DE2616724C3 - Hydroxylalkylamide von Hydroxyphenylalaninen, ein Verfahren zu ihrer Herstellung und deren Verwendung - Google Patents

Hydroxylalkylamide von Hydroxyphenylalaninen, ein Verfahren zu ihrer Herstellung und deren Verwendung

Info

Publication number
DE2616724C3
DE2616724C3 DE2616724A DE2616724A DE2616724C3 DE 2616724 C3 DE2616724 C3 DE 2616724C3 DE 2616724 A DE2616724 A DE 2616724A DE 2616724 A DE2616724 A DE 2616724A DE 2616724 C3 DE2616724 C3 DE 2616724C3
Authority
DE
Germany
Prior art keywords
preparation
solution
water
hydroxyphenylalanines
hydroxylalkylamides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2616724A
Other languages
German (de)
English (en)
Other versions
DE2616724A1 (de
DE2616724B2 (de
Inventor
Hans-Georg Dr.Rer.Nat. 8132 Tutzing Batz
Hans-Ralf Dr.Phil. Nat. 8121 Wielenbach Linke
Klaus Dr.Rer.Nat. 8131 Bernried Stellner
Guenter Dr.Rer.Nat. 8132 Tutzing Weimann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Priority to DE2616724A priority Critical patent/DE2616724C3/de
Priority to DE19762659837 priority patent/DE2659837A1/de
Priority to FI770339A priority patent/FI66593C/fi
Priority to IT1999377A priority patent/IT1086281B/it
Priority to NL7701293A priority patent/NL7701293A/xx
Priority to AT172377A priority patent/AT348988B/de
Priority to SE7703207A priority patent/SE427749B/xx
Priority to US05/782,868 priority patent/US4202873A/en
Priority to FR7710079A priority patent/FR2348191A1/fr
Priority to BE176432A priority patent/BE853257A/xx
Priority to CH451577A priority patent/CH628876A5/de
Priority to GB15303/77A priority patent/GB1523845A/en
Priority to JP4343277A priority patent/JPS52128349A/ja
Publication of DE2616724A1 publication Critical patent/DE2616724A1/de
Priority to AT371178A priority patent/AT356824B/de
Publication of DE2616724B2 publication Critical patent/DE2616724B2/de
Application granted granted Critical
Publication of DE2616724C3 publication Critical patent/DE2616724C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE2616724A 1976-04-15 1976-04-15 Hydroxylalkylamide von Hydroxyphenylalaninen, ein Verfahren zu ihrer Herstellung und deren Verwendung Expired DE2616724C3 (de)

Priority Applications (14)

Application Number Priority Date Filing Date Title
DE2616724A DE2616724C3 (de) 1976-04-15 1976-04-15 Hydroxylalkylamide von Hydroxyphenylalaninen, ein Verfahren zu ihrer Herstellung und deren Verwendung
DE19762659837 DE2659837A1 (de) 1976-04-15 1976-04-15 Alkylolamide jodierbarer aminosaeuren, ein verfahren zu ihrer herstellung und deren verwendung
FI770339A FI66593C (fi) 1976-04-15 1977-01-31 N'-(hydroxialkyl)- och n'-(dihydroxialkyl)amider av hydroxifenyl- och dihydroxifenylalanin som kan anvaendas foer framstaellning av reagenser maerkta med jod och foerfarande foer framstaellning av dessa
IT1999377A IT1086281B (it) 1976-04-15 1977-02-04 Alchilolamidi di aminoacidi iodurabili,processo per la loro preparazione e loro impiego
NL7701293A NL7701293A (nl) 1976-04-15 1977-02-08 Alkylolamiden van jodeerbare aminozuren en werk- wijze voor hun bereiding.
AT172377A AT348988B (de) 1976-04-15 1977-03-14 Verfahren zur herstellung von neuen alkylol- amiden jodierbarer aminosaeuren
SE7703207A SE427749B (sv) 1976-04-15 1977-03-21 Alkylolamider av joderbara aminosyror for framstellning av lett joderbara sparemnes-substanser
US05/782,868 US4202873A (en) 1976-04-15 1977-03-30 Alkylolamides of iodizable amino acids and immune test reagents containing them
FR7710079A FR2348191A1 (fr) 1976-04-15 1977-04-04 Alkylolamides d'aminoacides iodables, procede pour les obtenir et leur application
BE176432A BE853257A (fr) 1976-04-15 1977-04-05 Alkylolamides d'amino-acides iodables procede pour les obtenir et leurapplication
CH451577A CH628876A5 (de) 1976-04-15 1977-04-12 Verfahren zur herstellung neuer alkylolamide jodierbarer aminosaeuren und deren verwendung.
GB15303/77A GB1523845A (en) 1976-04-15 1977-04-13 Alkylolamides of iodisable amino acids a process for theirpreparation and their use
JP4343277A JPS52128349A (en) 1976-04-15 1977-04-15 Alkylolamide of iodizable amino acid and production thereof
AT371178A AT356824B (de) 1976-04-15 1978-05-22 Verfahren zur herstellung von jodierbaren bindungsanalogstoffen fuer radioimmunologische versuche

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19762659837 DE2659837A1 (de) 1976-04-15 1976-04-15 Alkylolamide jodierbarer aminosaeuren, ein verfahren zu ihrer herstellung und deren verwendung
DE2616724A DE2616724C3 (de) 1976-04-15 1976-04-15 Hydroxylalkylamide von Hydroxyphenylalaninen, ein Verfahren zu ihrer Herstellung und deren Verwendung

Publications (3)

Publication Number Publication Date
DE2616724A1 DE2616724A1 (de) 1977-10-20
DE2616724B2 DE2616724B2 (de) 1979-02-15
DE2616724C3 true DE2616724C3 (de) 1979-10-04

Family

ID=25770350

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2616724A Expired DE2616724C3 (de) 1976-04-15 1976-04-15 Hydroxylalkylamide von Hydroxyphenylalaninen, ein Verfahren zu ihrer Herstellung und deren Verwendung
DE19762659837 Pending DE2659837A1 (de) 1976-04-15 1976-04-15 Alkylolamide jodierbarer aminosaeuren, ein verfahren zu ihrer herstellung und deren verwendung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19762659837 Pending DE2659837A1 (de) 1976-04-15 1976-04-15 Alkylolamide jodierbarer aminosaeuren, ein verfahren zu ihrer herstellung und deren verwendung

Country Status (9)

Country Link
US (1) US4202873A (enExample)
JP (1) JPS52128349A (enExample)
AT (1) AT348988B (enExample)
BE (1) BE853257A (enExample)
CH (1) CH628876A5 (enExample)
DE (2) DE2616724C3 (enExample)
FR (1) FR2348191A1 (enExample)
GB (1) GB1523845A (enExample)
NL (1) NL7701293A (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654451B1 (en) * 1993-01-14 2000-02-22 Magainin Pharma Amino acids and peptides having modified c-terminals and modified n-terminals
BRPI0608330A2 (pt) 2005-05-05 2009-12-29 Acergy France Sa rebocamento e instalação submarina de artigos compridos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3189646A (en) * 1962-04-26 1965-06-15 Coastal Interchemical Company Process for the preparation of n-methylol amide derivatives
US3763234A (en) * 1970-12-03 1973-10-02 Halcon International Inc Preparation of amides
US3714249A (en) * 1971-01-22 1973-01-30 Sun Oil Co Hydroxyalkylaminoalkylamides and their preparation

Also Published As

Publication number Publication date
US4202873A (en) 1980-05-13
FR2348191B1 (enExample) 1980-02-15
FR2348191A1 (fr) 1977-11-10
CH628876A5 (de) 1982-03-31
AT348988B (de) 1979-03-12
BE853257A (fr) 1977-10-05
DE2659837A1 (de) 1977-10-20
ATA172377A (de) 1978-08-15
GB1523845A (en) 1978-09-06
DE2616724A1 (de) 1977-10-20
DE2616724B2 (de) 1979-02-15
JPS52128349A (en) 1977-10-27
NL7701293A (nl) 1977-10-18
JPS5715102B2 (enExample) 1982-03-29

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee