DE3004370A1 - 1- eckige klammer auf (acylthio)- und (mercapto)-1-oxoalkyl eckige klammer zu -1,2,3,4-tetrahydrochinolin-2-carbonsaeuren - Google Patents

1- eckige klammer auf (acylthio)- und (mercapto)-1-oxoalkyl eckige klammer zu -1,2,3,4-tetrahydrochinolin-2-carbonsaeuren

Info

Publication number
DE3004370A1
DE3004370A1 DE19803004370 DE3004370A DE3004370A1 DE 3004370 A1 DE3004370 A1 DE 3004370A1 DE 19803004370 DE19803004370 DE 19803004370 DE 3004370 A DE3004370 A DE 3004370A DE 3004370 A1 DE3004370 A1 DE 3004370A1
Authority
DE
Germany
Prior art keywords
tetrahydro
quinolinecarboxylic acid
oxopropyl
solution
yield
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19803004370
Other languages
German (de)
English (en)
Other versions
DE3004370C2 (US20020051482A1-20020502-M00012.png
Inventor
David E Portlock
George C Wright
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Chilcott Pharmaceuticals Inc
Original Assignee
Morton Norwich Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morton Norwich Products Inc filed Critical Morton Norwich Products Inc
Publication of DE3004370A1 publication Critical patent/DE3004370A1/de
Application granted granted Critical
Publication of DE3004370C2 publication Critical patent/DE3004370C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE19803004370 1979-02-07 1980-02-06 1- eckige klammer auf (acylthio)- und (mercapto)-1-oxoalkyl eckige klammer zu -1,2,3,4-tetrahydrochinolin-2-carbonsaeuren Granted DE3004370A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1016579A 1979-02-07 1979-02-07
US06/090,862 US4461896A (en) 1979-02-07 1979-11-02 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids

Publications (2)

Publication Number Publication Date
DE3004370A1 true DE3004370A1 (de) 1980-08-14
DE3004370C2 DE3004370C2 (US20020051482A1-20020502-M00012.png) 1989-10-26

Family

ID=26680853

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803004370 Granted DE3004370A1 (de) 1979-02-07 1980-02-06 1- eckige klammer auf (acylthio)- und (mercapto)-1-oxoalkyl eckige klammer zu -1,2,3,4-tetrahydrochinolin-2-carbonsaeuren

Country Status (16)

Country Link
US (1) US4461896A (US20020051482A1-20020502-M00012.png)
AU (1) AU527887B2 (US20020051482A1-20020502-M00012.png)
CH (1) CH645355A5 (US20020051482A1-20020502-M00012.png)
DE (1) DE3004370A1 (US20020051482A1-20020502-M00012.png)
DK (1) DK152209C (US20020051482A1-20020502-M00012.png)
ES (1) ES488313A0 (US20020051482A1-20020502-M00012.png)
FR (1) FR2448533A1 (US20020051482A1-20020502-M00012.png)
GB (1) GB2042535B (US20020051482A1-20020502-M00012.png)
GR (1) GR74103B (US20020051482A1-20020502-M00012.png)
IE (1) IE49350B1 (US20020051482A1-20020502-M00012.png)
IL (1) IL59089A (US20020051482A1-20020502-M00012.png)
IT (1) IT1145330B (US20020051482A1-20020502-M00012.png)
NL (1) NL8000641A (US20020051482A1-20020502-M00012.png)
NZ (1) NZ192613A (US20020051482A1-20020502-M00012.png)
PT (1) PT70793A (US20020051482A1-20020502-M00012.png)
SE (1) SE436031B (US20020051482A1-20020502-M00012.png)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052870A1 (de) * 1980-11-25 1982-06-02 Hoechst Aktiengesellschaft Aminosäurederivate und Verfahren zu ihrer Herstellung
US4390700A (en) 1980-11-10 1983-06-28 Ciba-Geigy Corporation 1-Carboxyazaalkanoyl-tetrahydroquinoline-2-carboxylic acids
US4401818A (en) 1980-12-24 1983-08-30 Ciba-Geigy Corporation 1-Carboxyalkanoyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acids
US4599357A (en) * 1979-12-17 1986-07-08 Ciba-Geigy Corporation 1-mercaptoalkanoylindoline-2-carboxylic acids

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2937779A1 (de) * 1979-09-19 1981-04-09 Hoechst Ag, 6000 Frankfurt Aminosaeurederivate und verfahren zu ihrer herstellung
US4595675A (en) * 1979-09-19 1986-06-17 Hoechst Aktiengesellschaft Bicyclic α-iminocarboxylic acid compounds having hypotensive activity
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4350704A (en) 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
EP0278530A3 (de) * 1980-08-30 1989-08-02 Hoechst Aktiengesellschaft Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
DE3260423D1 (en) * 1981-02-17 1984-08-30 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-isoindole-1-carboxylic acids and esters
US4532342A (en) * 1981-02-20 1985-07-30 Warner-Lambert Company N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
US4374246A (en) * 1981-06-18 1983-02-15 Norwich Eaton Pharmaceuticals, Inc. 1-N-[(1-Carboxy-3-phenylpropyl)glycyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acid compounds
US5356890A (en) * 1988-06-15 1994-10-18 Brigham And Women's Hospital S-nitroso derivatives of ace inhibitors and the use thereof
US5025001A (en) * 1988-06-15 1991-06-18 Brigham And Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
US5187183A (en) * 1988-06-15 1993-02-16 Brigham & Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
GB9010394D0 (en) * 1990-05-09 1990-06-27 Ici Plc Heterocyclic compounds
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
WO1995001353A1 (en) * 1993-06-30 1995-01-12 Ciba-Geigy Ag Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ace
ITMI20012060A1 (it) * 2001-10-05 2003-04-05 Recordati Chem Pharm Nuovi eterocilcli n-acilati
US7803790B2 (en) * 2005-05-09 2010-09-28 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
US8916550B2 (en) * 2005-05-09 2014-12-23 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
US11229746B2 (en) 2006-06-22 2022-01-25 Excelsior Medical Corporation Antiseptic cap
US9259535B2 (en) 2006-06-22 2016-02-16 Excelsior Medical Corporation Antiseptic cap equipped syringe
WO2008033564A1 (en) 2006-09-15 2008-03-20 Hydra Biosciences Inc. Compounds for modulating trpv3 function
US9078992B2 (en) 2008-10-27 2015-07-14 Pursuit Vascular, Inc. Medical device for applying antimicrobial to proximal end of catheter
WO2013009998A2 (en) 2011-07-12 2013-01-17 Pursuit Vascular, Inc. Device for delivery of antimicrobial agent into trans-dermal catheter
EP3137122B1 (en) 2014-05-02 2019-09-04 Excelsior Medical Corporation Strip package for antiseptic cap
WO2016182822A1 (en) 2015-05-08 2016-11-17 Icu Medical, Inc. Medical connectors configured to receive emitters of therapeutic agents
JP7005609B2 (ja) 2016-10-14 2022-02-10 アイシーユー・メディカル・インコーポレーテッド 医療用コネクタのための浄化キャップ
WO2018204206A2 (en) 2017-05-01 2018-11-08 Icu Medical, Inc. Medical fluid connectors and methods for providing additives in medical fluid lines
US11400195B2 (en) 2018-11-07 2022-08-02 Icu Medical, Inc. Peritoneal dialysis transfer set with antimicrobial properties
US11534595B2 (en) 2018-11-07 2022-12-27 Icu Medical, Inc. Device for delivering an antimicrobial composition into an infusion device
US11541220B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Needleless connector with antimicrobial properties
US11517732B2 (en) 2018-11-07 2022-12-06 Icu Medical, Inc. Syringe with antimicrobial properties
US11541221B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Tubing set with antimicrobial properties
EP3883638A1 (en) 2018-11-21 2021-09-29 ICU Medical, Inc. Antimicrobial device comprising a cap with ring and insert
US11807621B2 (en) 2020-01-29 2023-11-07 Kamari Pharma Ltd. Compounds and compositions for use in treating skin disorders
JP2024500319A (ja) 2020-12-07 2024-01-09 アイシーユー・メディカル・インコーポレーテッド 腹膜透析キャップ、システム、及び方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2703828A1 (de) * 1976-02-13 1977-08-18 Squibb & Sons Inc Prolinderivate und verwandte verbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR837847A (fr) * 1937-05-13 1939-02-21 Ste Ind Chim Bale Agents auxiliaires pour l'impression
US4104392A (en) * 1974-11-08 1978-08-01 Mitsubishi Chemical Industries Ltd. N2 -naphthalenesulfonyl-L-argininamides and the pharmaceutically acceptable salts thereof, and antithrombotic compositions and methods employing them
AU4091178A (en) * 1977-10-25 1980-04-24 Merck & Co Inc Substituted mercapto acid amides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2703828A1 (de) * 1976-02-13 1977-08-18 Squibb & Sons Inc Prolinderivate und verwandte verbindungen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599357A (en) * 1979-12-17 1986-07-08 Ciba-Geigy Corporation 1-mercaptoalkanoylindoline-2-carboxylic acids
US4390700A (en) 1980-11-10 1983-06-28 Ciba-Geigy Corporation 1-Carboxyazaalkanoyl-tetrahydroquinoline-2-carboxylic acids
EP0052870A1 (de) * 1980-11-25 1982-06-02 Hoechst Aktiengesellschaft Aminosäurederivate und Verfahren zu ihrer Herstellung
US4401818A (en) 1980-12-24 1983-08-30 Ciba-Geigy Corporation 1-Carboxyalkanoyl-1,2,3,4-tetrahydroquinoline-2-carboxylic acids

Also Published As

Publication number Publication date
ES8102559A1 (es) 1981-01-16
ES488313A0 (es) 1981-01-16
NZ192613A (en) 1981-10-19
AU527887B2 (en) 1983-03-31
DK152209C (da) 1988-06-20
SE8000209L (sv) 1980-08-08
IT8047730A0 (it) 1980-01-28
IE800014L (en) 1980-08-07
GB2042535B (en) 1983-01-26
CH645355A5 (de) 1984-09-28
SE436031B (sv) 1984-11-05
IT1145330B (it) 1986-11-05
GR74103B (US20020051482A1-20020502-M00012.png) 1984-06-06
GB2042535A (en) 1980-09-24
FR2448533B1 (US20020051482A1-20020502-M00012.png) 1983-01-07
DE3004370C2 (US20020051482A1-20020502-M00012.png) 1989-10-26
FR2448533A1 (fr) 1980-09-05
AU5472780A (en) 1980-08-14
DK51280A (da) 1980-08-08
IL59089A0 (en) 1980-05-30
IE49350B1 (en) 1985-09-18
IL59089A (en) 1982-08-31
US4461896A (en) 1984-07-24
NL8000641A (nl) 1980-08-11
PT70793A (en) 1980-03-01
DK152209B (da) 1988-02-08

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Legal Events

Date Code Title Description
8127 New person/name/address of the applicant

Owner name: NORWICH EATON PHARMACEUTICALS, INC., 13815 NORWICH

8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: C07D215/16

D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee