FR2456733A1 - NEW ACIDS 2- (MERCAPTO-1-OXO (LOWER ALKYL)) - 1,2,3,4-TETRAHYDROISOQUINOLEINE-3-CARBOXYLIQUES, ESPECIALLY USEFUL AS INHIBITORS OF THE ANGIOTENSIN I CONVERSION ENZYME - Google Patents

NEW ACIDS 2- (MERCAPTO-1-OXO (LOWER ALKYL)) - 1,2,3,4-TETRAHYDROISOQUINOLEINE-3-CARBOXYLIQUES, ESPECIALLY USEFUL AS INHIBITORS OF THE ANGIOTENSIN I CONVERSION ENZYME

Info

Publication number
FR2456733A1
FR2456733A1 FR8010941A FR8010941A FR2456733A1 FR 2456733 A1 FR2456733 A1 FR 2456733A1 FR 8010941 A FR8010941 A FR 8010941A FR 8010941 A FR8010941 A FR 8010941A FR 2456733 A1 FR2456733 A1 FR 2456733A1
Authority
FR
France
Prior art keywords
angiotensin
tetrahydroisoquinoleine
mercapto
oxo
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8010941A
Other languages
French (fr)
Other versions
FR2456733B1 (en
Inventor
David E Portlock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ATK Launch Systems LLC
Original Assignee
Morton Norwich Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morton Norwich Products Inc filed Critical Morton Norwich Products Inc
Publication of FR2456733A1 publication Critical patent/FR2456733A1/en
Application granted granted Critical
Publication of FR2456733B1 publication Critical patent/FR2456733B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

L'INVENTION A POUR OBJET DE NOUVEAUX ACIDES 2-MERCAPTO-1-OXO-(ALKYL INFERIEUR)-1,2,3,4-TETRAHYDROISOQUINOLEINE-3-CARBOXYLIQUES. LES MEDICAMENTS DE L'INVENTION SONT DES COMPOSES DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE R EST UN ATOME D'HYDROGENE OU UN GROUPE ACETYLE OU BENZOYLE, R ET R SONT CHACUN UN ATOME D'HYDROGENE OU UN GROUPE METHOXY, N EST EGAL A 1 OU 2 ET M EST EGAL A 0 OU 1, ET LEURS SELS ACCEPTABLES POUR L'USAGE PHARMACEUTIQUE. APPLICATIONS: LES COMPOSES SONT DES INHIBITEURS DE L'ENZYME DE CONVERSION DE L'ANGIOTENSINE I EN ANGIOTENSINE II UTILES DANS LE TRAITEMENT DE CERTAINS TYPES D'HYPERTENSION ASSOCIEES A L'ANGIOTENSINE II.THE SUBJECT OF THE INVENTION IS NEW 2-MERCAPTO-1-OXO- (LOWER ALKYL) -1,2,3,4-TETRAHYDROISOQUINOLEINE-3-CARBOXYLIC ACIDS. THE MEDICINAL PRODUCTS OF THE INVENTION ARE COMPOUNDS OF THE GENERAL FORMULA: (CF DRAWING IN BOPI) IN WHICH R IS A HYDROGEN ATOM OR AN ACETYL OR BENZOYL GROUP, R AND R ARE EACH A HYDROGEN ATOM OR A METHOXY GROUP, N IS EQUAL TO 1 OR 2 AND M IS EQUAL TO 0 OR 1, AND THEIR SALTS ACCEPTABLE FOR PHARMACEUTICAL USE. APPLICATIONS: THE COMPOUNDS ARE INHIBITORS OF THE CONVERTING ENZYME FROM ANGIOTENSIN I TO ANGIOTENSIN II USEFUL IN THE TREATMENT OF CERTAIN TYPES OF HYPERTENSION ASSOCIATED WITH ANGIOTENSIN II.

FR8010941A 1979-05-16 1980-05-14 NEW ACIDS 2- (MERCAPTO-1-OXO (LOWER ALKYL)) - 1,2,3,4-TETRAHYDROISOQUINOLEINE-3-CARBOXYLIQUES, ESPECIALLY USEFUL AS INHIBITORS OF THE ANGIOTENSIN I CONVERSION ENZYME Granted FR2456733A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3931779A 1979-05-16 1979-05-16

Publications (2)

Publication Number Publication Date
FR2456733A1 true FR2456733A1 (en) 1980-12-12
FR2456733B1 FR2456733B1 (en) 1983-08-26

Family

ID=21904828

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8010941A Granted FR2456733A1 (en) 1979-05-16 1980-05-14 NEW ACIDS 2- (MERCAPTO-1-OXO (LOWER ALKYL)) - 1,2,3,4-TETRAHYDROISOQUINOLEINE-3-CARBOXYLIQUES, ESPECIALLY USEFUL AS INHIBITORS OF THE ANGIOTENSIN I CONVERSION ENZYME

Country Status (7)

Country Link
JP (1) JPS55153769A (en)
BE (1) BE883320A (en)
DE (1) DE3018545A1 (en)
FR (1) FR2456733A1 (en)
GB (2) GB2048863B (en)
IT (1) IT1133009B (en)
NL (1) NL8002828A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2487829A2 (en) * 1979-12-07 1982-02-05 Science Union & Cie NOVEL SUBSTITUTED IMINO ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR
EP0049605A1 (en) * 1980-10-03 1982-04-14 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same
EP0049658A1 (en) * 1980-10-02 1982-04-14 Adir Substituted imino diacids, their preparation and pharmaceutical preparations containing them
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595675A (en) * 1979-09-19 1986-06-17 Hoechst Aktiengesellschaft Bicyclic α-iminocarboxylic acid compounds having hypotensive activity
DE3044236A1 (en) * 1980-11-25 1982-06-16 Hoechst Ag, 6000 Frankfurt AMINO ACID DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF
US5200416A (en) * 1980-05-12 1993-04-06 Usv Pharmaceutical Corporation Cyclic amides
US4432971A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
US4555506A (en) * 1981-12-24 1985-11-26 E. R. Squibb & Sons, Inc. Phosphorus containing compounds and use as hypotensives
US4452791A (en) * 1982-03-15 1984-06-05 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4560680A (en) * 1982-03-15 1985-12-24 E. R. Squibb & Sons, Inc. Aminoalkyl and related substituted phosphinic acid angiotensin converting enzyme inhibitors
US4427665A (en) 1982-05-19 1984-01-24 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted imino acids and their use in hypotensive compositions
US4736066A (en) * 1982-07-19 1988-04-05 E. R. Squibb & Sons, Inc. Intermediate for substituted peptide compounds
US4470973A (en) * 1982-07-19 1984-09-11 E. R. Squibb & Sons, Inc. Substituted peptide compounds
US4742067A (en) * 1982-07-22 1988-05-03 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4623729A (en) 1982-07-22 1986-11-18 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4621092A (en) * 1982-07-22 1986-11-04 E. R. Squibb & Sons, Inc. Substituted proline compounds, composition and method of use
US4524212A (en) * 1982-09-27 1985-06-18 E. R. Squibb & Sons, Inc. Acyloxyketone substituted imino and amino acids
US4642315A (en) * 1982-11-18 1987-02-10 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4456595A (en) * 1982-12-06 1984-06-26 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy aroly peptides
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds
EP0187037A3 (en) * 1984-12-21 1988-03-23 Takeda Chemical Industries, Ltd. Piperidine derivatives, their production and use
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012845A1 (en) * 1978-11-27 1980-07-09 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds, process for preparing same and pharmaceutical compositions containing them
EP0018104A2 (en) * 1979-03-26 1980-10-29 Takeda Chemical Industries, Ltd. Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
FR2470767A1 (en) * 1979-12-07 1981-06-12 Science Union & Cie N-Acyl-2-carboxy fused ring heterocyclic cpds. - useful for inhibiting angiotensin converting enzyme and enkephalin(s)

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0012845A1 (en) * 1978-11-27 1980-07-09 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds, process for preparing same and pharmaceutical compositions containing them
EP0018104A2 (en) * 1979-03-26 1980-10-29 Takeda Chemical Industries, Ltd. Tetrahydroisoquinolines, their production and the compounds and pharmaceutical compositions containing them for use in the prevention or treatment of hypertension
FR2470767A1 (en) * 1979-12-07 1981-06-12 Science Union & Cie N-Acyl-2-carboxy fused ring heterocyclic cpds. - useful for inhibiting angiotensin converting enzyme and enkephalin(s)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2487829A2 (en) * 1979-12-07 1982-02-05 Science Union & Cie NOVEL SUBSTITUTED IMINO ACIDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS AN ENZYME INHIBITOR
EP0049658A1 (en) * 1980-10-02 1982-04-14 Adir Substituted imino diacids, their preparation and pharmaceutical preparations containing them
EP0049605A1 (en) * 1980-10-03 1982-04-14 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids, salts thereof, pharmaceutical compositions containing the derivatives or salts, and the production of the same
US4344949A (en) 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids

Also Published As

Publication number Publication date
IT8048675A0 (en) 1980-05-14
IT1133009B (en) 1986-07-09
DE3018545A1 (en) 1980-11-27
NL8002828A (en) 1980-11-18
JPS55153769A (en) 1980-11-29
GB2048863A (en) 1980-12-17
FR2456733B1 (en) 1983-08-26
GB2116542A (en) 1983-09-28
GB2048863B (en) 1983-06-15
GB2116542B (en) 1984-02-15
BE883320A (en) 1980-11-14

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