DE2517219B2 - Verfahren zur gewinnung eines hypothyreoten kontrollserums, danach hergestelltes hypothreotes kontrollserum und verwendung desselben - Google Patents
Verfahren zur gewinnung eines hypothyreoten kontrollserums, danach hergestelltes hypothreotes kontrollserum und verwendung desselbenInfo
- Publication number
- DE2517219B2 DE2517219B2 DE19752517219 DE2517219A DE2517219B2 DE 2517219 B2 DE2517219 B2 DE 2517219B2 DE 19752517219 DE19752517219 DE 19752517219 DE 2517219 A DE2517219 A DE 2517219A DE 2517219 B2 DE2517219 B2 DE 2517219B2
- Authority
- DE
- Germany
- Prior art keywords
- serum
- concentration
- tbg
- binding
- tests
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 210000002966 serum Anatomy 0.000 title claims description 101
- 238000000034 method Methods 0.000 title claims description 39
- 238000012360 testing method Methods 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 10
- 239000006228 supernatant Substances 0.000 claims description 8
- 239000003610 charcoal Substances 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 210000001685 thyroid gland Anatomy 0.000 claims description 5
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 claims description 5
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 claims description 4
- 229940034208 thyroxine Drugs 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 3
- 239000002002 slurry Substances 0.000 claims description 2
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims 1
- 239000012503 blood component Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 210000004907 gland Anatomy 0.000 claims 1
- 102100028709 Thyroxine-binding globulin Human genes 0.000 description 16
- 241000282414 Homo sapiens Species 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 206010020850 Hyperthyroidism Diseases 0.000 description 6
- 239000003463 adsorbent Substances 0.000 description 6
- 239000012888 bovine serum Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 208000003532 hypothyroidism Diseases 0.000 description 6
- 241000736355 Euthyroides Species 0.000 description 5
- 230000002989 hypothyroidism Effects 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 4
- 238000009601 thyroid function test Methods 0.000 description 4
- 238000005119 centrifugation Methods 0.000 description 3
- 229940011871 estrogen Drugs 0.000 description 3
- 239000000262 estrogen Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 230000002285 radioactive effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229940035722 triiodothyronine Drugs 0.000 description 2
- 241000283707 Capra Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- KKCIOUWDFWQUBT-AWEZNQCLSA-N L-thyronine Chemical compound C1=CC(C[C@H](N)C(O)=O)=CC=C1OC1=CC=C(O)C=C1 KKCIOUWDFWQUBT-AWEZNQCLSA-N 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 108010000259 Thyroxine-Binding Globulin Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229940127234 oral contraceptive Drugs 0.000 description 1
- 239000003539 oral contraceptive agent Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000012958 reprocessing Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- 229940032953 thyroid therapy drug Drugs 0.000 description 1
- WRTMQOHKMFDUKX-UHFFFAOYSA-N triiodide Chemical compound I[I-]I WRTMQOHKMFDUKX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/106664—Blood serum or blood plasma standard or control
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Endocrinology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US473463A US3922145A (en) | 1974-05-28 | 1974-05-28 | Hypothyroid serum control |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE2517219A1 DE2517219A1 (de) | 1975-12-11 |
| DE2517219B2 true DE2517219B2 (de) | 1976-11-04 |
Family
ID=23879629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19752517219 Ceased DE2517219B2 (de) | 1974-05-28 | 1975-04-18 | Verfahren zur gewinnung eines hypothyreoten kontrollserums, danach hergestelltes hypothreotes kontrollserum und verwendung desselben |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3922145A (https=) |
| JP (1) | JPS552027B2 (https=) |
| CA (1) | CA1039185A (https=) |
| DE (1) | DE2517219B2 (https=) |
| DK (1) | DK233575A (https=) |
| FR (1) | FR2273282B1 (https=) |
| GB (1) | GB1480199A (https=) |
| IT (1) | IT1038419B (https=) |
| MX (1) | MX3040E (https=) |
| NO (1) | NO751877L (https=) |
| SE (1) | SE7506104L (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4230601A (en) * | 1978-05-03 | 1980-10-28 | Eastman Kodak Company | Calibrator composition based upon dialyzed blood serum |
| WO1983000023A1 (en) * | 1981-06-24 | 1983-01-06 | Amf Inc | Process for preparing a zero standard serum |
| US4431741A (en) * | 1981-12-17 | 1984-02-14 | Baxter Travenol Laboratories, Inc. | Hypothyroid control serum |
| JP3363342B2 (ja) * | 1997-05-14 | 2003-01-08 | 本田技研工業株式会社 | 車両用燃料タンクのベント装置 |
| JP7110360B2 (ja) | 2017-10-09 | 2022-08-01 | テルモ ビーシーティー バイオテクノロジーズ，エルエルシー | 凍結乾燥方法 |
| CN113614477B (zh) | 2019-03-14 | 2023-04-28 | 泰尔茂比司特生物技术有限公司 | 冷冻干燥装载托盘组件及系统 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3516794A (en) * | 1964-12-14 | 1970-06-23 | Squibb & Sons Inc | Apparatus and method for determining thyroid function |
| US3743482A (en) * | 1970-12-30 | 1973-07-03 | Nuclear Med Lab | Method and apparatus for determining thyroid function |
| US3775615A (en) * | 1971-07-06 | 1973-11-27 | Nuclear Med Lab | Method of determining thyroid function |
| US3776698A (en) * | 1972-01-24 | 1973-12-04 | Nuclear Med Lab | Test for thyroid hormone |
-
1974
- 1974-05-28 US US473463A patent/US3922145A/en not_active Expired - Lifetime
-
1975
- 1975-04-18 DE DE19752517219 patent/DE2517219B2/de not_active Ceased
- 1975-04-21 MX MX000428U patent/MX3040E/es unknown
- 1975-05-14 GB GB20352/75A patent/GB1480199A/en not_active Expired
- 1975-05-23 FR FR7516183A patent/FR2273282B1/fr not_active Expired
- 1975-05-23 CA CA227,609A patent/CA1039185A/en not_active Expired
- 1975-05-26 IT IT23724/75A patent/IT1038419B/it active
- 1975-05-27 NO NO751877A patent/NO751877L/no unknown
- 1975-05-27 JP JP6341675A patent/JPS552027B2/ja not_active Expired
- 1975-05-27 DK DK233575A patent/DK233575A/da unknown
- 1975-05-28 SE SE7506104A patent/SE7506104L/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1039185A (en) | 1978-09-26 |
| US3922145A (en) | 1975-11-25 |
| JPS552027B2 (https=) | 1980-01-18 |
| FR2273282B1 (https=) | 1978-02-03 |
| GB1480199A (en) | 1977-07-20 |
| DE2517219A1 (de) | 1975-12-11 |
| MX3040E (es) | 1980-03-04 |
| AU8061975A (en) | 1976-11-04 |
| DK233575A (da) | 1975-11-29 |
| IT1038419B (it) | 1979-11-20 |
| SE7506104L (sv) | 1975-12-01 |
| JPS513290A (https=) | 1976-01-12 |
| FR2273282A1 (https=) | 1975-12-26 |
| NO751877L (https=) | 1975-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2705897C3 (de) | Verfahren zur radioimmunologischen Bestimmung von cyclischem Adenosin-3', 5'-monophosphat und/oder cyclischem Guanosin-3'3'-monophosphat | |
| DE2037087B2 (de) | Verfahren zur Bestimmung von Schilddrüsenhormongehalt | |
| DE1648999A1 (de) | Verfahren zur immunochemischen Bestimmung von Antigenen und Antikoerpern | |
| DE2936307A1 (de) | Verfahren zur direkten bestimmung eines freien analyten in einer probe | |
| DE2536713A1 (de) | Verfahren zur bestimmung von vitamin-b-12 mit radioisotopen | |
| CH642852A5 (de) | Material, das zur markierung mit einem radionuklid geeignet ist, verfahren zu dessen herstellung und dessen verwendung. | |
| DE2126680A1 (de) | Carcinoembryonisches Antigen | |
| DE2264255A1 (de) | Verfahren zur bestimmung des schilddruesenhormonspiegels und kombinationspackung zur durchfuehrung des verfahrens | |
| DE2132112B2 (de) | Verfahren zur in vitro Bestimmung von Serumthyroxin | |
| DE1192367B (de) | Verfahren zur Herstellung eines immunologischen Reagens | |
| DE2517219B2 (de) | Verfahren zur gewinnung eines hypothyreoten kontrollserums, danach hergestelltes hypothreotes kontrollserum und verwendung desselben | |
| DE2234382B2 (de) | Verfahren zur in-vitro-Bestimmung einer physiologisch aktiven Substanz in einer Körperflüssigkeit | |
| DE2850950C3 (de) | Verwendung von nativem oder thermisch modifiziertem Cytochrom c als Stabilisator für ein immunochemisches Meßreagens, immunochemisches Meßreagens sowie Pufferlösung zur Probenverdünnung bei immunchemischen Meßverfahren | |
| DE2806860B2 (de) | Verfahren zur Bestimmung der Konzentration der freien Fraktion eines Hormons in einer biologischen Flüssigkeit | |
| DE2551576C3 (de) | Träger für immunochemische Messungen | |
| DE2701928A1 (de) | Radiologisches verfahren zur quantitativen bestimmung von methotrexat | |
| EP0281089B1 (de) | Verfahren zur Herstellung von Faktor VIII:C-Mangelplasma und ein so erhaltenes Mangelplasma | |
| DE2054805A1 (de) | Indirekter Hamagglutmationstest bei gleichzeitiger Adsorption heterologer Antikörper | |
| DE2539258C3 (de) | Radioimmunologisches Analyseverfahren zur Bestimmung des Gesamt-Thyroxins in einer Serumprobe | |
| CH660634A5 (de) | Verfahren zur herstellung von natuerlichem immunoadsorbens. | |
| DE2748520A1 (de) | Hepatitis b-dane-teilchen | |
| DE960579C (de) | Verfahren zur Herstellung eines in der Hitze sterilisierbaren Adrenocorticotropin-Praeparates | |
| DE2539219A1 (de) | Radioimmunologisches untersuchungsverfahren zur in-vitro-bestimmung der renin-aktivitaet und besteck zur durchfuehrung dieses verfahrens | |
| DE2703668C2 (de) | Verfahren zur Messung der Menge an Schilddrüsenhormon in einer Serumprobe | |
| DE2243237A1 (de) | Nachweis der immunreaktion gegenueber krebs |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BHV | Refusal |