DE2657370C2 - Mittel zum Bedecken und/oder Ausfüllen von Knochendefekten - Google Patents
Mittel zum Bedecken und/oder Ausfüllen von KnochendefektenInfo
- Publication number
- DE2657370C2 DE2657370C2 DE2657370A DE2657370A DE2657370C2 DE 2657370 C2 DE2657370 C2 DE 2657370C2 DE 2657370 A DE2657370 A DE 2657370A DE 2657370 A DE2657370 A DE 2657370A DE 2657370 C2 DE2657370 C2 DE 2657370C2
- Authority
- DE
- Germany
- Prior art keywords
- weight
- bone
- solution
- agent
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000000988 bone and bone Anatomy 0.000 title claims description 35
- 230000007547 defect Effects 0.000 title description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 34
- 239000000243 solution Substances 0.000 claims description 34
- 239000000126 substance Substances 0.000 claims description 29
- 239000000499 gel Substances 0.000 claims description 21
- 239000007943 implant Substances 0.000 claims description 21
- 210000001519 tissue Anatomy 0.000 claims description 21
- 229940036811 bone meal Drugs 0.000 claims description 14
- 239000002374 bone meal Substances 0.000 claims description 14
- 239000002504 physiological saline solution Substances 0.000 claims description 14
- 229920001282 polysaccharide Polymers 0.000 claims description 13
- 239000005017 polysaccharide Substances 0.000 claims description 13
- 150000004676 glycans Chemical class 0.000 claims description 12
- 108010010803 Gelatin Proteins 0.000 claims description 9
- 239000008273 gelatin Substances 0.000 claims description 9
- 229920000159 gelatin Polymers 0.000 claims description 9
- 235000019322 gelatine Nutrition 0.000 claims description 9
- 235000011852 gelatine desserts Nutrition 0.000 claims description 9
- 230000003115 biocidal effect Effects 0.000 claims description 8
- 229920001817 Agar Polymers 0.000 claims description 7
- 229920000936 Agarose Polymers 0.000 claims description 7
- 239000008272 agar Substances 0.000 claims description 7
- 230000036760 body temperature Effects 0.000 claims description 7
- 229940124530 sulfonamide Drugs 0.000 claims description 7
- 150000003456 sulfonamides Chemical class 0.000 claims description 7
- 239000013078 crystal Substances 0.000 claims description 6
- 238000009792 diffusion process Methods 0.000 claims description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 5
- 239000003242 anti bacterial agent Substances 0.000 claims description 5
- 229910052586 apatite Inorganic materials 0.000 claims description 5
- 239000011575 calcium Substances 0.000 claims description 5
- 229910052791 calcium Inorganic materials 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 4
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 229910052744 lithium Inorganic materials 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- 229910001414 potassium ion Inorganic materials 0.000 claims description 4
- 230000001737 promoting effect Effects 0.000 claims description 4
- 150000003377 silicon compounds Chemical class 0.000 claims description 4
- 108010003272 Hyaluronate lyase Proteins 0.000 claims description 2
- 102000001974 Hyaluronidases Human genes 0.000 claims description 2
- 229960002773 hyaluronidase Drugs 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 238000007711 solidification Methods 0.000 description 11
- 230000008023 solidification Effects 0.000 description 11
- 208000027418 Wounds and injury Diseases 0.000 description 8
- 238000000034 method Methods 0.000 description 6
- 239000003708 ampul Substances 0.000 description 5
- 238000009835 boiling Methods 0.000 description 5
- 150000002500 ions Chemical class 0.000 description 5
- 238000001816 cooling Methods 0.000 description 4
- 238000002513 implantation Methods 0.000 description 4
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 210000003456 pulmonary alveoli Anatomy 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000008468 bone growth Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000006193 liquid solution Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 210000004872 soft tissue Anatomy 0.000 description 2
- 230000003685 thermal hair damage Effects 0.000 description 2
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000005168 Intussusception Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 206010048629 Wound secretion Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- ZMPZURBYCNDNBN-UHFFFAOYSA-K aluminum;calcium;phosphate Chemical compound [Al+3].[Ca+2].[O-]P([O-])([O-])=O ZMPZURBYCNDNBN-UHFFFAOYSA-K 0.000 description 1
- 230000000456 anti-sulfonamide effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000003633 blood substitute Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000010478 bone regeneration Effects 0.000 description 1
- 229910052796 boron Inorganic materials 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000004053 dental implant Substances 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 210000004394 hip joint Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000012432 intermediate storage Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000000214 mouth Anatomy 0.000 description 1
- 239000011224 oxide ceramic Substances 0.000 description 1
- 229910052574 oxide ceramic Inorganic materials 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003303 reheating Methods 0.000 description 1
- 230000008521 reorganization Effects 0.000 description 1
- 238000012958 reprocessing Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
- A61L2300/254—Enzymes, proenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Dental Preparations (AREA)
- Surgical Instruments (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2657370A DE2657370C2 (de) | 1976-12-17 | 1976-12-17 | Mittel zum Bedecken und/oder Ausfüllen von Knochendefekten |
| FR7737313A FR2374040A1 (fr) | 1976-12-17 | 1977-12-12 | Agent de recouvrement et/ou de remplissage d'imperfections osseuses et son procede de fabrication |
| AT0885877A AT370988B (de) | 1976-12-17 | 1977-12-12 | Hilfsmittel zum bedecken und/oder ausfuellen von knochendefekten, insbesondere zum einsetzen von enossalen implantaten |
| SE7714045A SE432872B (sv) | 1976-12-17 | 1977-12-12 | Hjelpmedel for teckning och/eller ifyllning av bendefekter, samt forfarande for framstellning av hjelpmedlet |
| US05/860,651 US4191747A (en) | 1976-12-17 | 1977-12-14 | Corrective agent for the covering and/or filling of bone defects, method for the preparation of same and method of using the same |
| AU31634/77A AU517844B2 (en) | 1976-12-17 | 1977-12-15 | Corrective agents for filling and/or covering of bone defects |
| BE6046271A BE861969A (fr) | 1976-12-17 | 1977-12-16 | Agent de recouvrement et/ou de remplissage d'imperfections osseuses et son procede de fabrication |
| CA293,276A CA1095412A (en) | 1976-12-17 | 1977-12-16 | Corrective agent for the covering and/or filling up of bone defects, and method for the preparation of same |
| GB52472/77A GB1590340A (en) | 1976-12-17 | 1977-12-16 | Corrective agent for the covering and/or filling of bone defects and method for the preparation of same |
| JP15232677A JPS53118887A (en) | 1976-12-17 | 1977-12-17 | Aid for covering and*or filling broken bone and method of preparing same |
| IT30883/77A IT1088847B (it) | 1976-12-17 | 1977-12-19 | Mezzo ausiliario per la copertura ed il riempimento di difetti ossei e procedimento per la fabbricazione dello stesso |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2657370A DE2657370C2 (de) | 1976-12-17 | 1976-12-17 | Mittel zum Bedecken und/oder Ausfüllen von Knochendefekten |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2657370A1 DE2657370A1 (de) | 1978-06-29 |
| DE2657370C2 true DE2657370C2 (de) | 1982-11-11 |
Family
ID=5995843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2657370A Expired DE2657370C2 (de) | 1976-12-17 | 1976-12-17 | Mittel zum Bedecken und/oder Ausfüllen von Knochendefekten |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4191747A (Direct) |
| JP (1) | JPS53118887A (Direct) |
| AT (1) | AT370988B (Direct) |
| AU (1) | AU517844B2 (Direct) |
| BE (1) | BE861969A (Direct) |
| CA (1) | CA1095412A (Direct) |
| DE (1) | DE2657370C2 (Direct) |
| FR (1) | FR2374040A1 (Direct) |
| GB (1) | GB1590340A (Direct) |
| IT (1) | IT1088847B (Direct) |
| SE (1) | SE432872B (Direct) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2918098A1 (de) * | 1978-05-19 | 1979-11-22 | Philip Nicholas Dr Sawyer | Haemostatisches mittel, verfahren zu seiner herstellung und seine verwendung zur kontrolle doer stillung einer blutung |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5654841A (en) * | 1979-10-08 | 1981-05-15 | Mitsubishi Mining & Cement Co | Bone broken portion and filler for void portion and method of treating bone of animal using said filler |
| EP0030583B1 (de) * | 1979-12-18 | 1984-06-13 | Oscobal Ag | Knochenersatzmaterial und Verfahren zur Herstellung eines Knochenersatzmaterials |
| CA1190855A (en) * | 1980-09-03 | 1985-07-23 | Rolf W. Pfirrmann | Treatment of osteitis |
| JPS5767521A (en) * | 1980-09-25 | 1982-04-24 | Yamanouchi Pharmaceut Co Ltd | Agent for improving circulation blood vessel |
| FR2516796B1 (fr) * | 1981-11-20 | 1986-06-06 | Altulor Sa | Compositions pour ciment chirurgical a base d'au moins un monomere acrylique et d'au moins un polymere acrylique |
| US4440750A (en) * | 1982-02-12 | 1984-04-03 | Collagen Corporation | Osteogenic composition and method |
| US4485096A (en) * | 1982-02-26 | 1984-11-27 | Massachusetts Institute Of Technology | Tissue-equivalent and method for preparation thereof |
| DE3374659D1 (en) * | 1983-02-03 | 1988-01-07 | Ethicon Inc | Paste for hemostasis and for temporary relief of defects in the traumatism of bones |
| US4473670A (en) * | 1983-05-25 | 1984-09-25 | Ethicon, Inc. | Salt-filled absorbable polymers |
| GB8328074D0 (en) * | 1983-10-20 | 1983-11-23 | Geistlich Soehne Ag | Chemical compositions |
| NL8402534A (nl) * | 1984-08-17 | 1986-03-17 | Gerrit Johannes Brinks | Materiaal, geschikt voor toepassing als implantatiemateriaal bij mens en dier ter vervanging van afwezig botweefsel, alsmede werkwijze ter bereiding van het materiaal. |
| US5053049A (en) * | 1985-05-29 | 1991-10-01 | Baxter International | Flexible prostheses of predetermined shapes and process for making same |
| US4678470A (en) * | 1985-05-29 | 1987-07-07 | American Hospital Supply Corporation | Bone-grafting material |
| US6150328A (en) * | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US5180426A (en) * | 1987-12-28 | 1993-01-19 | Asahi Kogaku Kogyo K.K. | Composition for forming calcium phosphate type setting material and process for producing setting material |
| US5290558A (en) * | 1989-09-21 | 1994-03-01 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
| US5073373A (en) * | 1989-09-21 | 1991-12-17 | Osteotech, Inc. | Flowable demineralized bone powder composition and its use in bone repair |
| US6990982B1 (en) | 1990-06-28 | 2006-01-31 | Bonutti Ip, Llc | Method for harvesting and processing cells from tissue fragments |
| US5269785A (en) * | 1990-06-28 | 1993-12-14 | Bonutti Peter M | Apparatus and method for tissue removal |
| US6503277B2 (en) | 1991-08-12 | 2003-01-07 | Peter M. Bonutti | Method of transplanting human body tissue |
| US5329846A (en) | 1991-08-12 | 1994-07-19 | Bonutti Peter M | Tissue press and system |
| US20080139474A1 (en) * | 1991-11-04 | 2008-06-12 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
| DE69233022T2 (de) * | 1991-11-04 | 2004-02-12 | Genetics Institute, LLC, Cambridge | Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung |
| ZA93506B (en) * | 1992-02-11 | 1994-05-11 | Bristol Myers Squibb Co | Soft tissue augmentation material |
| US7060287B1 (en) * | 1992-02-11 | 2006-06-13 | Bioform Inc. | Tissue augmentation material and method |
| US7968110B2 (en) * | 1992-02-11 | 2011-06-28 | Merz Aesthetics, Inc. | Tissue augmentation material and method |
| US6537574B1 (en) * | 1992-02-11 | 2003-03-25 | Bioform, Inc. | Soft tissue augmentation material |
| US5242910A (en) * | 1992-10-13 | 1993-09-07 | The Procter & Gamble Company | Sustained release compositions for treating periodontal disease |
| US5447725A (en) * | 1993-06-11 | 1995-09-05 | The Procter & Gamble Company | Methods for aiding periodontal tissue regeneration |
| US6291206B1 (en) * | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| AU689184B2 (en) | 1993-12-07 | 1998-03-26 | Genetics Institute, Llc | BMP-12, BMP-13 and tendon-inducing compositions thereof |
| AU1051597A (en) * | 1995-11-09 | 1997-05-29 | University Of Massachusetts | Tissue re-surfacing with hydrogel-cell compositions |
| US5718717A (en) | 1996-08-19 | 1998-02-17 | Bonutti; Peter M. | Suture anchor |
| US20020098222A1 (en) * | 1997-03-13 | 2002-07-25 | John F. Wironen | Bone paste |
| US6475230B1 (en) * | 1997-08-01 | 2002-11-05 | Peter M. Bonutti | Method and apparatus for securing a suture |
| US20020076429A1 (en) * | 1998-01-28 | 2002-06-20 | John F. Wironen | Bone paste subjected to irradiative and thermal treatment |
| US6045551A (en) | 1998-02-06 | 2000-04-04 | Bonutti; Peter M. | Bone suture |
| USRE38522E1 (en) * | 1998-02-27 | 2004-05-25 | Musculoskeletal Transplant Foundation | Malleable paste for filling bone defects |
| US6326018B1 (en) | 1998-02-27 | 2001-12-04 | Musculoskeletal Transplant Foundation | Flexible sheet of demineralized bone |
| US6437018B1 (en) | 1998-02-27 | 2002-08-20 | Musculoskeletal Transplant Foundation | Malleable paste with high molecular weight buffered carrier for filling bone defects |
| US7019192B2 (en) * | 1998-02-27 | 2006-03-28 | Musculoskeletal Transplant Foundation | Composition for filling bone defects |
| US6030635A (en) * | 1998-02-27 | 2000-02-29 | Musculoskeletal Transplant Foundation | Malleable paste for filling bone defects |
| US6911212B2 (en) | 1998-02-27 | 2005-06-28 | Musculoskeletal Transplant Foundation | Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects |
| US7045141B2 (en) | 1998-02-27 | 2006-05-16 | Musculoskeletal Transplant Foundation | Allograft bone composition having a gelatin binder |
| US6027744A (en) * | 1998-04-24 | 2000-02-22 | University Of Massachusetts Medical Center | Guided development and support of hydrogel-cell compositions |
| US6171610B1 (en) * | 1998-04-24 | 2001-01-09 | University Of Massachusetts | Guided development and support of hydrogel-cell compositions |
| US6727224B1 (en) * | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| US6368343B1 (en) | 2000-03-13 | 2002-04-09 | Peter M. Bonutti | Method of using ultrasonic vibration to secure body tissue |
| US6447516B1 (en) | 1999-08-09 | 2002-09-10 | Peter M. Bonutti | Method of securing tissue |
| US20030228288A1 (en) | 1999-10-15 | 2003-12-11 | Scarborough Nelson L. | Volume maintaining osteoinductive/osteoconductive compositions |
| EP2286847A1 (en) | 1999-10-15 | 2011-02-23 | Genetics Institute, LLC | Formulations of hyaluronic acid for delivery of osteogenic proteins |
| US7575921B2 (en) * | 1999-12-30 | 2009-08-18 | Vbi Technologies, L.L.C. | Spore-like cells and uses thereof |
| US7560275B2 (en) * | 1999-12-30 | 2009-07-14 | Vbi Technologies, L.L.C. | Compositions and methods for generating skin |
| US6635073B2 (en) | 2000-05-03 | 2003-10-21 | Peter M. Bonutti | Method of securing body tissue |
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- 1976-12-17 DE DE2657370A patent/DE2657370C2/de not_active Expired
-
1977
- 1977-12-12 AT AT0885877A patent/AT370988B/de not_active IP Right Cessation
- 1977-12-12 SE SE7714045A patent/SE432872B/sv unknown
- 1977-12-12 FR FR7737313A patent/FR2374040A1/fr active Granted
- 1977-12-14 US US05/860,651 patent/US4191747A/en not_active Expired - Lifetime
- 1977-12-15 AU AU31634/77A patent/AU517844B2/en not_active Expired
- 1977-12-16 CA CA293,276A patent/CA1095412A/en not_active Expired
- 1977-12-16 GB GB52472/77A patent/GB1590340A/en not_active Expired
- 1977-12-16 BE BE6046271A patent/BE861969A/xx unknown
- 1977-12-17 JP JP15232677A patent/JPS53118887A/ja active Pending
- 1977-12-19 IT IT30883/77A patent/IT1088847B/it active
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| NICHTS-ERMITTELT |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2918098A1 (de) * | 1978-05-19 | 1979-11-22 | Philip Nicholas Dr Sawyer | Haemostatisches mittel, verfahren zu seiner herstellung und seine verwendung zur kontrolle doer stillung einer blutung |
Also Published As
| Publication number | Publication date |
|---|---|
| SE7714045L (sv) | 1978-06-18 |
| FR2374040B1 (Direct) | 1982-10-15 |
| JPS53118887A (en) | 1978-10-17 |
| DE2657370A1 (de) | 1978-06-29 |
| SE432872B (sv) | 1984-04-30 |
| US4191747A (en) | 1980-03-04 |
| AU517844B2 (en) | 1981-08-27 |
| FR2374040A1 (fr) | 1978-07-13 |
| BE861969A (fr) | 1978-06-16 |
| CA1095412A (en) | 1981-02-10 |
| ATA885877A (de) | 1982-10-15 |
| GB1590340A (en) | 1981-05-28 |
| AU3163477A (en) | 1979-06-21 |
| AT370988B (de) | 1983-05-25 |
| IT1088847B (it) | 1985-06-10 |
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