DE2522369C2 - - Google Patents

Info

Publication number
DE2522369C2
DE2522369C2 DE19752522369 DE2522369A DE2522369C2 DE 2522369 C2 DE2522369 C2 DE 2522369C2 DE 19752522369 DE19752522369 DE 19752522369 DE 2522369 A DE2522369 A DE 2522369A DE 2522369 C2 DE2522369 C2 DE 2522369C2
Authority
DE
Germany
Prior art keywords
fluorouracil
reaction
product
derivatives
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE19752522369
Other languages
German (de)
English (en)
Other versions
DE2522369A1 (de
Inventor
Madayasu Osaka Jp Kurono
Takeshi Takatsuki Jp Chiba
Setsuro Tokushima Jp Fujii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FUJII, SETSURO, KYOTO, JP
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19752522369 priority Critical patent/DE2522369A1/de
Publication of DE2522369A1 publication Critical patent/DE2522369A1/de
Application granted granted Critical
Publication of DE2522369C2 publication Critical patent/DE2522369C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19752522369 1975-05-21 1975-05-21 5-fluoruracilderivate und verfahren zu ihrer herstellung Granted DE2522369A1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19752522369 DE2522369A1 (de) 1975-05-21 1975-05-21 5-fluoruracilderivate und verfahren zu ihrer herstellung

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752522369 DE2522369A1 (de) 1975-05-21 1975-05-21 5-fluoruracilderivate und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
DE2522369A1 DE2522369A1 (de) 1976-12-02
DE2522369C2 true DE2522369C2 (pt) 1988-11-17

Family

ID=5947010

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19752522369 Granted DE2522369A1 (de) 1975-05-21 1975-05-21 5-fluoruracilderivate und verfahren zu ihrer herstellung

Country Status (1)

Country Link
DE (1) DE2522369A1 (pt)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001452A1 (en) * 1990-07-19 1992-02-06 The Wellcome Foundation Limited Enzyme inactivators
US5643913A (en) * 1990-07-19 1997-07-01 Glaxo Wellcome Inc. Pharmaceutical compositions of 5-substituted uracil compounds
US5817664A (en) * 1990-09-26 1998-10-06 Glaxo Wellcome Inc. Uracil reductase inactivators

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992001452A1 (en) * 1990-07-19 1992-02-06 The Wellcome Foundation Limited Enzyme inactivators
EP0711555A2 (en) * 1990-07-19 1996-05-15 The Wellcome Foundation Limited Enzyme inactivators
EP0711555A3 (pt) * 1990-07-19 1996-06-26 Wellcome Found
US5643913A (en) * 1990-07-19 1997-07-01 Glaxo Wellcome Inc. Pharmaceutical compositions of 5-substituted uracil compounds
US6177436B1 (en) 1990-07-19 2001-01-23 Glaxo Wellcome Inc. Pharmaceutical compositions of 5-alkynyl uracil compounds
US6221852B1 (en) 1990-07-19 2001-04-24 Glaxo Wellcome Inc. Pharmaceutical compositions of 5-alkynyl-dideoxyribouracil
US5817664A (en) * 1990-09-26 1998-10-06 Glaxo Wellcome Inc. Uracil reductase inactivators
US6268374B1 (en) 1990-09-26 2001-07-31 Glaxo Wellcome Inc. Uracil reductase inactivators
US6297223B1 (en) 1990-09-26 2001-10-02 Glaxo Wellcome Inc. Uracil reductase inactivatores
US7119096B2 (en) 1990-09-26 2006-10-10 Smithklinebeecham Corporation Uracil reductase inactivators
US7704971B2 (en) 1990-09-26 2010-04-27 Smithklinebeecham Corporation Uracil reductase inactivators

Also Published As

Publication number Publication date
DE2522369A1 (de) 1976-12-02

Similar Documents

Publication Publication Date Title
DE2105490A1 (de) Imidazolderivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
DE69307577T2 (de) Verfahren zur Herstellung eines Biphenylderivates
DE1695970C3 (de) Lincomycin-2-phosphat und Clindamycin-2-phosphat, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE2901730C2 (pt)
DE2522369C2 (pt)
DE2125112C3 (de) Verfahren zur Herstellung von 7-Halogen-7-desoxy-lincomycinen
DE60200298T2 (de) Verbessertes Verfahren zur Herstellung von non-hygroscopischem Azithromycin Dihydrat
DE3026045A1 (de) Verfahren zur herstellung von estern der polyen-makroliden und ihrer n-substituierten derivate
DD289526A5 (de) Neue chemische prozesse
DE2167180C3 (de) Methyl-7-desoxy-7(S)-methoxy-α-thiolincosaminid und Verfahren zu dessen Herstellung
DE2948142C2 (de) Verfahren zur Herstellung von 21-Acylthio-Steroiden
DE2607459A1 (de) Neue antibiotische verbindungen, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2027699B2 (de) Verfahren zur Herstellung von N-Desalkyl-lincomycin und dessen Analogen
DE1912941B2 (de) 1 -PhenyM-amino-e-methoxypridaziniumsalze
DE3390129C2 (de) Verfahren zur Herstellung von kristallinem Dl-Cystein
DE2264638C2 (de) 5'-Acetyl-2,2'-cyclocytidin-Derivate
DE2606299C2 (de) Verfahren zur Herstellung von 3-Ethoxy-11β-hydroxy-Δ3,5-pregnadien-Derivaten
DE3500029A1 (de) Anthracyclinester
DE2112778B2 (de) Verfahren zur Herstellung von 2-CyBn-S^Ae-IeITaChIOr- bzw. brombenzoesäurealkylestern
DE1618616C3 (pt)
AT269369B (de) Verfahren zur Herstellung von neuen Isoajmalinderivaten
DE2146733A1 (en) 1-(beta-d-arabinofuranosyl)-cytosine prepn - from tri-o-acyl 1-(beta-d-arabinofuranosyl)-uracil
DE2656604A1 (de) Verfahren zur herstellung von 1-(2-tetrahydrofuryl)-5-fluoruracil
DE1944789C3 (de) Verfahren zur Herstellung von 4-Chlorderivaten der Phenylformamidine und deren Salzen
DE1104951B (de) Verfahren zur Herstellung von Kondensationsprodukten der Tetracycline bzw. ihren Salzen

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8127 New person/name/address of the applicant

Owner name: FUJII, SETSURO, KYOTO, JP

D2 Grant after examination
8364 No opposition during term of opposition