DE2742588B2 - Verfahren zur Sterilisation eines Dialysators mit semipermeabler Membran - Google Patents
Verfahren zur Sterilisation eines Dialysators mit semipermeabler MembranInfo
- Publication number
- DE2742588B2 DE2742588B2 DE2742588A DE2742588A DE2742588B2 DE 2742588 B2 DE2742588 B2 DE 2742588B2 DE 2742588 A DE2742588 A DE 2742588A DE 2742588 A DE2742588 A DE 2742588A DE 2742588 B2 DE2742588 B2 DE 2742588B2
- Authority
- DE
- Germany
- Prior art keywords
- dialyzer
- hydrogen peroxide
- dialyzers
- filled
- sterilization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000012528 membrane Substances 0.000 title claims description 24
- 238000000034 method Methods 0.000 title claims description 19
- 230000001954 sterilising effect Effects 0.000 title claims description 18
- 238000004659 sterilization and disinfection Methods 0.000 title description 14
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 47
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 28
- 239000007864 aqueous solution Substances 0.000 claims description 13
- 239000007788 liquid Substances 0.000 claims description 9
- 239000003242 anti bacterial agent Substances 0.000 claims description 8
- 230000000844 anti-bacterial effect Effects 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000010894 electron beam technology Methods 0.000 claims description 3
- 239000007900 aqueous suspension Substances 0.000 claims description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 26
- 241000894006 Bacteria Species 0.000 description 18
- 239000012510 hollow fiber Substances 0.000 description 15
- 239000008213 purified water Substances 0.000 description 9
- 239000002504 physiological saline solution Substances 0.000 description 8
- 238000000502 dialysis Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- 230000003385 bacteriostatic effect Effects 0.000 description 6
- 239000007789 gas Substances 0.000 description 5
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 5
- 230000005855 radiation Effects 0.000 description 5
- 229920002678 cellulose Polymers 0.000 description 4
- 239000001913 cellulose Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000004926 polymethyl methacrylate Substances 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000000385 dialysis solution Substances 0.000 description 3
- 239000002158 endotoxin Substances 0.000 description 3
- 210000003734 kidney Anatomy 0.000 description 3
- 229920002239 polyacrylonitrile Polymers 0.000 description 3
- 230000001698 pyrogenic effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- GUTLYIVDDKVIGB-OUBTZVSYSA-N Cobalt-60 Chemical compound [60Co] GUTLYIVDDKVIGB-OUBTZVSYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- -1 Polyethylene methacrylate Polymers 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 239000000022 bacteriostatic agent Substances 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 229920002301 cellulose acetate Polymers 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 229910017053 inorganic salt Inorganic materials 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 235000002639 sodium chloride Nutrition 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- LVZIWKFQFKNSMO-UHFFFAOYSA-N 1-chlorobutan-1-ol Chemical class CCCC(O)Cl LVZIWKFQFKNSMO-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 125000005442 diisocyanate group Chemical group 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- MMBMIVSDYYPRHH-UHFFFAOYSA-N hydrogen peroxide Chemical compound OO.OO MMBMIVSDYYPRHH-UHFFFAOYSA-N 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 125000005395 methacrylic acid group Chemical group 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 238000012414 sterilization procedure Methods 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-L sulfite Chemical class [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
- B01D65/02—Membrane cleaning or sterilisation ; Membrane regeneration
- B01D65/022—Membrane sterilisation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
- B01D2321/16—Use of chemical agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
- B01D2321/34—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling by radiation
- B01D2321/346—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling by radiation by gamma radiation
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP51113716A JPS6022946B2 (ja) | 1976-09-24 | 1976-09-24 | 生体用透析装置の滅菌法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2742588A1 DE2742588A1 (de) | 1978-03-30 |
| DE2742588B2 true DE2742588B2 (de) | 1979-09-27 |
Family
ID=14619327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2742588A Ceased DE2742588B2 (de) | 1976-09-24 | 1977-09-22 | Verfahren zur Sterilisation eines Dialysators mit semipermeabler Membran |
Country Status (6)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4331934C1 (de) * | 1993-09-16 | 1995-05-04 | Elbau Elektronik Bauelemente G | Implantierbare Biosensor- und Pharmakaapplikationsanordnung und Verfahren zur Sterilisation |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4233263A (en) * | 1979-04-02 | 1980-11-11 | Northwestern University | Method of maintaining bacterial sterility in urine drainage bags |
| US4269712A (en) * | 1979-05-14 | 1981-05-26 | Cordis Dow Corp. | Hollow fiber separatory element and method of making same |
| US4278548A (en) * | 1979-08-20 | 1981-07-14 | E. I. Du Pont De Nemours And Company | Control of biological growth in reverse osmosis permeators |
| US4473474A (en) * | 1980-10-27 | 1984-09-25 | Amf Inc. | Charge modified microporous membrane, process for charge modifying said membrane and process for filtration of fluid |
| US4708803A (en) * | 1980-10-27 | 1987-11-24 | Cuno Incorporated | Liquid filtration using hydrophilic cationic isotropic microporous nylon membrane |
| US4711793A (en) * | 1980-10-27 | 1987-12-08 | Cuno Incorporated | Process for charge modifying a microphorous membrane |
| JPS6332093B2 (US20110232667A1-20110929-C00004.png) * | 1980-10-27 | 1988-06-28 | Kyuno Inc | |
| US4673504A (en) * | 1980-10-27 | 1987-06-16 | Cuno Inc. | Charge modified microporous membrane |
| US4743418A (en) * | 1981-05-29 | 1988-05-10 | Cuno Incorporated | Process for charge modifying a microporous membrane |
| US4737291A (en) * | 1981-05-29 | 1988-04-12 | Cuno Incorporated | Charge modified microporous membrane |
| EP0108661A1 (en) * | 1982-10-04 | 1984-05-16 | Merck & Co. Inc. | Stabilized hydroxypropyl cellulose ophthalmic inserts and process to sterilize the same |
| SE8303413L (sv) * | 1983-06-15 | 1984-12-16 | Gambro Dialysatoren | Sett att behandla en cellulosahalfiber |
| US4622206A (en) * | 1983-11-21 | 1986-11-11 | University Of Pittsburgh | Membrane oxygenator and method and apparatus for making the same |
| EP0152012A3 (en) * | 1984-02-10 | 1986-03-12 | General Electric Company | Method for enhancing ionizing radiation resistance of polymer compositions |
| CA1236960A (en) * | 1985-04-16 | 1988-05-24 | Shohei Masuhara | Method for sterilizing artificial organs and apparatus used therefor |
| JPH0761510B2 (ja) * | 1987-04-25 | 1995-07-05 | トヨタ自動車株式会社 | 軸とその外周に組付けられる部材との固定方法 |
| EP0672424A1 (en) * | 1994-03-16 | 1995-09-20 | Teijin Limited | Method of sterilizing a blood dialyzer having semipermeable polymeric membranes by gamma-ray irradiation |
| DE19526094A1 (de) * | 1995-07-18 | 1997-01-23 | Geesthacht Gkss Forschung | Membranen aus Polyacrylnitril |
| NO20014746D0 (no) * | 2001-09-28 | 2001-09-28 | Clas M Kjoelberg | Smertelindrende middel |
| US9624568B2 (en) | 2008-04-08 | 2017-04-18 | Federal-Mogul Corporation | Thermal spray applications using iron based alloy powder |
| DE102015120003A1 (de) * | 2015-11-18 | 2017-06-01 | B. Braun Avitum Ag | Verfahren zur Sterilisation und Integritätsprüfung von Dialysatoren |
| DE102018100568A1 (de) | 2018-01-11 | 2019-07-11 | B. Braun Avitum Ag | Blutbehandlungsmaschine mit einem Hohlfaserfiltermodul zur horizontalen Anordnung sowie ein Hohlfaserfiltermodul und dessen Verwendung |
| CN112083005A (zh) * | 2020-09-17 | 2020-12-15 | 江苏关怀医疗科技有限公司 | 一种透析器生产加工用复检湿膜装置 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2785313A (en) * | 1952-07-26 | 1957-03-12 | High Voltage Engineering Corp | Method and apparatus for sterilizing by electron bombardment |
| US2904392A (en) * | 1956-04-19 | 1959-09-15 | Pomerantz Reuben | Method of packaging and treating articles |
| US2839355A (en) * | 1956-05-08 | 1958-06-17 | Johnson & Johnson | Sterilization of surgical dressings |
| US3117832A (en) * | 1960-02-09 | 1964-01-14 | Thomas Andre | Method and apparatus for biological sterilization and related processes |
| GB947699A (en) * | 1960-10-03 | 1964-01-29 | Bendix Corp | Sterilization method and apparatus |
| GB942374A (en) * | 1962-02-27 | 1963-11-20 | American Cyanamid Co | Sterilization of sutures |
| US3537967A (en) * | 1966-07-29 | 1970-11-03 | Dart Ind Inc | Radiation sterilized,thiodipropionic acid ester stabilized,propylene polymers |
| US3725003A (en) * | 1969-11-04 | 1973-04-03 | Moore Perk Corp | Method of sterile packaging |
| US3618283A (en) * | 1969-11-04 | 1971-11-09 | Moore Perk Corp | Method for sterile packaging of articles |
| US3758273A (en) * | 1970-04-03 | 1973-09-11 | Gillette Co | Processes for sterilizing polypropylene objects |
| US3851436A (en) * | 1971-12-13 | 1974-12-03 | Boeing Co | Sterilizing and packaging process utilizing gas plasma |
| US3750367A (en) * | 1972-03-28 | 1973-08-07 | Mead Corp | Web sterilizing system |
| US3948601A (en) * | 1972-12-11 | 1976-04-06 | The Boeing Company | Sterilizing process and apparatus utilizing gas plasma |
-
1976
- 1976-09-24 JP JP51113716A patent/JPS6022946B2/ja not_active Expired
-
1977
- 1977-08-12 FR FR7724917A patent/FR2365348A1/fr active Granted
- 1977-08-15 SE SE7709189A patent/SE438094B/xx not_active IP Right Cessation
- 1977-08-16 IT IT68864/77A patent/IT1082849B/it active
- 1977-09-22 DE DE2742588A patent/DE2742588B2/de not_active Ceased
- 1977-09-22 US US05/835,597 patent/US4148606A/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4331934C1 (de) * | 1993-09-16 | 1995-05-04 | Elbau Elektronik Bauelemente G | Implantierbare Biosensor- und Pharmakaapplikationsanordnung und Verfahren zur Sterilisation |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5339693A (en) | 1978-04-11 |
| SE438094B (sv) | 1985-04-01 |
| SE7709189L (sv) | 1978-03-25 |
| FR2365348A1 (fr) | 1978-04-21 |
| DE2742588A1 (de) | 1978-03-30 |
| US4148606A (en) | 1979-04-10 |
| IT1082849B (it) | 1985-05-21 |
| FR2365348B1 (US20110232667A1-20110929-C00004.png) | 1980-05-16 |
| JPS6022946B2 (ja) | 1985-06-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OAP | Request for examination filed | ||
| OD | Request for examination | ||
| 8235 | Patent refused |