DE2545330A1 - Sulfonylpiperazine - Google Patents
SulfonylpiperazineInfo
- Publication number
- DE2545330A1 DE2545330A1 DE19752545330 DE2545330A DE2545330A1 DE 2545330 A1 DE2545330 A1 DE 2545330A1 DE 19752545330 DE19752545330 DE 19752545330 DE 2545330 A DE2545330 A DE 2545330A DE 2545330 A1 DE2545330 A1 DE 2545330A1
- Authority
- DE
- Germany
- Prior art keywords
- chloride
- piperazine
- formula
- stage
- sulfonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- ZECNLXUZYQZMAL-UHFFFAOYSA-N 2-sulfonylpiperazine Chemical compound O=S(=O)=C1CNCCN1 ZECNLXUZYQZMAL-UHFFFAOYSA-N 0.000 title claims description 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 5
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 2
- 150000004885 piperazines Chemical class 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- FXLVCHSCGBTGPL-UHFFFAOYSA-N 1-benzylsulfonylpiperazine Chemical compound C1CNCCN1S(=O)(=O)CC1=CC=CC=C1 FXLVCHSCGBTGPL-UHFFFAOYSA-N 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000001078 anti-cholinergic effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000002057 chronotropic effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000000297 inotrophic effect Effects 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000001129 nonadrenergic effect Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000816 toxic dose Toxicity 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES434834A ES434834A1 (es) | 1975-02-18 | 1975-02-18 | Procedimiento de obtencion de sulfonil piperazinas. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2545330A1 true DE2545330A1 (de) | 1976-08-26 |
Family
ID=8468653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19752545330 Pending DE2545330A1 (de) | 1975-02-18 | 1975-10-09 | Sulfonylpiperazine |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS51108078A (enrdf_load_html_response) |
| CH (1) | CH605876A5 (enrdf_load_html_response) |
| DE (1) | DE2545330A1 (enrdf_load_html_response) |
| ES (1) | ES434834A1 (enrdf_load_html_response) |
| FR (1) | FR2301255A1 (enrdf_load_html_response) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4871843A (en) * | 1983-10-18 | 1989-10-03 | Dropic-Societe Civile De Gestion De Droits De Propriete Industrielle | Cyclic benzenesulfonamides, process for their preparation and their use as active substance of pharmaceutical compositions |
| FR2553414B1 (fr) * | 1983-10-18 | 1986-08-14 | Choay Sa | Nouveaux benzenesulfonamides n-cyclises, leur procede de preparation et leur utilisation comme substance active de compositions pharmaceutiques |
-
1975
- 1975-02-18 ES ES434834A patent/ES434834A1/es not_active Expired
- 1975-10-02 FR FR7530225A patent/FR2301255A1/fr active Granted
- 1975-10-09 DE DE19752545330 patent/DE2545330A1/de active Pending
- 1975-10-20 CH CH1358775A patent/CH605876A5/xx not_active IP Right Cessation
-
1976
- 1976-02-16 JP JP51015006A patent/JPS51108078A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CH605876A5 (enrdf_load_html_response) | 1978-10-13 |
| JPS51108078A (enrdf_load_html_response) | 1976-09-25 |
| FR2301255A1 (fr) | 1976-09-17 |
| ES434834A1 (es) | 1976-12-01 |
| FR2301255B1 (enrdf_load_html_response) | 1980-06-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHN | Withdrawal |