuren, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE3227055A1 (de) Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung
EP0051301A1 (de) 1-Carboxy-azaalkanoylindolin-2-carbonsäuren, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung
DE3209708A1 (de) Peptidderivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE1445904A1 (de) Verfahren zur Herstellung von 4-Imidazolidon-Verbindungen
DE2410938A1 (de) Chinazolinderivate und diese enthaltende arzneimittel
CH622248A5 (enExample)
DE2347015C2 (de) Neue Pyrazolyloxyessigsäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel
DE3246757A1 (de) Neue 2-azabicyclo(2.2.1)heptan-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(2.2.1)heptan-derivate als zwischenprodukte und verfahren zu deren herstellung
DE2923817C2 (de) (3-Alkylamino-2-hydroxyproposy)-furan-2-carbonsäureanilide und deren physiologisch verträgliche Säureadditionssalze und Verfahren zu deren Herstellung sowie Arzneimittel mit einem Gehalt dieser Verbindungen
CH653996A5 (de) Tryptaminderivate und verfahren zu deren herstellung.
CH625217A5 (enExample)
DE3207023A1 (de) Amidinverbindungen, verfahren zu ihrer herstellung und antikomplement-mittel, die diese verbindungen enthalten
DE3151690A1 (de) "neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung"
EP0158312B1 (de) 1-[Cyclohexyl]-3,4-di-[hydro]-isochinolinderivate, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
DE2735589A1 (de) 1-phenyl-1-methoxy-2-amino-aethan- derivate und verfahren zu ihrer herstellung
DE2918748A1 (de) Benzoylphenoxyalkansaeurederivate, verfahren zu ihrer herstellung und solche enthaltende arzneimittel
AT367414B (de) Verfahren zur herstellung von neuen 4-thiazolidin-carbonsaeurederivaten und von deren salzen und stereoisomeren
DE2559928C2 (de) N-Aroyl-L-phenylalanyl-L-tyrosine, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: NORWICH EATON PHARMACEUTICALS, INC., 13815 NORWICH

8139 Disposal/non-payment of the annual fee