DE2652676A1 - N-alkylierte derivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel - Google Patents

N-alkylierte derivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel

Info

Publication number
DE2652676A1
DE2652676A1 DE19762652676 DE2652676A DE2652676A1 DE 2652676 A1 DE2652676 A1 DE 2652676A1 DE 19762652676 DE19762652676 DE 19762652676 DE 2652676 A DE2652676 A DE 2652676A DE 2652676 A1 DE2652676 A1 DE 2652676A1
Authority
DE
Germany
Prior art keywords
radical
carbon atoms
alkyl
group
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19762652676
Other languages
German (de)
English (en)
Inventor
Burton Grant Christensen
Raymond Armond Firestone
William Joseph Leanza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2652676A1 publication Critical patent/DE2652676A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE19762652676 1975-11-21 1976-11-19 N-alkylierte derivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel Withdrawn DE2652676A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63429775A 1975-11-21 1975-11-21

Publications (1)

Publication Number Publication Date
DE2652676A1 true DE2652676A1 (de) 1977-06-02

Family

ID=24543224

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19762652676 Withdrawn DE2652676A1 (de) 1975-11-21 1976-11-19 N-alkylierte derivate von thienamycin, verfahren zu deren herstellung und diese enthaltende arzneimittel

Country Status (8)

Country Link
JP (1) JPS5277085A (enExample)
CH (1) CH628051A5 (enExample)
DE (1) DE2652676A1 (enExample)
DK (1) DK523676A (enExample)
FR (1) FR2332014A1 (enExample)
GB (1) GB1570988A (enExample)
NL (1) NL7612937A (enExample)
SE (1) SE7612964L (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0001627A1 (en) * 1977-10-19 1979-05-02 Merck & Co. Inc. 3-Substituted-6-(1'hydroxethyl)-7-oxo-1-azabicyclo(3.2.0.)-hept-2-ene-2-carboxylic acid, its preparation and pharmaceutical compositions containing it
EP0001628A1 (en) * 1977-10-19 1979-05-02 Merck & Co. Inc. 3-Substituted-6-substituted-7-oxo-1-azabicyclo (3.2.0)-hept-2-ene-2-carboxylic acid, its preparation and pharmaceutical compositions containing it
EP0008888A1 (en) * 1978-08-23 1980-03-19 Beecham Group Plc Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them
EP0021082A1 (en) * 1979-05-29 1981-01-07 Merck & Co. Inc. N-heterocyclyl thienamycins, process for preparing and antibiotic pharmaceutical composition containing the same
DE3312533A1 (de) * 1982-04-09 1983-10-13 Bristol-Myers Co., 10154 New York, N.Y. Carbapenem-derivate, verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten
DE3321864A1 (de) * 1982-06-18 1983-12-22 Bristol-Myers Co., 10154 New York, N.Y. Carbapenem-derivate, verfahren zu ihrer herstellung und pharmazeutische mittel

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0017992A1 (en) * 1979-04-19 1980-10-29 Merck & Co. Inc. 2-Substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids, processes for preparing them, antibiotic pharmaceutical compositions containing same and process for preparing intermediates
DE3167774D1 (en) * 1980-02-28 1985-01-31 Fujisawa Pharmaceutical Co 4-substituted-2-oxoazetidine compounds, processes for their preparation, and their use for preparing antibiotics
JPS5798257A (en) * 1980-12-10 1982-06-18 Sankyo Co Ltd 3,4-disubstituted azetidine-2-one compound and its preparation
EP0062407A1 (en) * 1981-03-10 1982-10-13 Beecham Group Plc Therapeutic compounds containing beta-lactams
BE897086A (fr) * 1982-06-18 1983-12-19 Bristol Myers Co Produits nouveaux de la classe des carbapenems et leur application en tant qu'antibiotiques
AU2004296261B2 (en) * 2003-12-09 2007-08-23 Choongwae Pharm. Co. A new process for preparation of imipenem

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0001627A1 (en) * 1977-10-19 1979-05-02 Merck & Co. Inc. 3-Substituted-6-(1'hydroxethyl)-7-oxo-1-azabicyclo(3.2.0.)-hept-2-ene-2-carboxylic acid, its preparation and pharmaceutical compositions containing it
EP0001628A1 (en) * 1977-10-19 1979-05-02 Merck & Co. Inc. 3-Substituted-6-substituted-7-oxo-1-azabicyclo (3.2.0)-hept-2-ene-2-carboxylic acid, its preparation and pharmaceutical compositions containing it
EP0008888A1 (en) * 1978-08-23 1980-03-19 Beecham Group Plc Beta-lactam antibacterial compounds, their preparation and pharmaceutical compositions containing them
EP0021082A1 (en) * 1979-05-29 1981-01-07 Merck & Co. Inc. N-heterocyclyl thienamycins, process for preparing and antibiotic pharmaceutical composition containing the same
DE3312533A1 (de) * 1982-04-09 1983-10-13 Bristol-Myers Co., 10154 New York, N.Y. Carbapenem-derivate, verfahren zu ihrer herstellung und pharmazeutische mittel, die diese verbindungen enthalten
DE3321864A1 (de) * 1982-06-18 1983-12-22 Bristol-Myers Co., 10154 New York, N.Y. Carbapenem-derivate, verfahren zu ihrer herstellung und pharmazeutische mittel

Also Published As

Publication number Publication date
JPS5277085A (en) 1977-06-29
SE7612964L (sv) 1977-05-22
FR2332014A1 (fr) 1977-06-17
CH628051A5 (en) 1982-02-15
DK523676A (da) 1977-05-22
GB1570988A (en) 1980-07-09
FR2332014B1 (enExample) 1978-11-10
NL7612937A (nl) 1977-05-24

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8139 Disposal/non-payment of the annual fee