FR2456733A1 - NEW ACIDS 2- (MERCAPTO-1-OXO (LOWER ALKYL)) - 1,2,3,4-TETRAHYDROISOQUINOLEINE-3-CARBOXYLIQUES, ESPECIALLY USEFUL AS INHIBITORS OF THE ANGIOTENSIN I CONVERSION ENZYME - Google Patents
NEW ACIDS 2- (MERCAPTO-1-OXO (LOWER ALKYL)) - 1,2,3,4-TETRAHYDROISOQUINOLEINE-3-CARBOXYLIQUES, ESPECIALLY USEFUL AS INHIBITORS OF THE ANGIOTENSIN I CONVERSION ENZYMEInfo
- Publication number
- FR2456733A1 FR2456733A1 FR8010941A FR8010941A FR2456733A1 FR 2456733 A1 FR2456733 A1 FR 2456733A1 FR 8010941 A FR8010941 A FR 8010941A FR 8010941 A FR8010941 A FR 8010941A FR 2456733 A1 FR2456733 A1 FR 2456733A1
- Authority
- FR
- France
- Prior art keywords
- angiotensin
- tetrahydroisoquinoleine
- mercapto
- oxo
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
L'INVENTION A POUR OBJET DE NOUVEAUX ACIDES 2-MERCAPTO-1-OXO-(ALKYL INFERIEUR)-1,2,3,4-TETRAHYDROISOQUINOLEINE-3-CARBOXYLIQUES. LES MEDICAMENTS DE L'INVENTION SONT DES COMPOSES DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST UN ATOME D'HYDROGENE OU UN GROUPE ACETYLE OU BENZOYLE, R ET R SONT CHACUN UN ATOME D'HYDROGENE OU UN GROUPE METHOXY, N EST EGAL A 1 OU 2 ET M EST EGAL A 0 OU 1, ET LEURS SELS ACCEPTABLES POUR L'USAGE PHARMACEUTIQUE. APPLICATIONS: LES COMPOSES SONT DES INHIBITEURS DE L'ENZYME DE CONVERSION DE L'ANGIOTENSINE I EN ANGIOTENSINE II UTILES DANS LE TRAITEMENT DE CERTAINS TYPES D'HYPERTENSION ASSOCIEES A L'ANGIOTENSINE II.THE SUBJECT OF THE INVENTION IS NEW 2-MERCAPTO-1-OXO- (LOWER ALKYL) -1,2,3,4-TETRAHYDROISOQUINOLEINE-3-CARBOXYLIC ACIDS. THE MEDICINAL PRODUCTS OF THE INVENTION ARE COMPOUNDS OF THE GENERAL FORMULA: (CF DRAWING IN BOPI) IN WHICH R IS A HYDROGEN ATOM OR AN ACETYL OR BENZOYL GROUP, R AND R ARE EACH A HYDROGEN ATOM OR A METHOXY GROUP, N IS EQUAL TO 1 OR 2 AND M IS EQUAL TO 0 OR 1, AND THEIR SALTS ACCEPTABLE FOR PHARMACEUTICAL USE. APPLICATIONS: THE COMPOUNDS ARE INHIBITORS OF THE CONVERTING ENZYME FROM ANGIOTENSIN I TO ANGIOTENSIN II USEFUL IN THE TREATMENT OF CERTAIN TYPES OF HYPERTENSION ASSOCIATED WITH ANGIOTENSIN II.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3931779A | 1979-05-16 | 1979-05-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2456733A1 true FR2456733A1 (en) | 1980-12-12 |
FR2456733B1 FR2456733B1 (en) | 1983-08-26 |
Family
ID=21904828
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8010941A Granted FR2456733A1 (en) | 1979-05-16 | 1980-05-14 | NEW ACIDS 2- (MERCAPTO-1-OXO (LOWER ALKYL)) - 1,2,3,4-TETRAHYDROISOQUINOLEINE-3-CARBOXYLIQUES, ESPECIALLY USEFUL AS INHIBITORS OF THE ANGIOTENSIN I CONVERSION ENZYME |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS55153769A (en) |
BE (1) | BE883320A (en) |
DE (1) | DE3018545A1 (en) |
FR (1) | FR2456733A1 (en) |
GB (2) | GB2048863B (en) |
IT (1) | IT1133009B (en) |
NL (1) | NL8002828A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2487829A2 (en) * | 1979-12-07 | 1982-02-05 | Science Union & Cie | NOVEL SUBSTITUTED IMINO ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR |
EP0049605A1 (en) * | 1980-10-03 | 1982-04-14 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same |
EP0049658A1 (en) * | 1980-10-02 | 1982-04-14 | Adir | Substituted imino diacids, their preparation and pharmaceutical preparations containing them |
US4532342A (en) * | 1981-02-20 | 1985-07-30 | Warner-Lambert Company | N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4595675A (en) * | 1979-09-19 | 1986-06-17 | Hoechst Aktiengesellschaft | Bicyclic α-iminocarboxylic acid compounds having hypotensive activity |
DE3044236A1 (en) * | 1980-11-25 | 1982-06-16 | Hoechst Ag, 6000 Frankfurt | AMINO ACID DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF |
US5200416A (en) * | 1980-05-12 | 1993-04-06 | Usv Pharmaceutical Corporation | Cyclic amides |
US4432971A (en) * | 1981-08-03 | 1984-02-21 | E. R. Squibb & Sons, Inc. | Phosphonamidate compounds |
US4555506A (en) * | 1981-12-24 | 1985-11-26 | E. R. Squibb & Sons, Inc. | Phosphorus containing compounds and use as hypotensives |
US4452791A (en) * | 1982-03-15 | 1984-06-05 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
US4560680A (en) * | 1982-03-15 | 1985-12-24 | E. R. Squibb & Sons, Inc. | Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors |
US4427665A (en) | 1982-05-19 | 1984-01-24 | E. R. Squibb & Sons, Inc. | Phosphinylalkanoyl substituted imino acids and their use in hypotensive compositions |
US4736066A (en) * | 1982-07-19 | 1988-04-05 | E. R. Squibb & Sons, Inc. | Intermediate for substituted peptide compounds |
US4470973A (en) * | 1982-07-19 | 1984-09-11 | E. R. Squibb & Sons, Inc. | Substituted peptide compounds |
US4742067A (en) * | 1982-07-22 | 1988-05-03 | E. R. Squibb & Sons, Inc. | Acylalkylaminocarbonyl substituted amino and imino acid compounds |
US4623729A (en) | 1982-07-22 | 1986-11-18 | E. R. Squibb & Sons, Inc. | Acylalkylaminocarbonyl substituted amino and imino acid compounds |
US4621092A (en) * | 1982-07-22 | 1986-11-04 | E. R. Squibb & Sons, Inc. | Substituted proline compounds, composition and method of use |
US4524212A (en) * | 1982-09-27 | 1985-06-18 | E. R. Squibb & Sons, Inc. | Acyloxyketone substituted imino and amino acids |
US4642315A (en) * | 1982-11-18 | 1987-02-10 | E. R. Squibb & Sons, Inc. | Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides |
US4499079A (en) * | 1982-11-18 | 1985-02-12 | E. R. Squibb & Sons, Inc. | Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides |
US4456595A (en) * | 1982-12-06 | 1984-06-26 | E. R. Squibb & Sons, Inc. | Carboxy and substituted carboxy aroly peptides |
US4514391A (en) * | 1983-07-21 | 1985-04-30 | E. R. Squibb & Sons, Inc. | Hydroxy substituted peptide compounds |
EP0187037A3 (en) * | 1984-12-21 | 1988-03-23 | Takeda Chemical Industries, Ltd. | Piperidine derivatives, their production and use |
US5246943A (en) * | 1992-05-19 | 1993-09-21 | Warner-Lambert Company | Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0012845A1 (en) * | 1978-11-27 | 1980-07-09 | Tanabe Seiyaku Co., Ltd. | Tetrahydroisoquinoline compounds, process for preparing same and pharmaceutical compositions containing them |
EP0018104A2 (en) * | 1979-03-26 | 1980-10-29 | Takeda Chemical Industries, Ltd. | Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension |
FR2470767A1 (en) * | 1979-12-07 | 1981-06-12 | Science Union & Cie | N-Acyl-2-carboxy fused ring heterocyclic cpds. - useful for inhibiting angiotensin converting enzyme and enkephalin(s) |
-
1980
- 1980-04-15 GB GB8012431A patent/GB2048863B/en not_active Expired
- 1980-05-14 NL NL8002828A patent/NL8002828A/en not_active Application Discontinuation
- 1980-05-14 IT IT48675/80A patent/IT1133009B/en active
- 1980-05-14 DE DE19803018545 patent/DE3018545A1/en not_active Withdrawn
- 1980-05-14 BE BE0/200636A patent/BE883320A/en unknown
- 1980-05-14 FR FR8010941A patent/FR2456733A1/en active Granted
- 1980-05-16 JP JP6518380A patent/JPS55153769A/en active Pending
-
1982
- 1982-12-02 GB GB08234339A patent/GB2116542B/en not_active Expired
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0012845A1 (en) * | 1978-11-27 | 1980-07-09 | Tanabe Seiyaku Co., Ltd. | Tetrahydroisoquinoline compounds, process for preparing same and pharmaceutical compositions containing them |
EP0018104A2 (en) * | 1979-03-26 | 1980-10-29 | Takeda Chemical Industries, Ltd. | Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension |
FR2470767A1 (en) * | 1979-12-07 | 1981-06-12 | Science Union & Cie | N-Acyl-2-carboxy fused ring heterocyclic cpds. - useful for inhibiting angiotensin converting enzyme and enkephalin(s) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2487829A2 (en) * | 1979-12-07 | 1982-02-05 | Science Union & Cie | NOVEL SUBSTITUTED IMINO ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR |
EP0049658A1 (en) * | 1980-10-02 | 1982-04-14 | Adir | Substituted imino diacids, their preparation and pharmaceutical preparations containing them |
EP0049605A1 (en) * | 1980-10-03 | 1982-04-14 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same |
US4344949A (en) | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
US4532342A (en) * | 1981-02-20 | 1985-07-30 | Warner-Lambert Company | N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
Also Published As
Publication number | Publication date |
---|---|
IT8048675A0 (en) | 1980-05-14 |
IT1133009B (en) | 1986-07-09 |
DE3018545A1 (en) | 1980-11-27 |
NL8002828A (en) | 1980-11-18 |
JPS55153769A (en) | 1980-11-29 |
GB2048863A (en) | 1980-12-17 |
FR2456733B1 (en) | 1983-08-26 |
GB2116542A (en) | 1983-09-28 |
GB2048863B (en) | 1983-06-15 |
GB2116542B (en) | 1984-02-15 |
BE883320A (en) | 1980-11-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
ST | Notification of lapse |