DE2827445A1 - 3 alpha -hydroxycholest-5-en-derivate und verfahren zu ihrer herstellung - Google Patents

3 alpha -hydroxycholest-5-en-derivate und verfahren zu ihrer herstellung

Info

Publication number
DE2827445A1
DE2827445A1 DE19782827445 DE2827445A DE2827445A1 DE 2827445 A1 DE2827445 A1 DE 2827445A1 DE 19782827445 DE19782827445 DE 19782827445 DE 2827445 A DE2827445 A DE 2827445A DE 2827445 A1 DE2827445 A1 DE 2827445A1
Authority
DE
Germany
Prior art keywords
reaction
carried out
chloride
general formula
mercury
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19782827445
Other languages
German (de)
English (en)
Inventor
Chikara Kaneko
Isao Matsunaga
Kiyoshige Ochi
Minoru Shindo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP7452677A external-priority patent/JPS6039279B2/ja
Priority claimed from JP10059177A external-priority patent/JPS5436250A/ja
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of DE2827445A1 publication Critical patent/DE2827445A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
DE19782827445 1977-06-24 1978-06-22 3 alpha -hydroxycholest-5-en-derivate und verfahren zu ihrer herstellung Ceased DE2827445A1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7452677A JPS6039279B2 (ja) 1977-06-24 1977-06-24 エピデスモステロ−ル誘導体
JP10059177A JPS5436250A (en) 1977-08-24 1977-08-24 25-hydroxyepicholesterol derivatives

Publications (1)

Publication Number Publication Date
DE2827445A1 true DE2827445A1 (de) 1979-03-22

Family

ID=26415681

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19782827445 Ceased DE2827445A1 (de) 1977-06-24 1978-06-22 3 alpha -hydroxycholest-5-en-derivate und verfahren zu ihrer herstellung

Country Status (4)

Country Link
US (1) US4225524A (enExample)
DE (1) DE2827445A1 (enExample)
FR (1) FR2397427A1 (enExample)
GB (1) GB1595020A (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997042215A1 (en) * 1996-05-06 1997-11-13 Bionumerik Pharmaceuticals, Inc. Process for preparing 27-hydroxy cholesterol and related derivatives
US8399441B2 (en) 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
WO2006047022A1 (en) 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
US9034859B2 (en) 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
RS63474B1 (sr) 2013-12-24 2022-08-31 Univ Virginia Commonwealth Upotreba oksidovanih holesterol sulfata (ocs) za lečenje disfunkcije bubrega
US20190269695A1 (en) 2016-08-02 2019-09-05 Virginia Commonwealth University Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2407381A1 (de) * 1973-02-16 1974-08-22 Eisai Co Ltd Verfahren zur herstellung von 25hydroxycholesterin und dessen 3-ester
DE2429644A1 (de) * 1973-06-20 1975-01-09 Teijin Ltd Verfahren zur herstellung von desmosterolderivaten

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3846455A (en) * 1972-05-22 1974-11-05 Eisai Co Ltd Process for the preparation of 25-hydroxy-cholesterol and esters thereof
JPS50149662A (enExample) * 1974-05-22 1975-11-29

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2407381A1 (de) * 1973-02-16 1974-08-22 Eisai Co Ltd Verfahren zur herstellung von 25hydroxycholesterin und dessen 3-ester
DE2429644A1 (de) * 1973-06-20 1975-01-09 Teijin Ltd Verfahren zur herstellung von desmosterolderivaten

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.C.S. Chem. Comm., 1974, S.203-204 *

Also Published As

Publication number Publication date
GB1595020A (en) 1981-08-05
FR2397427B1 (enExample) 1982-03-26
US4225524A (en) 1980-09-30
FR2397427A1 (fr) 1979-02-09

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Legal Events

Date Code Title Description
OAM Search report available
OC Search report available
8128 New person/name/address of the agent

Representative=s name: VOSSIUS, V., DIPL.-CHEM. DR.RER.NAT. VOSSIUS, D.,

8110 Request for examination paragraph 44
8131 Rejection