DE2725992C2 - Benzylcyanoacetale, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von 2,4-Diamino-5-benzylpyrimidinen - Google Patents

Benzylcyanoacetale, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von 2,4-Diamino-5-benzylpyrimidinen

Info

Publication number
DE2725992C2
DE2725992C2 DE2725992A DE2725992A DE2725992C2 DE 2725992 C2 DE2725992 C2 DE 2725992C2 DE 2725992 A DE2725992 A DE 2725992A DE 2725992 A DE2725992 A DE 2725992A DE 2725992 C2 DE2725992 C2 DE 2725992C2
Authority
DE
Germany
Prior art keywords
general formula
preparation
ethanol
reaction
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2725992A
Other languages
German (de)
English (en)
Other versions
DE2725992A1 (de
Inventor
Roy Archibald Durham N.C. Swaringen jun.
David Arthur Chapel Hill N.C. Yeowell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE2725992A1 publication Critical patent/DE2725992A1/de
Application granted granted Critical
Publication of DE2725992C2 publication Critical patent/DE2725992C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
    • A01G5/00—Floral handling
    • A01G5/04—Mountings for wreaths, or the like; Racks or holders for flowers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/27—Preparation of carboxylic acid esters from ortho-esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2725992A 1976-06-09 1977-06-08 Benzylcyanoacetale, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von 2,4-Diamino-5-benzylpyrimidinen Expired DE2725992C2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB23756/76A GB1582245A (en) 1976-06-09 1976-06-09 Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives

Publications (2)

Publication Number Publication Date
DE2725992A1 DE2725992A1 (de) 1977-12-29
DE2725992C2 true DE2725992C2 (de) 1983-02-17

Family

ID=10200818

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2725992A Expired DE2725992C2 (de) 1976-06-09 1977-06-08 Benzylcyanoacetale, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von 2,4-Diamino-5-benzylpyrimidinen

Country Status (19)

Country Link
US (2) US4144263A (US06544258-20030408-M00015.png)
JP (2) JPS5826908B2 (US06544258-20030408-M00015.png)
AT (1) AT350537B (US06544258-20030408-M00015.png)
AU (1) AU510298B2 (US06544258-20030408-M00015.png)
BE (1) BE855505A (US06544258-20030408-M00015.png)
CA (2) CA1091672A (US06544258-20030408-M00015.png)
CH (1) CH632239A5 (US06544258-20030408-M00015.png)
DE (1) DE2725992C2 (US06544258-20030408-M00015.png)
DK (1) DK254077A (US06544258-20030408-M00015.png)
FI (1) FI68612C (US06544258-20030408-M00015.png)
FR (1) FR2354317A1 (US06544258-20030408-M00015.png)
GB (1) GB1582245A (US06544258-20030408-M00015.png)
GR (1) GR63824B (US06544258-20030408-M00015.png)
HU (2) HU178138B (US06544258-20030408-M00015.png)
IL (1) IL52278A (US06544258-20030408-M00015.png)
NL (1) NL172541C (US06544258-20030408-M00015.png)
NZ (1) NZ184330A (US06544258-20030408-M00015.png)
SE (1) SE7706655L (US06544258-20030408-M00015.png)
ZA (1) ZA773466B (US06544258-20030408-M00015.png)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use
JPS62188328A (ja) * 1986-02-14 1987-08-17 Toshiba Seiki Kk ペレツト装着装置
JPH01152656A (ja) * 1987-12-09 1989-06-15 Sanken Electric Co Ltd リードフレームへのスクリーン印刷方法
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
BRPI0508461B8 (pt) * 2004-03-05 2021-05-25 Hoffmann La Roche diaminopirimidinas, seus usos, e composição farmacêutica
EP1924564B1 (en) * 2005-09-01 2016-11-09 F.Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
EP1924566B1 (en) * 2005-09-01 2016-01-13 F.Hoffmann-La Roche Ag Diaminopyrimidines as p2x3 and p2x2/3 modulators
KR101025381B1 (ko) * 2005-09-01 2011-03-28 에프. 호프만-라 로슈 아게 Ｐ2ｘ3 및 ｐ2ｘ2/3 조정자로서의 다이아미노피리미딘

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2579259A (en) * 1951-12-18 Iamino-s-
US2755298A (en) * 1956-07-17 pwiiq
US2576939A (en) * 1951-12-04 -diamino-s-phenyl-e-alkyl-
US3485840A (en) * 1964-11-12 1969-12-23 Hoffmann La Roche 2,4-diamino - 5 - (2',4',5'-substituted benzyl) pyrimidines,intermediates and processes
GB1142654A (en) * 1965-10-28 1969-02-12 Wellcome Found Cyano-acetals and their use in benzylpyrimidine synthesis
US3772289A (en) * 1970-10-22 1973-11-13 Burroughs Wellcome Co Alkyl substituted benzyl pyrimidines
BE795023A (fr) * 1972-02-07 1973-08-06 Hoffmann La Roche Nouvelles benzylpyrimidines

Also Published As

Publication number Publication date
JPS52151145A (en) 1977-12-15
US4144263A (en) 1979-03-13
NL172541B (nl) 1983-04-18
CA1091673A (en) 1980-12-16
CH632239A5 (de) 1982-09-30
AU2591777A (en) 1978-12-14
NZ184330A (en) 1979-03-28
IL52278A (en) 1981-07-31
JPS57136577A (en) 1982-08-23
ATA405777A (de) 1978-11-15
GB1582245A (en) 1981-01-07
ZA773466B (en) 1978-04-26
FI771816A (US06544258-20030408-M00015.png) 1977-12-10
CA1091672A (en) 1980-12-16
HU178806B (en) 1982-06-28
JPS5826908B2 (ja) 1983-06-06
DK254077A (da) 1977-12-10
NL7706284A (nl) 1977-12-13
HU178138B (en) 1982-03-28
DE2725992A1 (de) 1977-12-29
JPS6049633B2 (ja) 1985-11-02
FI68612C (fi) 1985-10-10
IL52278A0 (en) 1977-08-31
NL172541C (nl) 1983-09-16
FI68612B (fi) 1985-06-28
GR63824B (en) 1979-12-19
AT350537B (de) 1979-06-11
SE7706655L (sv) 1977-12-10
US4216319A (en) 1980-08-05
FR2354317B1 (US06544258-20030408-M00015.png) 1980-02-01
BE855505A (fr) 1977-12-08
FR2354317A1 (fr) 1978-01-06
AU510298B2 (en) 1980-06-19

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Legal Events

Date Code Title Description
OD Request for examination
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee