FR2456733A1 - Nouveaux acides 2-(mercapto-1-oxo(alkyl inferieur))-1,2,3,4-tetrahydroisoquinoleine-3-carboxyliques, utiles notamment comme inhibiteurs de l'enzyme de conversion de l'angiotensine i - Google Patents

Nouveaux acides 2-(mercapto-1-oxo(alkyl inferieur))-1,2,3,4-tetrahydroisoquinoleine-3-carboxyliques, utiles notamment comme inhibiteurs de l'enzyme de conversion de l'angiotensine i

Info

Publication number
FR2456733A1
FR2456733A1 FR8010941A FR8010941A FR2456733A1 FR 2456733 A1 FR2456733 A1 FR 2456733A1 FR 8010941 A FR8010941 A FR 8010941A FR 8010941 A FR8010941 A FR 8010941A FR 2456733 A1 FR2456733 A1 FR 2456733A1
Authority
FR
France
Prior art keywords
angiotensin
tetrahydroisoquinoleine
mercapto
oxo
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8010941A
Other languages
English (en)
French (fr)
Other versions
FR2456733B1 (enExample
Inventor
David E Portlock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ATK Launch Systems LLC
Original Assignee
Morton Norwich Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morton Norwich Products Inc filed Critical Morton Norwich Products Inc
Publication of FR2456733A1 publication Critical patent/FR2456733A1/fr
Application granted granted Critical
Publication of FR2456733B1 publication Critical patent/FR2456733B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
FR8010941A 1979-05-16 1980-05-14 Nouveaux acides 2-(mercapto-1-oxo(alkyl inferieur))-1,2,3,4-tetrahydroisoquinoleine-3-carboxyliques, utiles notamment comme inhibiteurs de l'enzyme de conversion de l'angiotensine i Granted FR2456733A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3931779A 1979-05-16 1979-05-16

Publications (2)

Publication Number Publication Date
FR2456733A1 true FR2456733A1 (fr) 1980-12-12
FR2456733B1 FR2456733B1 (enExample) 1983-08-26

Family

ID=21904828

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8010941A Granted FR2456733A1 (fr) 1979-05-16 1980-05-14 Nouveaux acides 2-(mercapto-1-oxo(alkyl inferieur))-1,2,3,4-tetrahydroisoquinoleine-3-carboxyliques, utiles notamment comme inhibiteurs de l'enzyme de conversion de l'angiotensine i

Country Status (7)

Country Link
JP (1) JPS55153769A (enExample)
BE (1) BE883320A (enExample)
DE (1) DE3018545A1 (enExample)
FR (1) FR2456733A1 (enExample)
GB (2) GB2048863B (enExample)
IT (1) IT1133009B (enExample)
NL (1) NL8002828A (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
EP0049658A1 (fr) * 1980-10-02 1982-04-14 Adir Iminodiacides substitués, leur préparation et compositions pharmaceutiques les contenant
EP0049605A1 (en) * 1980-10-03 1982-04-14 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595675A (en) * 1979-09-19 1986-06-17 Hoechst Aktiengesellschaft Bicyclic α-iminocarboxylic acid compounds having hypotensive activity
DE3044236A1 (de) * 1980-11-25 1982-06-16 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate und verfahren zu ihrer herstellung
US5200416A (en) * 1980-05-12 1993-04-06 Usv Pharmaceutical Corporation Cyclic amides
US4432971A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4427665A (en) 1982-05-19 1984-01-24 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted imino acids and their use in hypotensive compositions
US4736066A (en) * 1982-07-19 1988-04-05 E. R. Squibb & Sons, Inc. Intermediate for substituted peptide compounds
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
US4621092A (en) * 1982-07-22 1986-11-04 E. R. Squibb & Sons, Inc. Substituted proline compounds, composition and method of use
US4623729A (en) 1982-07-22 1986-11-18 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4742067A (en) * 1982-07-22 1988-05-03 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4524212A (en) * 1982-09-27 1985-06-18 E. R. Squibb & Sons, Inc. Acyloxyketone substituted imino and amino acids
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4642315A (en) * 1982-11-18 1987-02-10 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4456595A (en) * 1982-12-06 1984-06-26 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy aroly peptides
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012845A1 (en) * 1978-11-27 1980-07-09 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds, process for preparing same and pharmaceutical compositions containing them
EP0018104A2 (en) * 1979-03-26 1980-10-29 Takeda Chemical Industries, Ltd. Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
FR2470767A1 (fr) * 1979-12-07 1981-06-12 Science Union & Cie Nouveaux iminoacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzymes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012845A1 (en) * 1978-11-27 1980-07-09 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds, process for preparing same and pharmaceutical compositions containing them
EP0018104A2 (en) * 1979-03-26 1980-10-29 Takeda Chemical Industries, Ltd. Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
FR2470767A1 (fr) * 1979-12-07 1981-06-12 Science Union & Cie Nouveaux iminoacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzymes

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
EP0049658A1 (fr) * 1980-10-02 1982-04-14 Adir Iminodiacides substitués, leur préparation et compositions pharmaceutiques les contenant
EP0049605A1 (en) * 1980-10-03 1982-04-14 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same
US4344949A (en) 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

Also Published As

Publication number Publication date
GB2048863B (en) 1983-06-15
GB2116542B (en) 1984-02-15
JPS55153769A (en) 1980-11-29
NL8002828A (nl) 1980-11-18
IT1133009B (it) 1986-07-09
GB2048863A (en) 1980-12-17
IT8048675A0 (it) 1980-05-14
FR2456733B1 (enExample) 1983-08-26
BE883320A (fr) 1980-11-14
GB2116542A (en) 1983-09-28
DE3018545A1 (de) 1980-11-27

Similar Documents

Publication Publication Date Title
FR2456733A1 (fr) Nouveaux acides 2-(mercapto-1-oxo(alkyl inferieur))-1,2,3,4-tetrahydroisoquinoleine-3-carboxyliques, utiles notamment comme inhibiteurs de l'enzyme de conversion de l'angiotensine i
FR2448533A1 (fr) Nouveaux acides 1-(acylthio- et mercapto-1-oxoalkyl)-1,2,3,4-tetrahydroquinoleine-2-carboxyliques et leurs sels, utiles notamment comme hypotenseurs
FR2592048A1 (fr) Inhibiteurs d'ureido-renine, a action therapeutique
NO812311L (no) Bronchospasmolytisk virksomme forbindelser og fremgangsmaate for deres fremstilling
FR2449089A1 (fr) B-lactames derives de l'acide penicillanique, leur preparation et leurs utilisations therapeutiques
HUP9902092A2 (hu) Metalloproteináz gátló benzolszulfonamidszármazékok, intermedierjeik, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények
DK463986A (da) (n-substitueret-2-hydroxy)-benzamider og n-substitueret-2-hydroxy-alfa-oxo-benzenacetamider, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende forbindelserne
NO170280C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive sulfamatderivater
CA1273942C (en) Derivatives of imidazole, their preparation and utilisation, and pharmaceutical compositions containing these derivatives
BE902876A (fr) Derives d'aminophenol
BE900192A (fr) Nouvelles 1,5-benzothiazepines d'utilite cardiovasculaire, procedes pour leur preparation et compositions pharmaceutiques en contenant.
ATE41772T1 (de) Polymethoxybenzyl-piperazin-derivate, verfahren zu ihrer herstellung und diese derivate enthaltende pharmazeutische zusammensetzungen.
ATE13765T1 (de) 2-(1,4-benzodioxan-2-ylalkyl)-imidazole, deren herstellung und sie enthaltende pharmazeutische mittel.
FR2707089B1 (fr) Nouveaux dérivés d'acide phosphonique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2375245A1 (fr) Acides carboxyphosphoniques utilisables pour le traitement d'eaux
ATE30152T1 (de) 1-methyl-5-nitro-imidazolin-derivate und diese enthaltende therapeutische zusammensetzungen.
US4092412A (en) Treatment of herpes simplex infections
TNSN91055A1 (fr) Nouvelles tetrahydroimidazo (1,4) benzodiazepine -2-(thi) ones
FR2436134A1 (fr) Derives d'acide hydroxamique, leur procede de preparation et medicament les contenant
FR2449689A1 (fr) Nouveaux derives condenses de pyrrolidine ou de piperidine, leur procede de preparation et leurs applications en therapeutique
FR2451375A1 (fr) 2-azaergolines et 2-aza-8 (ou 9) ergolenes et leur utilisation therapeutique
ES476354A1 (es) Procedimientos para la obtencion de nuevos derivados de ari-laminoimidazolina.
FR2390954A1 (fr) Nouvelles guanylhydrazones, leurs procedes de preparation et medicaments les contenant
FR2455569A1 (fr) Nouvelles isoprenylamines et leurs sels acides d'addition et leur utilisation comme substances actives dans des compositions pharmaceutiques antivirales pour animaux vertebres
FR2424912A1 (fr) Derives de l'imidazole utilisables notamment pour le traitement de l'hypertension

Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse