DE2709504A1 - Neue essigsaeurederivate und verfahren zu deren herstellung - Google Patents

Neue essigsaeurederivate und verfahren zu deren herstellung

Info

Publication number
DE2709504A1
DE2709504A1 DE19772709504 DE2709504A DE2709504A1 DE 2709504 A1 DE2709504 A1 DE 2709504A1 DE 19772709504 DE19772709504 DE 19772709504 DE 2709504 A DE2709504 A DE 2709504A DE 2709504 A1 DE2709504 A1 DE 2709504A1
Authority
DE
Germany
Prior art keywords
formula
added
mixture
acetic acid
thienyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19772709504
Other languages
German (de)
English (en)
Other versions
DE2709504B2 (da
DE2709504C3 (da
Inventor
Katsuyuki Ogura
Genichi Tsuchihashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2267376A external-priority patent/JPS52106862A/ja
Priority claimed from JP2267276A external-priority patent/JPS52106815A/ja
Priority claimed from JP15635676A external-priority patent/JPS5382748A/ja
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Publication of DE2709504A1 publication Critical patent/DE2709504A1/de
Publication of DE2709504B2 publication Critical patent/DE2709504B2/de
Application granted granted Critical
Publication of DE2709504C3 publication Critical patent/DE2709504C3/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/02—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/07—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/02—Monothiocarboxylic acids
    • C07C327/04—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/10—Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/377—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19772709504 1976-03-04 1977-03-04 Neue essigsaeurederivate und verfahren zu deren herstellung Granted DE2709504A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2267376A JPS52106862A (en) 1976-03-04 1976-03-04 Furyl-or thienyl-acetic acids having sulfur-containing functional grou ps at alpha-position
JP2267276A JPS52106815A (en) 1976-03-04 1976-03-04 Preparation of alpha-alkylthioacetic acid derivatives
JP15635676A JPS5382748A (en) 1976-12-27 1976-12-27 P-aminophenylacetic acid derivs. having sulfur functional gp. at alpha-position

Publications (3)

Publication Number Publication Date
DE2709504A1 true DE2709504A1 (de) 1977-09-15
DE2709504B2 DE2709504B2 (da) 1979-11-22
DE2709504C3 DE2709504C3 (da) 1980-07-31

Family

ID=27283935

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19772709504 Granted DE2709504A1 (de) 1976-03-04 1977-03-04 Neue essigsaeurederivate und verfahren zu deren herstellung

Country Status (10)

Country Link
US (2) US4144248A (da)
CA (1) CA1110635A (da)
CH (1) CH631440A5 (da)
DE (1) DE2709504A1 (da)
DK (1) DK92777A (da)
ES (1) ES456484A1 (da)
FR (1) FR2342969A1 (da)
GB (1) GB1533505A (da)
NL (1) NL173644C (da)
SE (1) SE440777B (da)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243014A1 (en) * 1986-04-17 1987-10-28 Imperial Chemical Industries Plc Fungicides
US4833161A (en) * 1987-01-13 1989-05-23 Boehringer Mannheim Gmbh Carboxylic acid derivatives and pharmaceutical compositions and uses
US5098928A (en) * 1988-01-14 1992-03-24 Nihon Nohyaku Co., Ltd. Ketendithioacetal derivatives and pharmaceutical compositions containing the same
US5258360A (en) * 1986-04-17 1993-11-02 Imperial Chemical Industries Plc Alphamethoxy acrylic acid derivatives as fungicides

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU182472B (en) * 1978-05-23 1984-01-30 Chinoin Gyogyszer Es Vegyeszet Process for preparing 2-phenyl-alkancarboxylic acid derivatives
US8198434B2 (en) 2008-05-07 2012-06-12 Idexx Laboratories, Inc. Process for preparing cefsulodin sodium

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910958A (en) * 1971-10-04 1975-10-07 Sagami Chem Res Process for preparing arylacetic acids and esters thereof
US3929778A (en) * 1974-08-08 1975-12-30 Squibb & Sons Inc {8 (Acylcarbamoyl) thioacetyl{9 {0 cephalosporin derivatives
US4045438A (en) * 1975-10-24 1977-08-30 Yeda Research And Development Co. Ltd. Cephalosporin antibiotics

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243014A1 (en) * 1986-04-17 1987-10-28 Imperial Chemical Industries Plc Fungicides
US4863503A (en) * 1986-04-17 1989-09-05 Imperial Chemical Industries Plc Fungicides
US5053073A (en) * 1986-04-17 1991-10-01 Imperial Chemical Industries Plc Thiophene derivatives useful as fungicidal, insecticidal or plant growth regulating agents
US5073184A (en) * 1986-04-17 1991-12-17 Imperial Chemical Industries Plc Fungicidal thienyl propenoates
US5160364A (en) * 1986-04-17 1992-11-03 Imperial Chemical Industries Plc Fungicides
US5258360A (en) * 1986-04-17 1993-11-02 Imperial Chemical Industries Plc Alphamethoxy acrylic acid derivatives as fungicides
US4833161A (en) * 1987-01-13 1989-05-23 Boehringer Mannheim Gmbh Carboxylic acid derivatives and pharmaceutical compositions and uses
US5098928A (en) * 1988-01-14 1992-03-24 Nihon Nohyaku Co., Ltd. Ketendithioacetal derivatives and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
DE2709504B2 (da) 1979-11-22
GB1533505A (en) 1978-11-29
SE440777B (sv) 1985-08-19
SE7702306L (sv) 1977-09-05
NL173644C (nl) 1984-02-16
US4237298A (en) 1980-12-02
DK92777A (da) 1977-09-05
NL173644B (nl) 1983-09-16
CA1110635A (en) 1981-10-13
FR2342969A1 (fr) 1977-09-30
US4144248A (en) 1979-03-13
ES456484A1 (es) 1978-07-01
FR2342969B1 (da) 1980-12-19
NL7702370A (nl) 1977-09-06
CH631440A5 (de) 1982-08-13
DE2709504C3 (da) 1980-07-31

Similar Documents

Publication Publication Date Title
DE69512930T2 (de) Stilben-derivate verwendbar als cyclooxygenase-2 hemmer
DE2543249A1 (de) Phenylsulfinylphenylessigsaeuren, verfahren zu ihrer herstellung und diese enthaltende heilmittel
DE2605382A1 (de) 4-substituierte phenoxyderivate, verfahren zu ihrer herstellung und arzneimittel
US4074057A (en) 2-Halopropionic acid and its derivatives
DE2709504A1 (de) Neue essigsaeurederivate und verfahren zu deren herstellung
DE2505106A1 (de) Neue hydroaromatische verbindungen
DD202866A5 (de) Verfahren zur herstellung von alpha-substituierten alkansaeuren
DE69803909T2 (de) Verfahren und Zwischenprodukte, die für die Herstellung von Antifolaten verwendbar sind
DE2533397C2 (da)
DE2746754A1 (de) Alpha-thio-alkansaeurederivate
DE2034240C2 (de) Isoindolinderivate, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung
EP0132566B1 (de) Substituierte Benzophenone
DE68911295T2 (de) Verfahren zur herstellung von 2-oxo-3-aromatischen karbonsäure-derivaten.
EP0082109A2 (de) Substituierte 2-Hydroxy-phenylessigsäuren und Derivate davon
DE2352012A1 (de) Neue aliphatisch substituierte arylchalkogeno-kohlenwasserstoffderivate und verfahren zu ihrer herstellung
DE2339617A1 (de) Sulfoxide und sulfone sowie verfahren zu ihrer herstellung
DE3002659A1 (de) Neue organische verbindungen, verfahren zu ihrer herstellung und ihre verwendung
DE4115540A1 (de) Verfahren zur herstellung von 2,2-di-(methyl)-5-(2',5'-di-(methyl)-phenoxy) -pentansaeure sowie di-(halogencarbonsaeure)-ester von mehrwertigen alkoholen und verfahren zur herstellung der letzteren
BE852030A (fr) Derives d'acide acetique aromatique ayant un atome de soufre a la position alpha et procede pour leur preparation
EP0107620A1 (de) Phenol-Derivate
DE2829346A1 (de) Verfahren zur herstellung von substituierten benzaldehyden
CH636621A5 (de) Verfahren zur herstellung von keteniminen als vorstufen zu antibakteriell wirksamen cephalosporin-derivaten.
DE2365469C3 (de) 18.10.72 Japan 103606-72 alpha-Acylamino- eckige Klammer auf alpha-alkyl-(oder -aryl)-thio eckige Klammer zu -carbonsäure-thlolester und Verfahren zu ihrer Herstellung
DE2626018A1 (de) Alkinole und verfahren zu ihrer herstellung
DE2163908C3 (de) 2-Aminomethylphenolderivate deren nichtgiftige, pharmazeutisch verwertbare Säureadditionssalze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Mittel Merck & Co., Inc., Rahway, N.J. (V.St.A.)

Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee