DE2556110C3 - 2-(3-Alkylamino-2-hydroxypropoxy)-3cyanpyridine, ihre Herstellung und pharmazeutische Verwendung - Google Patents

2-(3-Alkylamino-2-hydroxypropoxy)-3cyanpyridine, ihre Herstellung und pharmazeutische Verwendung

Info

Publication number
DE2556110C3
DE2556110C3 DE2556110A DE2556110A DE2556110C3 DE 2556110 C3 DE2556110 C3 DE 2556110C3 DE 2556110 A DE2556110 A DE 2556110A DE 2556110 A DE2556110 A DE 2556110A DE 2556110 C3 DE2556110 C3 DE 2556110C3
Authority
DE
Germany
Prior art keywords
hydroxypropoxy
tert
general formula
alkylamino
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2556110A
Other languages
German (de)
English (en)
Other versions
DE2556110B2 (de
DE2556110A1 (de
Inventor
John James Lansdale Pa. Baldwin (V.St.A.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE2556110A1 publication Critical patent/DE2556110A1/de
Publication of DE2556110B2 publication Critical patent/DE2556110B2/de
Application granted granted Critical
Publication of DE2556110C3 publication Critical patent/DE2556110C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE2556110A 1974-12-16 1975-12-12 2-(3-Alkylamino-2-hydroxypropoxy)-3cyanpyridine, ihre Herstellung und pharmazeutische Verwendung Expired DE2556110C3 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/533,385 US4000282A (en) 1974-12-16 1974-12-16 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
US05/713,558 US4096151A (en) 1974-12-16 1976-08-11 Certain 3-cyanopyridine intermediates

Publications (3)

Publication Number Publication Date
DE2556110A1 DE2556110A1 (de) 1976-06-24
DE2556110B2 DE2556110B2 (de) 1978-06-15
DE2556110C3 true DE2556110C3 (de) 1979-02-22

Family

ID=27064163

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2556110A Expired DE2556110C3 (de) 1974-12-16 1975-12-12 2-(3-Alkylamino-2-hydroxypropoxy)-3cyanpyridine, ihre Herstellung und pharmazeutische Verwendung
DE19752559755 Withdrawn DE2559755A1 (de) 1974-12-16 1975-12-12 Substituierte oxazolidine

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19752559755 Withdrawn DE2559755A1 (de) 1974-12-16 1975-12-12 Substituierte oxazolidine

Country Status (11)

Country Link
US (3) US4000282A (enExample)
JP (1) JPS5186473A (enExample)
AU (1) AU502129B2 (enExample)
BE (1) BE836627A (enExample)
CA (1) CA1064499A (enExample)
DE (2) DE2556110C3 (enExample)
FR (1) FR2294702A1 (enExample)
GB (2) GB1496579A (enExample)
LU (1) LU74000A1 (enExample)
NL (1) NL7514164A (enExample)
SE (1) SE7513571L (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053605A (en) * 1976-06-15 1977-10-11 Merck & Co., Inc. Esterified-2(3-lower-alkyl-amino-propoxy)-3-cyano-pyridines and derivatives
US4060601A (en) * 1976-06-15 1977-11-29 Merck & Co., Inc. Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines
US4091104A (en) * 1976-06-15 1978-05-23 Merck & Co., Inc. Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use
US4144343A (en) * 1978-01-04 1979-03-13 Merck & Co., Inc. Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines
US4279913A (en) * 1978-01-04 1981-07-21 Merck & Co., Inc. Polysubstituted-2-(3-loweralkylamino-2-R1 O-propoxy)pyridines
JPS54106476A (en) * 1978-01-04 1979-08-21 Merck & Co Inc Multiisubstituted 22*33lower alkylaminoo22 r100propoxy*pyridine
US4294966A (en) * 1978-07-28 1981-10-13 Ciba-Geigy Corporation Process for inverting the configuration in optically active compounds
US4294969A (en) * 1979-01-29 1981-10-13 Merck & Co., Inc. Process for producing 2-bromo-3,5-disubstituted pyridines
US4393212A (en) * 1979-01-29 1983-07-12 Merck & Co., Inc. Certain nicotinic acid esters and corresponding nicotinonitriles
US4234590A (en) * 1979-02-05 1980-11-18 Merck & Co., Inc. Thiosubstituted pyridines
US4259327A (en) * 1979-04-02 1981-03-31 Merck & Co., Inc. Substituted aminoalkoxypyridines, compositions and use thereof
US4329351A (en) * 1979-10-01 1982-05-11 Merck & Co., Inc. 2-Substituted propoxy-3-cyano-5-RO-pyridines and intermediates
DE2943774A1 (de) * 1979-10-26 1981-05-14 1000 Berlin Schering Ag Berlin Und Bergkamen Substituierte pyridine, verfahren zu ihrer herstellung und ihre verwendung
US4254263A (en) * 1979-11-02 1981-03-03 Merck & Co., Inc. Process for purifying a cyanopyridine compound
US4349673A (en) * 1980-12-23 1982-09-14 Merck & Co., Inc. Benzoxazines
US4656168A (en) * 1980-12-23 1987-04-07 Merck & Co., Inc. (3-aralkylamino-2-or-propoxy)heterocyclic compounds in method of effecting bronchodilation
US4331679A (en) * 1980-12-23 1982-05-25 Merck Sharp & Dohme (I.A.) Corp. (3-Aralkylamino-2-or-propoxy) heterocyclic compounds
US4442094A (en) * 1980-12-23 1984-04-10 Merck & Co., Inc. (3-Aralkylamino-2-or-propoxy)heterocyclic compounds
US4436740A (en) 1982-07-26 1984-03-13 Merck & Co., Inc. 3-Cycloalkylamino-2-OR-propoxycyanopyridines
US4550117A (en) * 1982-07-26 1985-10-29 Merck & Co., Inc. 3-Cycloalkylamino-2-OR-propoxycyanopyridines, derivatives thereof, having anti-hypertensive activity
ES523901A0 (es) * 1983-07-06 1985-04-01 Fabr Prod Quimicos Y Farmaceut Un procedimiento para la preparacion de derivados de 3-sulfonamidopiridinas 2 -sustituidas.
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
US20110305751A1 (en) 2009-02-20 2011-12-15 To-Bbb Holding B.V. Glutathione-based drug delivery system
AU2010245823B2 (en) 2009-05-06 2016-11-24 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459782A (en) * 1963-08-26 1969-08-05 Boehringer Sohn Ingelheim 1-substituted phenoxy-2-hydroxy-3-isopropylamino-propanes
DE1919342A1 (de) 1969-04-16 1970-12-03 Boehringer Sohn Ingelheim Herzwirksame Kombinationspraeparate
AR208397A1 (es) * 1973-02-20 1976-12-27 Ciba Geigy Ag Procedimiento para la elaboracion de compuestos de 1-piridiloxi-2-hidroxi-3-amino-propano1-piraziniloxi-2-hidroxi-3-amino-propano y 1-pirimidiniloxi-2-hidroxi-3-amino-propan
JPS5839832B2 (ja) * 1974-02-20 1983-09-01 チバ ガイギ− アクチエンゲゼルシヤフト 新規ピラジン化合物の製法
US4060601A (en) * 1976-06-15 1977-11-29 Merck & Co., Inc. Certain lower-alkyl amino-2'-hydroxy-propoxy pyridines
US4053605A (en) * 1976-06-15 1977-10-11 Merck & Co., Inc. Esterified-2(3-lower-alkyl-amino-propoxy)-3-cyano-pyridines and derivatives

Also Published As

Publication number Publication date
US4000282A (en) 1976-12-28
BE836627A (fr) 1976-06-15
AU8743675A (en) 1977-06-16
FR2294702B1 (enExample) 1979-09-28
NL7514164A (nl) 1976-06-18
CA1064499A (en) 1979-10-16
DE2559755A1 (de) 1977-11-03
DE2556110B2 (de) 1978-06-15
GB1496579A (en) 1977-12-30
DE2556110A1 (de) 1976-06-24
JPS5186473A (enExample) 1976-07-29
GB1496580A (en) 1977-12-30
US4096151A (en) 1978-06-20
AU502129B2 (en) 1979-07-12
SE7513571L (sv) 1976-06-17
LU74000A1 (enExample) 1976-11-11
US4139535A (en) 1979-02-13
FR2294702A1 (fr) 1976-07-16

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
8339 Ceased/non-payment of the annual fee