DE2651979C2 - 9-Phenyl-3,7-dimethyl-2,4,6,8-nonatetraenverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung - Google Patents

9-Phenyl-3,7-dimethyl-2,4,6,8-nonatetraenverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung

Info

Publication number
DE2651979C2
DE2651979C2 DE2651979A DE2651979A DE2651979C2 DE 2651979 C2 DE2651979 C2 DE 2651979C2 DE 2651979 A DE2651979 A DE 2651979A DE 2651979 A DE2651979 A DE 2651979A DE 2651979 C2 DE2651979 C2 DE 2651979C2
Authority
DE
Germany
Prior art keywords
methoxy
fluoro
trimethylphenyl
dimethyl
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2651979A
Other languages
German (de)
English (en)
Other versions
DE2651979A1 (de
Inventor
Ka-Kong Hopatcong N.J. Chan
Beverly Ann Montclair N.J. Pawson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE2651979A1 publication Critical patent/DE2651979A1/de
Application granted granted Critical
Publication of DE2651979C2 publication Critical patent/DE2651979C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/26—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydration of carbon-to-carbon triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/31—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with compounds containing mercury atoms, which may be regenerated in situ, e.g. by oxygen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE2651979A 1975-11-14 1976-11-15 9-Phenyl-3,7-dimethyl-2,4,6,8-nonatetraenverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung Expired DE2651979C2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63202875A 1975-11-14 1975-11-14
US72293976A 1976-09-13 1976-09-13

Publications (2)

Publication Number Publication Date
DE2651979A1 DE2651979A1 (de) 1977-05-26
DE2651979C2 true DE2651979C2 (de) 1985-10-31

Family

ID=27091530

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2651979A Expired DE2651979C2 (de) 1975-11-14 1976-11-15 9-Phenyl-3,7-dimethyl-2,4,6,8-nonatetraenverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung

Country Status (5)

Country Link
JP (1) JPS5265239A (enExample)
CH (1) CH624373A5 (enExample)
DE (1) DE2651979C2 (enExample)
FR (1) FR2331331A1 (enExample)
GB (1) GB1563732A (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4171318A (en) * 1978-08-24 1979-10-16 Hoffmann-La Roche Inc. Fluorinated polyenes
US4335248A (en) 1975-11-14 1982-06-15 Hoffmann-La Roche Inc. Fluorinated polyenes
US4299995A (en) 1979-05-10 1981-11-10 Hoffmann-La Roche Inc. Fluorinated polyenes
US4231944A (en) 1975-11-14 1980-11-04 Hoffmann-La Roche Inc. Fluorinated polyenes
US4395575A (en) 1975-11-14 1983-07-26 Hoffmann-La Roche, Inc. 5(Halophenyl)-2-fluoro-pentadienals
US4200647A (en) * 1977-12-21 1980-04-29 Hoffmann-La Roche Inc. Vitamin A compositions to treat rheumatic disease
CH651007A5 (de) * 1982-06-24 1985-08-30 Hoffmann La Roche Polyenverbindungen.
FR2590259B1 (fr) * 1985-11-20 1989-05-12 Roussel Uclaf Procede de preparation de derives fluores de l'acide phosphonique, et produits obtenus par la mise en oeuvre de ce procede

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH585166A5 (enExample) * 1973-03-30 1977-02-28 Hoffmann La Roche

Also Published As

Publication number Publication date
FR2331331B1 (enExample) 1979-06-29
FR2331331A1 (fr) 1977-06-10
JPS5265239A (en) 1977-05-30
CH624373A5 (en) 1981-07-31
JPS6160062B2 (enExample) 1986-12-19
DE2651979A1 (de) 1977-05-26
GB1563732A (en) 1980-03-26

Similar Documents

Publication Publication Date Title
DE69415445T2 (de) Zytotoxische Stilben-Derivate und diese enthaltende pharmazeutische Zusammensetzungen
DE2414619C2 (de) 9-Phenyl-3,7-dimethyl-2,4,6,8-tetraenverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel
EP0315071A2 (de) Neue Benzocyclohepten-Derivate, deren Herstellung und Verwendung für Pharmazeutika
DE3726806A1 (de) Arylphosphorderivate, ihre herstellung und verwendung
DE2440606A1 (de) Polyenverbindungen
DE2437607A1 (de) Polyenverbindungen
DE2651979C2 (de) 9-Phenyl-3,7-dimethyl-2,4,6,8-nonatetraenverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung
DE3434245A1 (de) 7-oxabicycloheptan-substituierte-prostaglandin-phenyl-carbonsaeure-derivate und ihre verwendung
DE2542612C2 (enExample)
DE2756652C2 (enExample)
DE2440525A1 (de) Polyenverbindungen
EP0519291B1 (de) Aminomethyl-substituierte 2,3-Dihydropyrano(2,3-b)pyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
EP0111124A1 (de) Polyenverbindungen, ihre Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
DE2651968C2 (enExample)
DE2929760C2 (enExample)
DE3002545A1 (de) 5-amino-tetrazol-derivate von retinsaeuren, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
EP0533056A2 (de) Substituierte Aminopropane, Verfahren zu ihrer Herstellung und ihre Verwendung als Antimykutiku
DE2039426C3 (de) 1-Benzyliden-indenyl-(3)-essigsäuren, deren nicht-toxische, pharmakologisch verträgliche Salze, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
AT392780B (de) Verfahren zur herstellung von neuen saeurederivaten
DE68905361T2 (de) Trienische Derivate mit chromenischer Struktur, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen.
DE3606431A1 (de) Thiabicycloheptan-substituierte aminoprostaglandin-analoge
EP0056617B1 (de) Cycloheptenderivate, Verfahren und Zwischenprodukte für ihre Herstellung, sowie diese enthaltende Arzneimittel
DD201590A5 (de) Verfahren zur herstellung von neuen heterocyclischen verbindungen
EP0023593B1 (de) Dihydronicotinsäurederivate und deren Herstellung sowie Verwendung
EP0056616B1 (de) Cycloheptenderivate, Verfahren zu ihrer Herstellung, sowie diese enthaltende Arzneimittel

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: C07C 69/734

D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: F. HOFFMANN-LA ROCHE AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: LEDERER, F., DIPL.-CHEM. DR., 8000 MUENCHEN RIEDERER FRHR. VON PAAR ZU SCHOENAU, A., DIPL.-ING., PAT.-ANWAELTE, 8300 LANDSHUT

8339 Ceased/non-payment of the annual fee