DE3006899C2 - - Google Patents
Info
- Publication number
- DE3006899C2 DE3006899C2 DE3006899A DE3006899A DE3006899C2 DE 3006899 C2 DE3006899 C2 DE 3006899C2 DE 3006899 A DE3006899 A DE 3006899A DE 3006899 A DE3006899 A DE 3006899A DE 3006899 C2 DE3006899 C2 DE 3006899C2
- Authority
- DE
- Germany
- Prior art keywords
- reagent
- particulate
- particles
- agglutinate
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003153 chemical reaction reagent Substances 0.000 claims description 86
- 239000002245 particle Substances 0.000 claims description 78
- 238000000034 method Methods 0.000 claims description 42
- 229920000126 latex Polymers 0.000 claims description 29
- 239000004816 latex Substances 0.000 claims description 28
- 239000000427 antigen Substances 0.000 claims description 22
- 102000036639 antigens Human genes 0.000 claims description 22
- 108091007433 antigens Proteins 0.000 claims description 22
- 239000007788 liquid Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 11
- 238000000926 separation method Methods 0.000 claims description 7
- 239000006249 magnetic particle Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 238000005119 centrifugation Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 description 18
- 230000004520 agglutination Effects 0.000 description 14
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 12
- 239000013566 allergen Substances 0.000 description 11
- 239000000725 suspension Substances 0.000 description 8
- 241000283707 Capra Species 0.000 description 7
- 239000000872 buffer Substances 0.000 description 7
- 229940046528 grass pollen Drugs 0.000 description 7
- 238000001179 sorption measurement Methods 0.000 description 7
- 239000004471 Glycine Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 5
- 239000004793 Polystyrene Substances 0.000 description 4
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 229920002678 cellulose Polymers 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 102000014914 Carrier Proteins Human genes 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 229960004784 allergens Drugs 0.000 description 3
- 108091008324 binding proteins Proteins 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 238000007885 magnetic separation Methods 0.000 description 3
- 206010003445 Ascites Diseases 0.000 description 2
- 102000008857 Ferritin Human genes 0.000 description 2
- 108050000784 Ferritin Proteins 0.000 description 2
- 238000008416 Ferritin Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 244000144987 brood Species 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229940072221 immunoglobulins Drugs 0.000 description 2
- 239000003550 marker Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- JMANVNJQNLATNU-UHFFFAOYSA-N oxalonitrile Chemical compound N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 description 2
- 239000011236 particulate material Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 229960003387 progesterone Drugs 0.000 description 2
- 239000000186 progesterone Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- HXFCUMCLVYNZDM-UHFFFAOYSA-N 2-aminoacetic acid;sodium Chemical compound [Na].NCC(O)=O HXFCUMCLVYNZDM-UHFFFAOYSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000589562 Brucella Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000712079 Measles morbillivirus Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 239000003418 antiprogestin Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 238000009739 binding Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003518 caustics Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000003623 progesteronic effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/819—Multifunctional antigen or antibody
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7906686 | 1979-02-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE3006899A1 DE3006899A1 (de) | 1980-09-11 |
| DE3006899C2 true DE3006899C2 (en, 2012) | 1989-02-09 |
Family
ID=10503430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19803006899 Granted DE3006899A1 (de) | 1979-02-26 | 1980-02-23 | Biologische analyse |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4279617A (en, 2012) |
| JP (1) | JPS55156866A (en, 2012) |
| CA (1) | CA1132902A (en, 2012) |
| DE (1) | DE3006899A1 (en, 2012) |
| FR (1) | FR2449892B1 (en, 2012) |
| GB (1) | GB2045431B (en, 2012) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4696907A (en) * | 1980-07-18 | 1987-09-29 | Science Research Center, Inc. | Identification of reagins in the blood serum of allergen sensitized vertebrates |
| US4427781A (en) | 1981-03-16 | 1984-01-24 | International Institute Of Cellular And Molecular Pathology | Particle agglutination immunoassay with agglutinator for determining haptens; PACIA |
| US4476231A (en) * | 1981-07-22 | 1984-10-09 | International Remote Imaging Systems, Inc. | Method of analyzing the distribution of a reagent between particles and liquid in a suspension |
| JPS59500832A (ja) * | 1982-05-07 | 1984-05-10 | パラゴン・ダイアグノスティクス・インコ−ポレイテッド | 競合的免疫螢光検定法及び試験セット |
| JPS58209994A (ja) * | 1982-05-10 | 1983-12-07 | Fujirebio Inc | 活性蛋白等固定化物を用いた抗原の測定方法 |
| US4459361A (en) * | 1982-06-04 | 1984-07-10 | Angenics, Inc. | Ligand assay with one or two particulate reagents and filter |
| GB2123146B (en) * | 1982-06-28 | 1985-09-25 | Abbott Lab | Dual parameter flow immunoassays |
| JPS5931453A (ja) * | 1982-07-14 | 1984-02-20 | Fujirebio Inc | 梅毒抗体の測定方法 |
| US4521521A (en) * | 1983-03-11 | 1985-06-04 | E. I. Du Pont De Nemours And Company | Particle reagent size distribution measurements for immunoassay |
| US4547466A (en) * | 1983-06-01 | 1985-10-15 | Allied Corporation | Detecting rheumatoid factor with synthetic particles having immune complexes thereon |
| US4590169A (en) * | 1983-11-18 | 1986-05-20 | Beckman Instruments, Inc. | Direct particle agglutination immunoassays avoiding false negatives at high antigen concentrations |
| US4595661A (en) * | 1983-11-18 | 1986-06-17 | Beckman Instruments, Inc. | Immunoassays and kits for use therein which include low affinity antibodies for reducing the hook effect |
| DE3446714A1 (de) * | 1984-12-21 | 1986-06-26 | Boehringer Mannheim Gmbh | Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens |
| DE3507574A1 (de) * | 1985-03-04 | 1986-09-04 | Gödecke AG, 1000 Berlin | Zweistufiger agglutinationsschnelltest zum kombinierten nachweis "seropositiver" und "seronegativer" rheumafaktoren |
| JPS6270764A (ja) * | 1985-03-08 | 1987-04-01 | Sanko Junyaku Kk | 血清中の免疫抗体測定方法 |
| US4721681A (en) * | 1985-05-14 | 1988-01-26 | Fisher Scientific Company | Immunoassay in centrifugal field with complementary particles of differing specific gravities |
| US4921787A (en) * | 1987-05-01 | 1990-05-01 | Cambridge Bioscience Corporation | Detection of antibodies to human immunodeficiency virus by agglutination of antigen coated latex |
| GB8717862D0 (en) * | 1987-07-28 | 1987-09-03 | Acade Diagnostic Systems Sa Nv | Turbidimetric assay |
| US4859612A (en) * | 1987-10-07 | 1989-08-22 | Hygeia Sciences, Inc. | Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite |
| US5158871A (en) * | 1988-02-12 | 1992-10-27 | University Of Connecticut | Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates |
| US5202267A (en) * | 1988-04-04 | 1993-04-13 | Hygeia Sciences, Inc. | Sol capture immunoassay kit and procedure |
| US5145784A (en) * | 1988-05-04 | 1992-09-08 | Cambridge Biotech Corporation | Double capture assay method employing a capillary flow device |
| JP3127449B2 (ja) * | 1989-07-28 | 2001-01-22 | 三菱化学株式会社 | 抗体の測定法 |
| PL286914A1 (en) * | 1989-09-14 | 1991-08-12 | Baxter Int | Method of obtaining a pharmaceutic, method of obtaining predetermined amount of antibody from physiologic saline, apparatus for selectively isolating a specific ppopulation of desirable antibody and set for isolating such antibody |
| JPH03123861A (ja) * | 1989-10-06 | 1991-05-27 | Mitsubishi Kasei Corp | ハプテンの免疫化学的測定法 |
| GB9028038D0 (en) * | 1990-12-24 | 1991-02-13 | Nycomed Pharma As | Test method and reagent kit therefor |
| US5286452A (en) * | 1991-05-20 | 1994-02-15 | Sienna Biotech, Inc. | Simultaneous multiple assays |
| US5998220A (en) | 1991-05-29 | 1999-12-07 | Beckman Coulter, Inc. | Opposable-element assay devices, kits, and methods employing them |
| US6168956B1 (en) | 1991-05-29 | 2001-01-02 | Beckman Coulter, Inc. | Multiple component chromatographic assay device |
| US5877028A (en) | 1991-05-29 | 1999-03-02 | Smithkline Diagnostics, Inc. | Immunochromatographic assay device |
| CA2164725A1 (en) * | 1993-06-08 | 1994-12-22 | Alexander Saunders | Two-phase optical assay method and apparatus |
| US5561049A (en) * | 1994-09-21 | 1996-10-01 | Behringwerke Ag | Method for detecting antibodies |
| US6159748A (en) * | 1995-03-13 | 2000-12-12 | Affinitech, Ltd | Evaluation of autoimmune diseases using a multiple parameter latex bead suspension and flow cytometry |
| US5858648A (en) * | 1996-11-04 | 1999-01-12 | Sienna Biotech, Inc. | Assays using reference microparticles |
| JP3468750B2 (ja) * | 1998-01-22 | 2003-11-17 | ルミネックス コーポレイション | 多数の蛍光シグナルを有する微小粒子 |
| US6379909B1 (en) * | 1998-06-24 | 2002-04-30 | Alk-Abello A/S | Method of detecting an antibody in a liquid sample |
| US20050112607A1 (en) * | 1999-01-23 | 2005-05-26 | Bamdad Cynthia C. | Rapid and sensitive detection of protein aggregation |
| GB9910155D0 (en) * | 1999-04-30 | 1999-06-30 | Microbiological Research Agenc | Augmented agglutination assay |
| US6649414B1 (en) * | 1999-08-17 | 2003-11-18 | Luminex Corporation | Microparticles with multiple fluorescent signals and methods of using same |
| US6797481B1 (en) * | 2000-10-17 | 2004-09-28 | Dade Behring Marburg Gmbh | Simultaneous screening of multiple analytes |
| US8148171B2 (en) | 2001-10-09 | 2012-04-03 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
| US20050164261A1 (en) * | 2001-10-09 | 2005-07-28 | Chandler Don J. | Multiplexed analysis of clinical specimens apparatus and methods |
| US20030109067A1 (en) * | 2001-12-06 | 2003-06-12 | Immunetech, Inc. | Homogeneous immunoassays for multiple allergens |
| US20040101822A1 (en) | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
| GB2420850A (en) | 2004-12-03 | 2006-06-07 | Orion Diagnostica Oy | Particle based binding assay |
| US8084001B2 (en) * | 2005-05-02 | 2011-12-27 | Cornell Research Foundation, Inc. | Photoluminescent silica-based sensors and methods of use |
| GB2432211B (en) * | 2005-11-12 | 2009-04-22 | Platform Diagnostics Ltd | Agglutination based assay system |
| EP1952158A2 (en) * | 2005-11-12 | 2008-08-06 | Platform Diagnostics Limited | Agglutination assay |
| US20100130367A1 (en) * | 2006-07-11 | 2010-05-27 | Drexel University | Methods of Quantitatively Assessing Inflammation with Biosensing Nanoparticles |
| GB2443694B (en) | 2006-11-10 | 2011-09-14 | Platform Diagnostics Ltd | Analyte saturation assay, methods and kits and devices |
| WO2018075913A1 (en) | 2016-10-20 | 2018-04-26 | Quantum Diamond Technologies Inc. | Methods and apparatus for magnetic particle analysis using wide-field diamond magnetic imaging |
| EP3559668B1 (en) | 2016-12-23 | 2023-07-19 | Quantum Diamond Technologies Inc. | Methods and apparatus for magnetic multi-bead assays |
| JP7204733B2 (ja) | 2017-07-31 | 2023-01-16 | クアンタム ダイヤモンド テクノロジーズ インク． | 試料測定のための方法および装置 |
| WO2019211218A1 (en) * | 2018-05-02 | 2019-11-07 | Hahn-Schickard-Gesellschaft Für Angewandte Forschung E. V. | Immunoassay for an automated system |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4138213A (en) * | 1974-05-20 | 1979-02-06 | Technicon Instruments Corporation | Agglutination immunoassay of immune complex with RF or Clq |
| GB1508132A (en) * | 1974-05-20 | 1978-04-19 | Technicon Instr | Analysis of biological fluids |
| US4169138A (en) * | 1974-05-29 | 1979-09-25 | Pharmacia Diagnostics Ab | Method for the detection of antibodies |
| US4189466A (en) * | 1975-09-19 | 1980-02-19 | Technical Research Affiliates, Inc. | Detection of rheumatoid factor by antibody sensitized microbial particles |
| JPS604422B2 (ja) * | 1976-10-07 | 1985-02-04 | 持田製薬株式会社 | 抗原の定量方法 |
| US4092114A (en) * | 1976-10-20 | 1978-05-30 | Fisher Scientific Company | Indirect latex test for determination of immunoglobulins |
| GB1590524A (en) * | 1976-11-24 | 1981-06-03 | Nat Res Dev | Assay of immune complexes |
| GB1590525A (en) * | 1976-12-10 | 1981-06-03 | Technicon Instr | Biological analysis |
| GB1592450A (en) * | 1976-12-10 | 1981-07-08 | Technicon Instr | Biological analysis |
| US4210622A (en) * | 1977-09-07 | 1980-07-01 | National Research Development Corporation | Kit for assay of immune complexes |
| US4102990A (en) * | 1977-12-05 | 1978-07-25 | General Electric Company | Electrophoretic assay for antigen-antibody reaction based on particle-particle coupling |
-
1980
- 1980-02-21 GB GB8005824A patent/GB2045431B/en not_active Expired
- 1980-02-23 DE DE19803006899 patent/DE3006899A1/de active Granted
- 1980-02-26 JP JP2235680A patent/JPS55156866A/ja active Granted
- 1980-02-26 FR FR8004162A patent/FR2449892B1/fr not_active Expired
- 1980-02-26 CA CA346,462A patent/CA1132902A/en not_active Expired
- 1980-02-26 US US06/124,849 patent/US4279617A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE3006899A1 (de) | 1980-09-11 |
| JPS55156866A (en) | 1980-12-06 |
| JPS6362699B2 (en, 2012) | 1988-12-05 |
| FR2449892B1 (fr) | 1985-08-23 |
| GB2045431A (en) | 1980-10-29 |
| US4279617A (en) | 1981-07-21 |
| CA1132902A (en) | 1982-10-05 |
| GB2045431B (en) | 1983-04-20 |
| FR2449892A1 (fr) | 1980-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3006899C2 (en, 2012) | ||
| DE3883351T2 (de) | Latex-Agglutinations-Immuntest in Gegenwart von Hämoglobin. | |
| DE2522087C2 (de) | Verfahren zum Nachweisen und Bestimmen von Ak:Ag-Komplexen in einer biologischen Fluidprobe | |
| DE68922844T2 (de) | Agglutinationsverfahren zur Bestimmung von mehreren Liganden. | |
| DE69126248T2 (de) | Immunchromatographischer assay und verfahren zur nutzung desselben | |
| DE69530861T2 (de) | Vorrichtung zur durchführung eines oder mehrerer kompetitiver immunoassays | |
| DE68924064T2 (de) | Verfahren zur Bestimmung eines oder mehrerer Analyte durch Anwendung verschiedene Typen von Partikeln, welche durchflusszytometrisch unterschieden sind. | |
| DE68908432T2 (de) | Schwellwertimmunoassay. | |
| DE3879000T2 (de) | Immunoassaymethode zum auffinden von antikoerpern zu antigenen. | |
| DE69328273T2 (de) | Verfahren zur Messung von glykosiliertem Hämoglobin | |
| DE69306804T2 (de) | Immunologischer test auf festphase | |
| EP0356964B1 (de) | Verfahren zur Bestimmung einer spezifisch bindefähigen Substanz | |
| EP0363942A2 (de) | Verfahren zur Bestimmung einer spezifisch bindefähigen Substanz | |
| WO1999005525A1 (de) | Verwendung von kontrollflächen zur detektion von störproben in einem nachweisverfahren | |
| DD202178A5 (de) | Verfahren und reagens zur untersuchung von antigen-antikoerper-reaktionen | |
| DE4434093A1 (de) | Verfahren zum qualitativen oder/und quantitativen Nachweis einer zu bestimmenden Substanz | |
| EP0033960A2 (de) | Verfahren zur Vorbehandlung von Proben, welche für die Bestimmung von carcinoembryonischem Antigen verwendet werden | |
| DE69808895T2 (de) | Leistungssteigerung von bindungsassays mit verwendung mehr als einer markierungsmittel | |
| DE3883729T2 (de) | Immunobestimmung mit Nichtmetallmarkierungen. | |
| DE2754645C2 (de) | Verfahren zum Nachweis und zur Bestimmung von Antigenen oder Antikörpern in Flüssigkeiten | |
| DE69021159T2 (de) | Verfahren zum immunochemischen Bestimmen von Haptenen. | |
| EP0366092B1 (de) | Verfahren zur Bestimmung von für ein Antigen klassenspezifischen Antikörpern und dazu geeignetes Reagenz | |
| DE68926479T2 (de) | Testverfahren für antigene oder antikörper | |
| DE2725594C2 (de) | Verfahren zur Bestimmung der Konzentration freier Schilddrüsenhormone in Flüssigkeiten, insbesondere Blutseren | |
| EP0557546B1 (de) | Kopplung von Antigenen und Antikörpern an nicht-fixierte Erythrozyten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8125 | Change of the main classification |
Ipc: G01N 33/53 |
|
| D2 | Grant after examination | ||
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: TECHNICON INSTRUMENTS CORP. (N.D.GES.D.STAATES DEL |
|
| 8339 | Ceased/non-payment of the annual fee |