AU517844B2 - Corrective agents for filling and/or covering of bone defects - Google Patents

Corrective agents for filling and/or covering of bone defects

Info

Publication number
AU517844B2
AU517844B2 AU31634/77A AU3163477A AU517844B2 AU 517844 B2 AU517844 B2 AU 517844B2 AU 31634/77 A AU31634/77 A AU 31634/77A AU 3163477 A AU3163477 A AU 3163477A AU 517844 B2 AU517844 B2 AU 517844B2
Authority
AU
Australia
Prior art keywords
filling
covering
bone defects
corrective agents
corrective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU31634/77A
Other languages
English (en)
Other versions
AU3163477A (en
Inventor
Nied Dr. Nied Dent Hans Schricker Dr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of AU3163477A publication Critical patent/AU3163477A/en
Application granted granted Critical
Publication of AU517844B2 publication Critical patent/AU517844B2/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/112Phosphorus-containing compounds, e.g. phosphates, phosphonates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254Enzymes, proenzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406Antibiotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
  • Surgical Instruments (AREA)
AU31634/77A 1976-12-17 1977-12-15 Corrective agents for filling and/or covering of bone defects Expired AU517844B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEDE2657370 1976-12-17
DE2657370A DE2657370C2 (de) 1976-12-17 1976-12-17 Mittel zum Bedecken und/oder Ausfüllen von Knochendefekten

Publications (2)

Publication Number Publication Date
AU3163477A AU3163477A (en) 1979-06-21
AU517844B2 true AU517844B2 (en) 1981-08-27

Family

ID=5995843

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31634/77A Expired AU517844B2 (en) 1976-12-17 1977-12-15 Corrective agents for filling and/or covering of bone defects

Country Status (11)

Country Link
US (1) US4191747A (Direct)
JP (1) JPS53118887A (Direct)
AT (1) AT370988B (Direct)
AU (1) AU517844B2 (Direct)
BE (1) BE861969A (Direct)
CA (1) CA1095412A (Direct)
DE (1) DE2657370C2 (Direct)
FR (1) FR2374040A1 (Direct)
GB (1) GB1590340A (Direct)
IT (1) IT1088847B (Direct)
SE (1) SE432872B (Direct)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4238480A (en) * 1978-05-19 1980-12-09 Sawyer Philip Nicholas Method for preparing an improved hemostatic agent and method of employing the same
JPS5654841A (en) * 1979-10-08 1981-05-15 Mitsubishi Mining & Cement Co Bone broken portion and filler for void portion and method of treating bone of animal using said filler
DE2967060D1 (en) * 1979-12-18 1984-07-19 Oscobal Ag Bone replacement material and process for producing a bone replacement material
CA1190855A (en) * 1980-09-03 1985-07-23 Rolf W. Pfirrmann Treatment of osteitis
JPS5767521A (en) * 1980-09-25 1982-04-24 Yamanouchi Pharmaceut Co Ltd Agent for improving circulation blood vessel
FR2516796B1 (fr) * 1981-11-20 1986-06-06 Altulor Sa Compositions pour ciment chirurgical a base d'au moins un monomere acrylique et d'au moins un polymere acrylique
US4440750A (en) * 1982-02-12 1984-04-03 Collagen Corporation Osteogenic composition and method
US4485096A (en) * 1982-02-26 1984-11-27 Massachusetts Institute Of Technology Tissue-equivalent and method for preparation thereof
EP0115549B1 (de) * 1983-02-03 1987-11-25 Ethicon, Inc. Paste zur Blutstillung und temporären Defektüberbrückung bei Knochentrauma
US4473670A (en) * 1983-05-25 1984-09-25 Ethicon, Inc. Salt-filled absorbable polymers
GB8328074D0 (en) * 1983-10-20 1983-11-23 Geistlich Soehne Ag Chemical compositions
NL8402534A (nl) * 1984-08-17 1986-03-17 Gerrit Johannes Brinks Materiaal, geschikt voor toepassing als implantatiemateriaal bij mens en dier ter vervanging van afwezig botweefsel, alsmede werkwijze ter bereiding van het materiaal.
US4678470A (en) * 1985-05-29 1987-07-07 American Hospital Supply Corporation Bone-grafting material
US5053049A (en) * 1985-05-29 1991-10-01 Baxter International Flexible prostheses of predetermined shapes and process for making same
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5180426A (en) * 1987-12-28 1993-01-19 Asahi Kogaku Kogyo K.K. Composition for forming calcium phosphate type setting material and process for producing setting material
US5290558A (en) * 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5073373A (en) * 1989-09-21 1991-12-17 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5269785A (en) * 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
US6990982B1 (en) 1990-06-28 2006-01-31 Bonutti Ip, Llc Method for harvesting and processing cells from tissue fragments
US5329846A (en) 1991-08-12 1994-07-19 Bonutti Peter M Tissue press and system
US6503277B2 (en) * 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
ATE238417T1 (de) 1991-11-04 2003-05-15 Inst Genetics Llc Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
US20080070842A1 (en) * 1991-11-04 2008-03-20 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
US7968110B2 (en) * 1992-02-11 2011-06-28 Merz Aesthetics, Inc. Tissue augmentation material and method
US6537574B1 (en) 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
ZA93506B (en) * 1992-02-11 1994-05-11 Bristol Myers Squibb Co Soft tissue augmentation material
US7060287B1 (en) 1992-02-11 2006-06-13 Bioform Inc. Tissue augmentation material and method
US5242910A (en) * 1992-10-13 1993-09-07 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5447725A (en) * 1993-06-11 1995-09-05 The Procter & Gamble Company Methods for aiding periodontal tissue regeneration
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
WO1995016035A2 (en) 1993-12-07 1995-06-15 Genetics Institute, Inc. Bmp-12, bmp-13 and tendon-inducing compositions thereof
DE69631490T2 (de) * 1995-11-09 2004-10-07 Univ Massachusetts Boston Wiederherstellung der gewebeoberfläche mit zusammensetzungen aus hydrogel-zellen
US5718717A (en) 1996-08-19 1998-02-17 Bonutti; Peter M. Suture anchor
US20020098222A1 (en) * 1997-03-13 2002-07-25 John F. Wironen Bone paste
US6475230B1 (en) * 1997-08-01 2002-11-05 Peter M. Bonutti Method and apparatus for securing a suture
US20020076429A1 (en) * 1998-01-28 2002-06-20 John F. Wironen Bone paste subjected to irradiative and thermal treatment
US6045551A (en) 1998-02-06 2000-04-04 Bonutti; Peter M. Bone suture
US7019192B2 (en) * 1998-02-27 2006-03-28 Musculoskeletal Transplant Foundation Composition for filling bone defects
US7045141B2 (en) 1998-02-27 2006-05-16 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
US6911212B2 (en) 1998-02-27 2005-06-28 Musculoskeletal Transplant Foundation Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects
US6030635A (en) * 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6437018B1 (en) 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
US6326018B1 (en) 1998-02-27 2001-12-04 Musculoskeletal Transplant Foundation Flexible sheet of demineralized bone
USRE38522E1 (en) * 1998-02-27 2004-05-25 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6171610B1 (en) 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
US6027744A (en) * 1998-04-24 2000-02-22 University Of Massachusetts Medical Center Guided development and support of hydrogel-cell compositions
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
US6368343B1 (en) 2000-03-13 2002-04-09 Peter M. Bonutti Method of using ultrasonic vibration to secure body tissue
US6447516B1 (en) 1999-08-09 2002-09-10 Peter M. Bonutti Method of securing tissue
DE60012557T2 (de) 1999-10-15 2005-08-04 Genetics Institute, LLC, Cambridge Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
US7575921B2 (en) * 1999-12-30 2009-08-18 Vbi Technologies, L.L.C. Spore-like cells and uses thereof
US7560275B2 (en) * 1999-12-30 2009-07-14 Vbi Technologies, L.L.C. Compositions and methods for generating skin
US6635073B2 (en) 2000-05-03 2003-10-21 Peter M. Bonutti Method of securing body tissue
US7635390B1 (en) 2000-01-14 2009-12-22 Marctec, Llc Joint replacement component having a modular articulating surface
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
WO2002057428A1 (en) * 2000-10-30 2002-07-25 University Of Massachusetts Isolation of spore-like cells from tissues exposed to extreme conditions
US20030082233A1 (en) * 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
US7323193B2 (en) 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
CA2449008A1 (en) * 2001-06-01 2002-12-12 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US7357947B2 (en) * 2001-09-10 2008-04-15 Biomet, Inc. Bone graft material incorporating demineralized bone matrix and lipids
US6565884B2 (en) 2001-09-10 2003-05-20 Interpore Cross International Bone graft material incorporating demineralized bone matrix and lipids
JP2005505351A (ja) * 2001-10-12 2005-02-24 オステオテック インコーポレーテッド 改善された骨移植片
US6719765B2 (en) 2001-12-03 2004-04-13 Bonutti 2003 Trust-A Magnetic suturing system and method
CA2486113A1 (en) * 2002-05-17 2003-12-04 Wyeth Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins
US20060204544A1 (en) * 2002-05-20 2006-09-14 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
FR2850282B1 (fr) * 2003-01-27 2007-04-06 Jerome Asius Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
KR20060031808A (ko) 2003-06-11 2006-04-13 오스테오테크, 인코포레이티드 뼈 임플란트 및 그의 제조 방법
EP2374471A1 (en) * 2003-09-12 2011-10-12 Wyeth LLC Injectable hardenable calcium phosphate pastes for delivery of osteogenic proteins
WO2005084725A1 (en) * 2004-03-02 2005-09-15 Nanotherapeutics, Inc. Compositions for repairing bone and methods for preparing and using such compositions
US20050244450A1 (en) * 2004-04-28 2005-11-03 Reddi A H Heat-treated implantable bone material
US7678385B2 (en) * 2004-04-28 2010-03-16 Biomet Manufacturing Corp. Irradiated implantable bone material
US7670384B2 (en) * 2004-10-14 2010-03-02 Biomet Manufacturing Corp. Bone graft composition comprising a bone material and a carrier comprising denatured demineralized bone
US20060083769A1 (en) 2004-10-14 2006-04-20 Mukesh Kumar Method and apparatus for preparing bone
EP1893174A2 (en) * 2005-05-10 2008-03-05 Cytophil, Inc. Injectable hydrogels and methods of making and using same
DE202005009755U1 (de) * 2005-06-21 2005-09-08 Cervitech, Inc. Halter für Zwischenwirbelprothesen
DE102006009793A1 (de) * 2005-10-31 2007-09-06 Sus Tech Gmbh & Co. Kg Verwendung von schwer wasserlöslichen Calciumsalzen und/oder deren Kompositen
WO2007056671A1 (en) * 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
US20070184087A1 (en) * 2006-02-06 2007-08-09 Bioform Medical, Inc. Polysaccharide compositions for use in tissue augmentation
DE102006009799A1 (de) * 2006-03-01 2007-09-06 Henkel Kgaa Vorwiegend plättchenförmige schwer wasserlösliche Calciumsalze und/oder deren Kompositmaterialien, umfassend diese
US7718616B2 (en) * 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
CA2742047A1 (en) * 2008-10-24 2010-04-29 Warsaw Orthopedic, Inc. Compositions and methods for promoting bone formation
CN104726394B (zh) 2009-11-12 2018-12-18 VCell治疗股份有限公司 类孢子细胞子群及其用途
JP2013542837A (ja) 2010-11-15 2013-11-28 ジンマー オーソバイオロジクス,インコーポレイティド 骨空隙充填剤
US8992949B1 (en) 2011-11-17 2015-03-31 Unicare Biomedical, Inc. Biocompatible polymeric compositions having microcrystalline and amorphous components and methods for their manufacture
EP2897560A4 (en) * 2012-09-18 2016-04-20 Novabone Products Llc BIOVERRE AT GLYCOSAMINOGLYCANES
US10549011B2 (en) 2015-10-26 2020-02-04 Osteolife Biomedical, Llc Bone putty and gel systems and methods
US20170128633A1 (en) 2015-11-10 2017-05-11 Theodore Malinin Bioactive Implants and Methods of Making and Using
EP3582749A4 (en) * 2017-02-18 2020-12-30 Advanced Aesthetic Technologies, Inc. KITS AND METHODS OF USING HYALURONIDASE TO MODIFY POLYSACCHARIDE FILLERS AND DISPENSING SYSTEMS
CN111459036B (zh) * 2020-02-24 2021-11-16 珠海格力电器股份有限公司 一种智能橱柜控制方法、装置、电子设备及存储介质
US20230390398A1 (en) * 2020-10-14 2023-12-07 Next Science IP Holdings Pty Ltd Methods and compositions useful for reducing bioburden in wounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2642375A (en) * 1951-08-21 1953-06-16 Ethicon Suture Lab Inc Hemostatic compositions
US3476855A (en) * 1965-02-26 1969-11-04 Leslie L Balassa Sterilizing and enhancing activity of a finely divided cartilage powder
US3767784A (en) * 1970-12-01 1973-10-23 S Gluck Composition for the protection and treatment of injured body tissue and method of utilizing the same
US3703575A (en) * 1970-12-23 1972-11-21 Heinrich Thiele Reconstructed cartilaginous tissue and method of implanting it into the human or animal body
JPS5126211A (en) * 1974-08-24 1976-03-04 Masakuni Kanai Honeno seiseisokushinzaino seizohoho
DE2502884A1 (de) 1975-01-24 1976-07-29 Juergen J Dipl Phy Hildebrandt Mittel zur biologischen implantation von knochen- und gelenkersatz
US3968567A (en) * 1975-04-21 1976-07-13 Nevins Alan J Endodontic composition and method
CH627078A5 (en) 1975-06-05 1981-12-31 Pentapharm Ag Process for the preparation of a sterile collagen product with felt-like or web-like fibre structure

Also Published As

Publication number Publication date
FR2374040B1 (Direct) 1982-10-15
FR2374040A1 (fr) 1978-07-13
JPS53118887A (en) 1978-10-17
BE861969A (fr) 1978-06-16
IT1088847B (it) 1985-06-10
AT370988B (de) 1983-05-25
DE2657370A1 (de) 1978-06-29
DE2657370C2 (de) 1982-11-11
US4191747A (en) 1980-03-04
ATA885877A (de) 1982-10-15
CA1095412A (en) 1981-02-10
GB1590340A (en) 1981-05-28
AU3163477A (en) 1979-06-21
SE432872B (sv) 1984-04-30
SE7714045L (sv) 1978-06-18

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