DE3787958T2 - Abkömmlinge von (trans)- und 13-(cis)-Retionsäure sowie Verfahren zur Herstellung derselben. - Google Patents

Abkömmlinge von (trans)- und 13-(cis)-Retionsäure sowie Verfahren zur Herstellung derselben.

Info

Publication number
DE3787958T2
DE3787958T2 DE87904165T DE3787958T DE3787958T2 DE 3787958 T2 DE3787958 T2 DE 3787958T2 DE 87904165 T DE87904165 T DE 87904165T DE 3787958 T DE3787958 T DE 3787958T DE 3787958 T2 DE3787958 T2 DE 3787958T2
Authority
DE
Germany
Prior art keywords
descendants
cis
trans
production
retionic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE87904165T
Other languages
English (en)
Other versions
DE3787958D1 (de
Inventor
Hector Deluca
Andrzej Kutner
Heinrich Schnoes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wisconsin Alumni Research Foundation
Original Assignee
Wisconsin Alumni Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Application granted granted Critical
Publication of DE3787958D1 publication Critical patent/DE3787958D1/de
Publication of DE3787958T2 publication Critical patent/DE3787958T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE87904165T 1986-06-02 1987-06-01 Abkömmlinge von (trans)- und 13-(cis)-Retionsäure sowie Verfahren zur Herstellung derselben. Expired - Fee Related DE3787958T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/869,791 US4757140A (en) 1986-06-02 1986-06-02 Coenzyme a derivatives of all-trans- and 13-cis retionic acid

Publications (2)

Publication Number Publication Date
DE3787958D1 DE3787958D1 (de) 1993-12-02
DE3787958T2 true DE3787958T2 (de) 1994-02-17

Family

ID=25354273

Family Applications (1)

Application Number Title Priority Date Filing Date
DE87904165T Expired - Fee Related DE3787958T2 (de) 1986-06-02 1987-06-01 Abkömmlinge von (trans)- und 13-(cis)-Retionsäure sowie Verfahren zur Herstellung derselben.

Country Status (5)

Country Link
US (1) US4757140A (de)
EP (1) EP0271552B1 (de)
JP (1) JPH0651716B2 (de)
DE (1) DE3787958T2 (de)
WO (1) WO1987007604A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968940A (en) * 1995-06-08 1999-10-19 Institute Of Materia Medica Retinoids and methods of use of same
JP2001512484A (ja) * 1997-02-21 2001-08-21 ブリストル−マイヤーズ・スクイブ・カンパニー 虚血損傷を予防または軽減するためのレチノイド似活性を有する置換（５，６）−ジヒドロナフタレニル化合物の用途
US5880292A (en) * 1997-09-11 1999-03-09 Wisconsin Alumni Research Foundation All-trans-retinol metabolite
EP1046630B1 (de) * 1999-04-23 2003-03-19 Nikken Chemicals Company, Limited Verfahren zur Reinigung von 3,7,11,15-Tetramethyl-2,4,6,10,14-hexadecapentaenonsäure
DE60142038D1 (de) * 2000-04-24 2010-06-17 Kowa Co Aktivatoren des peroxisome proliferator-activated rezeptors
ATE381920T1 (de) * 2001-01-16 2008-01-15 Enprani Co Ltd Retinolderivate und verfahren zu deren herstellung
WO2003097034A1 (fr) * 2002-05-17 2003-11-27 Nikken Chemicals Co., Ltd. Inhibiteurs de l'expression du tgf-$g(a)
JP4398862B2 (ja) * 2002-08-20 2010-01-13 興和株式会社 軟カプセル剤
JP5156890B2 (ja) * 2002-09-11 2013-03-06 独立行政法人物質・材料研究機構 高分子架橋体及びその製造方法
US8404667B2 (en) 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2128314A1 (de) * 1970-06-26 1972-01-05 Ciba-Geigy Ag, Basel (Schweiz) Terpenoide Verbindungen, ihre Herstellung und ihre Verwendung zur Beeinflussung der Entwicklung von Insekten und Vertretern der Ordnung Akarina
US4108880A (en) * 1975-11-03 1978-08-22 Johnson & Johnson Esters of retinoic acid
US4190594A (en) * 1975-11-03 1980-02-26 Johnson & Johnson Retinoic acid derivatives
US4055659A (en) * 1975-11-03 1977-10-25 Johnson & Johnson Retinoic acid derivatives
US4207315A (en) * 1976-10-20 1980-06-10 University Patents, Inc. Process for treating proliferative skin diseases using certain diamino compounds
DE3002545A1 (de) * 1980-01-25 1981-07-30 Basf Ag, 6700 Ludwigshafen 5-amino-tetrazol-derivate von retinsaeuren, ihre herstellung und diese enthaltende pharmazeutische zubereitungen
US4568757A (en) * 1984-01-30 1986-02-04 Research Triangle Institute Configurationally locked retinoids

Also Published As

Publication number Publication date
EP0271552B1 (de) 1993-10-27
JPH0651716B2 (ja) 1994-07-06
DE3787958D1 (de) 1993-12-02
WO1987007604A1 (en) 1987-12-17
JPH01500190A (ja) 1989-01-26
EP0271552A1 (de) 1988-06-22
US4757140A (en) 1988-07-12
EP0271552A4 (de) 1990-02-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee