DE2726836A1 - 6,7-benzomorphane, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel - Google Patents

6,7-benzomorphane, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Info

Publication number
DE2726836A1
DE2726836A1 DE19772726836 DE2726836A DE2726836A1 DE 2726836 A1 DE2726836 A1 DE 2726836A1 DE 19772726836 DE19772726836 DE 19772726836 DE 2726836 A DE2726836 A DE 2726836A DE 2726836 A1 DE2726836 A1 DE 2726836A1
Authority
DE
Germany
Prior art keywords
group
formula
compound
alkyl
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19772726836
Other languages
German (de)
English (en)
Inventor
Marie Akkerman
Carolus Catharina Karel Bakel
Geb Uurbanus Henriet Breevoort
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ACF Chemiefarma NV
Original Assignee
ACF Chemiefarma NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ACF Chemiefarma NV filed Critical ACF Chemiefarma NV
Publication of DE2726836A1 publication Critical patent/DE2726836A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE19772726836 1976-06-21 1977-06-14 6,7-benzomorphane, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel Withdrawn DE2726836A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB25577/76A GB1575009A (en) 1976-06-21 1976-06-21 6,7-benzomorphan derivatives

Publications (1)

Publication Number Publication Date
DE2726836A1 true DE2726836A1 (de) 1977-12-29

Family

ID=10229936

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772726836 Withdrawn DE2726836A1 (de) 1976-06-21 1977-06-14 6,7-benzomorphane, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel

Country Status (11)

Country Link
US (2) US4234591A (enExample)
JP (1) JPS52156869A (enExample)
BE (1) BE855938A (enExample)
CH (1) CH634562A5 (enExample)
DE (1) DE2726836A1 (enExample)
DK (1) DK270077A (enExample)
FR (1) FR2355830A1 (enExample)
GB (1) GB1575009A (enExample)
IE (1) IE44938B1 (enExample)
LU (1) LU77585A1 (enExample)
NL (1) NL7706328A (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2460298A1 (fr) * 1979-06-28 1981-01-23 Sterling Drug Inc Procede de preparation de 2,6-methano-3-benzazocines
DE19907874A1 (de) * 1999-02-23 2000-08-24 Boehringer Ingelheim Pharma N-(5-Phenyl-tetrahydrofuranyl)methyl- und N-(6-Phenyl-tetrahydropyranyl)methyl substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7501433B2 (en) * 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
EP1506174B1 (en) 2002-05-17 2015-09-30 Taiwanj Pharmaceuticals Co., Ltd. Use of naltrexone for treating kidney and liver damage
US7923454B2 (en) * 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
TW201431842A (zh) * 2012-11-09 2014-08-16 Purdue Pharma Lp 苯並嗎啡烷類似物及其應用
WO2014118618A1 (en) * 2013-01-31 2014-08-07 Purdue Pharma L.P. Benzomorphan analogs and the use thereof
MA39956A (fr) * 2014-05-06 2015-11-12 Purdue Pharma Lp Analogues du benzomorphane et leur utilisation

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE582575A (enExample) * 1958-09-22
NL130089C (enExample) * 1963-11-07
US3639407A (en) * 1965-05-05 1972-02-01 Geigy Chem Corp Novel 1 2 3 4 5 6-hexahydro-6-phenyl-2 6-methano-3-benzazocines
DE1545827C3 (de) * 1965-06-25 1975-09-11 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von 6,7-Benzomorphanen
US3499906A (en) * 1966-05-20 1970-03-10 Merck & Co Inc 5,9-diethyl-2'-hydroxy-2-substituted-6,7-benzomorphans
SE394277B (sv) * 1967-06-07 1977-06-20 Sumitomo Chemical Co Forfarande for framstellning av 6,7-bensomorfanderivat
US3553223A (en) * 1968-01-05 1971-01-05 Hoffmann La Roche Acid catalyzed cyclization of tetrahydropyridines containing an electron withdrawing group on the nitrogen
US3639410A (en) * 1968-07-26 1972-02-01 Sterling Drug Inc 1 2 3 4 5 6 - hexahydro - 8 - substituted-6-alkyl-11-(h or a lkyl) - 26-methano-3-benzazocines
US3511846A (en) * 1968-12-16 1970-05-12 Geigy Chem Corp Process for the preparation of optically active benzazocines
BR6914879D0 (pt) * 1969-01-23 1973-02-08 Merck & Co Inc Processos quimicos
CS166802B2 (enExample) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim
DE2217420C3 (de) * 1972-04-12 1981-03-12 C.H. Boehringer Sohn, 6507 Ingelheim N-Thienylmethyl-Heterocyclen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2229695A1 (de) * 1972-06-19 1974-01-31 Boehringer Sohn Ingelheim 2-(heteroaryl-methyl)-5,9 beta-dialkyl6,7-benzomorphane, deren saeureadditionssalze sowie verfahren zu deren herstellung
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
US3932422A (en) * 1974-05-20 1976-01-13 Sterling Drug Inc. 8-Methylene-3-azabicyclo[3.3.1]non-6-en-4-ones
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
US4108857A (en) * 1975-08-18 1978-08-22 Sterling Drug Inc. Imidazolylmethyl methanobenzazocines
DE2716687A1 (de) * 1977-04-15 1978-10-19 Boehringer Sohn Ingelheim 2'-hydroxy-2-(5-isoxazolylmethyl)-6,7benzomorphane, deren saeureadditionssalze und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
LU77585A1 (enExample) 1977-09-29
DK270077A (da) 1977-12-22
GB1575009A (en) 1980-09-17
JPS52156869A (en) 1977-12-27
FR2355830A1 (fr) 1978-01-20
US4288444A (en) 1981-09-08
CH634562A5 (de) 1983-02-15
FR2355830B1 (enExample) 1981-04-30
NL7706328A (nl) 1977-12-23
IE44938B1 (en) 1982-05-19
IE44938L (en) 1977-12-21
BE855938A (nl) 1977-12-21
US4234591A (en) 1980-11-18

Similar Documents

Publication Publication Date Title
DE2606267A1 (de) 6,7-benzomorphane, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
CH619229A5 (enExample)
DE2828039A1 (de) 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
DE2411382B2 (de) 2-Tetrahydrofurfuryl-6,7-benzomorphane, Verfahren zur Herstellung und deren Verwendung
DE2437610A1 (de) Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
DE2027077A1 (de) 6,7-Benzomorphane, Verfahren zu ihrer Herstellung und ihre Verwendung
DE2002840A1 (de) 2,3,5-trisubstit,-2'-Hydroxy-6,7-benzomorphane und Verfahren zu deren Herstellung
DE2105743B2 (de) benzomorphane, Verfahren zu ihrer Herstellung und deren Verwendung
DE2726836A1 (de) 6,7-benzomorphane, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DD147537A5 (de) Verfahren zur herstellung von 1,2,4,5-tetra-alkyl-4-aryl-piperidinen
DE1445845A1 (de) Neue Benzomorphane und Verfahren zu ihrer Herstellung
CH555831A (de) Verfahren zur herstellung von neuen benzazepinen.
DE2512109A1 (de) Hexahydro-gamma-carbolinderivate, deren salze, verfahren zu ihrer herstellung und arzneipraeparate
DE69810560T2 (de) Indanol-Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE2451474A1 (de) Neue phenylpropenylaminderivate
DD299425A5 (de) Neue 4,4-disubstituierte piperidin-derivate und verfahren zu ihrer herstellung
DE2016721A1 (enExample)
DE69804853T2 (de) Verfahren zur herstellung von mequitazin und zwischenprodukt der synthese
DE3873786T2 (de) Substituierte 1,3,4,9-tetrahydropyrano(3,4-b)indol-1-essigsaeuren.
DD202553A5 (de) Verfahren zur herstellung von 2-acylaminomethyl-1,4-benzodiazepin-verbindungen
DE2233088A1 (de) Benzomorphanderivate
DE2336559A1 (de) 4a-aryl-trans-decahydrochinoline und verfahren zu ihrer herstellung
DE2229770A1 (de) N-(heteroarylmethyl)-7alpha-acyl6,14-endoaethenotetrahydro-nororipavine und -thebaine, deren hydrierungsprodukte und saeureadditionssalze sowie verfahren zu deren herstellung
DE2421165A1 (de) N-substituierte dihydroxyphenylaethylamine
DD206986A5 (de) Verfahren zur herstellung von pharmakologisch wirksamen 4-/2-hydroxy-4-(subst.)phenyl/-naphthalin-2(1h)-onen und -2-olen

Legal Events

Date Code Title Description
OI Miscellaneous see part 1
8139 Disposal/non-payment of the annual fee