DE2943789A1 - Verfahren zur herstellung von tabletten sowie tablettierungsmaschine zur verwirklichung des verfahrens - Google Patents
Verfahren zur herstellung von tabletten sowie tablettierungsmaschine zur verwirklichung des verfahrensInfo
- Publication number
- DE2943789A1 DE2943789A1 DE19792943789 DE2943789A DE2943789A1 DE 2943789 A1 DE2943789 A1 DE 2943789A1 DE 19792943789 DE19792943789 DE 19792943789 DE 2943789 A DE2943789 A DE 2943789A DE 2943789 A1 DE2943789 A1 DE 2943789A1
- Authority
- DE
- Germany
- Prior art keywords
- temperature
- pressing
- regulated
- tableting machine
- unit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims description 12
- 230000008569 process Effects 0.000 title claims description 8
- 238000004519 manufacturing process Methods 0.000 title claims description 6
- 238000003825 pressing Methods 0.000 claims description 34
- 230000001105 regulatory effect Effects 0.000 claims description 25
- 239000008187 granular material Substances 0.000 claims description 11
- 238000011049 filling Methods 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 7
- 238000005485 electric heating Methods 0.000 claims description 4
- 239000003826 tablet Substances 0.000 description 37
- 239000000243 solution Substances 0.000 description 13
- 239000000203 mixture Substances 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 5
- 238000011161 development Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000007944 soluble tablet Substances 0.000 description 2
- 238000009475 tablet pressing Methods 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 206010010219 Compulsions Diseases 0.000 description 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 1
- 101100400378 Mus musculus Marveld2 gene Proteins 0.000 description 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 244000221110 common millet Species 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002074 deregulated effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- PPKKOTLGXBHLAB-XVHSACDVSA-N nocii Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(O)=O)C(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1C=CC=CC=1)C1=CC=C(O)C=C1 PPKKOTLGXBHLAB-XVHSACDVSA-N 0.000 description 1
- 229960001789 papaverine Drugs 0.000 description 1
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 235000012015 potatoes Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
- B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/34—Heating or cooling presses or parts thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B15/00—Details of, or accessories for, presses; Auxiliary measures in connection with pressing
- B30B15/0023—Drive arrangements for movable carriers, e.g. turntables
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Formation And Processing Of Food Products (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU78LI1863A HU179442B (en) | 1978-10-30 | 1978-10-30 | Process and equipment for preparing tablets |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2943789A1 true DE2943789A1 (de) | 1980-05-14 |
Family
ID=10994709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19792943789 Withdrawn DE2943789A1 (de) | 1978-10-30 | 1979-10-30 | Verfahren zur herstellung von tabletten sowie tablettierungsmaschine zur verwirklichung des verfahrens |
Country Status (8)
| Country | Link |
|---|---|
| JP (2) | JPS5594255A (enrdf_load_stackoverflow) |
| BE (1) | BE879722A (enrdf_load_stackoverflow) |
| CH (1) | CH642001A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2943789A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2440188B1 (enrdf_load_stackoverflow) |
| GB (1) | GB2035195B (enrdf_load_stackoverflow) |
| HU (1) | HU179442B (enrdf_load_stackoverflow) |
| IT (1) | IT1119937B (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004051006A1 (de) * | 2004-10-20 | 2006-04-27 | Fette Gmbh | Rundlaufpresse |
| DE102007052552A1 (de) * | 2007-10-29 | 2009-04-30 | Luxner, Peter, Dipl.-Ing. | Verfahren und Vorrichtung zur Ermittlung von Steuer- und Regelparametern für Tablettenpressen |
| CN109203550A (zh) * | 2018-10-07 | 2019-01-15 | 南京正宽医药科技有限公司 | 一种中药复方黄连素片压片装置 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0661481B2 (ja) * | 1985-08-20 | 1994-08-17 | 株式会社佐竹製作所 | 禾本科植物等の繊維物擂潰機の制御装置 |
| JP4985899B2 (ja) * | 2001-05-25 | 2012-07-25 | 日産化学工業株式会社 | 混練物製品の製造方法 |
| FR2857253B1 (fr) | 2003-07-07 | 2007-02-09 | Ethypharm Sa | Installation comprenant une machine de fabrication de comprimes en particulier a usage therapeuthique |
| DE102012102496A1 (de) * | 2012-03-22 | 2013-09-26 | Hexal Ag | Konfektioniervorrichtung für eine flächige Darreichungsform |
| CN110774648B (zh) * | 2019-11-08 | 2021-06-29 | 安徽亳药千草中药饮片有限公司 | 一种中药饮片压制方法 |
| CN113910668B (zh) * | 2021-10-04 | 2022-07-01 | 丽申药业股份有限公司 | 一种复合酶片剂生产制备方法 |
| CN114013093A (zh) * | 2021-10-28 | 2022-02-08 | 南京恒士丹电气设备有限公司 | 一种智能环保节能药品加工机 |
| CN114055842A (zh) * | 2021-11-12 | 2022-02-18 | 山东新马制药装备有限公司 | 应用于旋转式压片机生产过程降温装置 |
| CN116473151B (zh) * | 2023-05-11 | 2024-08-09 | 丽申药业股份有限公司 | 一种改善肠道功能复合酶压片糖果生产制造工艺 |
| CN117984603B (zh) * | 2024-02-02 | 2024-11-22 | 贵州四季常青药业有限公司 | 一种复合润喉含片的制片软硬控制装置 |
| CN118893857B (zh) * | 2024-10-09 | 2024-12-10 | 山西鑫煜制药股份有限公司 | 一种药品片剂压片机 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB357194A (en) * | 1930-03-20 | 1931-09-21 | Maurice Michael Eaton | Improvements relating to the manufacture of moulded articles from synthetic resin and like materials |
| GB544472A (en) * | 1940-07-13 | 1942-04-15 | Edouard Lecluyse | Improvements in or relating to moulding presses |
| US3090296A (en) * | 1959-12-19 | 1963-05-21 | Strunck & Co H | Method and apparatus for the application of coloring matter to tablets, such as dragees |
| DE1172237B (de) * | 1962-04-14 | 1964-06-18 | Basf Ag | Verfahren und Vorrichtung zum Herstellen von perl- oder tropfenaehnlichem Granulat aus schmelzbaren Stoffen |
| DE2454168A1 (de) * | 1973-11-17 | 1975-05-28 | Manesty Machines | Vorrichtung zum herstellen von tabletten |
| US4009239A (en) * | 1973-07-12 | 1977-02-22 | Bowen Max E | Method of forming tablets with separators of sheet material |
| DE2556561A1 (de) * | 1975-12-16 | 1977-06-30 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von poroesen tabletten |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE360314C (de) * | 1922-10-02 | Heinrich Schott | Brikettpresse mit gekuehlten Pressformen und Stempeln | |
| DE464592C (de) * | 1928-08-21 | Baum Act Ges Maschf | Elektrische Beheizung fuer die Stempelplatten von Stempelpressen | |
| US2431095A (en) * | 1944-11-06 | 1947-11-18 | Hpm Dev Corp | Apparatus for hot pressing powdered metal |
| GB1139779A (en) * | 1967-01-13 | 1969-01-15 | Manesty Machines | Rotary tablet-making machines |
| DE2363921A1 (de) * | 1973-12-19 | 1975-07-03 | Korsch Spezialfab Emil | Tablettenpresse, insbesondere rundlauf-tablettenpresse |
| DE2714614C3 (de) * | 1977-04-01 | 1979-12-06 | Projektierung Chemische Verfahrenstechnik Gmbh, 4030 Ratingen | Verfahren und Vorrichtung zum Herstellen von Briketts aus wenigstens teilweise körnigem oder pulverartigem Einsatzgut |
-
1978
- 1978-10-30 HU HU78LI1863A patent/HU179442B/hu not_active IP Right Cessation
-
1979
- 1979-10-29 CH CH967479A patent/CH642001A5/de not_active IP Right Cessation
- 1979-10-29 FR FR7926739A patent/FR2440188B1/fr not_active Expired
- 1979-10-30 GB GB7937575A patent/GB2035195B/en not_active Expired
- 1979-10-30 DE DE19792943789 patent/DE2943789A1/de not_active Withdrawn
- 1979-10-30 BE BE0/197887A patent/BE879722A/fr not_active IP Right Cessation
- 1979-10-30 IT IT69114/79A patent/IT1119937B/it active
- 1979-10-30 JP JP14041279A patent/JPS5594255A/ja active Pending
-
1989
- 1989-01-20 JP JP1989005398U patent/JPH0324187Y2/ja not_active Expired
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB357194A (en) * | 1930-03-20 | 1931-09-21 | Maurice Michael Eaton | Improvements relating to the manufacture of moulded articles from synthetic resin and like materials |
| GB544472A (en) * | 1940-07-13 | 1942-04-15 | Edouard Lecluyse | Improvements in or relating to moulding presses |
| US3090296A (en) * | 1959-12-19 | 1963-05-21 | Strunck & Co H | Method and apparatus for the application of coloring matter to tablets, such as dragees |
| DE1172237B (de) * | 1962-04-14 | 1964-06-18 | Basf Ag | Verfahren und Vorrichtung zum Herstellen von perl- oder tropfenaehnlichem Granulat aus schmelzbaren Stoffen |
| US4009239A (en) * | 1973-07-12 | 1977-02-22 | Bowen Max E | Method of forming tablets with separators of sheet material |
| DE2454168A1 (de) * | 1973-11-17 | 1975-05-28 | Manesty Machines | Vorrichtung zum herstellen von tabletten |
| DE2556561A1 (de) * | 1975-12-16 | 1977-06-30 | Boehringer Mannheim Gmbh | Verfahren zur herstellung von poroesen tabletten |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004051006A1 (de) * | 2004-10-20 | 2006-04-27 | Fette Gmbh | Rundlaufpresse |
| DE102004051006B4 (de) * | 2004-10-20 | 2009-07-02 | Fette Gmbh | Rundlaufpresse |
| US7654814B2 (en) | 2004-10-20 | 2010-02-02 | Fette Gmbh | Rotary press |
| DE102007052552A1 (de) * | 2007-10-29 | 2009-04-30 | Luxner, Peter, Dipl.-Ing. | Verfahren und Vorrichtung zur Ermittlung von Steuer- und Regelparametern für Tablettenpressen |
| DE102007052552B4 (de) * | 2007-10-29 | 2010-01-07 | Luxner, Peter, Dipl.-Ing. | Verfahren und Vorrichtung zur Ermittlung von Steuer- und Regelparametern für Tablettenpressen |
| CN109203550A (zh) * | 2018-10-07 | 2019-01-15 | 南京正宽医药科技有限公司 | 一种中药复方黄连素片压片装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5594255A (en) | 1980-07-17 |
| IT7969114A0 (it) | 1979-10-30 |
| FR2440188B1 (fr) | 1986-09-26 |
| HU179442B (en) | 1982-10-28 |
| FR2440188A1 (fr) | 1980-05-30 |
| IT1119937B (it) | 1986-03-19 |
| CH642001A5 (de) | 1984-03-30 |
| GB2035195A (en) | 1980-06-18 |
| GB2035195B (en) | 1983-05-11 |
| JPH01133930U (enrdf_load_stackoverflow) | 1989-09-12 |
| BE879722A (fr) | 1980-02-15 |
| JPH0324187Y2 (enrdf_load_stackoverflow) | 1991-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8110 | Request for examination paragraph 44 | ||
| 8130 | Withdrawal |