FR2592048A1 - UREIDO-RENIN INHIBITORS, WITH THERAPEUTIC ACTION - Google Patents

UREIDO-RENIN INHIBITORS, WITH THERAPEUTIC ACTION

Info

Publication number
FR2592048A1
FR2592048A1 FR8616673A FR8616673A FR2592048A1 FR 2592048 A1 FR2592048 A1 FR 2592048A1 FR 8616673 A FR8616673 A FR 8616673A FR 8616673 A FR8616673 A FR 8616673A FR 2592048 A1 FR2592048 A1 FR 2592048A1
Authority
FR
France
Prior art keywords
bopi
ureido
therapeutic action
renin inhibitors
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8616673A
Other languages
French (fr)
Other versions
FR2592048B1 (en
Inventor
Sesha Iyer Natarajan
Denis Evan Ryono
Edward William Petrillo Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2592048A1 publication Critical patent/FR2592048A1/en
Application granted granted Critical
Publication of FR2592048B1 publication Critical patent/FR2592048B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups

Abstract

Composés de formule (CF DESSIN DANS BOPI) dans laquelle, de préférence : X est (CF DESSIN DANS BOPI) R1 est (CF DESSIN DANS BOPI) ou -CH-(CH3)2 ; R2 est un atome d'hydrogène ou un groupement -CH2-CH-(CH3)2, ou -CH-(CH3)2 ; R5 est (CF DESSIN DANS BOPI) R4 est (CF DESSIN DANS BOPI) R3 est -CH2-CH-(CH3)2 ; R9 est (CF DESSIN DANS BOPI) ou (CF DESSIN DANS BOPI) R10 est -0-CH3 ; q est égal à un. Ces composés interviennent dans la transformation de l'angiotensinogène en angiotensine II en inhibant la rénine, et ils sont donc utiles comme agents antihypertenseurs.Compounds of formula (CF DRAWING IN BOPI) in which, preferably: X is (CF DRAWING IN BOPI) R1 is (CF DRAWING IN BOPI) or -CH- (CH3) 2; R2 is a hydrogen atom or a group -CH2-CH- (CH3) 2, or -CH- (CH3) 2; R5 is (CF DRAWING IN BOPI) R4 is (CF DRAWING IN BOPI) R3 is -CH2-CH- (CH3) 2; R9 is (CF DRAWING IN BOPI) or (CF DRAWING IN BOPI) R10 is -0-CH3; q is equal to one. These compounds mediate the conversion of angiotensinogen to angiotensin II by inhibiting renin, and therefore are useful as antihypertensive agents.

FR8616673A 1985-12-23 1986-11-28 UREIDO-RENIN INHIBITORS, WITH THERAPEUTIC ACTION Expired - Fee Related FR2592048B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81256185A 1985-12-23 1985-12-23

Publications (2)

Publication Number Publication Date
FR2592048A1 true FR2592048A1 (en) 1987-06-26
FR2592048B1 FR2592048B1 (en) 1995-07-07

Family

ID=25209973

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8616673A Expired - Fee Related FR2592048B1 (en) 1985-12-23 1986-11-28 UREIDO-RENIN INHIBITORS, WITH THERAPEUTIC ACTION

Country Status (6)

Country Link
JP (1) JPS62164658A (en)
CA (1) CA1297631C (en)
DE (1) DE3643977A1 (en)
FR (1) FR2592048B1 (en)
GB (1) GB2184730B (en)
IT (1) IT1213574B (en)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599198A (en) * 1985-08-02 1986-07-08 Pfizer Inc. Intermediates in polypeptide synthesis
US5049548A (en) * 1989-03-03 1991-09-17 Merck & Co., Inc. Renin-inhibitory di-, tri-, and tetrapeptides
US5648511A (en) * 1990-11-19 1997-07-15 G.D. Searle & Co. Method for making intermediates useful in the synthesis of retroviral protease inhibitors
CA2096528C (en) 1990-11-19 2005-12-06 Kathryn Lea Reed Retroviral protease inhibitors
US5510378A (en) * 1990-11-19 1996-04-23 G.D. Searle & Co. Retroviral protease inhibitors
ATE296625T1 (en) * 1990-11-19 2005-06-15 Monsanto Co RETROVIRUS PROTEASE INHIBITORS
US5614522A (en) * 1990-11-19 1997-03-25 G.D. Searle & Co. Retroviral protease inhibitors
ATE155779T1 (en) * 1990-11-19 1997-08-15 Monsanto Co RETROVIRAL PROTEASE INHIBITORS
US5482947A (en) * 1990-11-19 1996-01-09 Talley; John J. Retroviral protease inhibitors
US5583238A (en) * 1990-11-19 1996-12-10 G. D. Searle & Co. Method for making intermediates useful in synthesis of retroviral protease inhibitors
US5475027A (en) * 1990-11-19 1995-12-12 G.D. Searle & Co. Retroviral protease inhibitors
US5475013A (en) * 1990-11-19 1995-12-12 Monsanto Company Retroviral protease inhibitors
EP0641333B1 (en) * 1992-05-20 1996-08-14 G.D. Searle & Co. Method for making intermediates useful in synthesis of retroviral protease inhibitors
EP0641325B1 (en) * 1992-05-21 2001-03-07 Monsanto Company Retroviral protease inhibitors
US5968942A (en) * 1992-08-25 1999-10-19 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
JP4091653B2 (en) * 1992-08-25 2008-05-28 ジー．ディー．サール、リミテッド、ライアビリティ、カンパニー N- (alkanoylamino-2-hydroxypropyl) sulfonamides useful as retroviral protease inhibitors
US6022994A (en) 1992-08-25 2000-02-08 G. D. Searle &. Co. Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
CA2140928C (en) * 1992-08-25 2008-01-29 Michael L. Vazquez Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US6743929B1 (en) 1992-08-25 2004-06-01 G. D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5760076A (en) * 1992-08-25 1998-06-02 G.D Searle & Co. Succinoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US6046190A (en) * 1992-08-25 2000-04-04 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
DK0656887T3 (en) 1992-08-25 1999-07-05 Searle & Co Hydroxyethylaminosulfonamides for use as inhibitors of retroviral proteases
US7141609B2 (en) 1992-08-25 2006-11-28 G.D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
US5830897A (en) * 1992-08-27 1998-11-03 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
ES2118364T3 (en) 1992-10-30 1998-09-16 Searle & Co HYDROXYETHYLAMINO-SULPHAMIC ACID DERIVATIVES USEFUL AS RETROVIRAL PROTEASE INHIBITORS.
US6337398B1 (en) 1992-10-30 2002-01-08 G.D. Searle & Co. Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
US5756498A (en) * 1992-10-30 1998-05-26 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
DE69326077T2 (en) * 1992-10-30 2000-01-27 Searle & Co SULFONYLALKANOYLAMINOHYDROXYETHYLAMINOSULFAMINIC ACIDS USED AS INHIBITORS OF RETROVIRAL PROTEASES
US5578606A (en) 1992-10-30 1996-11-26 G. D. Searle & Co. α- and β-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors
US5514801A (en) 1992-12-29 1996-05-07 Monsanto Company Cyclic sulfone containing retroviral protease inhibitors
US5830888A (en) * 1993-04-16 1998-11-03 Monsanto Company Macrocyclic retroviral protease inhibitors
US5750648A (en) * 1993-08-20 1998-05-12 G.D. Searle & Co. Retroviral protease inhibitors and combinations thereof
US5602119A (en) * 1993-10-29 1997-02-11 Vazquez; Michael L. Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors
US6133444A (en) * 1993-12-22 2000-10-17 Perseptive Biosystems, Inc. Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions
DE69515465T2 (en) * 1994-11-04 2000-08-03 Santen Pharmaceutical Co Ltd NEW HYDROXY-SUBSTITUTED 1,3-DIALKYL UREA DERIVATIVES
EP0804428B1 (en) 1995-01-20 2007-12-26 G.D. Searle LLC. Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
US5831117A (en) 1995-01-20 1998-11-03 G. D. Searle & Co. Method of preparing retroviral protease inhibitor intermediates
US6140505A (en) 1995-03-10 2000-10-31 G. D. Searle & Co. Synthesis of benzo fused heterocyclic sulfonyl chlorides
US5756533A (en) * 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
EP1188766A1 (en) 1995-03-10 2002-03-20 G.D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US7339078B2 (en) 1995-03-10 2008-03-04 G.D. Searle Llc Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5776971A (en) 1995-03-10 1998-07-07 G.D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) * 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5985870A (en) * 1995-03-10 1999-11-16 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6861539B1 (en) 1995-03-10 2005-03-01 G. D. Searle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6407134B1 (en) 1995-03-10 2002-06-18 G. D. Searle & Co. Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6169085B1 (en) 1995-03-10 2001-01-02 G. D. Searle & Company Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6667307B2 (en) 1997-12-19 2003-12-23 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
HUP9800518A3 (en) 1995-03-10 1998-09-28 G D Searle & Co Chicago Heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US5753660A (en) * 1995-11-15 1998-05-19 G. D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
PL337755A1 (en) * 1997-05-08 2000-09-11 Smithkline Beecham Corp Protease inhibitors
WO2000002862A1 (en) 1998-07-08 2000-01-20 G.D. Searle & Co. Retroviral protease inhibitors
US6696488B2 (en) 2000-08-11 2004-02-24 The Brigham And Women's Hospital, Inc. (Hydroxyethyl)ureas as inhibitors of alzheimer's β-amyloid production
KR100750102B1 (en) 2001-06-14 2007-08-17 삼성전자주식회사 Disk Cartridge
BR0211119A (en) * 2001-07-11 2005-12-13 Elan Pharm Inc Compound, method of treating a patient who has, or preventing a patient from catching, a disease or condition, use of a compound, and method for making a compound
US7351738B2 (en) * 2002-11-27 2008-04-01 Elan Pharmaceuticals, Inc. Substituted ureas and carbamates

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0104041A1 (en) * 1982-09-15 1984-03-28 Aktiebolaget Hässle Enzyme inhibitors
WO1984003044A1 (en) * 1983-02-07 1984-08-16 Ferring Ab Enzyme inhibitors
EP0159156A1 (en) * 1984-03-30 1985-10-23 E.R. Squibb & Sons, Inc. Hydroxy substituted ureido amino and imino acids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599198A (en) * 1985-08-02 1986-07-08 Pfizer Inc. Intermediates in polypeptide synthesis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0104041A1 (en) * 1982-09-15 1984-03-28 Aktiebolaget Hässle Enzyme inhibitors
WO1984003044A1 (en) * 1983-02-07 1984-08-16 Ferring Ab Enzyme inhibitors
EP0159156A1 (en) * 1984-03-30 1985-10-23 E.R. Squibb & Sons, Inc. Hydroxy substituted ureido amino and imino acids

Also Published As

Publication number Publication date
IT1213574B (en) 1989-12-20
JPS62164658A (en) 1987-07-21
GB2184730A (en) 1987-07-01
GB8630006D0 (en) 1987-01-28
GB2184730B (en) 1990-02-07
FR2592048B1 (en) 1995-07-07
CA1297631C (en) 1992-03-17
DE3643977A1 (en) 1987-07-02
IT8622804A0 (en) 1986-12-22

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