DE2961652D1 - 2-nitro aminopyrimidone derivatives, a process for their preparation and their use to prepare 2-aminopyrimidone derivatives which have histamine h2-antagonist activity - Google Patents

2-nitro aminopyrimidone derivatives, a process for their preparation and their use to prepare 2-aminopyrimidone derivatives which have histamine h2-antagonist activity

Info

Publication number
DE2961652D1
DE2961652D1 DE7979300598T DE2961652T DE2961652D1 DE 2961652 D1 DE2961652 D1 DE 2961652D1 DE 7979300598 T DE7979300598 T DE 7979300598T DE 2961652 T DE2961652 T DE 2961652T DE 2961652 D1 DE2961652 D1 DE 2961652D1
Authority
DE
Germany
Prior art keywords
aminopyrimidone
derivatives
histamine
nitro
prepare
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7979300598T
Other languages
English (en)
Inventor
Thomas Henry Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Application granted granted Critical
Publication of DE2961652D1 publication Critical patent/DE2961652D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
DE7979300598T 1978-04-11 1979-04-11 2-nitro aminopyrimidone derivatives, a process for their preparation and their use to prepare 2-aminopyrimidone derivatives which have histamine h2-antagonist activity Expired DE2961652D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1404978 1978-04-11

Publications (1)

Publication Number Publication Date
DE2961652D1 true DE2961652D1 (en) 1982-02-18

Family

ID=10034068

Family Applications (1)

Application Number Title Priority Date Filing Date
DE7979300598T Expired DE2961652D1 (en) 1978-04-11 1979-04-11 2-nitro aminopyrimidone derivatives, a process for their preparation and their use to prepare 2-aminopyrimidone derivatives which have histamine h2-antagonist activity

Country Status (31)

Country Link
US (1) US4523015A (de)
EP (1) EP0004793B1 (de)
JP (1) JPS54138580A (de)
KR (1) KR820002136B1 (de)
AT (1) AT372956B (de)
AU (1) AU527202B2 (de)
CA (1) CA1138453A (de)
CS (1) CS210684B2 (de)
CY (1) CY1194A (de)
DD (1) DD142878A5 (de)
DE (1) DE2961652D1 (de)
DK (1) DK147379A (de)
ES (1) ES479469A1 (de)
FI (1) FI791143A (de)
GR (1) GR66986B (de)
HU (1) HU180081B (de)
IE (1) IE48080B1 (de)
IL (1) IL57005A (de)
IT (1) IT1118476B (de)
KE (1) KE3284A (de)
MX (1) MX5898E (de)
MY (1) MY8500703A (de)
NO (1) NO791225L (de)
NZ (1) NZ190122A (de)
PH (2) PH16240A (de)
PL (2) PL118404B1 (de)
PT (1) PT69464A (de)
RO (1) RO76810A (de)
SU (2) SU944504A3 (de)
YU (1) YU84179A (de)
ZA (1) ZA791616B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN151188B (de) * 1978-02-13 1983-03-05 Smith Kline French Lab
CA1140129A (en) * 1979-08-21 1983-01-25 Ronald J. King 4-pyrimidone derivatives
CA1155842A (en) * 1980-03-29 1983-10-25 Thomas H. Brown Compounds
US4352933A (en) * 1981-02-06 1982-10-05 Smithkline Beckman Corporation Chemical methods and intermediates for preparing substituted pyrimidinones
ZA823149B (en) * 1981-05-27 1983-03-30 Smithkline Beckman Corp Chemical process
PT74865B (en) * 1981-05-27 1983-12-07 Smithkline Beckman Corp Process of preparing a 2-(pyridylbutylamino)-pyrimidone and of its pharmaceutically acceptable salts
DK230482A (da) * 1981-05-30 1982-12-01 Smith Kline French Lab Pyrimidonsalt og fremstilling heraf
US4772704A (en) * 1983-09-21 1988-09-20 Bristol-Myers Company 2,5-disubstituted-4(3H)-pyrimidones having histamine H2 -receptor antagonist activity
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
GB8421427D0 (en) * 1984-08-23 1984-09-26 Smith Kline French Lab Chemical compounds
DE3532880A1 (de) * 1985-09-14 1987-03-26 Basf Ag 1,4-disubstituierte pyrazolderivate
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
CN107698501A (zh) * 2017-10-25 2018-02-16 遵义医学院 5,6‑二甲基‑2‑羟基烟酸的制备工艺
EP4196793A1 (de) 2020-08-11 2023-06-21 Université de Strasbourg Auf lebermakrophagen abzielende h2-blocker zur prävention und behandlung von lebererkrankungen und krebs

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787372A (fr) * 1971-08-09 1973-02-09 Ici Ltd 2-nitroamino-6-hydroxy-4-methylpyrimidines substituees en position 5
GB1383676A (en) * 1972-07-14 1974-02-12 Ici Ltd Process for making diethylamino pyrimidine derivatives
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
US4145546A (en) * 1975-10-02 1979-03-20 Smith Kline & French Laboratories Limited 4-Pyrimidone compounds
IN146736B (de) * 1975-10-02 1979-08-25 Smith Kline French Lab
MW5076A1 (en) * 1975-12-29 1978-02-08 Smith Kline French Lab Pharmacologicalle active compounds
US4216318A (en) * 1975-12-29 1980-08-05 Smith Kline & French Laboratories Limited Heterocyclic alkyl 4-pyrimidones
US4154834A (en) * 1975-12-29 1979-05-15 Smith Kline & French Laboratories Limited Substituted isocytosines having histamine H2 -antagonist activity
US4227000A (en) * 1978-04-11 1980-10-07 Smith Kline & French Laboratories Limited Intermediates in the process for making histamine antagonists
ZA793392B (en) * 1978-07-15 1980-08-27 Smith Kline French Lab Isoureas and isothioureas

Also Published As

Publication number Publication date
EP0004793A2 (de) 1979-10-17
US4523015A (en) 1985-06-11
PH16240A (en) 1983-08-11
KR820002136B1 (ko) 1982-11-15
PL118404B1 (en) 1981-10-31
CA1138453A (en) 1982-12-28
CY1194A (en) 1983-12-31
ZA791616B (en) 1980-04-30
IE790364L (en) 1979-10-11
EP0004793A3 (en) 1979-11-28
ATA267079A (de) 1983-04-15
MY8500703A (en) 1985-12-31
IT7967751A0 (it) 1979-04-09
GR66986B (de) 1981-05-15
YU84179A (en) 1983-04-30
IT1118476B (it) 1986-03-03
EP0004793B1 (de) 1981-12-30
IE48080B1 (en) 1984-09-19
AT372956B (de) 1983-12-12
MX5898E (es) 1984-08-22
FI791143A (fi) 1979-10-12
PH16841A (en) 1984-03-15
DD142878A5 (de) 1980-07-16
NO791225L (no) 1979-10-12
JPS54138580A (en) 1979-10-27
SU944504A3 (ru) 1982-07-15
PL214792A1 (de) 1980-03-24
DK147379A (da) 1979-10-12
PT69464A (en) 1979-05-01
AU527202B2 (en) 1983-02-24
NZ190122A (en) 1982-03-09
SU906376A3 (ru) 1982-02-15
PL117998B1 (en) 1981-09-30
HU180081B (en) 1983-01-28
KE3284A (en) 1983-05-13
AU4571479A (en) 1979-10-18
CS210684B2 (en) 1982-01-29
ES479469A1 (es) 1979-07-16
IL57005A (en) 1983-11-30
RO76810A (ro) 1981-05-30

Similar Documents

Publication Publication Date Title
PT69684A (en) Process for preparing sulfonamides for agricultural use
DE2961652D1 (en) 2-nitro aminopyrimidone derivatives, a process for their preparation and their use to prepare 2-aminopyrimidone derivatives which have histamine h2-antagonist activity
EG13648A (en) Oximino-triazolyl-ethanes,a process for their preparation and their use as fungicides
IL56444A0 (en) 3-azolyl-benzotriazines and their 1-oxides, their preparation and their use for combating plant diseases
EG13729A (en) A-azolyl-hydroxy-ketones,a process for their preparation and their use as fungicides
ZA793724B (en) -azolyl-keto derivatives,processes for their preparation and their use as fungicides
EG13793A (en) Stilbene derivatives,processes for their preparation and their use as insecticides
DE3065868D1 (en) Sulphonamide derivatives, a process for their preparation and their use as medicines
DE2963203D1 (en) Urea derivatives, process for their preparation and their use as insecticides
ZA791092B (en) Novel pentafluorobenzyloxycarbonyl derivatives,a process for their preparation and their use as insecticides and acaricides
DE2960238D1 (en) N-azolylalkyl-halogenoacetanilides, process for their preparation and their use as herbicides
EG14049A (en) 1-ethene-ozol derivatives,a process for their preparation and their use as fungicides
DE2962873D1 (en) Aminodibenzoxaphosphorines, process for their preparation and their use as stabilisators
DE2960083D1 (en) Phenoxypropanoic acid derivatives, process for their preparation and their use as herbicides
ZA795815B (en) Substituted n-propargyl-anilines,processes for their preparation and their use as fungicides
DE2965252D1 (en) Monoazo-compounds, process for their preparation and their use
DE2962169D1 (en) Chromanon derivatives, process for their preparation, and their use as medicines and growth-promoting agents
DE2962540D1 (en) Benzodioxole derivatives, process for their preparation and their use as synergists in pesticides
DE2960979D1 (en) 5-arylamino-2,2-difluoro-benzodioxolanes, process for their preparation, and their use as pesticides
DE2960253D1 (en) 3-chloro-3-methyl-butane- or 3-methyl-2-butene-1,4-dial-bis acetals, process for their preparation and their use
DE2960156D1 (en) 3-phenoxybenzylidene amines and 3-benzylbenzylidene amines, process for their preparation and their use to prepare the corresponding aldehydes
DE2962151D1 (en) Bis-n-dialkylcarbamyl-quinacridones, process for their preparation and their application
DE2960236D1 (en) Aminomethyl-cyclododecanes, a process for their preparation and their use as anticorrosives
DE2962084D1 (en) Stabilized nicotinamide-adenine-dinucleotides, process for their preparation and use of a stabilizator
DE2860087D1 (en) Haloalkyldithiophosphates, process for their preparation and their use as pesticides

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee