DE2558090C2 - Verfahren zur Herstellung von 4-Androsten-3,17-dion-Derivaten - Google Patents

Verfahren zur Herstellung von 4-Androsten-3,17-dion-Derivaten

Info

Publication number
DE2558090C2
DE2558090C2 DE2558090A DE2558090A DE2558090C2 DE 2558090 C2 DE2558090 C2 DE 2558090C2 DE 2558090 A DE2558090 A DE 2558090A DE 2558090 A DE2558090 A DE 2558090A DE 2558090 C2 DE2558090 C2 DE 2558090C2
Authority
DE
Germany
Prior art keywords
androstene
dione
derivatives
preparation
cholesten
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2558090A
Other languages
German (de)
English (en)
Other versions
DE2558090A1 (de
Inventor
Ulrich Dr. Eder
Mario Dr. Kennecke
Rudolf Dr. Müller
Alfred Dr. Weber
Rudolf Prof. 1000 Berlin Wiechert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE2558090A priority Critical patent/DE2558090C2/de
Priority to CH1586176A priority patent/CH625554A5/de
Priority to DK566376A priority patent/DK139269C/da
Priority to HU76SCHE587A priority patent/HU183021B/hu
Priority to DD76204018A priority patent/DD134107A5/xx
Priority to DD7600196439A priority patent/DD129333A5/xx
Priority to BE173401A priority patent/BE849559A/xx
Priority to CS768343A priority patent/CS187347B2/cs
Priority to US05/751,677 priority patent/US4100026A/en
Priority to AT0935876A priority patent/AT367094B/de
Priority to NL7614036A priority patent/NL7614036A/xx
Priority to IE2787/76A priority patent/IE44516B1/en
Priority to JP15412876A priority patent/JPS5294495A/ja
Priority to GB53147/76A priority patent/GB1571912A/en
Priority to FR7638310A priority patent/FR2335524A1/fr
Publication of DE2558090A1 publication Critical patent/DE2558090A1/de
Priority to DK109278A priority patent/DK109278A/da
Application granted granted Critical
Publication of DE2558090C2 publication Critical patent/DE2558090C2/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0025—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/005—3 membered carbocyclic rings in position 12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/83—Arthrobacter
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/84—Brevibacterium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/863—Mycobacterium
    • Y10S435/866—Mycobacterium smegmatis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/872—Nocardia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE2558090A 1975-12-19 1975-12-19 Verfahren zur Herstellung von 4-Androsten-3,17-dion-Derivaten Expired DE2558090C2 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE2558090A DE2558090C2 (de) 1975-12-19 1975-12-19 Verfahren zur Herstellung von 4-Androsten-3,17-dion-Derivaten
DK566376A DK139269C (da) 1975-12-19 1976-12-16 Fremgangsmaade til fremstilling af 4-androsten-3,17-dionderivater
CH1586176A CH625554A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-12-19 1976-12-16
AT0935876A AT367094B (de) 1975-12-19 1976-12-17 Verfahren zur herstellung von 4-androsten-3,17dion-derivaten
DD7600196439A DD129333A5 (de) 1975-12-19 1976-12-17 Verfahren zur herstellung von 4-androsten-3,17-dion-derivaten
BE173401A BE849559A (fr) 1975-12-19 1976-12-17 Procede de preparation de derives de 4-androstane-3,17-dione, et produits obtenus
CS768343A CS187347B2 (en) 1975-12-19 1976-12-17 Method of producing derivatives of 4-androstene-3,17-dione
US05/751,677 US4100026A (en) 1975-12-19 1976-12-17 Process for the preparation of 4-androstene-3,17-dione derivatives
HU76SCHE587A HU183021B (en) 1975-12-19 1976-12-17 Process for producing 4-androstene-3,17-dione derivatives
NL7614036A NL7614036A (nl) 1975-12-19 1976-12-17 Werkwijze voor het bereiden van 4-androsteen- -3,17-dion-derivaten.
DD76204018A DD134107A5 (de) 1975-12-19 1976-12-17 Verfahren zur herstellung von 17 beta-hydroxy-4-androsten-3-on-derivaten
IE2787/76A IE44516B1 (en) 1975-12-19 1976-12-20 Process for the manufacture of 4-androstene-3-,17-dione derivatives
JP15412876A JPS5294495A (en) 1975-12-19 1976-12-20 Production of 44 androstenn3*177dione derivative
GB53147/76A GB1571912A (en) 1975-12-19 1976-12-20 Process for the manufacture of -androstene-3,17-dione derivatives
FR7638310A FR2335524A1 (fr) 1975-12-19 1976-12-20 Procede de preparation de derives de l'androstene-4 dione-3,17
DK109278A DK109278A (da) 1975-12-19 1978-03-10 Fremgangsmaade til fremstilling af 17beta-hydroxy-4-androsten-3-onderivater

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2558090A DE2558090C2 (de) 1975-12-19 1975-12-19 Verfahren zur Herstellung von 4-Androsten-3,17-dion-Derivaten

Publications (2)

Publication Number Publication Date
DE2558090A1 DE2558090A1 (de) 1977-07-07
DE2558090C2 true DE2558090C2 (de) 1985-05-30

Family

ID=5965332

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2558090A Expired DE2558090C2 (de) 1975-12-19 1975-12-19 Verfahren zur Herstellung von 4-Androsten-3,17-dion-Derivaten

Country Status (14)

Country Link
US (1) US4100026A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS5294495A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT367094B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE849559A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH625554A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (1) CS187347B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (2) DD134107A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2558090C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK139269C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2335524A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1571912A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU183021B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE44516B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL7614036A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4212940A (en) * 1978-12-19 1980-07-15 Schering Aktiengesellschaft Process for the preparation of 21-hydroxy-20-methylpregnane derivatives
AU8779898A (en) * 1997-08-11 1999-03-01 Weider Nutrition International, Inc. Compositions and treatments to reduce side effects of administration of androgenic testosterone precursors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1092145A (en) * 1964-06-02 1967-11-22 Noda Inst For Scientific Res Microbiological conversion of steroids
NL6705450A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1965-10-22 1968-10-21
US3684657A (en) * 1970-05-11 1972-08-15 Searle & Co Selective microbiological degradation of steroidal 17-alkyls
DE2046640C3 (de) * 1970-09-14 1973-10-18 Schering Ag Verfahren zur Herstellung von Delta hoch 4 -3-Oxo-l alpha-methyl·Steroiden
US3759791A (en) * 1970-12-10 1973-09-18 Searle & Co Selective microbiological preparation of androst-4-ene-3,17-dione

Also Published As

Publication number Publication date
IE44516B1 (en) 1981-12-30
NL7614036A (nl) 1977-06-21
BE849559A (fr) 1977-06-17
JPS5294495A (en) 1977-08-09
DD129333A5 (de) 1978-01-11
DD134107A5 (de) 1979-02-07
FR2335524B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-09-12
DK566376A (da) 1977-06-20
FR2335524A1 (fr) 1977-07-15
DK139269C (da) 1979-07-09
JPS615716B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1986-02-20
DK139269B (da) 1979-01-22
HU183021B (en) 1984-04-28
US4100026A (en) 1978-07-11
CS187347B2 (en) 1979-01-31
IE44516L (en) 1977-06-19
ATA935876A (de) 1981-10-15
AT367094B (de) 1982-05-25
GB1571912A (en) 1980-07-23
CH625554A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1981-09-30
DE2558090A1 (de) 1977-07-07

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
D2 Grant after examination
8364 No opposition during term of opposition
8330 Complete disclaimer