DE3010544C2 - 1H-Pyrrolo[2,1-c][1,4]benzodiazepin-2-acrylsäureamid-Verbindungen und ihre Verwendung bei der Bekämpfung maligner Neoplasien - Google Patents

1H-Pyrrolo[2,1-c][1,4]benzodiazepin-2-acrylsäureamid-Verbindungen und ihre Verwendung bei der Bekämpfung maligner Neoplasien

Info

Publication number
DE3010544C2
DE3010544C2 DE3010544A DE3010544A DE3010544C2 DE 3010544 C2 DE3010544 C2 DE 3010544C2 DE 3010544 A DE3010544 A DE 3010544A DE 3010544 A DE3010544 A DE 3010544A DE 3010544 C2 DE3010544 C2 DE 3010544C2
Authority
DE
Germany
Prior art keywords
deep
benzodiazepine
pyrrolo
acrylic acid
acid amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE3010544A
Other languages
German (de)
English (en)
Other versions
DE3010544A1 (de
Inventor
Yoshio Kashiwara Kagitani
Nobuhiko Tokyo Komatsu
Eiji Osaka Sako
Daisuke Nishinomiya Satoh
Tadakazu Kyoto Suyama
Yasuo Hirakata Ueda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Publication of DE3010544A1 publication Critical patent/DE3010544A1/de
Application granted granted Critical
Publication of DE3010544C2 publication Critical patent/DE3010544C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE3010544A 1979-07-17 1980-03-19 1H-Pyrrolo[2,1-c][1,4]benzodiazepin-2-acrylsäureamid-Verbindungen und ihre Verwendung bei der Bekämpfung maligner Neoplasien Expired DE3010544C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8988679A JPS5615289A (en) 1979-07-17 1979-07-17 Novel benzodiazepinnbased compound 3

Publications (2)

Publication Number Publication Date
DE3010544A1 DE3010544A1 (de) 1981-01-29
DE3010544C2 true DE3010544C2 (de) 1982-07-01

Family

ID=13983232

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3010544A Expired DE3010544C2 (de) 1979-07-17 1980-03-19 1H-Pyrrolo[2,1-c][1,4]benzodiazepin-2-acrylsäureamid-Verbindungen und ihre Verwendung bei der Bekämpfung maligner Neoplasien

Country Status (11)

Country Link
US (1) US4309437A (cg-RX-API-DMAC7.html)
JP (1) JPS5615289A (cg-RX-API-DMAC7.html)
BE (1) BE882305A (cg-RX-API-DMAC7.html)
CA (1) CA1152985A (cg-RX-API-DMAC7.html)
CH (1) CH648848A5 (cg-RX-API-DMAC7.html)
DE (1) DE3010544C2 (cg-RX-API-DMAC7.html)
FR (1) FR2461711A1 (cg-RX-API-DMAC7.html)
GB (1) GB2053894B (cg-RX-API-DMAC7.html)
LU (1) LU82272A1 (cg-RX-API-DMAC7.html)
NL (1) NL8001531A (cg-RX-API-DMAC7.html)
SE (1) SE436882B (cg-RX-API-DMAC7.html)

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JPS59152329A (ja) * 1983-02-17 1984-08-31 Green Cross Corp:The 局所障害抑制剤
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GB0226593D0 (en) * 2002-11-14 2002-12-24 Consultants Ltd Compounds
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GB0404577D0 (en) * 2004-03-01 2004-04-07 Spirogen Ltd Pyrrolobenzodiazepines
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CN103068405A (zh) 2010-04-15 2013-04-24 西雅图基因公司 靶向吡咯并苯并二氮杂卓结合物
EP2558475A1 (en) 2010-04-15 2013-02-20 Spirogen Sàrl Pyrrolobenzodiazepines used to treat proliferative diseases
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EP2839860B1 (en) 2012-10-12 2019-05-01 MedImmune Limited Pyrrolobenzodiazepines and conjugates thereof
DK2906298T3 (en) 2012-10-12 2018-12-17 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
RS57694B1 (sr) 2012-10-12 2018-11-30 Adc Therapeutics Sa Pirolobenzodiazepin - anti-psma konjugati antitela
PT3470086T (pt) 2012-10-12 2021-02-01 Medimmune Ltd Pirrolobenzodiazepinas e conjugados das mesmas
WO2014057072A1 (en) 2012-10-12 2014-04-17 Spirogen Sàrl Synthesis and intermediates of pyrrolobenzodiazepine derivatives for conjugation
KR101995621B1 (ko) 2012-10-12 2019-07-03 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항-cd22 항체 컨주게이트
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EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
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GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
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GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
US10143695B2 (en) 2016-05-18 2018-12-04 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
US10526294B2 (en) 2016-06-24 2020-01-07 Mersana Therapeutics, Inc. Pyrrolobenzodiazepines and conjugates thereof
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
PL3544636T3 (pl) 2017-02-08 2021-12-06 Adc Therapeutics Sa Koniugaty pirolobenzodiazepina-przeciwciało
SMT202200490T1 (it) 2017-04-18 2023-01-13 Medimmune Ltd Coniugati di pirrolobenzodiazepina
PL3612234T3 (pl) 2017-04-20 2024-09-02 Adc Therapeutics Sa Terapia skojarzona z koniugatem anty-AXL przeciwciało-lek
BR112019026564A2 (pt) 2017-06-14 2020-06-30 Adc Therapeutics Sa regimes de dosagem para a administração de um adc anti-cd19
SMT202200225T1 (it) 2017-08-18 2022-07-21 Medimmune Ltd Coniugati di pirrolobenzodiazepina
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
AU2020242747B2 (en) 2019-03-15 2025-09-18 Medimmune Limited Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer
USD925487S1 (en) * 2019-10-22 2021-07-20 Lg Electronics Inc. Audio player

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US3523941A (en) * 1967-03-06 1970-08-11 Hoffmann La Roche Benzodiazepine compounds and process for their preparation
US3524849A (en) * 1967-10-27 1970-08-18 Hoffmann La Roche Process for the preparation of pyrrolo-benzodiazepine acrylamides and intermediates useful therein

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHTS-ERMITTELT

Also Published As

Publication number Publication date
JPS5615289A (en) 1981-02-14
SE8001458L (sv) 1981-01-18
JPS6237631B2 (cg-RX-API-DMAC7.html) 1987-08-13
FR2461711B1 (cg-RX-API-DMAC7.html) 1983-05-13
GB2053894B (en) 1983-04-20
SE436882B (sv) 1985-01-28
GB2053894A (en) 1981-02-11
LU82272A1 (fr) 1980-07-01
US4309437A (en) 1982-01-05
BE882305A (fr) 1980-07-16
FR2461711A1 (fr) 1981-02-06
NL8001531A (nl) 1981-01-20
CH648848A5 (de) 1985-04-15
DE3010544A1 (de) 1981-01-29
CA1152985A (en) 1983-08-30

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