DE278776T1 - Verfahren und Desoxyribonukleinsäure zur Herstellung von Gewebefaktor-Protein. - Google Patents
Verfahren und Desoxyribonukleinsäure zur Herstellung von Gewebefaktor-Protein.Info
- Publication number
- DE278776T1 DE278776T1 DE0278776T DE88301190T DE278776T1 DE 278776 T1 DE278776 T1 DE 278776T1 DE 0278776 T DE0278776 T DE 0278776T DE 88301190 T DE88301190 T DE 88301190T DE 278776 T1 DE278776 T1 DE 278776T1
- Authority
- DE
- Germany
- Prior art keywords
- tissue factor
- factor protein
- cell
- protein
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010000499 Thromboplastin Proteins 0.000 title claims abstract 24
- 102000002262 Thromboplastin Human genes 0.000 title claims abstract 24
- 238000000034 method Methods 0.000 title claims abstract 6
- 108020004414 DNA Proteins 0.000 title claims 6
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 102000053602 DNA Human genes 0.000 title 1
- 206010053567 Coagulopathies Diseases 0.000 claims abstract 4
- 208000015294 blood coagulation disease Diseases 0.000 claims abstract 4
- 230000009852 coagulant defect Effects 0.000 claims abstract 4
- 238000003259 recombinant expression Methods 0.000 claims abstract 3
- 210000004027 cell Anatomy 0.000 claims 11
- 210000004962 mammalian cell Anatomy 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 239000004475 Arginine Substances 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 210000003292 kidney cell Anatomy 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 101000635804 Homo sapiens Tissue factor Proteins 0.000 claims 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims 1
- 108091092195 Intron Proteins 0.000 claims 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/42—Vector systems having a special element relevant for transcription being an intron or intervening sequence for splicing and/or stability of RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1374387A | 1987-02-12 | 1987-02-12 | |
| US3540987A | 1987-04-07 | 1987-04-07 | |
| US15269888A | 1988-02-05 | 1988-02-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE278776T1 true DE278776T1 (de) | 1995-06-29 |
Family
ID=27359940
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE0278776T Pending DE278776T1 (de) | 1987-02-12 | 1988-02-12 | Verfahren und Desoxyribonukleinsäure zur Herstellung von Gewebefaktor-Protein. |
| DE3856580T Expired - Lifetime DE3856580T2 (de) | 1987-02-12 | 1988-02-12 | Verfahren und Desoxyribonukleinsäure zur Herstellung von Gewebefaktor-Protein |
| DE3855921T Expired - Lifetime DE3855921T3 (de) | 1987-02-12 | 1988-02-12 | Verfahren und Desoxyribonukleinsäure zur Herstellung von Gewebefaktor-Protein |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE3856580T Expired - Lifetime DE3856580T2 (de) | 1987-02-12 | 1988-02-12 | Verfahren und Desoxyribonukleinsäure zur Herstellung von Gewebefaktor-Protein |
| DE3855921T Expired - Lifetime DE3855921T3 (de) | 1987-02-12 | 1988-02-12 | Verfahren und Desoxyribonukleinsäure zur Herstellung von Gewebefaktor-Protein |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP0278776B2 (enExample) |
| JP (1) | JP2869920B2 (enExample) |
| AT (2) | ATE298800T1 (enExample) |
| AU (1) | AU617302B2 (enExample) |
| DE (3) | DE278776T1 (enExample) |
| ES (2) | ES2244989T3 (enExample) |
| GR (1) | GR3024263T3 (enExample) |
| IE (1) | IE81149B1 (enExample) |
| IL (1) | IL85411A (enExample) |
| NZ (1) | NZ223506A (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6994988B1 (en) | 1987-02-12 | 2006-02-07 | Genetech, Inc. | Methods and deoxyribonucleic acid for the preparation of tissue factor protein |
| US7084251B1 (en) | 1987-02-12 | 2006-08-01 | Genentech, Inc. | Methods and Deoxyribonucleic acid for the preparation of tissue factor protein |
| US5223427A (en) * | 1987-03-31 | 1993-06-29 | The Scripps Research Institute | Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain |
| US5110730A (en) * | 1987-03-31 | 1992-05-05 | The Scripps Research Institute | Human tissue factor related DNA segments |
| EP0321526A1 (en) * | 1987-06-12 | 1989-06-28 | Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of human tissue factor |
| IL87172A (en) * | 1987-07-23 | 1994-12-29 | Univ Washington | Method of isolating highly purified tissue factor inhibitor |
| US5336603A (en) * | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
| US6710169B2 (en) | 1987-10-02 | 2004-03-23 | Genentech, Inc. | Adheson variants |
| JPH02142475A (ja) * | 1988-06-17 | 1990-05-31 | Mount Sinai School Medicine City Univ New York | ヒトの組織因子のクローニングと形質発現 |
| DE68929402T2 (de) * | 1988-12-22 | 2002-12-05 | Genentech, Inc. | Verfahren zur herstellung von wasserlöslichen polypeptiden |
| US5472850A (en) * | 1991-04-10 | 1995-12-05 | Oklahoma Medical Research Foundation | Quantitative clotting assay for activated factor VII |
| US5298599A (en) * | 1988-12-30 | 1994-03-29 | Oklahoma Medical Research Foundation | Expression and purification of recombinant soluble tissue factor |
| WO1990008956A1 (en) * | 1989-02-02 | 1990-08-09 | Teijin Limited | Detection of human tissue factor activator |
| US5314695A (en) † | 1990-11-13 | 1994-05-24 | Corvas International, Inc. | Tissue factor based prothrombin time reagent |
| US5374617A (en) * | 1992-05-13 | 1994-12-20 | Oklahoma Medical Research Foundation | Treatment of bleeding with modified tissue factor in combination with FVIIa |
| US5504064A (en) * | 1991-04-10 | 1996-04-02 | Oklahoma Medical Research Foundation | Treatment of bleeding with modified tissue factor in combination with an activator of FVII |
| US6749853B1 (en) | 1992-03-05 | 2004-06-15 | Board Of Regents, The University Of Texas System | Combined methods and compositions for coagulation and tumor treatment |
| DE4240103A1 (de) * | 1992-05-26 | 1993-12-02 | Behringwerke Ag | Verfahren zur Inaktivierung von Viren in Präparationen von Proteinen |
| EP0706658B1 (en) * | 1994-04-28 | 2001-06-27 | Dade Behring Inc. | Calibrator for prothrombin time (pt) assays |
| US5696086A (en) * | 1994-11-03 | 1997-12-09 | Genentech, Inc. | Methods and kits using macrophage stimulating protein |
| CA2249206A1 (en) | 1996-04-01 | 1997-10-09 | Genentech, Inc. | Apo-2li and apo-3 apoptosis polypeptides |
| US6462176B1 (en) | 1996-09-23 | 2002-10-08 | Genentech, Inc. | Apo-3 polypeptide |
| AU735187C (en) | 1997-01-22 | 2002-04-18 | Board Of Regents, The University Of Texas System | Tissue factor methods and compositions for coagulation and tumor treatment |
| WO1998051335A1 (en) * | 1997-05-15 | 1998-11-19 | Transplantation Technologies Inc. | Methods of modulating immune coagulation |
| US6642433B1 (en) | 1997-05-15 | 2003-11-04 | Trillium Therapeutics Inc. | Fgl-2 knockout mice |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| DE19749259A1 (de) * | 1997-11-07 | 1999-05-12 | Dade Behring Marburg Gmbh | Verfahren zur Herstellung von funktionalem rekombinantem Gewebsfaktor |
| NZ508873A (en) | 1998-07-13 | 2003-10-31 | Univ Texas | Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids |
| US6818213B1 (en) | 1998-07-13 | 2004-11-16 | Board Of Regents, The University Of Texas System | Cancer treatment compositions comprising therapeutic conjugates that bind to aminophospholipids |
| HUP0203486A2 (hu) * | 1999-10-01 | 2003-02-28 | Chugai Seiyaku Kabushiki Kaisha | Véralvadással összefüggő betegségek megelőzése és kezelése |
| EP1757311B1 (en) | 1999-12-24 | 2009-02-11 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| JP2003518075A (ja) | 1999-12-24 | 2003-06-03 | ジェネンテック・インコーポレーテッド | 生理活性化合物の消失半減期延長のための方法及び組成物 |
| US6703494B2 (en) | 2000-03-16 | 2004-03-09 | Genentech, Inc. | Anti-tissue factor antibodies with enhanced anticoagulant potency |
| US7087726B2 (en) | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
| AU2002327192B2 (en) | 2001-07-03 | 2007-02-15 | Oklahoma Medical Research Foundation | Assay for measuring factor VIIa-antithrombin complexes |
| US7164002B2 (en) | 2002-02-06 | 2007-01-16 | Genentech, Inc. | FVIIa antagonists |
| JP2008504033A (ja) * | 2004-06-25 | 2008-02-14 | アルター・バイオサイエンス・コーポレーション | 植物に於ける組織因子の産生 |
| ES2651268T3 (es) | 2006-09-12 | 2018-01-25 | Beth Israel Deaconess Medical Center, Inc. | Composiciones que contienen alfa-1-antitripsina y métodos para su uso |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4663283A (en) | 1980-03-24 | 1987-05-05 | Genentech, Inc. | Method of altering double-stranded DNA |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| NZ201918A (en) | 1981-09-18 | 1987-04-30 | Genentech Inc | N-terminal methionyl analogues of bovine growth hormone |
| NZ209308A (en) | 1983-08-30 | 1991-08-27 | Genentech Inc | Vaccine against hsv involving a truncated membrane-free derivative of a membrane-bound protein |
| NZ209307A (en) | 1983-08-30 | 1990-07-26 | Genentech Inc | Diagnostic product: antigenic peptide produced by recombinant dna techniques |
| US4680262A (en) | 1984-10-05 | 1987-07-14 | Genentech, Inc. | Periplasmic protein recovery |
| EP0321526A1 (en) * | 1987-06-12 | 1989-06-28 | Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of human tissue factor |
| DE10124940A1 (de) | 2001-05-21 | 2002-11-28 | Philips Corp Intellectual Pty | Netzwerk mit logischen Kanälen und Transportkanälen |
-
1988
- 1988-02-11 IE IE38088A patent/IE81149B1/en not_active IP Right Cessation
- 1988-02-12 ES ES97200009T patent/ES2244989T3/es not_active Expired - Lifetime
- 1988-02-12 EP EP88301190A patent/EP0278776B2/en not_active Expired - Lifetime
- 1988-02-12 EP EP97200009A patent/EP0787802B1/en not_active Expired - Lifetime
- 1988-02-12 DE DE0278776T patent/DE278776T1/de active Pending
- 1988-02-12 JP JP63031693A patent/JP2869920B2/ja not_active Expired - Lifetime
- 1988-02-12 IL IL8541188A patent/IL85411A/en not_active IP Right Cessation
- 1988-02-12 AU AU11705/88A patent/AU617302B2/en not_active Expired
- 1988-02-12 DE DE3856580T patent/DE3856580T2/de not_active Expired - Lifetime
- 1988-02-12 DE DE3855921T patent/DE3855921T3/de not_active Expired - Lifetime
- 1988-02-12 NZ NZ223506A patent/NZ223506A/xx unknown
- 1988-02-12 AT AT97200009T patent/ATE298800T1/de not_active IP Right Cessation
- 1988-02-12 ES ES88301190T patent/ES2068791T5/es not_active Expired - Lifetime
- 1988-02-12 AT AT88301190T patent/ATE153696T1/de not_active IP Right Cessation
-
1997
- 1997-07-30 GR GR970401911T patent/GR3024263T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1170588A (en) | 1988-08-18 |
| EP0787802B1 (en) | 2005-06-29 |
| IL85411A0 (en) | 1988-07-31 |
| ATE153696T1 (de) | 1997-06-15 |
| JPS63301797A (ja) | 1988-12-08 |
| IL85411A (en) | 1994-07-31 |
| DE3855921T3 (de) | 2005-03-10 |
| GR3024263T3 (en) | 1997-10-31 |
| DE3855921T2 (de) | 1998-01-15 |
| ES2068791T1 (es) | 1995-05-01 |
| IE880380L (en) | 1988-08-12 |
| EP0278776A3 (en) | 1989-09-13 |
| NZ223506A (en) | 1991-09-25 |
| ES2244989T3 (es) | 2005-12-16 |
| ATE298800T1 (de) | 2005-07-15 |
| IE81149B1 (en) | 2000-05-03 |
| EP0278776A2 (en) | 1988-08-17 |
| EP0787802A3 (enExample) | 1997-08-27 |
| DE3856580T2 (de) | 2006-05-24 |
| DE3856580D1 (de) | 2005-08-04 |
| EP0278776B1 (en) | 1997-05-28 |
| EP0278776B2 (en) | 2004-04-14 |
| AU617302B2 (en) | 1991-11-28 |
| JP2869920B2 (ja) | 1999-03-10 |
| DE3855921D1 (de) | 1997-07-03 |
| ES2068791T5 (es) | 2004-12-16 |
| ES2068791T3 (es) | 1997-10-01 |
| EP0787802A2 (en) | 1997-08-06 |
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