DE2709581C2 - - Google Patents

Info

Publication number
DE2709581C2
DE2709581C2 DE2709581A DE2709581A DE2709581C2 DE 2709581 C2 DE2709581 C2 DE 2709581C2 DE 2709581 A DE2709581 A DE 2709581A DE 2709581 A DE2709581 A DE 2709581A DE 2709581 C2 DE2709581 C2 DE 2709581C2
Authority
DE
Germany
Prior art keywords
density
rotor
gradient
plasma
density gradient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2709581A
Other languages
German (de)
English (en)
Other versions
DE2709581A1 (de
Inventor
William Joseph Ambler Pa. Us Macaleer
Edward Henry Telford Pa. Us Wasmuth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2709581A1 publication Critical patent/DE2709581A1/de
Application granted granted Critical
Publication of DE2709581C2 publication Critical patent/DE2709581C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Centrifugal Separators (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE19772709581 1977-02-23 1977-03-04 Hepatitis b-antigen Granted DE2709581A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7657/77A GB1554811A (en) 1977-02-23 1977-02-23 Purifying hepatitis b surface antigen

Publications (2)

Publication Number Publication Date
DE2709581A1 DE2709581A1 (de) 1978-09-07
DE2709581C2 true DE2709581C2 (enExample) 1988-04-07

Family

ID=9837320

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772709581 Granted DE2709581A1 (de) 1977-02-23 1977-03-04 Hepatitis b-antigen

Country Status (6)

Country Link
JP (2) JPS53115812A (enExample)
CA (1) CA1088426A (enExample)
CH (1) CH636269A5 (enExample)
DE (1) DE2709581A1 (enExample)
FR (1) FR2382238A1 (enExample)
GB (1) GB1554811A (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7711378A (nl) * 1976-11-02 1978-05-05 Merck & Co Inc Werkwijze voor het bereiden van preparaten die dane-deeltjes bevatten.
FR2470795A1 (fr) * 1979-12-07 1981-06-12 Pasteur Institut Procede de purification de particules d'origine biologique, notamment de l'antigene de surface du virus de l'hepatite b (aghbs) et les produits obtenus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636191A (en) * 1969-10-08 1972-01-18 Cancer Res Inst Vaccine against viral hepatitis and process
US4029764A (en) * 1974-12-09 1977-06-14 Merck & Co., Inc. Hepatitis A antigen
US4017360A (en) * 1975-05-14 1977-04-12 Merck & Co., Inc. Method for purifying hepatitis B antigen

Also Published As

Publication number Publication date
CA1088426A (en) 1980-10-28
CH636269A5 (en) 1983-05-31
JPS53115812A (en) 1978-10-09
GB1554811A (en) 1979-10-31
FR2382238A1 (fr) 1978-09-29
JPS58180431A (ja) 1983-10-21
FR2382238B1 (enExample) 1981-05-29
JPS6313969B2 (enExample) 1988-03-29
DE2709581A1 (de) 1978-09-07

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee