DE2601372C3 - Verfahren zur Bestimmung von Antithrombin III - Google Patents

Verfahren zur Bestimmung von Antithrombin III

Info

Publication number
DE2601372C3
DE2601372C3 DE2601372A DE2601372A DE2601372C3 DE 2601372 C3 DE2601372 C3 DE 2601372C3 DE 2601372 A DE2601372 A DE 2601372A DE 2601372 A DE2601372 A DE 2601372A DE 2601372 C3 DE2601372 C3 DE 2601372C3
Authority
DE
Germany
Prior art keywords
thrombin
iii
determination
solution
heparin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2601372A
Other languages
German (de)
English (en)
Other versions
DE2601372A1 (de
DE2601372B2 (de
Inventor
Norbert Dr. Heimburger
Hermann E. Dr. Karges
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Priority to DE2601372A priority Critical patent/DE2601372C3/de
Priority to US05/694,815 priority patent/US4106990A/en
Priority to CA257,534A priority patent/CA1079166A/en
Priority to CH36277A priority patent/CH626919A5/de
Priority to AU21292/77A priority patent/AU515025B2/en
Priority to ZA770210A priority patent/ZA77210B/xx
Priority to DK15077A priority patent/DK15077A/da
Priority to JP52002521A priority patent/JPS6033480B2/ja
Priority to GB1568/77A priority patent/GB1569392A/en
Priority to ES455030A priority patent/ES455030A1/es
Priority to AT18877A priority patent/AT350193B/de
Priority to FR7701173A priority patent/FR2338496A1/fr
Priority to BE174134A priority patent/BE850453A/xx
Publication of DE2601372A1 publication Critical patent/DE2601372A1/de
Publication of DE2601372B2 publication Critical patent/DE2601372B2/de
Application granted granted Critical
Publication of DE2601372C3 publication Critical patent/DE2601372C3/de
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G01N2333/8128—Antithrombin III
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974—Thrombin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
    • G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE2601372A 1976-01-15 1976-01-15 Verfahren zur Bestimmung von Antithrombin III Expired DE2601372C3 (de)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DE2601372A DE2601372C3 (de) 1976-01-15 1976-01-15 Verfahren zur Bestimmung von Antithrombin III
US05/694,815 US4106990A (en) 1976-01-15 1976-06-10 Quantitative determination of antithrombin III
CA257,534A CA1079166A (en) 1976-01-15 1976-07-22 Process for the quantitative determination of antithrombin iii
CH36277A CH626919A5 (enExample) 1976-01-15 1977-01-12
AU21292/77A AU515025B2 (en) 1976-01-15 1977-01-13 Determination of antithrombin iii
DK15077A DK15077A (da) 1976-01-15 1977-01-14 Fremgangsmade til kvantitativ bestemmelse af antithrombin iii
ZA770210A ZA77210B (en) 1976-01-15 1977-01-14 Process for the quantitative determination of antithrombin iii
JP52002521A JPS6033480B2 (ja) 1976-01-15 1977-01-14 アンチトロンビン３の定量測定方法
GB1568/77A GB1569392A (en) 1976-01-15 1977-01-14 Method and reagent for the determin. of antithrombin iii
ES455030A ES455030A1 (es) 1976-01-15 1977-01-14 Procedimiento para la determinacion cuantitativa de anti- trombina iii en plasma o suero.
AT18877A AT350193B (de) 1976-01-15 1977-01-14 Verfahren und mittel zur bestimmung von antithrombin iii
FR7701173A FR2338496A1 (fr) 1976-01-15 1977-01-17 Procede de dosage quantitatif de l'antithrombine iii
BE174134A BE850453A (fr) 1976-01-15 1977-01-17 Procede de dosage quantitatif de l'antithrombine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2601372A DE2601372C3 (de) 1976-01-15 1976-01-15 Verfahren zur Bestimmung von Antithrombin III

Publications (3)

Publication Number Publication Date
DE2601372A1 DE2601372A1 (de) 1977-07-28
DE2601372B2 DE2601372B2 (de) 1979-07-19
DE2601372C3 true DE2601372C3 (de) 1980-03-27

Family

ID=5967533

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2601372A Expired DE2601372C3 (de) 1976-01-15 1976-01-15 Verfahren zur Bestimmung von Antithrombin III

Country Status (13)

Country Link
US (1) US4106990A (enExample)
JP (1) JPS6033480B2 (enExample)
AT (1) AT350193B (enExample)
AU (1) AU515025B2 (enExample)
BE (1) BE850453A (enExample)
CA (1) CA1079166A (enExample)
CH (1) CH626919A5 (enExample)
DE (1) DE2601372C3 (enExample)
DK (1) DK15077A (enExample)
ES (1) ES455030A1 (enExample)
FR (1) FR2338496A1 (enExample)
GB (1) GB1569392A (enExample)
ZA (1) ZA77210B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2812943C3 (de) * 1978-03-23 1981-05-14 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma
US4302538A (en) * 1978-03-27 1981-11-24 Ortho Diagnostics Inc. Buffer system in an anti-thrombin III test
US4195072A (en) * 1978-07-05 1980-03-25 Abbott Laboratories Stabilized platelet factor 4 immunoassay standards
DE2903701C2 (de) * 1979-01-31 1980-10-16 Boehringer Mannheim Gmbh, 6800 Mannheim Kontrollreagens für die Bestimmung der Heparinaktivität
SE422081B (sv) * 1979-08-22 1982-02-15 Ird Biomaterial Ab Sett att pavisa proteolytiska enzymer
WO1982001377A1 (en) * 1980-10-09 1982-04-29 Lill Helmut Method for determining a bm-antithrombin
US5221614A (en) * 1988-03-03 1993-06-22 Nippon Shoji Kabushiki Kaisha Method and reagent for determining the biological activity of antithrombin III by measuring coagulation time
US5780255A (en) * 1995-06-09 1998-07-14 Instrumentation Laboratory, S.P.A. Protein C pathway screening test
EP1045250A1 (en) * 1999-04-12 2000-10-18 INSTRUMENTATION LABORATORY S.p.A. A global test for evaluating the functionality of the thrombin/antithrombin system
US6432658B1 (en) 2000-09-13 2002-08-13 Affinity Biologicals, Inc. Method for measuring antithrombin activity
JP6278454B2 (ja) * 2013-03-29 2018-02-14 株式会社Ｌｓｉメディエンス 生体試料中の直接トロンビン阻害薬の測定試薬及び測定方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3497319A (en) * 1966-11-02 1970-02-24 Pfizer & Co C Diagnostic reagent
US3853710A (en) * 1973-01-15 1974-12-10 Ass For Pharmacologic Res Inc Serum diagnostic test for maladies causing change in fibrinolytic activity in the blood
US3985618A (en) * 1975-05-02 1976-10-12 Irving Innerfield Method for detection of thrombosis and prethrombosis

Also Published As

Publication number Publication date
DE2601372A1 (de) 1977-07-28
AT350193B (de) 1979-05-10
JPS6033480B2 (ja) 1985-08-02
JPS5288094A (en) 1977-07-22
GB1569392A (en) 1980-06-11
ATA18877A (de) 1978-10-15
ES455030A1 (es) 1978-04-01
CH626919A5 (enExample) 1981-12-15
ZA77210B (en) 1977-12-28
DK15077A (da) 1977-07-16
AU2129277A (en) 1978-07-20
DE2601372B2 (de) 1979-07-19
FR2338496B1 (enExample) 1983-01-28
FR2338496A1 (fr) 1977-08-12
CA1079166A (en) 1980-06-10
US4106990A (en) 1978-08-15
BE850453A (fr) 1977-07-18
AU515025B2 (en) 1981-03-12

Similar Documents

Publication Publication Date Title
DE2812943C3 (de) Verfahren und Reagens zur Bestimmung der biologischen Aktivität von Heparin im Plasma
DE69919702T2 (de) Verfahren zur Bestimmung der Blutgerinnung in Plasma
EP0137269B1 (de) Verfahren zur gleichzeitigen Bestimmung von Fibrinogen und Fibrinogen-Spaltprodukten im Plasma
DE60315151T2 (de) Diagnostischer test zur bestimmung der konzentration einer transienten proteolytischen aktivität in zusammengesetzten biologischen medien
DE2601372C3 (de) Verfahren zur Bestimmung von Antithrombin III
EP0158254A1 (de) Reagenz zur Bestimmung der Thromboplastinzeit
DE19749197A1 (de) Verfahren zur Bestimmung des antikoagulatorischen Potentials einer Probe
EP0537490A2 (de) Funktioneller Test und Reagenz zur Bestimmung von Fibrinogen
DE102005028018A1 (de) Verfahren zur Standardisierung von Gerinnungstesten
EP0656424B1 (de) Test zur Bestimmung der Empfindlichkeit gegenüber aktiviertem Protein C
DE3536903A1 (de) Verfahren zur photometrischen bestimmung von protein c
DE69013834T2 (de) Reagenz zum Nachweis und zur quantitativen Bestimmung von Leukozyten in biologischen Flüssigkeiten und Verfahren zu seiner Verwendung.
DE3430906A1 (de) Verfahren zur bestimmung von fibrinmonomer in plasma
DE69016858T2 (de) Verfahren und Reagenziensatz zur Bestimmung der funktionalen Aktivität von Protein S in menschlichem Plasma.
Ødegård et al. 2.7 Determination of Antithrombin III and Antifactor X a Activity
AT399055B (de) Verfahren zur bestimmung von fibrinogen
EP0711839B1 (de) Kalibrator zur Verwendung in Testverfahren zum Nachweis eines defekten Gerinnungsfaktors V
EP0408075B1 (de) Verfahren und Reagenz zur Bestimmung von Antithrombin III
DE69111399T2 (de) Chromogenes bestimmungsverfahren für den faktor viii:ca.
EP0445626B1 (de) Funktioneller Test zur Bestimmung der Protein S-Aktivität
DE69916816T2 (de) Verbesserter blutgerinnungstest
DE1943881C3 (de) Verfahren zur quantitativen Bestimmung der Thrombinaktivität in Blutplasma und dessen Fraktionen
EP4394045B1 (de) Verfahren zur bestimmung von fibrinogen
EP0264753A2 (de) Verfahren zur Bestimmung von Plasminogen
DE10016139A1 (de) Verfahren zur Bestimmung von löslichem Fibrin

Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)