CA1132902A - Agglutination immuno assay using two different particulate agents - Google Patents
Agglutination immuno assay using two different particulate agentsInfo
- Publication number
- CA1132902A CA1132902A CA346,462A CA346462A CA1132902A CA 1132902 A CA1132902 A CA 1132902A CA 346462 A CA346462 A CA 346462A CA 1132902 A CA1132902 A CA 1132902A
- Authority
- CA
- Canada
- Prior art keywords
- reagent
- particulate
- particles
- assay
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000004520 agglutination Effects 0.000 title abstract description 12
- 238000003018 immunoassay Methods 0.000 title description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 91
- 239000002245 particle Substances 0.000 claims abstract description 77
- 238000003556 assay Methods 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims description 35
- 229920000126 latex Polymers 0.000 claims description 27
- 239000004816 latex Substances 0.000 claims description 24
- 239000007788 liquid Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 10
- 238000000926 separation method Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 7
- 239000006249 magnetic particle Substances 0.000 claims description 4
- 238000010998 test method Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 230000001419 dependent effect Effects 0.000 claims description 2
- 238000005112 continuous flow technique Methods 0.000 claims 1
- 239000000427 antigen Substances 0.000 abstract description 14
- 102000036639 antigens Human genes 0.000 abstract description 14
- 108091007433 antigens Proteins 0.000 abstract description 14
- 102000014914 Carrier Proteins Human genes 0.000 abstract description 4
- 108091008324 binding proteins Proteins 0.000 abstract description 4
- 108060003951 Immunoglobulin Proteins 0.000 abstract description 2
- 238000004458 analytical method Methods 0.000 abstract description 2
- 102000018358 immunoglobulin Human genes 0.000 abstract description 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 238000007818 agglutination assay Methods 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 description 15
- 239000013566 allergen Substances 0.000 description 12
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 10
- 241000283707 Capra Species 0.000 description 7
- 239000000872 buffer Substances 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- 241000283973 Oryctolagus cuniculus Species 0.000 description 6
- 229940046528 grass pollen Drugs 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000004471 Glycine Substances 0.000 description 5
- 238000001179 sorption measurement Methods 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000000523 sample Substances 0.000 description 4
- 229960004784 allergens Drugs 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 2
- 238000007792 addition Methods 0.000 description 2
- 210000003567 ascitic fluid Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000007885 magnetic separation Methods 0.000 description 2
- 239000011236 particulate material Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000208841 Ambrosia trifida Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 102000008857 Ferritin Human genes 0.000 description 1
- 108050000784 Ferritin Proteins 0.000 description 1
- 238000008416 Ferritin Methods 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 230000003172 anti-dna Effects 0.000 description 1
- 239000003418 antiprogestin Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000009739 binding Methods 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000727 fraction Substances 0.000 description 1
- 239000007986 glycine-NaOH buffer Substances 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 101150043924 metXA gene Proteins 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229960003387 progesterone Drugs 0.000 description 1
- 239000000186 progesterone Substances 0.000 description 1
- 230000003623 progesteronic effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000009342 ragweed pollen Substances 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/819—Multifunctional antigen or antibody
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7906686 | 1979-02-26 | ||
| GB7906686 | 1979-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1132902A true CA1132902A (en) | 1982-10-05 |
Family
ID=10503430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA346,462A Expired CA1132902A (en) | 1979-02-26 | 1980-02-26 | Agglutination immuno assay using two different particulate agents |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4279617A (en, 2012) |
| JP (1) | JPS55156866A (en, 2012) |
| CA (1) | CA1132902A (en, 2012) |
| DE (1) | DE3006899A1 (en, 2012) |
| FR (1) | FR2449892B1 (en, 2012) |
| GB (1) | GB2045431B (en, 2012) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4696907A (en) * | 1980-07-18 | 1987-09-29 | Science Research Center, Inc. | Identification of reagins in the blood serum of allergen sensitized vertebrates |
| US4427781A (en) | 1981-03-16 | 1984-01-24 | International Institute Of Cellular And Molecular Pathology | Particle agglutination immunoassay with agglutinator for determining haptens; PACIA |
| US4476231A (en) * | 1981-07-22 | 1984-10-09 | International Remote Imaging Systems, Inc. | Method of analyzing the distribution of a reagent between particles and liquid in a suspension |
| JPS59500832A (ja) * | 1982-05-07 | 1984-05-10 | パラゴン・ダイアグノスティクス・インコ−ポレイテッド | 競合的免疫螢光検定法及び試験セット |
| JPS58209994A (ja) * | 1982-05-10 | 1983-12-07 | Fujirebio Inc | 活性蛋白等固定化物を用いた抗原の測定方法 |
| US4459361A (en) * | 1982-06-04 | 1984-07-10 | Angenics, Inc. | Ligand assay with one or two particulate reagents and filter |
| GB2123146B (en) * | 1982-06-28 | 1985-09-25 | Abbott Lab | Dual parameter flow immunoassays |
| JPS5931453A (ja) * | 1982-07-14 | 1984-02-20 | Fujirebio Inc | 梅毒抗体の測定方法 |
| US4521521A (en) * | 1983-03-11 | 1985-06-04 | E. I. Du Pont De Nemours And Company | Particle reagent size distribution measurements for immunoassay |
| US4547466A (en) * | 1983-06-01 | 1985-10-15 | Allied Corporation | Detecting rheumatoid factor with synthetic particles having immune complexes thereon |
| US4590169A (en) * | 1983-11-18 | 1986-05-20 | Beckman Instruments, Inc. | Direct particle agglutination immunoassays avoiding false negatives at high antigen concentrations |
| US4595661A (en) * | 1983-11-18 | 1986-06-17 | Beckman Instruments, Inc. | Immunoassays and kits for use therein which include low affinity antibodies for reducing the hook effect |
| DE3446714A1 (de) * | 1984-12-21 | 1986-06-26 | Boehringer Mannheim Gmbh | Verfahren zum nachweis des vorliegens einer allergie und zum spezifischen nachweis des fuer die allergie verantwortlichen allergens |
| DE3507574A1 (de) * | 1985-03-04 | 1986-09-04 | Gödecke AG, 1000 Berlin | Zweistufiger agglutinationsschnelltest zum kombinierten nachweis "seropositiver" und "seronegativer" rheumafaktoren |
| JPS6270764A (ja) * | 1985-03-08 | 1987-04-01 | Sanko Junyaku Kk | 血清中の免疫抗体測定方法 |
| US4721681A (en) * | 1985-05-14 | 1988-01-26 | Fisher Scientific Company | Immunoassay in centrifugal field with complementary particles of differing specific gravities |
| US4921787A (en) * | 1987-05-01 | 1990-05-01 | Cambridge Bioscience Corporation | Detection of antibodies to human immunodeficiency virus by agglutination of antigen coated latex |
| GB8717862D0 (en) * | 1987-07-28 | 1987-09-03 | Acade Diagnostic Systems Sa Nv | Turbidimetric assay |
| US4859612A (en) * | 1987-10-07 | 1989-08-22 | Hygeia Sciences, Inc. | Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite |
| US5158871A (en) * | 1988-02-12 | 1992-10-27 | University Of Connecticut | Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates |
| US5202267A (en) * | 1988-04-04 | 1993-04-13 | Hygeia Sciences, Inc. | Sol capture immunoassay kit and procedure |
| US5145784A (en) * | 1988-05-04 | 1992-09-08 | Cambridge Biotech Corporation | Double capture assay method employing a capillary flow device |
| JP3127449B2 (ja) * | 1989-07-28 | 2001-01-22 | 三菱化学株式会社 | 抗体の測定法 |
| PL286914A1 (en) * | 1989-09-14 | 1991-08-12 | Baxter Int | Method of obtaining a pharmaceutic, method of obtaining predetermined amount of antibody from physiologic saline, apparatus for selectively isolating a specific ppopulation of desirable antibody and set for isolating such antibody |
| JPH03123861A (ja) * | 1989-10-06 | 1991-05-27 | Mitsubishi Kasei Corp | ハプテンの免疫化学的測定法 |
| GB9028038D0 (en) * | 1990-12-24 | 1991-02-13 | Nycomed Pharma As | Test method and reagent kit therefor |
| US5286452A (en) * | 1991-05-20 | 1994-02-15 | Sienna Biotech, Inc. | Simultaneous multiple assays |
| US5998220A (en) | 1991-05-29 | 1999-12-07 | Beckman Coulter, Inc. | Opposable-element assay devices, kits, and methods employing them |
| US6168956B1 (en) | 1991-05-29 | 2001-01-02 | Beckman Coulter, Inc. | Multiple component chromatographic assay device |
| US5877028A (en) | 1991-05-29 | 1999-03-02 | Smithkline Diagnostics, Inc. | Immunochromatographic assay device |
| CA2164725A1 (en) * | 1993-06-08 | 1994-12-22 | Alexander Saunders | Two-phase optical assay method and apparatus |
| US5561049A (en) * | 1994-09-21 | 1996-10-01 | Behringwerke Ag | Method for detecting antibodies |
| US6159748A (en) * | 1995-03-13 | 2000-12-12 | Affinitech, Ltd | Evaluation of autoimmune diseases using a multiple parameter latex bead suspension and flow cytometry |
| US5858648A (en) * | 1996-11-04 | 1999-01-12 | Sienna Biotech, Inc. | Assays using reference microparticles |
| JP3468750B2 (ja) * | 1998-01-22 | 2003-11-17 | ルミネックス コーポレイション | 多数の蛍光シグナルを有する微小粒子 |
| US6379909B1 (en) * | 1998-06-24 | 2002-04-30 | Alk-Abello A/S | Method of detecting an antibody in a liquid sample |
| US20050112607A1 (en) * | 1999-01-23 | 2005-05-26 | Bamdad Cynthia C. | Rapid and sensitive detection of protein aggregation |
| GB9910155D0 (en) * | 1999-04-30 | 1999-06-30 | Microbiological Research Agenc | Augmented agglutination assay |
| US6649414B1 (en) * | 1999-08-17 | 2003-11-18 | Luminex Corporation | Microparticles with multiple fluorescent signals and methods of using same |
| US6797481B1 (en) * | 2000-10-17 | 2004-09-28 | Dade Behring Marburg Gmbh | Simultaneous screening of multiple analytes |
| US8148171B2 (en) | 2001-10-09 | 2012-04-03 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
| US20050164261A1 (en) * | 2001-10-09 | 2005-07-28 | Chandler Don J. | Multiplexed analysis of clinical specimens apparatus and methods |
| US20030109067A1 (en) * | 2001-12-06 | 2003-06-12 | Immunetech, Inc. | Homogeneous immunoassays for multiple allergens |
| US20040101822A1 (en) | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
| GB2420850A (en) | 2004-12-03 | 2006-06-07 | Orion Diagnostica Oy | Particle based binding assay |
| US8084001B2 (en) * | 2005-05-02 | 2011-12-27 | Cornell Research Foundation, Inc. | Photoluminescent silica-based sensors and methods of use |
| GB2432211B (en) * | 2005-11-12 | 2009-04-22 | Platform Diagnostics Ltd | Agglutination based assay system |
| EP1952158A2 (en) * | 2005-11-12 | 2008-08-06 | Platform Diagnostics Limited | Agglutination assay |
| US20100130367A1 (en) * | 2006-07-11 | 2010-05-27 | Drexel University | Methods of Quantitatively Assessing Inflammation with Biosensing Nanoparticles |
| GB2443694B (en) | 2006-11-10 | 2011-09-14 | Platform Diagnostics Ltd | Analyte saturation assay, methods and kits and devices |
| WO2018075913A1 (en) | 2016-10-20 | 2018-04-26 | Quantum Diamond Technologies Inc. | Methods and apparatus for magnetic particle analysis using wide-field diamond magnetic imaging |
| EP3559668B1 (en) | 2016-12-23 | 2023-07-19 | Quantum Diamond Technologies Inc. | Methods and apparatus for magnetic multi-bead assays |
| JP7204733B2 (ja) | 2017-07-31 | 2023-01-16 | クアンタム ダイヤモンド テクノロジーズ インク． | 試料測定のための方法および装置 |
| WO2019211218A1 (en) * | 2018-05-02 | 2019-11-07 | Hahn-Schickard-Gesellschaft Für Angewandte Forschung E. V. | Immunoassay for an automated system |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4138213A (en) * | 1974-05-20 | 1979-02-06 | Technicon Instruments Corporation | Agglutination immunoassay of immune complex with RF or Clq |
| GB1508132A (en) * | 1974-05-20 | 1978-04-19 | Technicon Instr | Analysis of biological fluids |
| US4169138A (en) * | 1974-05-29 | 1979-09-25 | Pharmacia Diagnostics Ab | Method for the detection of antibodies |
| US4189466A (en) * | 1975-09-19 | 1980-02-19 | Technical Research Affiliates, Inc. | Detection of rheumatoid factor by antibody sensitized microbial particles |
| JPS604422B2 (ja) * | 1976-10-07 | 1985-02-04 | 持田製薬株式会社 | 抗原の定量方法 |
| US4092114A (en) * | 1976-10-20 | 1978-05-30 | Fisher Scientific Company | Indirect latex test for determination of immunoglobulins |
| GB1590524A (en) * | 1976-11-24 | 1981-06-03 | Nat Res Dev | Assay of immune complexes |
| GB1590525A (en) * | 1976-12-10 | 1981-06-03 | Technicon Instr | Biological analysis |
| GB1592450A (en) * | 1976-12-10 | 1981-07-08 | Technicon Instr | Biological analysis |
| US4210622A (en) * | 1977-09-07 | 1980-07-01 | National Research Development Corporation | Kit for assay of immune complexes |
| US4102990A (en) * | 1977-12-05 | 1978-07-25 | General Electric Company | Electrophoretic assay for antigen-antibody reaction based on particle-particle coupling |
-
1980
- 1980-02-21 GB GB8005824A patent/GB2045431B/en not_active Expired
- 1980-02-23 DE DE19803006899 patent/DE3006899A1/de active Granted
- 1980-02-26 JP JP2235680A patent/JPS55156866A/ja active Granted
- 1980-02-26 FR FR8004162A patent/FR2449892B1/fr not_active Expired
- 1980-02-26 CA CA346,462A patent/CA1132902A/en not_active Expired
- 1980-02-26 US US06/124,849 patent/US4279617A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE3006899A1 (de) | 1980-09-11 |
| JPS55156866A (en) | 1980-12-06 |
| JPS6362699B2 (en, 2012) | 1988-12-05 |
| FR2449892B1 (fr) | 1985-08-23 |
| GB2045431A (en) | 1980-10-29 |
| US4279617A (en) | 1981-07-21 |
| GB2045431B (en) | 1983-04-20 |
| DE3006899C2 (en, 2012) | 1989-02-09 |
| FR2449892A1 (fr) | 1980-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |