DE2735392A1 - Aktive gele und verfahren zu ihrer herstellung - Google Patents
Aktive gele und verfahren zu ihrer herstellungInfo
- Publication number
- DE2735392A1 DE2735392A1 DE19772735392 DE2735392A DE2735392A1 DE 2735392 A1 DE2735392 A1 DE 2735392A1 DE 19772735392 DE19772735392 DE 19772735392 DE 2735392 A DE2735392 A DE 2735392A DE 2735392 A1 DE2735392 A1 DE 2735392A1
- Authority
- DE
- Germany
- Prior art keywords
- gel
- active
- inorganic
- feed solution
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims description 35
- 238000004519 manufacturing process Methods 0.000 title claims description 14
- 239000000499 gel Substances 0.000 claims description 109
- 239000012527 feed solution Substances 0.000 claims description 31
- 239000004480 active ingredient Substances 0.000 claims description 21
- 239000000126 substance Substances 0.000 claims description 19
- 229910010272 inorganic material Inorganic materials 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 13
- 239000008252 pharmaceutical gel Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 150000002484 inorganic compounds Chemical class 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- 238000010533 azeotropic distillation Methods 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 230000018044 dehydration Effects 0.000 claims description 5
- 238000006297 dehydration reaction Methods 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 230000009466 transformation Effects 0.000 claims description 5
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 4
- 239000013543 active substance Substances 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 239000007863 gel particle Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 3
- 230000002363 herbicidal effect Effects 0.000 claims description 3
- 229910018072 Al 2 O 3 Inorganic materials 0.000 claims description 2
- 239000003619 algicide Substances 0.000 claims description 2
- 238000001246 colloidal dispersion Methods 0.000 claims description 2
- 239000004009 herbicide Substances 0.000 claims description 2
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 claims description 2
- 239000000575 pesticide Substances 0.000 claims description 2
- 239000002243 precursor Substances 0.000 claims description 2
- 239000012266 salt solution Substances 0.000 claims description 2
- 239000012798 spherical particle Substances 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 230000000704 physical effect Effects 0.000 claims 1
- 239000002574 poison Substances 0.000 claims 1
- 231100000614 poison Toxicity 0.000 claims 1
- 239000011147 inorganic material Substances 0.000 description 5
- XZZXIYZZBJDEEP-UHFFFAOYSA-N imipramine hydrochloride Chemical compound [Cl-].C1CC2=CC=CC=C2N(CCC[NH+](C)C)C2=CC=CC=C21 XZZXIYZZBJDEEP-UHFFFAOYSA-N 0.000 description 4
- 229960002102 imipramine hydrochloride Drugs 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 2
- 238000005342 ion exchange Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- DOETVZCFKJCYJV-UHFFFAOYSA-N 6-(4,5-dihydro-1h-imidazol-2-yl)-2-[4-(4,5-dihydro-1h-imidazol-2-yl)phenyl]-1h-indole Chemical compound N1CCN=C1C1=CC=C(C=2NC3=CC(=CC=C3C=2)C=2NCCN=2)C=C1 DOETVZCFKJCYJV-UHFFFAOYSA-N 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 101100286286 Dictyostelium discoideum ipi gene Proteins 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000002353 algacidal effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229910001593 boehmite Inorganic materials 0.000 description 1
- 230000002925 chemical effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- LVYZJEPLMYTTGH-UHFFFAOYSA-H dialuminum chloride pentahydroxide dihydrate Chemical compound [Cl-].[Al+3].[OH-].[OH-].[Al+3].[OH-].[OH-].[OH-].O.O LVYZJEPLMYTTGH-UHFFFAOYSA-H 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- 239000004312 hexamethylene tetramine Substances 0.000 description 1
- FAHBNUUHRFUEAI-UHFFFAOYSA-M hydroxidooxidoaluminium Chemical compound O[Al]=O FAHBNUUHRFUEAI-UHFFFAOYSA-M 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- -1 nitrate ions Chemical class 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000003980 solgel method Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/06—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a liquid medium
- B01J2/08—Gelation of a colloidal solution
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/0052—Preparation of gels
- B01J13/0056—Preparation of gels containing inorganic material and water
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pest Control & Pesticides (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agronomy & Crop Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3297176A GB1590574A (en) | 1976-08-06 | 1976-08-06 | Biologically active gels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2735392A1 true DE2735392A1 (de) | 1978-02-09 |
Family
ID=10346741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19772735392 Withdrawn DE2735392A1 (de) | 1976-08-06 | 1977-08-05 | Aktive gele und verfahren zu ihrer herstellung |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS5320411A (cs) |
| CH (1) | CH639869A5 (cs) |
| DE (1) | DE2735392A1 (cs) |
| FR (1) | FR2360345A1 (cs) |
| GB (1) | GB1590574A (cs) |
| IE (1) | IE45648B1 (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0305968A3 (en) * | 1987-08-31 | 1989-04-05 | Yeda Research And Development Company Limited | Compositions against protozoal diseases |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6227048Y2 (cs) * | 1979-04-10 | 1987-07-11 | ||
| JPS55138311A (en) * | 1979-04-17 | 1980-10-29 | Yanmar Agricult Equip | Harvester |
| JPS6334486Y2 (cs) * | 1979-06-14 | 1988-09-13 | ||
| DE3775880D1 (cs) * | 1986-09-18 | 1992-02-20 | London School Of Pharmacy Innovations Ltd., London, Gb | |
| EP0680753A3 (de) * | 1994-05-06 | 1996-08-28 | Feinchemie Gmbh Sebnitz | Metalloxidkomposit mit steuerbarer Wirkstoffabgabe. |
| GB9504630D0 (en) * | 1995-03-08 | 1995-04-26 | Kodak Ltd | A material and method for inhibiting bacterial growth in an aqueous medium |
| FR2732189B1 (fr) * | 1995-03-27 | 1997-05-09 | Kodak Pathe | Gels organiques-inorganiques pour delivrer des quantites controlees de composes actifs dans des solutions aqueuses |
| GB9615944D0 (en) * | 1996-07-30 | 1996-09-11 | Kodak Ltd | A material,method and apparatus for inhibiting microbial growth in an aqueous medium |
| AUPQ573300A0 (en) | 2000-02-21 | 2000-03-16 | Australian Nuclear Science & Technology Organisation | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use |
| DE102006008534A1 (de) * | 2006-02-22 | 2007-08-30 | Stiftung Nano Innovations - For A Better Living, Olten | Behälterverschlussbeschichtungszusammensetzung, Behälterverschlussbeschichtung, deren Herstellung und Anwendung |
| DE102006008535A1 (de) * | 2006-02-22 | 2007-08-30 | Stiftung Nano Innovations - For A Better Living, Olten | Anitbakterielle Beschichtungszusammensetzung auf Basis eines Siliziumdioxid erzeugenden Mittels, ein Anwendungsset, eine nanoskalige Beschichtung, die Herstellung der Beschichtung, die Weiterverarbeitung der Beschichtung sowie deren Verwendung |
| US9017697B2 (en) | 2006-10-12 | 2015-04-28 | The University Of Queensland | Compositions and methods for modulating immune responses |
| BR112013010926A2 (pt) | 2010-11-01 | 2016-08-23 | Univ Technology Sidney | agentes imunomoduladores e seus usos |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR881457A (fr) * | 1941-12-24 | 1943-04-27 | Cie De Prod Chim Et Electro Me | Perfectionnement aux bouillies antiparasites |
| FR891043A (fr) * | 1942-06-29 | 1944-02-24 | Gel instantané d'alumine | |
| GB880261A (en) * | 1957-03-13 | 1961-10-18 | Albright & Wilson Mfg Ltd | Improvements in or relating to the production of aqueous aluminium chlorhydrate gels |
| FR1366891A (fr) * | 1963-06-04 | 1964-07-17 | Stull Chemical | Préparation et application simultanées de mélanges de produits chimiques pour l'agriculture |
| AU6650174A (en) * | 1973-03-14 | 1975-09-11 | John Thompson | Spraying gels |
| DE2500350A1 (de) * | 1975-01-07 | 1976-07-08 | Kali Chemie Ag | Verfahren zur herstellung von aluminiumfluorid enthaltenden kugelfoermigen teilchen |
-
1976
- 1976-08-06 GB GB3297176A patent/GB1590574A/en not_active Expired
-
1977
- 1977-08-02 IE IE160877A patent/IE45648B1/en unknown
- 1977-08-05 CH CH964777A patent/CH639869A5/de not_active IP Right Cessation
- 1977-08-05 DE DE19772735392 patent/DE2735392A1/de not_active Withdrawn
- 1977-08-05 FR FR7724314A patent/FR2360345A1/fr active Granted
- 1977-08-05 JP JP9403777A patent/JPS5320411A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0305968A3 (en) * | 1987-08-31 | 1989-04-05 | Yeda Research And Development Company Limited | Compositions against protozoal diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| IE45648L (en) | 1978-02-06 |
| GB1590574A (en) | 1981-06-03 |
| FR2360345B1 (cs) | 1983-10-14 |
| IE45648B1 (en) | 1982-10-20 |
| JPS5320411A (en) | 1978-02-24 |
| FR2360345A1 (fr) | 1978-03-03 |
| CH639869A5 (en) | 1983-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8141 | Disposal/no request for examination |