DE3011182A1 - Zur oralen verabreichung geeignete zusammensetzung - Google Patents
Zur oralen verabreichung geeignete zusammensetzungInfo
- Publication number
- DE3011182A1 DE3011182A1 DE19803011182 DE3011182A DE3011182A1 DE 3011182 A1 DE3011182 A1 DE 3011182A1 DE 19803011182 DE19803011182 DE 19803011182 DE 3011182 A DE3011182 A DE 3011182A DE 3011182 A1 DE3011182 A1 DE 3011182A1
- Authority
- DE
- Germany
- Prior art keywords
- urea
- plaque
- hydrogen peroxide
- oral administration
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims description 10
- 208000002064 Dental Plaque Diseases 0.000 claims description 15
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical group OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 239000002253 acid Substances 0.000 claims description 11
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 23
- 239000004202 carbamide Substances 0.000 description 23
- 239000003826 tablet Substances 0.000 description 16
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 14
- 150000001720 carbohydrates Chemical class 0.000 description 14
- 235000014633 carbohydrates Nutrition 0.000 description 14
- 208000002925 dental caries Diseases 0.000 description 13
- 239000000243 solution Substances 0.000 description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 11
- 239000001301 oxygen Substances 0.000 description 11
- 229910052760 oxygen Inorganic materials 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 10
- 108010046334 Urease Proteins 0.000 description 9
- 210000000214 mouth Anatomy 0.000 description 9
- 235000000346 sugar Nutrition 0.000 description 8
- 150000007513 acids Chemical class 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 235000013305 food Nutrition 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 229930006000 Sucrose Natural products 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 210000003296 saliva Anatomy 0.000 description 6
- 239000005720 sucrose Substances 0.000 description 6
- 239000000606 toothpaste Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 230000001013 cariogenic effect Effects 0.000 description 5
- 230000003902 lesion Effects 0.000 description 5
- 102000013415 peroxidase activity proteins Human genes 0.000 description 5
- 108040007629 peroxidase activity proteins Proteins 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 102000045576 Lactoperoxidases Human genes 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 108010023244 Lactoperoxidase Proteins 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 239000007891 compressed tablet Substances 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 229940057428 lactoperoxidase Drugs 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 3
- 229940045872 sodium percarbonate Drugs 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 239000004254 Ammonium phosphate Substances 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- 230000035508 accumulation Effects 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000003113 alkalizing effect Effects 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 229910000148 ammonium phosphate Inorganic materials 0.000 description 2
- 235000019289 ammonium phosphates Nutrition 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 229940112822 chewing gum Drugs 0.000 description 2
- 235000015218 chewing gum Nutrition 0.000 description 2
- 235000011967 chocolate pudding Nutrition 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 208000007565 gingivitis Diseases 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- -1 sugar in food Chemical class 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Chinese gallotannin Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 240000000896 Dyera costulata Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 208000007976 Ketosis Diseases 0.000 description 1
- 108700037001 Lactoperoxidases Proteins 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 206010058667 Oral toxicity Diseases 0.000 description 1
- 241000185992 Rhizobium viscosum Species 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- 229920006387 Vinylite Polymers 0.000 description 1
- 208000021017 Weight Gain Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001323 aldoses Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 230000002882 anti-plaque Effects 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 244000144987 brood Species 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 208000019884 chronic gingivitis Diseases 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 235000011850 desserts Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- DLINORNFHVEIFE-UHFFFAOYSA-N hydrogen peroxide;zinc Chemical compound [Zn].OO DLINORNFHVEIFE-UHFFFAOYSA-N 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 150000002584 ketoses Chemical class 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 231100000418 oral toxicity Toxicity 0.000 description 1
- 230000001706 oxygenating effect Effects 0.000 description 1
- 230000021962 pH elevation Effects 0.000 description 1
- 150000002972 pentoses Chemical class 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 235000021178 picnic Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000011962 puddings Nutrition 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 239000012487 rinsing solution Substances 0.000 description 1
- 235000019643 salty taste Nutrition 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 235000009561 snack bars Nutrition 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000017550 sodium carbonate Nutrition 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- WBGSMIRITKHZNA-UHFFFAOYSA-M trisodium;dioxido(oxidooxy)borane Chemical compound [Na+].[Na+].[Na+].[O-]OB([O-])[O-] WBGSMIRITKHZNA-UHFFFAOYSA-M 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 229940105296 zinc peroxide Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7913619A GB2047091B (en) | 1979-04-19 | 1979-04-19 | Orally administrable compositions containing urea hydrogen peroxide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3011182A1 true DE3011182A1 (de) | 1980-10-23 |
Family
ID=10504643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19803011182 Withdrawn DE3011182A1 (de) | 1979-04-19 | 1980-03-22 | Zur oralen verabreichung geeignete zusammensetzung |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4302441A (enExample) |
| DE (1) | DE3011182A1 (enExample) |
| FR (1) | FR2454301A1 (enExample) |
| GB (1) | GB2047091B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986006625A1 (en) * | 1985-05-10 | 1986-11-20 | Fertin Laboratories A/S (Dansk Tyggegummifabrik A/ | A solid oral anticariogenic composition |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4607101A (en) * | 1981-08-27 | 1986-08-19 | Jaye-Boern Laboratories, Inc. | Method of treating acne vulgaris with a composition containing carbamide peroxide |
| DE3278457D1 (en) * | 1981-08-27 | 1988-06-16 | Soft Sheen Products Inc | Use of carbamide peroxide for the manufacture of a medicament for treatment of acne vulgaris |
| US4521403A (en) * | 1983-01-20 | 1985-06-04 | Simon Gilbert I | Chemotherapeutic method for treating periodontal disease |
| US4518583A (en) * | 1983-02-22 | 1985-05-21 | Gallina Damian J | Hemorrhoid and anorectal disease treatment method |
| US4514384A (en) * | 1983-03-14 | 1985-04-30 | Gallina Damian J | Hemorrhoid treatment method |
| US4564519A (en) * | 1983-06-06 | 1986-01-14 | Laclede Professional Products, Inc. | Di-enzymatic chewable dentifrice |
| US4522805A (en) * | 1983-06-08 | 1985-06-11 | Norman Gordon | Tooth and gum dentifrice |
| US4567036A (en) * | 1983-12-30 | 1986-01-28 | Simon Gilbert I | Chemotherapeutic method for treating periodontal disease, and composition therefore |
| DE3702983A1 (de) * | 1986-06-09 | 1987-12-10 | Henkel Kgaa | Desinfektionsmittel und ihre verwendung zur haut- und schleimhautdesinfektion |
| US4812308A (en) * | 1987-02-20 | 1989-03-14 | Church & Dwight Co., Inc. | Hydrogen peroxide-releasing tooth powder |
| US4788052A (en) * | 1987-04-17 | 1988-11-29 | Colgate-Palmolive Company | Stable hydrogen peroxide dental gel containing fumed silicas |
| US4839156A (en) * | 1987-04-17 | 1989-06-13 | Colgate-Palmolive Company | Stable hydrogen peroxide dental gel |
| FR2627084B1 (fr) * | 1988-02-11 | 1991-11-08 | Rcd Labo Sarl | Formes galeniques solides contenant une ou plusieurs substances peroxydiques liberant de l'oxygene actif et utilisees en hygiene bucco-dentaire ou comme decontaminants de lentilles ophtalmiques |
| USRE34196E (en) * | 1988-08-23 | 1993-03-16 | Dunhall Pharmaceuticals, Inc. | Method and material for brightening teeth |
| US4990089A (en) * | 1988-08-23 | 1991-02-05 | Dunhall Pharmaceuticals, Inc. | Method and material for brightening teeth |
| US4968251A (en) * | 1989-07-03 | 1990-11-06 | Darnell Daniel H | Treatment of a tooth |
| US5855870A (en) * | 1990-03-22 | 1999-01-05 | Ultradent Products, Inc. | Method for treating sensitive teeth |
| US6036943A (en) * | 1990-03-22 | 2000-03-14 | Ultradent Products, Inc. | Methods for treating a person's teeth using sticky dental compositions in combination with passive-type dental trays |
| US5851512A (en) * | 1990-03-22 | 1998-12-22 | Ultradent Products, Inc. | Dental compositions having a sticky matrix material for treating sensitive teeth |
| US5376006A (en) * | 1990-03-22 | 1994-12-27 | Ultradent Products, Inc. | Dental bleaching compositions and methods for bleaching teeth surfaces |
| US5985249A (en) * | 1990-03-22 | 1999-11-16 | Ultradent Products, Inc. | Sticky dental compositions for adhering a passive-type dental tray over a person's teeth |
| US5234342A (en) * | 1990-03-22 | 1993-08-10 | Ultradent Products, Inc. | Sustained release method for treating teeth surfaces |
| US5098303A (en) * | 1990-03-22 | 1992-03-24 | Ultradent Products, Inc. | Method for bleaching teeth |
| US5059417A (en) * | 1990-06-26 | 1991-10-22 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Peroxide gel dentifrice |
| US5817294A (en) * | 1990-11-02 | 1998-10-06 | Arnold; Michael J. | Plaque adsorbent oral composition and method |
| ES2078186B1 (es) * | 1994-05-10 | 1996-07-16 | Cinfa S A Lab | Goma de mascar y su procedimiento de fabricacion. |
| US5616616A (en) * | 1994-06-01 | 1997-04-01 | Minntech Corporation | Room Temperature sterilant |
| US5939048A (en) * | 1994-09-20 | 1999-08-17 | Block Drug Co., Inc. | Taste masked desensitizing compositions |
| US5565190A (en) * | 1994-11-14 | 1996-10-15 | Colgate Palmolive Company | Dentifrice compositions containing reactive ingredients stabilized with alkali metal compounds |
| US5500207A (en) * | 1994-11-18 | 1996-03-19 | Goulet; Marie-Kateri | Method of whitening teeth and composition therefore |
| US5908614A (en) * | 1995-08-15 | 1999-06-01 | Montgomery; Robert Eric | Peroxidase-activating oral compositions |
| US5693334A (en) * | 1995-10-05 | 1997-12-02 | Church & Dwight Co., Inc. | Chewing gum product with dental health benefits |
| US5589507A (en) * | 1995-11-17 | 1996-12-31 | Minntech Corporation | Method for sterilizing medical devices utilizing a room temperature sterilant |
| US6149211A (en) * | 1995-12-12 | 2000-11-21 | Losee; Paul | Inclusion of tooth whitening oxidation chemistries into slow releasing food products |
| US5804165A (en) * | 1996-07-24 | 1998-09-08 | Arnold; Michael J. | Antiplaque oral composition |
| EP0824019B1 (en) * | 1996-08-13 | 2002-11-20 | Quest International B.V. | Inhibition or reduction of oral malodour |
| US6306370B1 (en) | 1997-05-30 | 2001-10-23 | Ultradent Products, Inc. | Compositions and methods for whitening and desensitizing teeth |
| US5972374A (en) * | 1998-04-02 | 1999-10-26 | Theisen; Thomas | Chewing gum with teeth whitener |
| US8936778B2 (en) | 1998-11-12 | 2015-01-20 | Ultradent Products, Inc. | Methods for bleaching and desensitizing teeth |
| US6309625B1 (en) | 1998-11-12 | 2001-10-30 | Ultradent Products, Inc. | One-part dental compositions and methods for bleaching and desensitizing teeth |
| WO2001070178A2 (en) | 2000-03-23 | 2001-09-27 | Dentsply International Inc. | Tooth whitening composition |
| US6696043B2 (en) * | 2000-09-20 | 2004-02-24 | Scientific Pharmaceuticals, Inc. | Teeth whitening composition in the form of a chewing gum |
| US6488913B2 (en) | 2000-09-20 | 2002-12-03 | Scientific Pharmaceuticals, Inc | Two-part composition for high efficacy teeth whitening comprising a mixture of peroxides and/or percarbonates of metals |
| US6685923B2 (en) | 2001-01-25 | 2004-02-03 | Dentsply Research & Development Corp. | Tooth whitening material and method of whitening teeth |
| US6573301B1 (en) * | 2002-04-23 | 2003-06-03 | Bradley Pharmaceuticals, Inc. | Carbamide peroxide compositions for the treatment of dermatological disorders and methods for their use |
| US8524198B2 (en) * | 2003-06-20 | 2013-09-03 | Donald W. Bailey | Xylitol dental maintenance system |
| US20100158820A1 (en) * | 2003-06-20 | 2010-06-24 | Bailey Donald W | Xylitol dental maintenance system |
| CN100496474C (zh) * | 2004-11-25 | 2009-06-10 | 张玲 | 口服过碳酰胺给氧剂及制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL293025A (enExample) * | ||||
| FR383839A (fr) * | 1907-11-11 | 1908-03-18 | Albert Westlake | Tablette dentifrice |
| DE551888C (de) * | 1931-05-14 | 1932-06-06 | Pektingesellschaft M B H Deuts | Verdickungsmittel fuer Zahnpasten und Mundpflegemittel |
| NL36202C (enExample) * | 1932-12-01 | |||
| DE1617430C3 (de) | 1966-07-29 | 1980-07-10 | Wuerttembergische Parfuemerie-Fabrik Gmbh, 7332 Eislingen | Schäumende lagerstabile Zahnpaste |
| US3657413A (en) * | 1969-08-28 | 1972-04-18 | Block Drug Co | Antiseptic composition containing peroxide glycerol and carboxypolymethylene polymer |
| DE2341176A1 (de) | 1973-08-14 | 1975-03-06 | Blendax Werke Schneider Co | Reinigungsmittel fuer zahnprothesen |
-
1979
- 1979-04-19 GB GB7913619A patent/GB2047091B/en not_active Expired
-
1980
- 1980-03-22 DE DE19803011182 patent/DE3011182A1/de not_active Withdrawn
- 1980-04-11 US US06/139,243 patent/US4302441A/en not_active Expired - Lifetime
- 1980-04-18 FR FR8008806A patent/FR2454301A1/fr active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986006625A1 (en) * | 1985-05-10 | 1986-11-20 | Fertin Laboratories A/S (Dansk Tyggegummifabrik A/ | A solid oral anticariogenic composition |
| AU585359B2 (en) * | 1985-05-10 | 1989-06-15 | Fertin Laboratories A/S | A solid oral anticariogenic composition |
| US5470566A (en) * | 1985-05-10 | 1995-11-28 | Fertin Laboratories A/S (Dansk Tyggegummi Fabrik A/S) | Solid oral anticariogenic composition |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2047091B (en) | 1983-05-18 |
| US4302441A (en) | 1981-11-24 |
| FR2454301B1 (enExample) | 1983-05-06 |
| GB2047091A (en) | 1980-11-26 |
| FR2454301A1 (fr) | 1980-11-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3011182A1 (de) | Zur oralen verabreichung geeignete zusammensetzung | |
| DE3587691T2 (de) | Zahnreinigendes wasser. | |
| DE69829583T2 (de) | Verwendung von polyolen zur bekämpfung von hefeinfektionen und polyolpräparate zur selben verwendung | |
| DD202245A5 (de) | Verfahren zur herstellung oraler kompositionen | |
| DE2212148A1 (de) | Wirksame Gemische gegen Kariesbefall | |
| DE69805201T2 (de) | Mundreinigungsmittel: verfahren und zusammensetzungen | |
| EP0003545B1 (de) | Zahnschonende, wasserarme, zuckerhaltige, speziell saccharosehaltige Lebensmittel und zahnschonende, wasserarme, pharmazeutische Zubereitungen, sowie Verfahren zu deren Herstellung | |
| DE2629884A1 (de) | Mund- und zahnpflegemittel | |
| DE2606533A1 (de) | Therapeutisches mittel | |
| EP0912162B1 (de) | Feste orale, antikariogene zusammensetzung zum reinigen der mundhöhle und zähne sowie verfahren zur herstellung derselben | |
| DE3211258A1 (de) | Zusammensetzung zum inhibieren oder verhindern von zahnkaries | |
| DE2613500A1 (de) | Mundpflegemittel und verfahren zur verhinderung von verfaerbungen der zaehne | |
| EP0757554B1 (de) | Lutschbonbon mit zahnbelags-neutralisierender wirkung | |
| EP0003544B1 (de) | Karieshemmende, wasserarme, zuckerhaltige, speziell saccharosehaltige Lebensmittel und karieshemmende, wasserarme, zuckerfreie pharmazeutische Zubereitungen, sowie Verfahren zu deren Herstellung | |
| CH506292A (de) | Mundpflegemittel | |
| DE3016359A1 (de) | Zahn- bzw. mundwasserloesung zur bildung von schutzfilem und hierfuer geeignetes verfahren | |
| DE2000851C3 (de) | Kaugummi | |
| DE2742411B1 (de) | Zahn- und Mundpflegemittel | |
| KR102666564B1 (ko) | 토판염이 함유되어 잇몸질환 개선 효과가 우수한 구강세정용 조성물 | |
| DE2814298A1 (de) | Bis-(carboxyalkoxy)-butandisaeureverbindungen in oralen zubereitungen zur zahnsteinhemmung | |
| KR100665891B1 (ko) | 하이드록시타이로졸을 함유한 구강위생 증진용 조성물 | |
| DE3104189C2 (enExample) | ||
| DE2044534A1 (de) | Mundpflegemittel | |
| DE3705434A1 (de) | Zahnpflegemittel | |
| AT255655B (de) | Verfahren zur Herstellung eines Zahnpflegemittels |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OAP | Request for examination filed | ||
| OD | Request for examination | ||
| 8130 | Withdrawal |