DE2861754D1 - Prostaglandin antagonists, their production and their pharmaceutical compositions - Google Patents

Prostaglandin antagonists, their production and their pharmaceutical compositions

Info

Publication number
DE2861754D1
DE2861754D1 DE7878300183T DE2861754T DE2861754D1 DE 2861754 D1 DE2861754 D1 DE 2861754D1 DE 7878300183 T DE7878300183 T DE 7878300183T DE 2861754 T DE2861754 T DE 2861754T DE 2861754 D1 DE2861754 D1 DE 2861754D1
Authority
DE
Germany
Prior art keywords
production
pharmaceutical compositions
prostaglandin antagonists
prostaglandin
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE7878300183T
Other languages
English (en)
Inventor
Joshua Rokach
Clarence Stanley Rooney
Edward Jethro Cragoe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE2861754D1 publication Critical patent/DE2861754D1/de
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D337/00Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02Seven-membered rings
    • C07D337/06Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/10Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D337/14[b,f]-condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00Thiols, sulfides, hydropolysulfides or polysulfides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE7878300183T 1977-07-26 1978-07-21 Prostaglandin antagonists, their production and their pharmaceutical compositions Expired DE2861754D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81919977A 1977-07-26 1977-07-26
US91721278A 1978-06-23 1978-06-23

Publications (1)

Publication Number Publication Date
DE2861754D1 true DE2861754D1 (en) 1982-06-03

Family

ID=27124337

Family Applications (1)

Application Number Title Priority Date Filing Date
DE7878300183T Expired DE2861754D1 (en) 1977-07-26 1978-07-21 Prostaglandin antagonists, their production and their pharmaceutical compositions

Country Status (16)

Country Link
EP (1) EP0011067B1 (de)
JP (1) JPS5444691A (de)
AR (2) AR226527A1 (de)
AU (1) AU517813B2 (de)
CA (1) CA1128048A (de)
DD (1) DD140746A5 (de)
DE (1) DE2861754D1 (de)
DK (1) DK330578A (de)
ES (5) ES471871A1 (de)
FI (1) FI782323A (de)
GR (1) GR67276B (de)
IE (1) IE47553B1 (de)
IT (1) IT1107485B (de)
NO (1) NO782539L (de)
PL (3) PL120813B1 (de)
PT (1) PT68303A (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536507A (en) * 1977-07-26 1985-08-20 Merck & Co., Inc. Prostaglandin antagonists
FI801638A (fi) * 1979-06-01 1980-12-02 Merck & Co Inc Prostaglandinantagonister
DE3068250D1 (en) * 1979-11-27 1984-07-19 Merck Sharp & Dohme 3-hydroxymethyldibenzo(b,f)thiepins and dibenzo(b,f)thiepin-3-carboxaldehydes as prostaglandin antagonists, process for their preparation and pharmaceutical compositions
US4237160A (en) * 1979-11-27 1980-12-02 Merck Sharp & Dohme (I.A.) Corp. 3-Hydroxymethyldibenzo[b,f]thiepins as prostaglandin antagonists
NO811187L (no) * 1980-11-24 1982-05-25 Merck & Co Inc Fremgangsmaate ved fremstilling av 7-fluor-dibenzo-(b,f)-thiepinderivater
US4535171A (en) * 1982-11-18 1985-08-13 Merck Frosst Canada, Inc. Dibenzo[b,f]thiepin-3-carboxaldehydes as prostaglandin antagonists
US4622403A (en) * 1983-10-11 1986-11-11 Merck Frosst Canada, Inc. 6-H dibenz[b,f]thiepin compounds
US4663347A (en) 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
CA1309557C (en) 1985-06-18 1992-10-27 Robert N. Young Leukotriene antagonists
DE3786030T2 (de) 1986-03-27 1993-12-02 Merck Frosst Canada Inc Tetrahydrocarbazole Ester.
CA2053216C (en) 1990-10-12 2003-04-08 Michel L. Belley Saturated hydroxyalkylquinoline acids as leukotriene antagonists
US5410054A (en) * 1993-07-20 1995-04-25 Merck Frosst Canada, Inc. Heteroaryl quinolines as inhibitors of leukotriene biosynthesis
KR19990081834A (ko) * 1996-01-19 1999-11-15 미노다 가츠스케 기관 평활근 이완제
RU2211837C2 (ru) 1999-06-03 2003-09-10 Ниппон Суйсан Кайся, Лтд. Трехъядерные конденсированные гетероциклические соединения, способ их получения (варианты) и фармацевтическая композиция
TWI275495B (en) * 2004-09-21 2007-03-11 Sony Corp Printer and printing method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4101667A (en) * 1975-05-30 1978-07-18 Nippon Chemiphar Co., Ltd. Benzo[b,f]thiepin derivatives
JPS5346989A (en) * 1976-10-06 1978-04-27 Nippon Chemiphar Co Ltd Novel dibenzo(b,f)thiepin derivatives and their preparation
JPS6021156B2 (ja) * 1976-12-03 1985-05-25 日本ケミフア株式会社 ベンゾチエピン誘導体およびその製法

Also Published As

Publication number Publication date
ES471871A1 (es) 1979-10-01
ES479218A1 (es) 1979-11-01
PL116355B1 (en) 1981-06-30
AR222666A1 (es) 1981-06-15
AU517813B2 (en) 1981-08-27
JPS5444691A (en) 1979-04-09
ES479216A1 (es) 1979-07-01
AU3817778A (en) 1980-01-24
JPS6250470B2 (de) 1987-10-24
PL117756B1 (en) 1981-08-31
NO782539L (no) 1979-01-29
ES479215A1 (es) 1979-07-01
FI782323A (fi) 1979-01-27
EP0011067B1 (de) 1982-04-21
DK330578A (da) 1979-01-27
IE781488L (en) 1979-01-26
CA1128048A (en) 1982-07-20
IE47553B1 (en) 1984-04-18
GR67276B (de) 1981-06-26
PT68303A (en) 1978-08-01
PL120813B1 (en) 1982-03-31
AR226527A1 (es) 1982-07-30
PL208653A1 (pl) 1979-06-04
IT1107485B (it) 1985-11-25
IT7850375A0 (it) 1978-07-19
DD140746A5 (de) 1980-03-26
ES479217A1 (es) 1979-07-01
EP0011067A1 (de) 1980-05-28

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee